| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
| Exanthema | D005076 | 11 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
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| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Spronk HM et al. | Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. | 2003 Nov-Dec | J. Vasc. Res. | pmid:14654717 |
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| Blake CJ | Committee on food nutrition. Fat-soluble vitamins. | 2003 Jan-Feb | J AOAC Int | pmid:12607754 |
| Kurilich AC et al. | Isotopic labeling and LC-APCI-MS quantification for investigating absorption of carotenoids and phylloquinone from kale (Brassica oleracea). | 2003 | J. Agric. Food Chem. | pmid:12903939 |
| Tsutaoka BT et al. | Superwarfarin and glass ingestion with prolonged coagulopathy requiring high-dose vitamin K1 therapy. | 2003 | Pharmacotherapy | pmid:14524650 |
| Braam LA et al. | Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. | 2003 | Calcif. Tissue Int. | pmid:14506950 |
| Schubiger G et al. | Prevention of vitamin K deficiency bleeding with oral mixed micellar phylloquinone: results of a 6-year surveillance in Switzerland. | 2003 | Eur. J. Pediatr. | pmid:14576936 |
| O'Shaughnessy D et al. | Echis time, under-carboxylated prothrombin and vitamin K status in intensive care patients. | 2003 | Clin Lab Haematol | pmid:14641145 |
| Fan J et al. | A retrospective evaluation of vitamin K1 therapy to reverse the anticoagulant effect of warfarin. | 2003 | Pharmacotherapy | pmid:14594342 |
| Wain AJ et al. | Electrochemical studies of vitamin K1 microdroplets: electrocatalytic hydrogen evolution. | 2003 | Chemphyschem | pmid:14562443 |
| Kurnik D et al. | Multivitamin supplements may affect warfarin anticoagulation in susceptible patients. | 2003 | Ann Pharmacother | pmid:14565795 |
| Dismore ML et al. | Vitamin K content of nuts and fruits in the US diet. | 2003 | J Am Diet Assoc | pmid:14647095 |
| Fleming RH et al. | Effects of dietary particulate limestone, vitamin K3 and fluoride and photostimulation on skeletal morphology and osteoporosis in laying hens. | 2003 | Br. Poult. Sci. | pmid:14965088 |
| Ben-Shem A et al. | Crystal structure of plant photosystem I. | 2003 | Nature | pmid:14668855 |
| Lochner K et al. | Phylloquinone, what can we learn from plants? | 2003 | Biofactors | pmid:14695922 |
| Carrié I et al. | Effects of long-term vitamin K (phylloquinone) intake on retina aging. | 2003 | Nutr Neurosci | pmid:14744039 |
| Lubetsky A et al. | Comparison of oral vs intravenous phytonadione (vitamin K1) in patients with excessive anticoagulation: a prospective randomized controlled study. | 2003 | Arch. Intern. Med. | pmid:14609783 |
| Wilson CR et al. | Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition. | 2003 | Toxicology | pmid:12832152 |
| Gong XM et al. | Control of electron transport in photosystem I by the iron-sulfur cluster FX in response to intra- and intersubunit interactions. | 2003 | J. Biol. Chem. | pmid:12626505 |
| Hangarter MA et al. | Primary photoreactions of phylloquinone (vitamin K1) and plastoquinone-1 in solution. | 2003 | Photochem. Photobiol. Sci. | pmid:12803075 |
| Lange BM and Ghassemian M | Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism. | 2003 | Plant Mol. Biol. | pmid:12777052 |
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| Xu W et al. | Electron transfer in cyanobacterial photosystem I: II. Determination of forward electron transfer rates of site-directed mutants in a putative electron transfer pathway from A0 through A1 to FX. | 2003 | J. Biol. Chem. | pmid:12721306 |
