MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fasco MJ et al. | Formation of hydroxyvitamin K by vitamin K epoxide reductase of warfarin-resistant rats. | 1983 | J. Biol. Chem. | pmid:6833262 |
Sarett HP et al. | Measurement of vitamin K1 in infant formulas. | 1983 | J. Nutr. | pmid:6822917 |
Boothman BR | Problems with anticoagulants. | 1982 Aug 28-Sep 4 | Br Med J (Clin Res Ed) | pmid:6819048 |
Barlow AM et al. | Difenacoum (Neosorexa) poisoning. | 1982 | Br Med J (Clin Res Ed) | pmid:6809162 |
Fasco MJ and Principe LM | Vitamin K1 hydroquinone formation catalyzed by DT-diaphorase. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6803779 |
Vermeer C et al. | A comparison between vitamin K-dependent carboxylase from normal and warfarin-treated cows. | 1982 | Biochim. Biophys. Acta | pmid:6799008 |
Verlander JW et al. | Factor IX deficiency (hemophilia B) in a litter of Labrador retrievers. | 1984 | J. Am. Vet. Med. Assoc. | pmid:6746380 |
Park BK et al. | Enzyme induction by phenobarbitone and vitamin K1 disposition in man. | 1984 | Br J Clin Pharmacol | pmid:6743493 |
Langenberg JP and Tjaden UR | Improved method for the determination of vitamin K1 epoxide in human plasma with electrofluorimetric reaction detection. | 1984 | J. Chromatogr. | pmid:6736159 |
Preusch PC and Suttie JW | Formation of 3-hydroxy-2,3-dihydrovitamin K1 in vivo: relationship to vitamin K epoxide reductase and warfarin resistance. | 1984 | J. Nutr. | pmid:6726460 |