MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Berkner KL | Vitamin K-dependent carboxylation. | 2008 | Vitam. Horm. | pmid:18374193 |
Bügel S | Vitamin K and bone health in adult humans. | 2008 | Vitam. Horm. | pmid:18374202 |
Gumulec J et al. | [Hemorrhagic complications during warfarin treatment]. | 2006 | Vnitr Lek | pmid:16637455 |
PATSCH J | [CONSTITUTION, STRESS AND BLOOD COAGULATION]. | 1964 | Wien Med Wochenschr | pmid:14237308 |
Fischer M et al. | [The therapeutic management of consumption coagulopathy in progressive liver cirrhosis: low-dosage heparin therapy (author's transl)]. | 1976 | Wien. Klin. Wochenschr. | pmid:997529 |
Du W et al. | Vitamin K1 enhances sorafenib-induced growth inhibition and apoptosis of human malignant glioma cells by blocking the Raf/MEK/ERK pathway. | 2012 | World J Surg Oncol | pmid:22520038 |
Sloane N | Enzymic hydroxylation of benzo(alpha)pyrene at the 6-position by vitamin K1-hydroperoxide and rat lung hydroperoxidase. | 1981 | Xenobiotica | pmid:6272502 |
Hayakawa Y and Takamura K | [Reaction of vitamin K3 with cysteine in aqueous ethanol and consecutive determination of vitamins K (author's transl)]. | 1974 | Yakugaku Zasshi | pmid:4476774 |
Nakata Y et al. | [Studies on photodegradation of vitamin K1. I. Determination of vitamin K1 by gas-liquid chromatography (author's transl)]. | 1976 | Yakugaku Zasshi | pmid:943509 |
Hiroshima O et al. | [Determination of phylloquinone-2,3-epoxide and menaquinone-4-2,3-epoxide in biological materials by high performance liquid chromatography and fluorometric reaction detection (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:544742 |