| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
| Exanthema | D005076 | 11 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shearer MJ | Vitamin K. | 1995 | Lancet | pmid:7823718 |
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| Booth SL et al. | Tea and coffee brews are not dietary sources of vitamin K-1 (phylloquinone). | 1995 | J Am Diet Assoc | pmid:7798585 |
| Nakamura K et al. | Anticoagulant effects of warfarin and kinetics of K vitamins in blood and feces. | 1994 | Artery | pmid:7794122 |
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| Hara K et al. | The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. | 1995 | Bone | pmid:7756045 |
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| Sakamoto N et al. | Changes of K vitamins in portal and femoral venous plasma of rats after oral administration of phylloquinone and menaquinone-4. | 1995 | Int J Vitam Nutr Res | pmid:7591528 |
| Groenen-van Dooren MM et al. | Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats. | 1995 | Biochem. Pharmacol. | pmid:7575640 |
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| Huisse MG et al. | Mechanism of the abnormal vitamin K-dependent gamma-carboxylation process in human hepatocellular carcinomas. | 1994 | Cancer | pmid:7520347 |
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| Carter A et al. | Multiple acquired haemostatic defects. Case report and review of the literature. | 1980 | Haemostasis | pmid:7358321 |
| Sherman PA and Sander EG | Vitamin K epoxide reductase: evidence that vitamin K dihydroquinone is a product of vitamin K epoxide reduction. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7332587 |
| Kolb E | [Recent discoveries on the biochemical significance of vitamin K and some characteristics of vitamin K dependent proteins]. | 1981 | Z Gesamte Inn Med | pmid:7331379 |
| Takahashi O and Hiraga K | Inhibition of phylloquinone epoxide-dependent carboxylation of microsomal proteins from rat liver by 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone. | 1981 | Food Cosmet Toxicol | pmid:7327471 |
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| McBurney A et al. | Preparative isolation and characterization of the urinary aglycones of vitamin K1 (phylloquinone in man. | 1980 | Biochem Med | pmid:7306367 |
| Meeks RG and Couri D | The effect of warfarin and vitamin K-1 on the carboxylation and glycosylation of prothrombin in vivo. | 1978 | Biochim. Biophys. Acta | pmid:728474 |
| Schultz G et al. | Site of prenylation reaction in synthesis of phylloquinone (vitamin K1) by spinach chloroplasts. | 1981 | Eur. J. Biochem. | pmid:7274213 |
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| Leck JB and Park BK | A comparative study of the effects of warfarin and brodifacoum on the relationship between vitamin K1 metabolism and clotting factor activity in warfarin-susceptible and warfarin-resistant rats. | 1981 | Biochem. Pharmacol. | pmid:7236301 |
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| Lichtenthaler HK et al. | Localization of prenylquinones in the envelope of spinach chloroplasts. | 1981 | Biochim. Biophys. Acta | pmid:7213720 |
| Fasco MJ and Principe LM | Vitamin K1 hydroquinone formation catalyzed by a microsomal reductase system. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7213374 |
| Breckenridge AM et al. | Mechanisms of action of the anticoagulants warfarin, 2-chloro-3-phytylnaphthoquinone (Cl-K), acenocoumarol, brodifacoum and difenacoum in the rabbit [proceedings]. | 1978 | Br. J. Pharmacol. | pmid:719257 |
| Kilian PL et al. | Reconstitution of acetylcholine receptor from Torpedo Californica with highly purified phospholipids: effect of alpha-tocopherol, phylloquinone, and other terpenoid quinones. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7190011 |
| Rich EC and Drage CW | Severe complications of intravenous phytonadione therapy. Two cases, with one fatality. | 1982 | Postgrad Med | pmid:7134079 |
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| Haroon Y et al. | The content of phylloquinone (vitamin K1) in human milk, cows' milk and infant formula foods determined by high-performance liquid chromatography. | 1982 | J. Nutr. | pmid:7086539 |
| Hall AL et al. | Mechanism of action of t-butyl hydroperoxide in the inhibition of vitamin K-dependent carboxylation. | 1982 | Arch. Biochem. Biophys. | pmid:7082011 |
| Bell RG | Vitamin K activity and metabolism of vitamin K-1 epoxide-1,4-diol. | 1982 | J. Nutr. | pmid:7057266 |
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| Haroon Y and Hauschka PV | Application of high-performance liquid chromatography to assay phylloquinone (vitamin K1) in rat liver. | 1983 | J. Lipid Res. | pmid:6854154 |
| O'Connor ME et al. | Vitamin K deficiency and breast-feeding. | 1983 | Am. J. Dis. Child. | pmid:6846298 |