phylloquinone

Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phylloquinone?

phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with phylloquinone

MeSH term MeSH ID Detail
Exanthema D005076 11 associated lipids
Thromboembolism D013923 6 associated lipids
Vitamin K Deficiency D014813 5 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with phylloquinone

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phylloquinone?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with phylloquinone?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with phylloquinone?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with phylloquinone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phylloquinone?

Knock-out

Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with phylloquinone

Download all related citations
Per page 10 20 50 100 | Total 1365
Authors Title Published Journal PubMed Link
Kutsop JJ Update on vitamin K1 content of enteral products. 1984 Am J Hosp Pharm pmid:6437219
Babcock J et al. Rodenticide-induced coagulopathy in a young child. A case of Munchausen syndrome by proxy. 1993 Am J Pediatr Hematol Oncol pmid:8447555
Glatstein M et al. Emergency use of intravenous phytonadione (vitamin K1) for treatment of severe bleeding in a child with chronic cholestasis. 2013 Nov-Dec Am J Ther pmid:21642829
Nee R et al. Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation. 1999 Am. J. Cardiol. pmid:10073841
Nimptsch K et al. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). 2008 Am. J. Clin. Nutr. pmid:18400723
Dashti HS et al. Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations. 2014 Am. J. Clin. Nutr. pmid:25411281
Jones DY et al. Vitamin K status of free-living subjects consuming olestra. 1991 Am. J. Clin. Nutr. pmid:2008873
Conly J et al. Dietary deficiency of phylloquinone and reduced serum levels in febrile neutropenic cancer patients. 1989 Am. J. Clin. Nutr. pmid:2750683
Binkley NC et al. Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults. 2000 Am. J. Clin. Nutr. pmid:11101481
Shea MK et al. Vitamin K, circulating cytokines, and bone mineral density in older men and women. 2008 Am. J. Clin. Nutr. pmid:18689371
Mummah-Schendel LL and Suttie JW Serum phylloquinone concentrations in a normal adult population. 1986 Am. J. Clin. Nutr. pmid:3766455
Tsugawa N et al. Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. 2006 Am. J. Clin. Nutr. pmid:16469998
Bach AU et al. Assessment of vitamin K status in human subjects administered "minidose" warfarin. 1996 Am. J. Clin. Nutr. pmid:8942414
Fournier B et al. Variations of phylloquinone concentration in human milk at various stages of lactation and in cow's milk at various seasons. 1987 Am. J. Clin. Nutr. pmid:3825982
Sokoll LJ et al. Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. 1997 Am. J. Clin. Nutr. pmid:9062529
Suttie JW et al. Vitamin K deficiency from dietary vitamin K restriction in humans. 1988 Am. J. Clin. Nutr. pmid:3348159
Camilo ME et al. Bioavailability of phylloquinone from an intravenous lipid emulsion. 1998 Am. J. Clin. Nutr. pmid:9537619
Kalkwarf HJ et al. Vitamin K, bone turnover, and bone mass in girls. 2004 Am. J. Clin. Nutr. pmid:15447922
Macdonald HM et al. Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms. 2008 Am. J. Clin. Nutr. pmid:18469278
Paiva SA et al. Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole. 1998 Am. J. Clin. Nutr. pmid:9734750
Yoshida M et al. Phylloquinone intake, insulin sensitivity, and glycemic status in men and women. 2008 Am. J. Clin. Nutr. pmid:18614743
Kumar R et al. Effect of phylloquinone supplementation on glucose homeostasis in humans. 2010 Am. J. Clin. Nutr. pmid:20881072
Bieri JG and McKenna MC Expressing dietary values for fat-soluble vitamins: changes in concepts and terminology. 1981 Am. J. Clin. Nutr. pmid:6259921
Lamon-Fava S et al. Plasma lipoproteins as carriers of phylloquinone (vitamin K1) in humans. 1998 Am. J. Clin. Nutr. pmid:9625097
Booth SL et al. Response of vitamin K status to different intakes and sources of phylloquinone-rich foods: comparison of younger and older adults. 1999 Am. J. Clin. Nutr. pmid:10479199
Saupe J et al. Phylloquinone transport and its influence on gamma-carboxyglutamate residues of osteocalcin in patients on maintenance hemodialysis. 1993 Am. J. Clin. Nutr. pmid:8393269
Booth SL et al. Effects of a hydrogenated form of vitamin K on bone formation and resorption. 2001 Am. J. Clin. Nutr. pmid:11722960
Shea MK et al. Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. 2009 Am. J. Clin. Nutr. pmid:19776145
Ibarrola-Jurado N et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. 2012 Am. J. Clin. Nutr. pmid:23034962
Almquist HJ The early history of vitamin K. 1975 Am. J. Clin. Nutr. pmid:805522
Shea MK et al. Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. 2013 Am. J. Clin. Nutr. pmid:23719555
Sokoll LJ and Sadowski JA Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. 1996 Am. J. Clin. Nutr. pmid:8599321
Nimptsch K et al. Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). 2010 Am. J. Clin. Nutr. pmid:20335553
Sadowski JA et al. Phylloquinone in plasma from elderly and young adults: factors influencing its concentration. 1989 Am. J. Clin. Nutr. pmid:2750682
Binkley NC et al. A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. 2002 Am. J. Clin. Nutr. pmid:12399278
Troy LM et al. Dihydrophylloquinone intake is associated with low bone mineral density in men and women. 2007 Am. J. Clin. Nutr. pmid:17684225
Wolk JA et al. Congenital and neonatal leukemia-- lymphocytic or myelocytic? 1974 Am. J. Dis. Child. pmid:4531222
O'Connor ME et al. Vitamin K deficiency and breast-feeding. 1983 Am. J. Dis. Child. pmid:6846298
KOZINN PJ et al. MASSIVE HEMORRHAGE--SCALPS OF NEWBORN INFANTS. 1964 Am. J. Dis. Child. pmid:14186662
Duggan P et al. Vitamin K status in patients with Crohn's disease and relationship to bone turnover. 2004 Am. J. Gastroenterol. pmid:15555000
Kowdley KV et al. Plasma vitamin K1 level is decreased in primary biliary cirrhosis. 1997 Am. J. Gastroenterol. pmid:9362192
Conly JM et al. The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. 1994 Am. J. Gastroenterol. pmid:8198105
Pauli RM et al. Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of teratogenicity of coumarin derivatives. 1987 Am. J. Hum. Genet. pmid:3499071
Essalihi R et al. A new model of isolated systolic hypertension induced by chronic warfarin and vitamin K1 treatment. 2003 Am. J. Hypertens. pmid:12559675
Pilkey RM et al. Subclinical vitamin K deficiency in hemodialysis patients. 2007 Am. J. Kidney Dis. pmid:17336705
O'Seaghdha CM et al. Phylloquinone and vitamin D status: associations with incident chronic kidney disease in the Framingham Offspring cohort. 2012 Am. J. Nephrol. pmid:22722822
Eronick J et al. Effects of sodium warfarin administered during pregnancy in mice. 1974 Am. J. Obstet. Gynecol. pmid:4815864
Hiraike H et al. Distribution of K vitamins (phylloquinone and menaquinones) in human placenta and maternal and umbilical cord plasma. 1988 Am. J. Obstet. Gynecol. pmid:3348316
Sann L et al. Serum vitamin K1 concentration and vitamin K-dependent clotting factor activity in maternal and fetal cord blood. 1985 Am. J. Obstet. Gynecol. pmid:4073142
Hollander D and Rim E Effect of luminal constituents on vitamin K1 absorption into thoracic duct lymph. 1978 Am. J. Physiol. pmid:623249