| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
| Exanthema | D005076 | 11 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kanai S et al. | Eicosapentaenoic acid reduces warfarin-induced arterial calcification in rats. | 2011 | Atherosclerosis | pmid:21193197 |
| Sogabe N et al. | Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats. | 2011 | Bone | pmid:21295170 |
| Srinivasan N et al. | Alteration of the H-bond to the A(1A) phylloquinone in Photosystem I: influence on the kinetics and energetics of electron transfer. | 2011 | J Phys Chem B | pmid:21299208 |
| Tie JK et al. | Functional study of the vitamin K cycle in mammalian cells. | 2011 | Blood | pmid:21239697 |
| Terachi T et al. | Plasma vitamin K concentration in horses supplemented with several vitamin K homologs. | 2011 | J. Anim. Sci. | pmid:21169510 |
| McConnell MD et al. | Double reduction of plastoquinone to plastoquinol in photosystem 1. | 2011 | Biochemistry | pmid:22103567 |
| Haraikawa M et al. | Vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) induces intestinal alkaline phosphatase gene expression. | 2011 | J. Nutr. Sci. Vitaminol. | pmid:22041909 |
| Clark TR and Burns S | Elevated international normalized ratio values associated with concomitant use of warfarin and ceftriaxone. | 2011 | Am J Health Syst Pharm | pmid:21856805 |
| Apalset EM et al. | Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study. | 2011 | Bone | pmid:21839190 |
| Ito A et al. | Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. | 2011 | Lipids Health Dis | pmid:21914161 |
| Carr BI et al. | c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition. | 2011 | Cancer Biol. Ther. | pmid:21734462 |
| Schimpf KJ et al. | Determination of trans vitamin K1 in infant and medical nutritional products using AOAC Method 999.15 with modified preparation and extraction procedures and C30 bonded phase chromatography: single-laboratory validation. | 2010 Mar-Apr | J AOAC Int | pmid:20480913 |
| Sousa T et al. | Letter: Localized cutaneous reaction to intramuscular vitamin K in a patient with acute fatty liver of pregnancy. | 2010 | Dermatol. Online J. | pmid:21199642 |
| Shea MK et al. | Adulthood obesity is positively associated with adipose tissue concentrations of vitamin K and inversely associated with circulating indicators of vitamin K status in men and women. | 2010 | J. Nutr. | pmid:20237066 |
| Wei G et al. | Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways. | 2010 | J. Cell. Physiol. | pmid:20301194 |
| Nowicka B and Kruk J | Occurrence, biosynthesis and function of isoprenoid quinones. | 2010 | Biochim. Biophys. Acta | pmid:20599680 |
| Furt F et al. | A bimodular oxidoreductase mediates the specific reduction of phylloquinone (vitamin Kâ‚) in chloroplasts. | 2010 | Plant J. | pmid:20626653 |
| Santabarbara S et al. | Interquinone electron transfer in photosystem I as evidenced by altering the hydrogen bond strength to the phylloquinone(s). | 2010 | J Phys Chem B | pmid:20583790 |
| Biron-Andréani C et al. | Use of human hepatocytes to investigate blood coagulation factor. | 2010 | Methods Mol. Biol. | pmid:20645066 |
| Holzer G et al. | Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study. | 2010 | Transl Res | pmid:20621035 |