MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hollander D and Rim E | Effect of luminal constituents on vitamin K1 absorption into thoracic duct lymph. | 1978 | Am. J. Physiol. | pmid:623249 |
Atkins GJ et al. | Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19675304 |
Waddell WR and Kirsch WM | Testolactone, sulindac, warfarin, and vitamin K1 for unresectable desmoid tumors. | 1991 | Am. J. Surg. | pmid:2035759 |
Mount ME and Feldman BF | Mechanism of diphacinone rodenticide toxicosis in the dog and its therapeutic implications. | 1983 | Am. J. Vet. Res. | pmid:6689111 |
Mount ME and Kass PH | Diagnostic importance of vitamin K1 and its epoxide measured in serum of dogs exposed to an anticoagulant rodenticide. | 1989 | Am. J. Vet. Res. | pmid:2802299 |
[Instruction sheet for the treatment of hemorrhagic diathesis]. | 1966 | Anaesthesist | pmid:5300603 | |
Pérez-Ruiz T et al. | Automatic determination of phylloquinone in vegetables and fruits using on-line photochemical reduction and fluorescence detection via solid phase extraction and flow injection. | 2006 | Anal Bioanal Chem | pmid:16292548 |
Nakamura A and Watanabe T | Separation and determination of minor photosynthetic pigments by reversed-phase HPLC with minimal alteration of chlorophylls. | 2001 | Anal Sci | pmid:11990566 |
Ueno T and Suttie JW | High-pressure liquid chromatographic-reductive electrochemical detection analysis of serum trans-phylloquinone. | 1983 | Anal. Biochem. | pmid:6638487 |
Ducros V et al. | Quantitative determination of plasma vitamin K1 by high-performance liquid chromatography coupled to isotope dilution tandem mass spectrometry. | 2010 | Anal. Biochem. | pmid:20175981 |