sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
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Sapra B et al. Effect of Asparagus racemosus extract on transdermal delivery of carvedilol: a mechanistic study. 2009 AAPS PharmSciTech pmid:19238554
Hopkins CR ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720). 2011 ACS Chem Neurosci pmid:22778861
Santos WL and Lynch KR Drugging sphingosine kinases. 2015 ACS Chem. Biol. pmid:25384187
Haberkant P et al. Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions. 2016 ACS Chem. Biol. pmid:26555438
Barth BM et al. PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate. 2013 ACS Nano pmid:23373542
Lundblad C et al. Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat. 2013 Acta Anaesthesiol Scand pmid:23683126
Dygas A et al. Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. 1999 Acta Biochim. Pol. pmid:10453985
Wójcik M and Barańska J Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells. 1999 Acta Biochim. Pol. pmid:10453988
Igarashi Y and Yatomi Y Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathophysiological roles. 1998 Acta Biochim. Pol. pmid:9821862
Krzemiński P Modulation of ERK1/2 activity is crucial for sphingosine-induced death of glioma C6 cells. 2005 Acta Biochim. Pol. pmid:16302024
Ayar A et al. Mobilization of intracellular calcium by intracellular flash photolysis of caged dihydrosphingosine in cultured neonatal rat sensory neurones. 1998 Acta Biochim. Pol. pmid:9821863
Chigorno V et al. Human fibroblasts in culture metabolize differently exogenous G(M3) ganglioside species containing C18 and C20 sphingosine. 1998 Acta Biochim. Pol. pmid:9821869
Hsia K et al. Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. 2017 Acta Biomater pmid:28110073
Suresh S et al. Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. 2005 Acta Biomater pmid:16701777
Ogle ME et al. Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. 2014 Acta Biomater pmid:25128750
Murakami M et al. Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment. 2014 Acta Biomater pmid:25038462
Scott EA et al. Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. 2010 Acta Biomater pmid:19607945
Zhang J and Song J Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. 2014 Acta Biomater pmid:24631657
Tang H et al. Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits. 2015 Acta Cir Bras pmid:26560422
Melnik BC Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. 2016 Acta Derm. Venereol. pmid:26304030
Wang Z et al. The Effect of Sphingosine 1-Phosphate/Sphingosine 1-Phosphate Receptor on Neutrophil Function and the Relevant Signaling Pathway. 2015 Acta Haematol. pmid:25872153
Zhao Z et al. Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. 2017 Acta Haematol. pmid:27802432
HECHT E [A systematic study of the significance of lipoids in blood coagulation. II. The effect of the diaminophosphatides and their degradation product sphingosine]. 1953 Acta Haematol. pmid:13064995
Miguel BG et al. Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes. 2001 Acta Neurobiol Exp (Wars) pmid:11512408
Czajkowski R et al. Sphingosine modulates Ca2+ signals via phospholipase C dependent pathway in glioma C6 cells. 1997 Acta Neurobiol Exp (Wars) pmid:9519554
Miguel BG et al. Sphingosylphosphorylcholine induces mitochondria-mediated apoptosis in neuro 2a cells: involvement of protein kinase C. 2008 Acta Neurobiol Exp (Wars) pmid:19112467
Sabała P et al. Sphingosine stimulates calcium mobilization and modulates calcium signals evoked by thapsigargin in glioma C6 cells. 1996 Acta Neurobiol Exp (Wars) pmid:8768300
Rolland WB et al. FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice. 2011 Acta Neurochir. Suppl. pmid:21725758
Signoriello E et al. Fingolimod efficacy in multiple sclerosis associated with Sjogren syndrome. 2015 Acta Neurol. Scand. pmid:25622658
Sempere AP et al. Switching from natalizumab to fingolimod: an observational study. 2013 Acta Neurol. Scand. pmid:23336398
