| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
| Exanthema | D005076 | 11 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fusaro M et al. | Vitamin K, bone fractures, and vascular calcifications in chronic kidney disease: an important but poorly studied relationship. | 2011 | J. Endocrinol. Invest. | pmid:21088475 |
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| Harrington DJ et al. | Urinary excretion of vitamin K metabolites in term and preterm infants: relationship to vitamin K status and prophylaxis. | 2010 | Pediatr. Res. | pmid:20814348 |
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| Chen XH et al. | [Analysis of thirteen cases with secondary coagulation disorder caused by raticide exposure]. | 2010 | Zhonghua Er Ke Za Zhi | pmid:21055312 |
| Kumar R et al. | Effect of phylloquinone supplementation on glucose homeostasis in humans. | 2010 | Am. J. Clin. Nutr. | pmid:20881072 |
| Nakagawa K et al. | Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme. | 2010 | Nature | pmid:20953171 |
| Davies BE et al. | Effect of oseltamivir treatment on anticoagulation: a cross-over study in warfarinized patients. | 2010 | Br J Clin Pharmacol | pmid:21175439 |
| Kidd PM | Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. | 2010 | Altern Med Rev | pmid:21155624 |
| Hong J et al. | Korean patients with superwarfarin intoxication and their outcome. | 2010 | J. Korean Med. Sci. | pmid:21165290 |
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| Heggen E et al. | Plant sterols from rapeseed and tall oils: effects on lipids, fat-soluble vitamins and plant sterol concentrations. | 2010 | Nutr Metab Cardiovasc Dis | pmid:19748247 |
| Kuwabara A et al. | Hypovitaminosis D and K are highly prevalent and independent of overall malnutrition in the institutionalized elderly. | 2010 | Asia Pac J Clin Nutr | pmid:20199987 |
| Lester GE et al. | gamma-Irradiation dose: effects on baby-leaf spinach ascorbic acid, carotenoids, folate, alpha-tocopherol, and phylloquinone concentrations. | 2010 | J. Agric. Food Chem. | pmid:20329797 |
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| McCormick PN et al. | The antipsychotics olanzapine, risperidone, clozapine, and haloperidol are D2-selective ex vivo but not in vitro. | 2010 | Neuropsychopharmacology | pmid:20410873 |
| Miyachi M et al. | A photosensing system composed of photosystem I, molecular wire, gold nanoparticle, and double surfactants in water. | 2010 | Chem. Commun. (Camb.) | pmid:20449307 |
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| Wei G et al. | Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways. | 2010 | J. Cell. Physiol. | pmid:20301194 |
| Nowicka B and Kruk J | Occurrence, biosynthesis and function of isoprenoid quinones. | 2010 | Biochim. Biophys. Acta | pmid:20599680 |
| Furt F et al. | A bimodular oxidoreductase mediates the specific reduction of phylloquinone (vitamin Kâ‚) in chloroplasts. | 2010 | Plant J. | pmid:20626653 |
| Santabarbara S et al. | Interquinone electron transfer in photosystem I as evidenced by altering the hydrogen bond strength to the phylloquinone(s). | 2010 | J Phys Chem B | pmid:20583790 |
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| Holzer G et al. | Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study. | 2010 | Transl Res | pmid:20621035 |
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| Babujee L et al. | The proteome map of spinach leaf peroxisomes indicates partial compartmentalization of phylloquinone (vitamin K1) biosynthesis in plant peroxisomes. | 2010 | J. Exp. Bot. | pmid:20150517 |
| Iwamoto J et al. | Urinary levels of cross-linked N-terminal telopeptide of type I collagen and nutritional status in Japanese professional baseball players. | 2010 | J. Bone Miner. Metab. | pmid:20162436 |
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| Ducros V et al. | Quantitative determination of plasma vitamin K1 by high-performance liquid chromatography coupled to isotope dilution tandem mass spectrometry. | 2010 | Anal. Biochem. | pmid:20175981 |
| Crivello NA et al. | Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides. | 2010 | J. Nutr. Biochem. | pmid:20092997 |
| Giuliano V et al. | Small intestinal bacterial overgrowth and warfarin dose requirement variability. | 2010 | Thromb. Res. | pmid:20051286 |
| Tanaka S et al. | Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activation. | 2010 | Clin. Exp. Immunol. | pmid:20030669 |
| Novotny JA et al. | Vitamin K absorption and kinetics in human subjects after consumption of 13C-labelled phylloquinone from kale. | 2010 | Br. J. Nutr. | pmid:20420753 |
| Beulens JW et al. | Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. | 2010 | Diabetes Care | pmid:20424220 |
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| Widhalm JR et al. | A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19321747 |
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| Shea MK et al. | Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. | 2009 | Am. J. Clin. Nutr. | pmid:19776145 |
| Srinivasan N and Golbeck JH | Protein-cofactor interactions in bioenergetic complexes: the role of the A1A and A1B phylloquinones in Photosystem I. | 2009 | Biochim. Biophys. Acta | pmid:19409369 |
| Pan Y and Jackson RT | Dietary phylloquinone intakes and metabolic syndrome in US young adults. | 2009 | J Am Coll Nutr | pmid:20368375 |