phylloquinone

Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phylloquinone?

phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with phylloquinone

MeSH term MeSH ID Detail
Exanthema D005076 11 associated lipids
Thromboembolism D013923 6 associated lipids
Vitamin K Deficiency D014813 5 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with phylloquinone

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phylloquinone?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with phylloquinone?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with phylloquinone?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with phylloquinone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phylloquinone?

Knock-out

Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with phylloquinone

Download all related citations
Per page 10 20 50 100 | Total 1365
Authors Title Published Journal PubMed Link
Shea MK et al. Genetic and non-genetic correlates of vitamins K and D. 2009 Eur J Clin Nutr pmid:18030310
Denas G et al. An oral vitamin K protocol to reverse over-anticoagulation in patients presenting with an International Normalised Ratio above 10.0. 2009 Thromb. Haemost. pmid:19190831
Gast GC et al. A high menaquinone intake reduces the incidence of coronary heart disease. 2009 Nutr Metab Cardiovasc Dis pmid:19179058
Srinivasan N et al. Role of the hydrogen bond from Leu722 to the A1A phylloquinone in photosystem I. 2009 Biochemistry pmid:19249875
Van Winckel M et al. Vitamin K, an update for the paediatrician. 2009 Eur. J. Pediatr. pmid:18982351
Widhalm JR et al. A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19321747
McDonald MG et al. CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant. 2009 Mol. Pharmacol. pmid:19297519
Koitaya N et al. Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. 2009 J. Nutr. Sci. Vitaminol. pmid:19352059
Shea MK et al. Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. 2009 Am. J. Clin. Nutr. pmid:19776145
Kuwabara A [Foods rich in fat-soluble vitamins and bone health]. 2009 Clin Calcium pmid:19721210
Nimptsch K et al. The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype. 2009 Br. J. Nutr. pmid:19025725
Wu YF et al. Superwarfarin intoxication: hematuria is a major clinical manifestation. 2009 Int. J. Hematol. pmid:19588218
Seeman P et al. The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors. 2009 Synapse pmid:19588469
Seeman P and Guan HC Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor. 2009 Synapse pmid:19588471
Niklas J et al. Electronic structure of the quinone radical anion A1*- of photosystem I investigated by advanced pulse EPR and ENDOR techniques. 2009 J Phys Chem B pmid:19588895
Atkins GJ et al. Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms. 2009 Am. J. Physiol., Cell Physiol. pmid:19675304
Miyachi M et al. Surface immobilization of PSI using vitamin K1-like molecular wires for fabrication of a bio-photoelectrode. 2009 J Nanosci Nanotechnol pmid:19435031
Crosier MD et al. Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status. 2009 J. Nutr. Sci. Vitaminol. pmid:19436136
Seeman P and Guan HC Glutamate agonists for treating schizophrenia have affinity for dopamine D2High and D3 receptors. 2009 Synapse pmid:19391149
Srinivasan N and Golbeck JH Protein-cofactor interactions in bioenergetic complexes: the role of the A1A and A1B phylloquinones in Photosystem I. 2009 Biochim. Biophys. Acta pmid:19409369
Pan Y and Jackson RT Dietary phylloquinone intakes and metabolic syndrome in US young adults. 2009 J Am Coll Nutr pmid:20368375
Cohen JL and Bhatia AC The role of topical vitamin K oxide gel in the resolution of postprocedural purpura. 2009 J Drugs Dermatol pmid:19894369
Harrington DJ et al. Urinary excretion of vitamin K metabolites in term and preterm infants: relationship to vitamin K status and prophylaxis. 2010 Pediatr. Res. pmid:20814348
Al Rajabi A et al. Measurement of menadione in urine by HPLC. 2010 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:20719580
Chen XH et al. [Analysis of thirteen cases with secondary coagulation disorder caused by raticide exposure]. 2010 Zhonghua Er Ke Za Zhi pmid:21055312
Nakagawa K et al. Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme. 2010 Nature pmid:20953171
Davies BE et al. Effect of oseltamivir treatment on anticoagulation: a cross-over study in warfarinized patients. 2010 Br J Clin Pharmacol pmid:21175439
Kidd PM Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. 2010 Altern Med Rev pmid:21155624
Hong J et al. Korean patients with superwarfarin intoxication and their outcome. 2010 J. Korean Med. Sci. pmid:21165290
Sousa T et al. Letter: Localized cutaneous reaction to intramuscular vitamin K in a patient with acute fatty liver of pregnancy. 2010 Dermatol. Online J. pmid:21199642
Cohen MR Medication errors. 2010 Nursing pmid:20016317
Holick MF et al. Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial. 2010 J. Bone Miner. Metab. pmid:20024591
García-Gavín J et al. Allergic contact dermatitis due to cosmetics containing vitamin K1 oxide. 2010 Contact Derm. pmid:20433446
McCormick PN et al. The antipsychotics olanzapine, risperidone, clozapine, and haloperidol are D2-selective ex vivo but not in vitro. 2010 Neuropsychopharmacology pmid:20410873
Miyachi M et al. A photosensing system composed of photosystem I, molecular wire, gold nanoparticle, and double surfactants in water. 2010 Chem. Commun. (Camb.) pmid:20449307
Shea MK et al. Adulthood obesity is positively associated with adipose tissue concentrations of vitamin K and inversely associated with circulating indicators of vitamin K status in men and women. 2010 J. Nutr. pmid:20237066
Wei G et al. Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways. 2010 J. Cell. Physiol. pmid:20301194
Nowicka B and Kruk J Occurrence, biosynthesis and function of isoprenoid quinones. 2010 Biochim. Biophys. Acta pmid:20599680
Furt F et al. A bimodular oxidoreductase mediates the specific reduction of phylloquinone (vitamin K₁) in chloroplasts. 2010 Plant J. pmid:20626653
Santabarbara S et al. Interquinone electron transfer in photosystem I as evidenced by altering the hydrogen bond strength to the phylloquinone(s). 2010 J Phys Chem B pmid:20583790
Biron-Andréani C et al. Use of human hepatocytes to investigate blood coagulation factor. 2010 Methods Mol. Biol. pmid:20645066
Holzer G et al. Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study. 2010 Transl Res pmid:20621035
Su Q and Li Y Interaction between warfarin and the herbal product Shengmai-yin: a case report of intracerebral hematoma. 2010 Yonsei Med. J. pmid:20635460
Babujee L et al. The proteome map of spinach leaf peroxisomes indicates partial compartmentalization of phylloquinone (vitamin K1) biosynthesis in plant peroxisomes. 2010 J. Exp. Bot. pmid:20150517
Iwamoto J et al. Urinary levels of cross-linked N-terminal telopeptide of type I collagen and nutritional status in Japanese professional baseball players. 2010 J. Bone Miner. Metab. pmid:20162436
Liu CH et al. Characterization and formulation optimization of solid lipid nanoparticles in vitamin K1 delivery. 2010 Drug Dev Ind Pharm pmid:20136495
Nie H et al. Superwarfarin poisoning as a cause of intestinal obstruction. 2010 Clin Toxicol (Phila) pmid:20141426
Ducros V et al. Quantitative determination of plasma vitamin K1 by high-performance liquid chromatography coupled to isotope dilution tandem mass spectrometry. 2010 Anal. Biochem. pmid:20175981
Crivello NA et al. Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides. 2010 J. Nutr. Biochem. pmid:20092997
Giuliano V et al. Small intestinal bacterial overgrowth and warfarin dose requirement variability. 2010 Thromb. Res. pmid:20051286