| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
| Exanthema | D005076 | 11 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hollander D and Rim E | Effect of luminal constituents on vitamin K1 absorption into thoracic duct lymph. | 1978 | Am. J. Physiol. | pmid:623249 |
| van Amstel WJ et al. | Successful prevention of coumarin-induced hemorrhagic skin necrosis by timely administration of vitamin k1. | 1978 | Blut | pmid:638263 |
| Garvey WT and Olson RE | In vitro vitamin K-dependent conversion of precursor to prothrombin in chick liver. | 1978 | J. Nutr. | pmid:660301 |
| Horn GB | Determination of phytonadione in elemental diets by TLC-spectrophotodensitometry. | 1978 | J Pharm Sci | pmid:660469 |
| Kammermann-Lüscher B | [Coumarin poisoning in dog and cat]. | 1978 | Schweiz. Arch. Tierheilkd. | pmid:663601 |
| McBurney A et al. | Changes in the urinary metabolites of phylloquinone (vitamin K1) in man following therapeutic anticoagulation with warfarin. | 1978 | Biochem. Pharmacol. | pmid:619911 |
| Hollander D et al. | Diurnal rhythmicity of absorption of a lipid compound (vitamin K-1) in vivo in the rat. | 1978 | Am J Dig Dis | pmid:569972 |
| Breckenridge AM et al. | Mechanisms of action of the anticoagulants warfarin, 2-chloro-3-phytylnaphthoquinone (Cl-K), acenocoumarol, brodifacoum and difenacoum in the rabbit [proceedings]. | 1978 | Br. J. Pharmacol. | pmid:719257 |
| Fasco MJ et al. | A new warfarin metabolite: structure and function. | 1978 | J. Med. Chem. | pmid:722713 |
| Meeks RG and Couri D | The effect of warfarin and vitamin K-1 on the carboxylation and glycosylation of prothrombin in vivo. | 1978 | Biochim. Biophys. Acta | pmid:728474 |
| Robison JW and Odom RB | Delayed cutaneous reaction to phytonadione. | 1978 | Arch Dermatol | pmid:736587 |
| Thoma K et al. | Biological effect of phytonadione administered orally as oily solution or solubilized with a non-ionic surfactant in rats. | 1978 | J. Pharm. Pharmacol. | pmid:24727 |
| Bjornsson TD and Blaschke TF | Vitamin K1 disposition and therapy of warfarin overdose. | 1978 | Lancet | pmid:81403 |
| Tentsova AI et al. | [Development of a technology for an aqueous vitamin K1 solution and its study]. | 1977 Nov-Dec | Farmatsiia | pmid:598524 |
| Heydenreich G | A further case of adverse skin reaction from vitamin K1. | 1977 | Br. J. Dermatol. | pmid:603752 |
| Gregory EM et al. | Production and some properties of catalase and superoxide dismutase from the anaerobe Bacteroides distasonis. | 1977 | J. Bacteriol. | pmid:845116 |
| Barkhan P and Shearer MJ | Metabolism of vitamin K1 (phylloquinone) in man. | 1977 | Proc. R. Soc. Med. | pmid:859820 |
| Shearer MJ et al. | Effect of warfarin on the metabolism of phylloquinone (vitamin K1):dose-response relationships in man. | 1977 | Clin Sci Mol Med | pmid:884934 |
| Tabushi I et al. | One-step preparation of vitamin K1 or K2 analogues by cyclodextrin inclusion catalysis. | 1977 | J. Am. Chem. Soc. | pmid:893897 |
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| Nakata Y et al. | [Studies on photodegradation of vitamin K1. I. Determination of vitamin K1 by gas-liquid chromatography (author's transl)]. | 1976 | Yakugaku Zasshi | pmid:943509 |
| Hollander D and Rim E | Factors affecting the absorption of vitamin K-1 in vitro. | 1976 | Gut | pmid:955502 |
| van Oosterom AT et al. | The influence of the thyroid function on the metabolic rate of prothrombin, factor VII, and factor X in the rat. | 1976 | Thromb. Haemost. | pmid:989968 |
| Fischer M et al. | [The therapeutic management of consumption coagulopathy in progressive liver cirrhosis: low-dosage heparin therapy (author's transl)]. | 1976 | Wien. Klin. Wochenschr. | pmid:997529 |
