| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Indyk HE and Woollard DC | Vitamin K in milk and infant formulas: determination and distribution of phylloquinone and menaquinone-4. | 1997 | Analyst | pmid:9246814 |
| Ahmed S et al. | Determination of vitamin K homologues by high-performance liquid chromatography with on-line photoreactor and peroxyoxalate chemiluminescence detection. | 2007 | Anal. Chim. Acta | pmid:17481401 |
| Aaron JJ and Winefordner JD | Phosphorescence study of excited triplet state properties of some K vitamins and their analytical usefulness. | 1972 | Anal. Chem. | pmid:5085190 |
| Suhara Y et al. | Method for the determination of vitamin K homologues in human plasma using high-performance liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Chem. | pmid:15679341 |
| Fu X et al. | Measurement of deuterium-labeled phylloquinone in plasma by high-performance liquid chromatography/mass spectrometry. | 2009 | Anal. Chem. | pmid:19563214 |
| Ueno T and Suttie JW | High-pressure liquid chromatographic-reductive electrochemical detection analysis of serum trans-phylloquinone. | 1983 | Anal. Biochem. | pmid:6638487 |
| Ducros V et al. | Quantitative determination of plasma vitamin K1 by high-performance liquid chromatography coupled to isotope dilution tandem mass spectrometry. | 2010 | Anal. Biochem. | pmid:20175981 |
| Nakamura A and Watanabe T | Separation and determination of minor photosynthetic pigments by reversed-phase HPLC with minimal alteration of chlorophylls. | 2001 | Anal Sci | pmid:11990566 |
| Pérez-Ruiz T et al. | Automatic determination of phylloquinone in vegetables and fruits using on-line photochemical reduction and fluorescence detection via solid phase extraction and flow injection. | 2006 | Anal Bioanal Chem | pmid:16292548 |
| [Instruction sheet for the treatment of hemorrhagic diathesis]. | 1966 | Anaesthesist | pmid:5300603 | |
| Mount ME and Feldman BF | Mechanism of diphacinone rodenticide toxicosis in the dog and its therapeutic implications. | 1983 | Am. J. Vet. Res. | pmid:6689111 |
| Mount ME and Kass PH | Diagnostic importance of vitamin K1 and its epoxide measured in serum of dogs exposed to an anticoagulant rodenticide. | 1989 | Am. J. Vet. Res. | pmid:2802299 |
| Waddell WR and Kirsch WM | Testolactone, sulindac, warfarin, and vitamin K1 for unresectable desmoid tumors. | 1991 | Am. J. Surg. | pmid:2035759 |
| Atkins GJ et al. | Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19675304 |
| Thierry MJ et al. | Vitamin K and warfarin distribution and metabolism in the warfarin-resistant rat. | 1970 | Am. J. Physiol. | pmid:5459483 |
| Hollander D and Rim E | Effect of luminal constituents on vitamin K1 absorption into thoracic duct lymph. | 1978 | Am. J. Physiol. | pmid:623249 |
| Eronick J et al. | Effects of sodium warfarin administered during pregnancy in mice. | 1974 | Am. J. Obstet. Gynecol. | pmid:4815864 |
| Hiraike H et al. | Distribution of K vitamins (phylloquinone and menaquinones) in human placenta and maternal and umbilical cord plasma. | 1988 | Am. J. Obstet. Gynecol. | pmid:3348316 |
| Sann L et al. | Serum vitamin K1 concentration and vitamin K-dependent clotting factor activity in maternal and fetal cord blood. | 1985 | Am. J. Obstet. Gynecol. | pmid:4073142 |
| O'Seaghdha CM et al. | Phylloquinone and vitamin D status: associations with incident chronic kidney disease in the Framingham Offspring cohort. | 2012 | Am. J. Nephrol. | pmid:22722822 |
| Pilkey RM et al. | Subclinical vitamin K deficiency in hemodialysis patients. | 2007 | Am. J. Kidney Dis. | pmid:17336705 |
| Essalihi R et al. | A new model of isolated systolic hypertension induced by chronic warfarin and vitamin K1 treatment. | 2003 | Am. J. Hypertens. | pmid:12559675 |
