MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Aaron JJ and Winefordner JD | Phosphorescence study of excited triplet state properties of some K vitamins and their analytical usefulness. | 1972 | Anal. Chem. | pmid:5085190 |
Suhara Y et al. | Method for the determination of vitamin K homologues in human plasma using high-performance liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Chem. | pmid:15679341 |
Fu X et al. | Measurement of deuterium-labeled phylloquinone in plasma by high-performance liquid chromatography/mass spectrometry. | 2009 | Anal. Chem. | pmid:19563214 |
Ahmed S et al. | Determination of vitamin K homologues by high-performance liquid chromatography with on-line photoreactor and peroxyoxalate chemiluminescence detection. | 2007 | Anal. Chim. Acta | pmid:17481401 |
Indyk HE and Woollard DC | Vitamin K in milk and infant formulas: determination and distribution of phylloquinone and menaquinone-4. | 1997 | Analyst | pmid:9246814 |
Hart JP et al. | Enhanced sensitivity for the determination of endogenous phylloquinone (vitamin K1) in plasma using high-performance liquid chromatography with dual-electrode electrochemical detection. | 1985 | Analyst | pmid:4083495 |
Lindquist J and Farroha SM | Application of differential pulse polarography to the assay of vitamins. | 1975 | Analyst | pmid:124542 |
Hart JP et al. | Voltammetric behaviour of phylloquinone (vitamin K1) at a glassy-carbon electrode and determination of the vitamin in plasma using high-performance liquid chromatography with electrochemical detection. | 1984 | Analyst | pmid:6721166 |
Barash P et al. | Acute cardiovascular collapse after intravenous phytonadione. | 1976 Mar-Apr | Anesth. Analg. | pmid:943998 |
Terasaki N et al. | Plugging a molecular wire into photosystem I: reconstitution of the photoelectric conversion system on a gold electrode. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19156784 |