| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Villines TC et al. | Vitamin K1 intake and coronary calcification. | 2005 | Coron. Artery Dis. | pmid:15818090 |
| Camidge R et al. | Significant effect of capecitabine on the pharmacokinetics and pharmacodynamics of warfarin in patients with cancer. | 2005 | J. Clin. Oncol. | pmid:16034047 |
| Li H et al. | Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 | Chem. Res. Toxicol. | pmid:15962942 |
| Suhara Y et al. | Method for the determination of vitamin K homologues in human plasma using high-performance liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Chem. | pmid:15679341 |
| Shimada H et al. | Inactivation and deficiency of core proteins of photosystems I and II caused by genetical phylloquinone and plastoquinone deficiency but retained lamellar structure in a T-DNA mutant of Arabidopsis. | 2005 | Plant J. | pmid:15686525 |
| Hitomi M et al. | Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo. | 2005 | Int. J. Oncol. | pmid:15703828 |
| Pereira SP et al. | Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease. | 2005 | J. Hepatol. | pmid:15710219 |
| Conway SP et al. | Vitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnover. | 2005 | Pediatrics | pmid:15867043 |
| Prynne CJ et al. | Intake and sources of phylloquinone (vitamin K(1)) in 4-year-old British children: comparison between 1950 and the 1990s. | 2005 | Public Health Nutr | pmid:15877910 |
| Giménez-Arnau AM et al. | Immediate cutaneous hypersensitivity response to phytomenadione induced by vitamin K in skin diagnostic procedure. | 2005 | Contact Derm. | pmid:15899004 |
| Erkkilä AT et al. | Determinants of plasma dihydrophylloquinone in men and women. | 2005 | Br. J. Nutr. | pmid:15975170 |
| Santabarbara S et al. | Modelling of the electron transfer reactions in Photosystem I by electron tunnelling theory: the phylloquinones bound to the PsaA and the PsaB reaction centre subunits of PS I are almost isoenergetic to the iron-sulfur cluster F(X). | 2005 | Biochim. Biophys. Acta | pmid:15975545 |
| Mimuro M et al. | The secondary electron acceptor of photosystem I in Gloeobacter violaceus PCC 7421 is menaquinone-4 that is synthesized by a unique but unknown pathway. | 2005 | FEBS Lett. | pmid:15955532 |
| Beermann W | [Ingestion of a rodenticide with subsequent prolonged coagulopathy]. | 2005 | Med. Klin. (Munich) | pmid:16010476 |
| Liu J et al. | [Level of vitamin K-dependent coagulation factors in premature infants and the influence of maternal antenatal administration of vitamin K1 on their activity]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:16412352 |
| Clarke P et al. | Vitamin K status of preterm infants with a prolonged prothrombin time. | 2005 | Acta Paediatr. | pmid:16421045 |
| Erkkilä AT et al. | Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women. | 2005 | Eur J Clin Nutr | pmid:15454972 |
| Akimoto T et al. | Viability and plasma vitamin K levels in the common bile duct-ligated rats. | 2005 | Exp. Anim. | pmid:15897625 |
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| Leonova NM et al. | [A model of the quinone-binding site of photosystem I: investigation of charge transfer complexes of phylloquinone and its derivatives with tryptophan]. | 2004 Nov-Dec | Biofizika | pmid:15612535 |
| Chambrier C et al. | Replacement of long-chain triglyceride with medium-chain triglyceride/long-chain triglyceride lipid emulsion in patients receiving long-term parenteral nutrition: effects on essential fatty acid status and plasma vitamin K1 levels. | 2004 Jan-Feb | JPEN J Parenter Enteral Nutr | pmid:14763787 |
| Kurnik D et al. | Over-the-counter vitamin K1-containing multivitamin supplements disrupt warfarin anticoagulation in vitamin K1-depleted patients. A prospective, controlled trial. | 2004 | Thromb. Haemost. | pmid:15543329 |
| Yan L et al. | Vitamin K status of older individuals in northern China is superior to that of older individuals in the UK. | 2004 | Br. J. Nutr. | pmid:15613256 |
