phylloquinone

Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phylloquinone?

phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with phylloquinone

MeSH term MeSH ID Detail
Thromboembolism D013923 6 associated lipids
Vitamin K Deficiency D014813 5 associated lipids
Exanthema D005076 11 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with phylloquinone

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phylloquinone?

Related references are published most in these journals:

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What functions are associated with phylloquinone?


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What lipids are associated with phylloquinone?

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What genes are associated with phylloquinone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phylloquinone?

Knock-out

Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with phylloquinone

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Authors Title Published Journal PubMed Link
Fischer M et al. [The therapeutic management of consumption coagulopathy in progressive liver cirrhosis: low-dosage heparin therapy (author's transl)]. 1976 Wien. Klin. Wochenschr. pmid:997529
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Huber AM et al. Gender differences in hepatic phylloquinone and menaquinones in the vitamin K-deficient and -supplemented rat. 1999 Biochim. Biophys. Acta pmid:9878685
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Sokoll LJ et al. Diurnal variation in total and undercarboxylated osteocalcin: influence of increased dietary phylloquinone. 1998 Calcif. Tissue Int. pmid:9541523
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Ronden JE et al. Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat. 1998 Biochim. Biophys. Acta pmid:9468334
Ronden JE et al. Tissue distribution of K-vitamers under different nutritional regimens in the rat. 1998 Biochim. Biophys. Acta pmid:9468327
Davidson RT et al. Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria. 1998 J. Nutr. pmid:9446847
Barash P et al. Acute cardiovascular collapse after intravenous phytonadione. 1976 Mar-Apr Anesth. Analg. pmid:943998
Nakata Y et al. [Studies on photodegradation of vitamin K1. I. Determination of vitamin K1 by gas-liquid chromatography (author's transl)]. 1976 Yakugaku Zasshi pmid:943509
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Kowdley KV et al. Plasma vitamin K1 level is decreased in primary biliary cirrhosis. 1997 Am. J. Gastroenterol. pmid:9362192
Bittl R et al. Pulsed EPR structure analysis of photosystem I single crystals: localization of the phylloquinone acceptor. 1997 Biochemistry pmid:9340008
Hanley J et al. ESEEM study of the phyllosemiquinone radical A1.- in 14N- and 15N-labeled photosystem I. 1997 Biochemistry pmid:9340006
Booth SL and Sadowski JA Determination of phylloquinone in foods by high-performance liquid chromatography. 1997 Meth. Enzymol. pmid:9330309
Usui Y Assay of phylloquinone and menaquinones in human liver. 1997 Meth. Enzymol. pmid:9330308
McCarthy PT et al. Assay of phylloquinone in plasma by high-performance liquid chromatography with electrochemical detection. 1997 Meth. Enzymol. pmid:9330306
Davidson KW and Sadowski JA Determination of vitamin K compounds in plasma or serum by high-performance liquid chromatography using postcolumn chemical reduction and fluorimetric detection. 1997 Meth. Enzymol. pmid:9330305
Konoplia EN et al. [Hepatoprotective and immunomodulating effect of phylloquinone in toxic damage to the liver]. 1997 May-Jun Eksp Klin Farmakol pmid:9324408
Frank J et al. Interaction of vitamins E and K: effect of high dietary vitamin E on phylloquinone activity in chicks. 1997 Int J Vitam Nutr Res pmid:9285253
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