MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Widhalm JR et al. | Phylloquinone (vitamin K(1) ) biosynthesis in plants: two peroxisomal thioesterases of Lactobacillales origin hydrolyze 1,4-dihydroxy-2-naphthoyl-CoA. | 2012 | Plant J. | pmid:22372525 |
Kanellakis S et al. | Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II. | 2012 | Calcif. Tissue Int. | pmid:22392526 |
Gajic-Veljanoski O et al. | Vitamin K supplementation for the primary prevention of osteoporotic fractures: is it cost-effective and is future research warranted? | 2012 | Osteoporos Int | pmid:22398856 |
Ozawa S et al. | 5'-monohydroxyphylloquinone is the dominant naphthoquinone of PSI in the green alga Chlamydomonas reinhardtii. | 2012 | Plant Cell Physiol. | pmid:22138100 |
Santabarbara S et al. | Kinetics of phyllosemiquinone oxidation in the Photosystem I reaction centre of Acaryochloris marina. | 2012 | Biochim. Biophys. Acta | pmid:22037394 |
Stevenson MD and Jones ML | The cost effectiveness of a randomized controlled trial to establish the relative efficacy of vitamin K1 compared with alendronate. | 2011 Jan-Feb | Med Decis Making | pmid:20375420 |
Kanai S et al. | Eicosapentaenoic acid reduces warfarin-induced arterial calcification in rats. | 2011 | Atherosclerosis | pmid:21193197 |
Clark TR and Burns S | Elevated international normalized ratio values associated with concomitant use of warfarin and ceftriaxone. | 2011 | Am J Health Syst Pharm | pmid:21856805 |
Apalset EM et al. | Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study. | 2011 | Bone | pmid:21839190 |
Ito A et al. | Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. | 2011 | Lipids Health Dis | pmid:21914161 |