MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Byrd DC et al. | Subcutaneous phytonadione for reversal of warfarin-induced elevation of the International Normalized Ratio. | 1999 | Am J Health Syst Pharm | pmid:10582823 |
Raj G et al. | Time course of reversal of anticoagulant effect of warfarin by intravenous and subcutaneous phytonadione. | 1999 Dec 13-27 | Arch. Intern. Med. | pmid:10597763 |
Wariyar U et al. | Six years' experience of prophylactic oral vitamin K. | 2000 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:10634845 |
Bridge A et al. | The plasma membrane NADH oxidase of soybean has vitamin K(1) hydroquinone oxidase activity. | 2000 | Biochim. Biophys. Acta | pmid:10675521 |
Fisher N and Rich PR | A motif for quinone binding sites in respiratory and photosynthetic systems. | 2000 | J. Mol. Biol. | pmid:10686111 |
Webster WS et al. | Measurement of DNA damage by the comet assay in rat embryos grown in media containing high concentrations of vitamin K(1). | 2000 | Toxicol In Vitro | pmid:10699366 |
Lamnaouer D | [Anticoagulant activity of coumarins from Ferula communis L]. | 1999 Nov-Dec | Therapie | pmid:10709451 |
Johnson TW et al. | Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. pcc 6803. | 2000 | J. Biol. Chem. | pmid:10722690 |
Zybailov B et al. | Recruitment of a foreign quinone into the A(1) site of photosystem I. II. Structural and functional characterization of phylloquinone biosynthetic pathway mutants by electron paramagnetic resonance and electron-nuclear double resonance spectroscopy. | 2000 | J. Biol. Chem. | pmid:10722691 |
Miyakawa T et al. | Vitamin K contents in liver tissue of hepatocellular carcinoma patients. | 2000 | Jpn. J. Cancer Res. | pmid:10744046 |