| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
| Exanthema | D005076 | 11 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
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| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shearer MJ et al. | Plasma vitamin K1 in mothers and their newborn babies. | 1982 | Lancet | pmid:6125638 |
| Dunn PM | Vitamin K1 for all newborn babies. | 1982 | Lancet | pmid:6125839 |
| Vermeer C et al. | A comparison between vitamin K-dependent carboxylase from normal and warfarin-treated cows. | 1982 | Biochim. Biophys. Acta | pmid:6799008 |
| Fasco MJ and Principe LM | Vitamin K1 hydroquinone formation catalyzed by DT-diaphorase. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6803779 |
| Barlow AM et al. | Difenacoum (Neosorexa) poisoning. | 1982 | Br Med J (Clin Res Ed) | pmid:6809162 |
| Hughes DE | Detection of phytonadione in vegetable oil. | 1982 | J Pharm Sci | pmid:7120078 |
| Hall AL et al. | Mechanism of action of t-butyl hydroperoxide in the inhibition of vitamin K-dependent carboxylation. | 1982 | Arch. Biochem. Biophys. | pmid:7082011 |
| Haroon Y et al. | The content of phylloquinone (vitamin K1) in human milk, cows' milk and infant formula foods determined by high-performance liquid chromatography. | 1982 | J. Nutr. | pmid:7086539 |
| Rich EC and Drage CW | Severe complications of intravenous phytonadione therapy. Two cases, with one fatality. | 1982 | Postgrad Med | pmid:7134079 |
| Kolb E | [Recent discoveries on the biochemical significance of vitamin K and some characteristics of vitamin K dependent proteins]. | 1981 | Z Gesamte Inn Med | pmid:7331379 |
| Sherman PA and Sander EG | Vitamin K epoxide reductase: evidence that vitamin K dihydroquinone is a product of vitamin K epoxide reduction. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7332587 |
| Lichtenthaler HK et al. | Localization of prenylquinones in the envelope of spinach chloroplasts. | 1981 | Biochim. Biophys. Acta | pmid:7213720 |
| Park BK and Leck JB | On the mechanism of salicylate-induced hypothrombinaemia. | 1981 | J. Pharm. Pharmacol. | pmid:6114147 |
| Bieri JG and McKenna MC | Expressing dietary values for fat-soluble vitamins: changes in concepts and terminology. | 1981 | Am. J. Clin. Nutr. | pmid:6259921 |
| Sloane N | Enzymic hydroxylation of benzo(alpha)pyrene at the 6-position by vitamin K1-hydroperoxide and rat lung hydroperoxidase. | 1981 | Xenobiotica | pmid:6272502 |
| Chander KS et al. | Effect of reduced vitamin K esters on vitamin K-dependent carboxylation. | 1981 | Biochim. Biophys. Acta | pmid:7213818 |
| Leck JB and Park BK | A comparative study of the effects of warfarin and brodifacoum on the relationship between vitamin K1 metabolism and clotting factor activity in warfarin-susceptible and warfarin-resistant rats. | 1981 | Biochem. Pharmacol. | pmid:7236301 |
| Bell RG and Ren P | Inhibition by warfarin enantiomers of prothrombin synthesis, protein carboxylation, and the regeneration of vitamin K from vitamin K epoxide. | 1981 | Biochem. Pharmacol. | pmid:7271884 |
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| Park BK et al. | The dose-dependent effect of warfarin on vitamin K1 metabolism and clotting factor synthesis in the rabbit. | 1980 | Biochem. Pharmacol. | pmid:7396990 |
| Haroon Y et al. | Assay of vitamin K1 (phylloquinone) by high performance liquid chromatography: values for human and cow's milk. | 1980 | Proc Nutr Soc | pmid:7403086 |
| Carter A et al. | Multiple acquired haemostatic defects. Case report and review of the literature. | 1980 | Haemostasis | pmid:7358321 |
| Nakata H and Tsuchida E | Determination of vitamin K1 in photodegradation products by gas-liquid chromatography. | 1980 | Meth. Enzymol. | pmid:7366421 |
| Elliott GR et al. | Assay procedure for the vitamin K1 2,3-epoxide-reducing system. | 1980 | Meth. Enzymol. | pmid:7366422 |
| Meeks RG and Couri D | Inhibition by warfarin of prothrombin synthesis and of lipid-saccharide synthesis in rat liver. | 1980 | Biochim. Biophys. Acta | pmid:7388053 |
