MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cornelissen EA and Monnens LA | [Evaluation of various forms of vitamin-K prophylaxis in breastfed infants]. | 1993 | Ned Tijdschr Geneeskd | pmid:8247166 |
Fujita K et al. | Vitamin K1 and K2 status and faecal flora in breast fed and formula fed 1-month-old infants. | 1993 | Eur. J. Pediatr. | pmid:8223791 |
Thijssen HH and Drittij-Reijnders MJ | Vitamin K metabolism and vitamin K1 status in human liver samples: a search for inter-individual differences in warfarin sensitivity. | 1993 | Br. J. Haematol. | pmid:8217828 |
Hodges SJ et al. | Detection and measurement of vitamins K1 and K2 in human cortical and trabecular bone. | 1993 | J. Bone Miner. Res. | pmid:8213250 |
Conly JM et al. | The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. | 1994 | Am. J. Gastroenterol. | pmid:8198105 |
Gupta JM et al. | Neonatal plasma vitamin K1 levels following oral and intramuscular administration of vitamin K1. | 1994 | Acta Paediatr. | pmid:8193487 |
Breton J et al. | The binding sites of quinones in photosynthetic bacterial reaction centers investigated by light-induced FTIR difference spectroscopy: assignment of the QA vibrations in Rhodobacter sphaeroides using 18O- or 13C-labeled ubiquinone and vitamin K1. | 1994 | Biochemistry | pmid:8161557 |
Bjornsson TD and Blaschke TF | Vitamin K1 disposition and therapy of warfarin overdose. | 1978 | Lancet | pmid:81403 |
Sheen SR et al. | Symptomatic brodifacoum ingestion requiring high-dose phytonadione therapy. | 1994 | Vet Hum Toxicol | pmid:8066968 |
Moënne-Loccoz P et al. | Path of electron transfer in photosystem 1: direct evidence of forward electron transfer from A1 to Fe-Sx. | 1994 | Biochemistry | pmid:8060972 |