| Barnes HM and Sarkany I | Adverse skin reaction from vitamin K1. | 1976 | Br. J. Dermatol. | pmid:1009013 |
| Shearer MJ et al. | Dose - response relationship between warfarin and the metabolism of phylloquinone (vitamin K1) in man. | 1976 | Int J Vitam Nutr Res | pmid:1032634 |
| Anderson SS et al. | Electron transfer across membranes using vitamin K1 and coenzyme Q10 as carrier molecules. | 1976 | Nature | pmid:1246352 |
| Green G et al. | Factor VII as a marker of hepatocellular synthetic function in liver disease. | 1976 | J. Clin. Pathol. | pmid:1002840 |
| Interaction between vitamin K1 and fat absorption. | 1976 | Nutr. Rev. | pmid:794771 | |
| Blalock JE and Gifford GE | Inhibition of interferon action by vitamin A. | 1975 | J. Gen. Virol. | pmid:173796 |
| Walz DA et al. | Effects of vitamin K deficiency, warfarin, and inhibitors of protein synthesis upon the plasma levels of vitamin K-dependent clotting factors in the chick. | 1975 | J. Nutr. | pmid:1142015 |
| Almquist HJ | The early history of vitamin K. | 1975 | Am. J. Clin. Nutr. | pmid:805522 |
| Lindquist J and Farroha SM | Application of differential pulse polarography to the assay of vitamins. | 1975 | Analyst | pmid:124542 |
| Shafer AW | Use of blood and blood components. | 1975 | South. Med. J. | pmid:1093259 |
| Owens DE et al. | Retropharyngeal hematoma. A complication of therapy with anticoagulants. | 1975 | Arch Otolaryngol | pmid:1164240 |
| Knauer TE et al. | Metabolism and biological activity of cis- and trans-phylloquinone in the rat. | 1975 | J. Nutr. | pmid:1195014 |
| Mulcahy JJ et al. | Transurethral prostatic resection in patients with prosthetic cardiac valves. | 1975 | J. Urol. | pmid:1127807 |
| Sciorelli G and Ricevuti G | [Vitamin K and blood capillaries]. | 1974 Apr-Jun | Arch Sci Med (Torino) | pmid:4417713 |
| Shearer MJ et al. | Studies on the absorption and metabolism of phylloquinone (vitamin K1) in man. | 1974 | Vitam. Horm. | pmid:4617407 |
| Wolk JA et al. | Congenital and neonatal leukemia-- lymphocytic or myelocytic? | 1974 | Am. J. Dis. Child. | pmid:4531222 |
| Noonan SM et al. | Warfarin effect on rat liver ultrastructure, RNA content and polysome distribution. | 1974 | Thromb Diath Haemorrh | pmid:4450191 |
| Rogner G | [Changes of blood coagulation potential during the prevention of hemorrhage in newborn infants born at risk]. | 1974 | Zentralbl Gynakol | pmid:4450830 |
| Hayakawa Y and Takamura K | [Reaction of vitamin K3 with cysteine in aqueous ethanol and consecutive determination of vitamins K (author's transl)]. | 1974 | Yakugaku Zasshi | pmid:4476774 |
| Aquilina JN and Bugeja TJ | Primary malignant lymphoma of the bladder: case report and review of the literature. | 1974 | J. Urol. | pmid:4366001 |
| Sewkow S et al. | [Nutritional requirements of Bacteroides melaninogenicus]. | 1974 | Zentralbl Bakteriol Orig A | pmid:4154688 |
| Willingham AK and Matschiner JT | Changes in phylloquinone epoxidase activity related to prothrombin synthesis and microsomal clotting activity in the rat. | 1974 | Biochem. J. | pmid:4155625 |
| Longe RL | Letter: Stability of phytonadione in hyperalimentation fluids. | 1974 | Am J Hosp Pharm | pmid:4215317 |
| Ren P et al. | Effects of warfarin, phenylindanedione, tetrachloropyridinol, and chloro-vitamin K1 on prothrombin synthesis and vitamin K metabolism in normal and warfarin-resistant rats. | 1974 | Mol. Pharmacol. | pmid:4851787 |
| Sadowski JA and Suttie JW | Mechanism of action of coumarins. Significance of vitamin K epoxide. | 1974 | Biochemistry | pmid:4853124 |
| Schneider DL et al. | Vitamin K1 content of infant formula products. | 1974 | Pediatrics | pmid:4855823 |