| Markovits J et al. | Differential effects of two growth inhibitory K vitamin analogs on cell cycle regulating proteins in human hepatoma cells. | 2003 | Life Sci. | pmid:12679193 |
| Agalarov R and Brettel K | Temperature dependence of biphasic forward electron transfer from the phylloquinone(s) A1 in photosystem I: only the slower phase is activated. | 2003 | Biochim. Biophys. Acta | pmid:12686416 |
| Pereira SP et al. | Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding. | 2003 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:12598499 |
| Essalihi R et al. | A new model of isolated systolic hypertension induced by chronic warfarin and vitamin K1 treatment. | 2003 | Am. J. Hypertens. | pmid:12559675 |
| Poli D et al. | Safety and effectiveness of low dose oral vitamin K1 administration in asymptomatic out-patients on warfarin or acenocoumarol with excessive anticoagulation. | 2003 | Haematologica | pmid:12604423 |
| Wade Johnson T et al. | The menD and menE homologs code for 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylate synthase and O-succinylbenzoic acid-CoA synthase in the phylloquinone biosynthetic pathway of Synechocystis sp. PCC 6803. | 2003 | Biochim. Biophys. Acta | pmid:12615349 |
| Golbeck JH | The binding of cofactors to photosystem I analyzed by spectroscopic and mutagenic methods. | 2003 | Annu Rev Biophys Biomol Struct | pmid:12524325 |
| Sato T et al. | The biological activity and tissue distribution of 2',3'-dihydrophylloquinone in rats. | 2003 | Biochim. Biophys. Acta | pmid:12928110 |
| Poli D et al. | Asymptomatic excessive coumarin anticoagulation is a risk factor for thrombotic and bleeding complications of oral anticoagulant therapy. | 2003 | J. Thromb. Haemost. | pmid:12911603 |
| Booth SL et al. | Dietary phylloquinone depletion and repletion in older women. | 2003 | J. Nutr. | pmid:12888638 |
| Hansen KN et al. | Weekly oral vitamin K prophylaxis in Denmark. | 2003 | Acta Paediatr. | pmid:12892158 |
| Li J et al. | Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons. | 2003 | J. Neurosci. | pmid:12843286 |
| Woollard DC et al. | Determination of vitamin K1 isomers in foods by liquid chromatography with C30 bonded-phase column. | 2002 May-Jun | J AOAC Int | pmid:12083261 |
| Cook KK et al. | Measurement of cis and trans isomers of vitamin K1 in rat tissues by liquid chromatography with a C30 column. | 2002 Jul-Aug | J AOAC Int | pmid:12180675 |
| Konoplia NA et al. | [Effects of riboxin, essentiale, and phylloquinone on the immunomodulating and antioxidant effect of laser and magneto-laser irradiation in liver toxicosis induced by gentamycin]. | 2002 Jan-Feb | Eksp Klin Farmakol | pmid:12025789 |
| Schurgers LJ and Vermeer C | Differential lipoprotein transport pathways of K-vitamins in healthy subjects. | 2002 | Biochim. Biophys. Acta | pmid:11960685 |
| Tsang CK and Kamei Y | Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells. | 2002 | Neurosci. Lett. | pmid:11911978 |
| Newman P et al. | The uptake of lipoprotein-borne phylloquinone (vitamin K1) by osteoblasts and osteoblast-like cells: role of heparan sulfate proteoglycans and apolipoprotein E. | 2002 | J. Bone Miner. Res. | pmid:11874234 |
| Tirapelli CR et al. | Vitamin K(1) prevents the effect of hypoxia on phenylephrine-induced contraction in the carotid artery. | 2002 | Pharmacology | pmid:12169764 |
| Roe DE et al. | Multilaboratory comparison of growth characteristics for anaerobes, using 5 different agar media. | 2002 | Clin. Infect. Dis. | pmid:12173106 |
| Roe DE et al. | Multilaboratory comparison of anaerobe susceptibility results using 3 different agar media. | 2002 | Clin. Infect. Dis. | pmid:12173107 |
| Dähnhardt D et al. | The hydroxyphenylpyruvate dioxygenase from Synechocystis sp. PCC 6803 is not required for plastoquinone biosynthesis. | 2002 | FEBS Lett. | pmid:12123828 |