Wipfler P et al. Natalizumab saturation: biomarker for individual treatment holiday after natalizumab withdrawal? 2014 Acta Neurol. Scand. pmid:24032536
Couttas TA et al. Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. 2014 Acta Neuropathol Commun pmid:24456642
van Doorn R et al. Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes. 2012 Acta Neuropathol. pmid:22810490
Lassmann H Targeting intracerebral inflammation in multiple sclerosis: is it feasible? 2012 Acta Neuropathol. pmid:22797580
Milstien S et al. Sphingosine 1-phosphate in neural signalling and function. 2007 Acta Paediatr Suppl pmid:17391440
Michel MC et al. Vascular effects of sphingolipids. 2007 Acta Paediatr Suppl pmid:17391441
Goetzl EJ et al. Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity. 2007 Acta Paediatr Suppl pmid:17391442
Wang MH et al. FTY720, a new immunosuppressant, as rescue therapy in mouse cardiac transplantation. 2003 Acta Pharmacol. Sin. pmid:12956930
Xu M et al. FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. 2014 Acta Pharmacol. Sin. pmid:25399649
Im DS Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. 2010 Acta Pharmacol. Sin. pmid:20729877
Im DS Two ligands for a GPCR, proton vs lysolipid. 2005 Acta Pharmacol. Sin. pmid:16297340
Lee HY et al. Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis. 2006 Acta Pharmacol. Sin. pmid:17007744
Ge D et al. Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn. 2012 Acta Pharmacol. Sin. pmid:22139003
Sacket SJ and Im DS Discovery of sphingosine 1-O-methyltransferase in rat kidney and liver homogenates. 2008 Acta Pharmacol. Sin. pmid:18817628
Chang CH et al. Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. 2013 Acta Pharmacol. Sin. pmid:23377549
Xu CB et al. Sphingosine signaling and atherogenesis. 2004 Acta Pharmacol. Sin. pmid:15210056
Zhang TH et al. Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases. 2007 Acta Pharmacol. Sin. pmid:17303009
Beech DJ Integration of transient receptor potential canonical channels with lipids. 2012 Acta Physiol (Oxf) pmid:21624095
Davletov B A multiple sclerosis drug sheds light on astrocyte biology. 2014 Acta Physiol (Oxf) pmid:24947320
Baranowski M et al. Exercise increases plasma levels of sphingoid base-1 phosphates in humans. 2011 Acta Physiol (Oxf) pmid:21535416
Stenovec M et al. Alterations of calcium homoeostasis in cultured rat astrocytes evoked by bioactive sphingolipids. 2014 Acta Physiol (Oxf) pmid:24825022
Törnquist K Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells. 2012 Acta Physiol (Oxf) pmid:21338471
Kusch A et al. Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury. 2013 Acta Physiol (Oxf) pmid:23432924
Fang P et al. Effects of motilin on intracellular free calcium in cultured smooth muscle cells from the antrum of neonatal rats. 2010 Acta Physiol (Oxf) pmid:20082607
Fischereder M Chemokines and chemokine receptors in renal transplantation--from bench to bedside. 2007 Acta Physiol Hung pmid:17444276
Vescovo G et al. Apoptosis and changes in contractile protein pattern in the skeletal muscle in heart failure. 2001 Acta Physiol. Scand. pmid:11412142
Vermelho AB et al. Heart muscle cells share common neutral glycosphingolipids with Trypanosoma cruzi. 1997 Acta Trop. pmid:9107361
Malaquias AT and Oliveira MM Phospholipid signalling pathways in Trypanosoma cruzi growth control. 1999 Acta Trop. pmid:10465050
Pyne NJ et al. The role of sphingosine 1-phosphate in inflammation and cancer. 2014 Adv Biol Regul pmid:24070975
Carroll B et al. Sphingolipids in the DNA damage response. 2015 Adv Biol Regul pmid:25434743
Siow D et al. Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. 2015 Adv Biol Regul pmid:25319495
Ebenezer DL et al. Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. 2017 Adv Biol Regul pmid:27720306
Maczis M et al. Sphingosine-1-phosphate and estrogen signaling in breast cancer. 2016 Adv Biol Regul pmid:26601898
Pyne NJ et al. Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation. 2016 Adv Biol Regul pmid:26429117