| Pauli RM et al. | Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of teratogenicity of coumarin derivatives. | 1987 | Am. J. Hum. Genet. | pmid:3499071 |
| Duggan P et al. | Vitamin K status in patients with Crohn's disease and relationship to bone turnover. | 2004 | Am. J. Gastroenterol. | pmid:15555000 |
| Kowdley KV et al. | Plasma vitamin K1 level is decreased in primary biliary cirrhosis. | 1997 | Am. J. Gastroenterol. | pmid:9362192 |
| Conly JM et al. | The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. | 1994 | Am. J. Gastroenterol. | pmid:8198105 |
| Wolk JA et al. | Congenital and neonatal leukemia-- lymphocytic or myelocytic? | 1974 | Am. J. Dis. Child. | pmid:4531222 |
| O'Connor ME et al. | Vitamin K deficiency and breast-feeding. | 1983 | Am. J. Dis. Child. | pmid:6846298 |
| KOZINN PJ et al. | MASSIVE HEMORRHAGE--SCALPS OF NEWBORN INFANTS. | 1964 | Am. J. Dis. Child. | pmid:14186662 |
| Dashti HS et al. | Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations. | 2014 | Am. J. Clin. Nutr. | pmid:25411281 |
| Conly J et al. | Dietary deficiency of phylloquinone and reduced serum levels in febrile neutropenic cancer patients. | 1989 | Am. J. Clin. Nutr. | pmid:2750683 |
| Tsugawa N et al. | Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. | 2006 | Am. J. Clin. Nutr. | pmid:16469998 |
| Bach AU et al. | Assessment of vitamin K status in human subjects administered "minidose" warfarin. | 1996 | Am. J. Clin. Nutr. | pmid:8942414 |
| Fournier B et al. | Variations of phylloquinone concentration in human milk at various stages of lactation and in cow's milk at various seasons. | 1987 | Am. J. Clin. Nutr. | pmid:3825982 |
| Sokoll LJ et al. | Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9062529 |
| Suttie JW et al. | Vitamin K deficiency from dietary vitamin K restriction in humans. | 1988 | Am. J. Clin. Nutr. | pmid:3348159 |
| Macdonald HM et al. | Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms. | 2008 | Am. J. Clin. Nutr. | pmid:18469278 |
| Paiva SA et al. | Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole. | 1998 | Am. J. Clin. Nutr. | pmid:9734750 |
| Kumar R et al. | Effect of phylloquinone supplementation on glucose homeostasis in humans. | 2010 | Am. J. Clin. Nutr. | pmid:20881072 |
| Booth SL et al. | Response of vitamin K status to different intakes and sources of phylloquinone-rich foods: comparison of younger and older adults. | 1999 | Am. J. Clin. Nutr. | pmid:10479199 |
| Saupe J et al. | Phylloquinone transport and its influence on gamma-carboxyglutamate residues of osteocalcin in patients on maintenance hemodialysis. | 1993 | Am. J. Clin. Nutr. | pmid:8393269 |
| Booth SL et al. | Effects of a hydrogenated form of vitamin K on bone formation and resorption. | 2001 | Am. J. Clin. Nutr. | pmid:11722960 |
| Shea MK et al. | Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. | 2009 | Am. J. Clin. Nutr. | pmid:19776145 |
| Ibarrola-Jurado N et al. | Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. | 2012 | Am. J. Clin. Nutr. | pmid:23034962 |
| Almquist HJ | The early history of vitamin K. | 1975 | Am. J. Clin. Nutr. | pmid:805522 |
| Shea MK et al. | Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. | 2013 | Am. J. Clin. Nutr. | pmid:23719555 |
| Nimptsch K et al. | Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). | 2010 | Am. J. Clin. Nutr. | pmid:20335553 |
| Sadowski JA et al. | Phylloquinone in plasma from elderly and young adults: factors influencing its concentration. | 1989 | Am. J. Clin. Nutr. | pmid:2750682 |
| Binkley NC et al. | A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. | 2002 | Am. J. Clin. Nutr. | pmid:12399278 |
| Troy LM et al. | Dihydrophylloquinone intake is associated with low bone mineral density in men and women. | 2007 | Am. J. Clin. Nutr. | pmid:17684225 |