| McKeown NM et al. | Dietary and nondietary determinants of vitamin K biochemical measures in men and women. | 2002 | J. Nutr. | pmid:12042454 |
| Thijssen HH et al. | Menaquinone-4 in breast milk is derived from dietary phylloquinone. | 2002 | Br. J. Nutr. | pmid:12064330 |
| Sato T et al. | Difference in the metabolism of vitamin K between liver and bone in vitamin K-deficient rats. | 2002 | Br. J. Nutr. | pmid:12064340 |
| Olson RE et al. | Total body phylloquinone and its turnover in human subjects at two levels of vitamin K intake. | 2002 | Br. J. Nutr. | pmid:12067424 |
| Thane CW et al. | Intake and sources of phylloquinone (vitamin K1): variation with socio-demographic and lifestyle factors in a national sample of British elderly people. | 2002 | Br. J. Nutr. | pmid:12067431 |
| Thane CW et al. | Plasma phylloquinone (vitamin K1) concentration and its relationship to intake in a national sample of British elderly people. | 2002 | Br. J. Nutr. | pmid:12067432 |
| Binkley N et al. | Vitamin K supplementation does not affect ovariectomy-induced bone loss in rats. | 2002 | Bone | pmid:12052460 |
| Rigby SE et al. | Photoaccumulation of the PsaB phyllosemiquinone in photosystem I of Chlamydomonas reinhardtii. | 2002 | Biochim. Biophys. Acta | pmid:12351214 |
| Fregin A et al. | Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16. | 2002 | Blood | pmid:12384421 |
| Shimizu N et al. | Shift of serum osteocalcin components between cord blood and blood at day 5 of life. | 2002 | Pediatr. Res. | pmid:12409510 |
| Booth SL et al. | Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women. | 2002 | J. Nutr. | pmid:12221218 |
| Riegert-Johnson DL and Volcheck GW | The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. | 2002 | Ann. Allergy Asthma Immunol. | pmid:12392385 |
| Binkley NC et al. | A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. | 2002 | Am. J. Clin. Nutr. | pmid:12399278 |
| Shinkarev VP et al. | Modeling of the P700+ charge recombination kinetics with phylloquinone and plastoquinone-9 in the A1 site of photosystem I. | 2002 | Biophys. J. | pmid:12496065 |
| Tirapelli CR et al. | Vitamin K1 attenuates hypoxia-induced relaxation of rat carotid artery. | 2002 | Pharmacol. Res. | pmid:12457620 |
| Okayasu H et al. | Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines. | 2001 Jul-Aug | Anticancer Res. | pmid:11724297 |
| Riegert-Johnson DL et al. | A patient with anaphylactoid hypersensitivity to intravenous cyclosporine and subcutaneous phytonadione (vitamin K(1)). | 2001 | Bone Marrow Transplant. | pmid:11803365 |
| Schurgers LJ et al. | Role of vitamin K and vitamin K-dependent proteins in vascular calcification. | 2001 | Z Kardiol | pmid:11374034 |
| Onaga IC and Oyenuga KO | Quantitative effects of interacting variables on vitamin K1, phylloquinone, entrapment in liposomes. | 2001 | Afr J Med Med Sci | pmid:14510120 |
| Mitchell GV et al. | Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4. | 2001 | Int J Vitam Nutr Res | pmid:11276919 |
| Cushman M et al. | The association of vitamin K status with warfarin sensitivity at the onset of treatment. | 2001 | Br. J. Haematol. | pmid:11260056 |
| MacLaren R et al. | Evaluation and survey of intravenous vitamin K1 for treatment of coagulopathy in critically ill patients. | 2001 | Pharmacotherapy | pmid:11213854 |
| Shields RC et al. | Efficacy and safety of intravenous phytonadione (vitamin K1) in patients on long-term oral anticoagulant therapy. | 2001 | Mayo Clin. Proc. | pmid:11243272 |
