MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Imanaka M et al. | Identification of phylloquinone (vitamin K1) as an unknown peak in electron capture detection gas chromatograms of pyrethroid insecticide residues. | 1996 Mar-Apr | J AOAC Int | pmid:8920143 |
Sundaram KS et al. | Vitamin K status influences brain sulfatide metabolism in young mice and rats. | 1996 | J. Nutr. | pmid:8914944 |
Stoeckel K et al. | Elimination half-life of vitamin K1 in neonates is longer than is generally assumed: implications for the prophylaxis of haemorrhaghic disease of the newborn. | 1996 | Eur. J. Clin. Pharmacol. | pmid:8866641 |
Shearer MJ et al. | Effect of warfarin on the metabolism of phylloquinone (vitamin K1):dose-response relationships in man. | 1977 | Clin Sci Mol Med | pmid:884934 |
Booth SL et al. | Dihydro-vitamin K1: primary food sources and estimated dietary intakes in the American diet. | 1996 | Lipids | pmid:8827694 |
Booth SL et al. | Plasma concentrations of dihydro-vitamin K1 following dietary intake of a hydrogenated vitamin K1-rich vegetable oil. | 1996 | Lipids | pmid:8827693 |
Loughnan PM et al. | Late onset haemorrhagic disease in premature infants who received intravenous vitamin K1. | 1996 | J Paediatr Child Health | pmid:8827551 |
Loughnan PM and McDougall PN | Does intramuscular vitamin K1 act as an unintended depot preparation? | 1996 | J Paediatr Child Health | pmid:8827545 |
Weathermon RA et al. | Comment: oral vitamin K1 to reverse warfarin activity. | 1996 Jul-Aug | Ann Pharmacother | pmid:8826584 |
Gijsbers BL et al. | Effect of food composition on vitamin K absorption in human volunteers. | 1996 | Br. J. Nutr. | pmid:8813897 |