| Duggan P et al. | Vitamin K status in patients with Crohn's disease and relationship to bone turnover. | 2004 | Am. J. Gastroenterol. | pmid:15555000 |
| Bui L et al. | Skin reaction to subcutaneous phytonadione injections. | 2004 | Am J Health Syst Pharm | pmid:15011773 |
| Santa-MarÃa I et al. | Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers. | 2004 | Biochemistry | pmid:15005624 |
| Oztopçu P et al. | Comparison of vitamins K1, K2 and K3 effects on growth of rat glioma and human glioblastoma multiforme cells in vitro. | 2004 | Acta Neurol Belg | pmid:15508263 |
| Geleijnse JM et al. | Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. | 2004 | J. Nutr. | pmid:15514282 |
| Baker RI et al. | Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis. | 2004 | Med. J. Aust. | pmid:15516194 |
| Booth SL et al. | Associations between vitamin K biochemical measures and bone mineral density in men and women. | 2004 | J. Clin. Endocrinol. Metab. | pmid:15472183 |
| Shirahata A | [Vitamin K compounds]. | 2004 | Nippon Rinsho | pmid:15658294 |
| Hadi AH et al. | Influence of plasma total antioxidant ability on lipid and protein oxidation products in plasma and erythrocyte ghost obtained from developing and adult rats pretreated with two vitamin K formulations. | 2004 | Mol. Cell. Biochem. | pmid:15663201 |
| Vogel MJ et al. | Flow-induced patterning of Langmuir monolayers. | 2004 | Langmuir | pmid:16459572 |
| Greer FR | Vitamin K in human milk--still not enough. | 2004 | Acta Paediatr. | pmid:15188967 |
| Kojima T et al. | Vitamin K concentrations in the maternal milk of Japanese women. | 2004 | Acta Paediatr. | pmid:15188971 |
| Chen JW et al. | [Analysis of vitamins and inorganic elements in the water extracts of Radix Changii]. | 2004 | Zhong Xi Yi Jie He Xue Bao | pmid:15383265 |
| Braam L et al. | Dietary phylloquinone intake as a potential marker for a heart-healthy dietary pattern in the Framingham Offspring cohort. | 2004 | J Am Diet Assoc | pmid:15354158 |
| Key N | Comparison of oral versus intravenous phytonadione in patients with excessive anticoagulation. | 2004 | Curr. Hematol. Rep. | pmid:15341696 |
| Wang LY et al. | Determination of phylloquinone (vitamin K1) in plasma and serum by HPLC with fluorescence detection. | 2004 | Clin. Chim. Acta | pmid:15313159 |
| Yang XB et al. | [Influence of liver lesions and vitamin K1 on bleeding after liver biopsy in patients with chronic renal failure]. | 2004 | Di Yi Jun Yi Da Xue Xue Bao | pmid:15257903 |
| Duggan P et al. | Phylloquinone (vitamin K1) intakes and food sources in 18-64-year-old Irish adults. | 2004 | Br. J. Nutr. | pmid:15230998 |
| Chaudhary V et al. | Effect of supplementary feeding of vitamin K1 on difethialone treated Indian gerbil, Tatera indica Hardwicke in laboratory. | 2004 | Indian J. Exp. Biol. | pmid:15233301 |
| Swartz AM et al. | On the alcohol- and water-catalyzed tautomerization of vitamins K1- and K2-derived quinone methide intermediates. | 2004 | J. Org. Chem. | pmid:15104464 |
| Biron-Andréani C et al. | Secretion of functional plasma haemostasis proteins in long-term primary cultures of human hepatocytes. | 2004 | Br. J. Haematol. | pmid:15147380 |
| Braam LA et al. | Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. | 2004 | Thromb. Haemost. | pmid:14961167 |
| Carrié I et al. | Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain. | 2004 | J. Nutr. | pmid:14704312 |
| Van Der Est A et al. | Removal of PsaF alters forward electron transfer in photosystem I: evidence for fast reoxidation of QK-A in subunit deletion mutants of Synechococcus sp. PCC 7002. | 2004 | Biochemistry | pmid:14756562 |
| Kalkwarf HJ et al. | Vitamin K, bone turnover, and bone mass in girls. | 2004 | Am. J. Clin. Nutr. | pmid:15447922 |
| Gao M et al. | Indirect identification of isoprenoid quinones in Escherichia coli by LC-MS with atmospheric pressure chemical ionization in negative mode. | 2004 | J. Basic Microbiol. | pmid:15558823 |
| Essalihi R et al. | Phenotypic modulation of vascular smooth muscle cells during medial arterial calcification: a role for endothelin? | 2004 | J. Cardiovasc. Pharmacol. | pmid:15838266 |