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| Udagawa M and Murai T | Content of phylloquinone and menaquinone in the tissues of mummichog Fundulus heteroclitus fed diets containing different forms of vitamin K. | 2001 | J. Nutr. Sci. Vitaminol. | pmid:11508712 |
| Boudreaux B et al. | Mutations in both sides of the photosystem I reaction center identify the phylloquinone observed by electron paramagnetic resonance spectroscopy. | 2001 | J. Biol. Chem. | pmid:11489879 |
| Johnson TW et al. | Recruitment of a foreign quinone into the A1 site of photosystem I. In vivo replacement of plastoquinone-9 by media-supplemented naphthoquinones in phylloquinone biosynthetic pathway mutants of Synechocystis sp. PCC 6803. | 2001 | J. Biol. Chem. | pmid:11470786 |
| Gettler SL and Fung MA | Off-center fold: indurated plaques on the arms of a 52-year-old man. Diagnosis: Cutaneous reaction to phytonadione injection. | 2001 | Arch Dermatol | pmid:11453820 |
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| Asakura H et al. | Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. | 2001 | Osteoporos Int | pmid:11846334 |
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| Itoh S et al. | Modification of photosystem I reaction center by the extraction and exchange of chlorophylls and quinones. | 2001 | Biochim. Biophys. Acta | pmid:11687211 |
| Bittl R and Zech SG | Pulsed EPR spectroscopy on short-lived intermediates in Photosystem I. | 2001 | Biochim. Biophys. Acta | pmid:11687215 |
| Deligiannakis Y and Rutherford AW | Electron spin echo envelope modulation spectroscopy in photosystem I. | 2001 | Biochim. Biophys. Acta | pmid:11687217 |
| Rigby SE et al. | Electron nuclear double resonance (ENDOR) spectroscopy of radicals in photosystem I and related Type 1 photosynthetic reaction centres. | 2001 | Biochim. Biophys. Acta | pmid:11687218 |
| Hastings G and Sivakumar V | A Fourier transform infrared absorption difference spectrum associated with the reduction of A1 in photosystem I: are both phylloquinones involved in electron transfer? | 2001 | Biochemistry | pmid:11297436 |
| Begent LA et al. | Characterization and purification of the vitamin K1 2,3 epoxide reductases system from rat liver. | 2001 | J. Pharm. Pharmacol. | pmid:11341364 |
| Purton S et al. | Site-directed mutagenesis of PsaA residue W693 affects phylloquinone binding and function in the photosystem I reaction center of Chlamydomonas reinhardtii. | 2001 | Biochemistry | pmid:11329285 |
| Fondevila CG et al. | Reversal of excessive oral anticoagulation with a low oral dose of vitamin K1 compared with acenocoumarine discontinuation. A prospective, randomized, open study. | 2001 | Blood Coagul. Fibrinolysis | pmid:11229833 |
| Kaneki M et al. | Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. | 2001 | Nutrition | pmid:11369171 |
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| Burgess TM et al. | Practitioner report involving intravenous use of vitamin K1 prompts label review and revision. | 2001 | J. Am. Vet. Med. Assoc. | pmid:11394826 |
| Nakamura A and Watanabe T | Separation and determination of minor photosynthetic pigments by reversed-phase HPLC with minimal alteration of chlorophylls. | 2001 | Anal Sci | pmid:11990566 |
| Bystrova NA et al. | [Immunomodulating effects of vitamin K preparations and its potentiation by riboxine in acute cold stress]. | 2000 Sep-Oct | Eksp Klin Farmakol | pmid:11109528 |
| Schurgers LJ and Vermeer C | Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. | 2000 Nov-Dec | Haemostasis | pmid:11356998 |
| Chase GW and Thompson B | Accelerated solvent extraction of vitamin K1 in medical foods in conjunction with matrix solid-phase dispersion. | 2000 Mar-Apr | J AOAC Int | pmid:10772179 |
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