MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Nagata M et al. | [Pharmaceutical studies on commercial phytonadion tablets and effect of polysorbate 80 on the dissolution test (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:544751 |
Su Q and Li Y | Interaction between warfarin and the herbal product Shengmai-yin: a case report of intracerebral hematoma. | 2010 | Yonsei Med. J. | pmid:20635460 |
Gessl H et al. | [Reducing lipid peroxidation of stored frozen trout fillet by supplementing feed with vitamin E]. | 1995 | Z Ernahrungswiss | pmid:7502541 |
Kolb E | [Recent discoveries on the biochemical significance of vitamin K and some characteristics of vitamin K dependent proteins]. | 1981 | Z Gesamte Inn Med | pmid:7331379 |
Schurgers LJ et al. | Role of vitamin K and vitamin K-dependent proteins in vascular calcification. | 2001 | Z Kardiol | pmid:11374034 |
Lichtenthaler HK and Tevini M | [Effect of UV-rays on the lipoquinone-pigment composition of isolated spinach chloroplasts]. | 1969 | Z. Naturforsch. B | pmid:4390030 |
Lichtenthaler HK | [Formation of excess plastidquinones in the leaves of Ficus elastica Roxb]. | 1969 | Z. Naturforsch. B | pmid:4391381 |
Hoppe W | [The importance of the treatment with marcumar in oral surgery]. | 1967 | Zahnarztl Prax | pmid:5298417 |
Sewkow S et al. | [Nutritional requirements of Bacteroides melaninogenicus]. | 1974 | Zentralbl Bakteriol Orig A | pmid:4154688 |
Rogner G | [Changes of blood coagulation potential during the prevention of hemorrhage in newborn infants born at risk]. | 1974 | Zentralbl Gynakol | pmid:4450830 |
Chen JW et al. | [Analysis of vitamins and inorganic elements in the water extracts of Radix Changii]. | 2004 | Zhong Xi Yi Jie He Xue Bao | pmid:15383265 |
Sun AY and Cheng JS | Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10374629 |
Liu J et al. | [Level of vitamin K-dependent coagulation factors in premature infants and the influence of maternal antenatal administration of vitamin K1 on their activity]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:16412352 |
Chen XH et al. | [Analysis of thirteen cases with secondary coagulation disorder caused by raticide exposure]. | 2010 | Zhonghua Er Ke Za Zhi | pmid:21055312 |
Jiang NX et al. | [Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients]. | 2007 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:17961434 |