MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Nimptsch K et al. | Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). | 2008 | Am. J. Clin. Nutr. | pmid:18400723 |
Binkley NC et al. | Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults. | 2000 | Am. J. Clin. Nutr. | pmid:11101481 |
Suttie JW et al. | Vitamin K deficiency from dietary vitamin K restriction in humans. | 1988 | Am. J. Clin. Nutr. | pmid:3348159 |
Camilo ME et al. | Bioavailability of phylloquinone from an intravenous lipid emulsion. | 1998 | Am. J. Clin. Nutr. | pmid:9537619 |
Macdonald HM et al. | Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms. | 2008 | Am. J. Clin. Nutr. | pmid:18469278 |
Yoshida M et al. | Phylloquinone intake, insulin sensitivity, and glycemic status in men and women. | 2008 | Am. J. Clin. Nutr. | pmid:18614743 |
Bieri JG and McKenna MC | Expressing dietary values for fat-soluble vitamins: changes in concepts and terminology. | 1981 | Am. J. Clin. Nutr. | pmid:6259921 |
Booth SL et al. | Effects of a hydrogenated form of vitamin K on bone formation and resorption. | 2001 | Am. J. Clin. Nutr. | pmid:11722960 |
Almquist HJ | The early history of vitamin K. | 1975 | Am. J. Clin. Nutr. | pmid:805522 |
Sadowski JA et al. | Phylloquinone in plasma from elderly and young adults: factors influencing its concentration. | 1989 | Am. J. Clin. Nutr. | pmid:2750682 |