Nagahashi M et al. Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. 2014 Adv Biol Regul pmid:24210073
Knapp M et al. Dose-dependent effect of aspirin on the level of sphingolipids in human blood. 2013 Adv Med Sci pmid:24101372
Knapp M et al. Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. 2012 Adv Med Sci pmid:22296975
Yeh EA and Weinstock-Guttman B Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis. 2011 Adv Ther pmid:21394595
Cuvillier O et al. Hypoxia, therapeutic resistance, and sphingosine 1-phosphate. 2013 Adv. Cancer Res. pmid:23290779
Alshaker H et al. Therapeutic potential of targeting SK1 in human cancers. 2013 Adv. Cancer Res. pmid:23290780
Heffernan-Stroud LA and Obeid LM Sphingosine kinase 1 in cancer. 2013 Adv. Cancer Res. pmid:23290781
Siow DL et al. Sphingosine kinase localization in the control of sphingolipid metabolism. 2011 Adv. Enzyme Regul. pmid:21075134
Pyne NJ et al. New aspects of sphingosine 1-phosphate signaling in mammalian cells. 2009 Adv. Enzyme Regul. pmid:19534035
Birbes H et al. Mitochondria and ceramide: intertwined roles in regulation of apoptosis. 2002 Adv. Enzyme Regul. pmid:12123710
Serra M and Saba JD Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. 2010 Adv. Enzyme Regul. pmid:19914275
Baranowski M and Górski J Heart sphingolipids in health and disease. 2011 Adv. Exp. Med. Biol. pmid:21910081
Hammad SM Blood sphingolipids in homeostasis and pathobiology. 2011 Adv. Exp. Med. Biol. pmid:21910082
Olivera A and Rivera J An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. 2011 Adv. Exp. Med. Biol. pmid:21713655
Strub GM et al. Extracellular and intracellular actions of sphingosine-1-phosphate. 2010 Adv. Exp. Med. Biol. pmid:20919652
Oskouian B and Saba JD Cancer treatment strategies targeting sphingolipid metabolism. 2010 Adv. Exp. Med. Biol. pmid:20919655
White CR et al. High-Density Lipoprotein Regulation of Mitochondrial Function. 2017 Adv. Exp. Med. Biol. pmid:28551800
Rivera J et al. New insights on mast cell activation via the high affinity receptor for IgE. 2008 Adv. Immunol. pmid:18772004
Silva VR et al. Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise. 2016 Aging (Albany NY) pmid:28039439
Green CL et al. The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. 2017 Aging Cell pmid:28139067
Saito M et al. Effects of gangliosides on ethanol-induced neurodegeneration in the developing mouse brain. 2007 Alcohol. Clin. Exp. Res. pmid:17374046
Makino Y et al. Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle. 2012 Allergol Int pmid:22441633
Sashio T et al. Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium. 2012 Allergol Int pmid:22361510
Fuerst E et al. Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells. 2014 Allergy pmid:25041788
Kleinjan A et al. Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. 2013 Allergy pmid:23253209
Herzinger T et al. Sphingosine-1-phosphate signaling and the skin. 2007 Am J Clin Dermatol pmid:18039015
Rosini JM et al. Delayed cardiac dysrhythmias after fingolimod administration. 2015 Am J Emerg Med pmid:25669873
Thomas RH and Wakefield RA Oral disease-modifying therapies for relapsing-remitting multiple sclerosis. 2015 Am J Health Syst Pharm pmid:25511835
Fox EJ Emerging oral agents for multiple sclerosis. 2010 Am J Manag Care pmid:20873946
Weinstock-Guttman B An update on new and emerging therapies for relapsing-remitting multiple sclerosis. 2013 Am J Manag Care pmid:24494635
Campbell JD et al. Comparative effectiveness of early natalizumab treatment in JC virus-negative relapsing-remitting multiple sclerosis. 2013 Am J Manag Care pmid:23725360
Camm J et al. Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. 2014 Am. Heart J. pmid:25440790
Deutschman DH et al. Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. 2003 Am. Heart J. pmid:12851609
Zhang Q et al. Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. 2016 Am. J. Chin. Med. pmid:27430910
Lev M Sphingolipid biosynthesis and vitamin K metabolism in Bacteroides melaninogenicus. 1979 Am. J. Clin. Nutr. pmid:32765