| Yen CS and Mack DO | Solubilized rat liver vitamin K carboxylase demonstrates little selectivity between vitamin K1 and the menaquinones. | 1980 | Proc. Soc. Exp. Biol. Med. | pmid:7443718 |
| Trenk D et al. | Age-dependent differences in the effect of phenprocoumon on the vitamin K1-epoxide cycle in rats. | 1980 | J. Pharm. Pharmacol. | pmid:6110746 |
| Kilian PL et al. | Reconstitution of acetylcholine receptor from Torpedo Californica with highly purified phospholipids: effect of alpha-tocopherol, phylloquinone, and other terpenoid quinones. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7190011 |
| Fasco MJ and Principe LM | Vitamin K1 hydroquinone formation catalyzed by a microsomal reductase system. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7213374 |
| McBurney A et al. | Preparative isolation and characterization of the urinary aglycones of vitamin K1 (phylloquinone in man. | 1980 | Biochem Med | pmid:7306367 |
| Seifert RM | Analysis of vitamin K1 in some green leafy vegetables by gas chromatography. | 1979 Nov-Dec | J. Agric. Food Chem. | pmid:544659 |
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| Lelong-Tissier MC et al. | [Neonatal hematemesis caused by peptic esophagitis]. | 1979 | Arch. Fr. Pediatr. | pmid:485769 |
| Wallin R | No strict coupling of vitamin K1 (2-methyl-3-phytyl-1,4-naphthoquinone)-dependent carboxylation and vitamin K1 epoxidation in detergent-solubilized microsomal fractions from rat liver. | 1979 | Biochem. J. | pmid:454361 |
| Cappuccini B et al. | [Preliminary study of the possibility of screening for hemorrhagic disease of the newborn by evaluation of the prothrombin complex]. | 1979 | Minerva Pediatr. | pmid:460093 |
| Takahashi O and Hiraga K | Preventive effects of phylloquinone on hemorrhagic death induced by butylated hydroxytoluene in male rats. | 1979 | J. Nutr. | pmid:430246 |
| Thielemann H | [The detection of vitamin K1, K2 and K3 with 4-aminophenazone]. | 1979 | Pharmazie | pmid:432259 |
| Lowenthal J and Vergel Rivera GM | Comparison of the activity of the cis and trans isomer of vitamin K1 in vitamin K-deficient and coumarin anticoagulant-pretreated rats. | 1979 | J. Pharmacol. Exp. Ther. | pmid:439009 |
| Park BK et al. | A study of the effect of anticoagulants on [3H]vitamin K1 metabolism and prothrombin complex activity in the rabbit. | 1979 | Biochem. Pharmacol. | pmid:444299 |
| Ikenoya S et al. | Electrochemical detector for high-performance liquid chromatography. II. Determination of tocopherols, ubiquinones and phylloquinone in blood. | 1979 | Chem. Pharm. Bull. | pmid:498377 |
| Decottignies-Le Maréchal P et al. | Vitamin K-dependent carboxylation of synthetic substrates. Nature of the products. | 1979 | Biochem. Biophys. Res. Commun. | pmid:508335 |
| Eichbaum FW et al. | Anti-inflammatory effect of warfarin and vitamin K1. | 1979 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:573373 |
| Keith DA and Gallop PM | Phenytoin, hemorrhage, skeletal defects and vitamin K in the newborn. | 1979 | Med. Hypotheses | pmid:537547 |
| Bechtold H and Jähnchen E | Quantitative analysis of vitamin K1 and vitamin K1 2,3-epoxide in plasma by electron-capture gas-liquid chromatography. | 1979 | J. Chromatogr. | pmid:541400 |
| Hiroshima O et al. | [Determination of phylloquinone-2,3-epoxide and menaquinone-4-2,3-epoxide in biological materials by high performance liquid chromatography and fluorometric reaction detection (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:544742 |
| Nagata M et al. | [Pharmaceutical studies on commercial phytonadion tablets and effect of polysorbate 80 on the dissolution test (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:544751 |
| Schmidt W et al. | Differential effect of the enantiomers of phenprocoumon and warfarin on the vitamin K1-epoxide/vitamin K1 ratio in rat plasma. | 1979 | J. Pharm. Pharmacol. | pmid:38329 |