MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Byrd DC et al. | Subcutaneous phytonadione for reversal of warfarin-induced elevation of the International Normalized Ratio. | 1999 | Am J Health Syst Pharm | pmid:10582823 |
Bui L et al. | Skin reaction to subcutaneous phytonadione injections. | 2004 | Am J Health Syst Pharm | pmid:15011773 |
Stork CM et al. | Elevated International Normalized Ratio associated with long-term azithromycin therapy in a child with cerebral palsy. | 2011 | Am J Health Syst Pharm | pmid:21593229 |
Lee R et al. | Moxifloxacin-acetaminophen-warfarin interaction during bacille Calmette-Guerin treatment for bladder cancer. | 2011 | Am J Health Syst Pharm | pmid:21515865 |
Nutescu EA | New approaches to reversing oral anticoagulant therapy. Introduction. | 2013 | Am J Health Syst Pharm | pmid:23640527 |
Kalus JS | Pharmacologic interventions for reversing the effects of oral anticoagulants. | 2013 | Am J Health Syst Pharm | pmid:23640528 |
Dager WE | Developing a management plan for oral anticoagulant reversal. | 2013 | Am J Health Syst Pharm | pmid:23640529 |
Sauberan JB et al. | Origins of and solutions for neonatal medication-dispensing errors. | 2010 | Am J Health Syst Pharm | pmid:20044369 |
Kutsop JJ | Update on vitamin K1 content of enteral products. | 1984 | Am J Hosp Pharm | pmid:6437219 |
Longe RL | Letter: Stability of phytonadione in hyperalimentation fluids. | 1974 | Am J Hosp Pharm | pmid:4215317 |