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Neuropharmacology |
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Neuroscience |
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Mol Oncol |
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Neuropharmacology |
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Nature |
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The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. |
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BMC Genomics |
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PLoS ONE |
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Cell Host Microbe |
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Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51). |
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Sphingosine metabolism as a therapeutic target in cutaneous melanoma. |
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Transl Res |
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Atherosclerotic dyslipidemia revealed by plasma lipidomics on ApoE mice fed a high-fat diet. |
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Atherosclerosis |
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Biochimie |
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Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study. |
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Endothelial glycocalyx as a critical signalling platform integrating the extracellular haemodynamic forces and chemical signalling. |
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Sphingolipids modulate the function of human serotonin receptors: Insights from sphingolipid-deficient cells. |
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Biochim. Biophys. Acta |
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The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. |
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PLoS ONE |
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Reduction of Pertussis Inflammatory Pathology by Therapeutic Treatment With Sphingosine-1-Phosphate Receptor Ligands by a Pertussis Toxin-Insensitive Mechanism. |
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Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
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Front Biosci (Landmark Ed) |
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
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Atherosclerosis |
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Phytosphingosine-1-phosphate and epidermal growth factor synergistically restore extracellular matrix in human dermal fibroblasts in vitro and in vivo. |
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Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. |
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PLoS ONE |
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Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. |
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Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. |
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Cell. Physiol. Biochem. |
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Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. |
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Mol. Immunol. |
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Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. |
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PLoS ONE |
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High-Density Lipoprotein Regulation of Mitochondrial Function. |
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Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. |
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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. |
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Nature |
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A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. |
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Dev. Cell |
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Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential. |
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Expert Opin. Ther. Targets |
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Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. |
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Invest. Ophthalmol. Vis. Sci. |
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Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. |
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Gastroenterology |
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Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. |
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Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. |
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Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation. |
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Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. |
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Yale J Biol Med |
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Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
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Sci Signal |
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Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
2017 |
PLoS ONE |
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Sphingosine 1-phosphate - A double edged sword in the brain. |
2017 |
Biochim. Biophys. Acta |
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A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. |
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J Pharm Biomed Anal |
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Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1. |
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Oncotarget |
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Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. |
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Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. |
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Biochim. Biophys. Acta |
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Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. |
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HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. |
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Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. |
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Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. |
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Diabetes |
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