| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yin GJ et al. | [Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro]. | 2012 | Zhonghua Zhong Liu Za Zhi | pmid:22780925 |
| Liu SQ et al. | [Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer LoVo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1]. | 2013 | Zhonghua Zhong Liu Za Zhi | pmid:24054007 |
| Liu SQ et al. | [Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms]. | 2011 | Zhonghua Zhong Liu Za Zhi | pmid:21575515 |
| Chen L et al. | [Inhibition of alphastatin on angiogenesis in human endothelial cells and the mechanism thereof: an experimental study]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16784712 |
| Cai JQ et al. | [Study of the effects of immunosuppressive agents on human islet cells in vitro]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:15932724 |
| Yu HM et al. | [Regulation of sphingosine kinase 1 in the TNF-α-induced expression of MUC5AC in airway epithelial cells]. | 2011 | Zhonghua Yi Xue Za Zhi | pmid:21418911 |
| Liao AJ et al. | [The study of FTY720 on inducing apoptosis and autophagy in multiple myeloma cell line U266]. | 2011 | Zhonghua Xue Ye Xue Za Zhi | pmid:22339823 |
| Yang LX et al. | [Association between murine double minute 2 expression and AngII and ceramide induced endothelial cells apoptosis]. | 2007 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:18206046 |
| Bao XH et al. | [Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. | 2016 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:27220580 |
| Song JH et al. | [FTY720-induced lymphocyte apoptosis inhibits acute graft versus host disease in rat small bowel transplantation]. | 2010 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:20099165 |
| Zhang L et al. | [Study the mechanisms and inducing transplantation immune tolerance of FTY720]. | 2003 | Zhonghua Wai Ke Za Zhi | pmid:14766054 |
| Liu H et al. | [Effect of C8-ceramide on apoptosis of alveolar type II epithelial cells]. | 2015 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:26702858 |
| Zhu GQ et al. | [Effect of FTY720 on glomerulosclerosis and expression of cell cycle regulatory proteins in subtotally nephrectomized rats]. | 2007 | Zhonghua Er Ke Za Zhi | pmid:18339282 |
| Xie M and Zhou JH | [FTY720 reduces peritubular micrangium loss in renal interstitial fibrotic rats]. | 2009 | Zhonghua Er Ke Za Zhi | pmid:19951479 |
| Tang Y et al. | [Updates on clinicopathologic findings of Niemann-Pick disease type C]. | 2010 | Zhonghua Bing Li Xue Za Zhi | pmid:20654165 |
| Jiang JY et al. | [FTY720 attenuates rat anti-Thy-1 mesangial proliferative glomerulonephritis by inhibition of transforming growth factor β1-connective tissue growth factor pathway]. | 2012 | Zhonghua Bing Li Xue Za Zhi | pmid:22455887 |
| Li Y and Yu KL | [Advances in thrombin-protease-activated receptor 1-sphingosine 1-phosphate pathway during sepsis]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19278594 |
| Huang Y et al. | [Ceramide participates in cell programmed death induced by Type II anti-CD20 mAb]. | 2015 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:26739069 |
| Xiong HB et al. | [Effect of mono and combination therapy with FTY720 and ICAM-1 mAb for mouse-to-rat cardiac xenotransplantation]. | 2007 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:17344585 |
| Huang RT | [Structure of brain gangliosides and of neuraminic-acid-containing oligosaccharides in milk]. | 1973 | Zentralbl Veterinarmed A | pmid:4196659 |
| Brinkmann V | FTY720: mechanism of action and potential benefit in organ transplantation. | 2004 | Yonsei Med. J. | pmid:15627289 |
| Bae JH et al. | Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii. | 2004 | Yeast | pmid:15116344 |
| Gusman DH and Shoemake C | Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. | 2017 | Yale J Biol Med | pmid:28356890 |
| Chiba K | [New therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)]. | 2009 | Yakugaku Zasshi | pmid:19483408 |
| Yu XQ et al. | Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate. | 2010 | Xenobiotica | pmid:20175664 |
| Taylor S et al. | The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists. | 2012 | Xenobiotica | pmid:22225501 |
| Syuto T et al. | Mammalian Diaphanous (mDia) may be involved in the signal transduction of sphingosine-1-phosphate on developing actin stress fiber of human fibroblasts. | 2009 Jul-Aug | Wound Repair Regen | pmid:19614924 |
| Watterson KR et al. | Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing. | 2007 Sep-Oct | Wound Repair Regen | pmid:17971005 |
| Yoneda H et al. | A prospective, multicenter, randomized study of the efficacy of eicosapentaenoic acid for cerebral vasospasm: the EVAS study. | 2014 | World Neurosurg | pmid:23032083 |
| Lei YC et al. | C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure. | 2016 | World J. Gastroenterol. | pmid:28028363 |
| Nguyen AV et al. | STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. | 2014 | World J. Gastroenterol. | pmid:25132744 |
| Sano N et al. | New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury. | 2015 | World J. Gastroenterol. | pmid:26668502 |
| Hu WM et al. | Effect of S1P5 on proliferation and migration of human esophageal cancer cells. | 2010 | World J. Gastroenterol. | pmid:20397263 |
| He JH et al. | Effect of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice. | 2005 | World J. Gastroenterol. | pmid:15641148 |
| Ren J et al. | Expression of sphingosine kinase gene in the interactions between human gastric carcinoma cell and vascular endothelial cell. | 2002 | World J. Gastroenterol. | pmid:12174364 |
| Zhang XF et al. | Apoptosis of human colon carcinoma HT-29 cells induced by ceramide. | 2006 | World J. Gastroenterol. | pmid:16773715 |
| Lei YC et al. | Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells. | 2015 | World J. Gastroenterol. | pmid:26676341 |
| Wang J et al. | Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. | 2007 | World J. Gastroenterol. | pmid:17373752 |
| Jin L et al. | The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. | 2016 | World J Surg Oncol | pmid:27129720 |
| Ohba M et al. | Long-term graft acceptance in rat heart transplantation by CTLA4Ig gene transfection combined with FTY720 treatment. | 2001 | World J Surg | pmid:11344387 |
| Fazekas F et al. | Fingolimod in the treatment algorithm of relapsing remitting multiple sclerosis: a statement of the Central and East European (CEE) MS Expert Group. | 2012 | Wien Med Wochenschr | pmid:22895849 |
| Zhang SQ et al. | Mutation of G234 amino acid residue in candida albicans drug-resistance-related protein Rta2p is associated with fluconazole resistance and dihydrosphingosine transport. | 2015 | Virulence | pmid:26220356 |
| Walsh KB et al. | Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection. | 2010 | Virology | pmid:19962171 |
| Seo YJ and Hahm B | Sphingosine analog AAL-R promotes activation of LCMV-infected dendritic cells. | 2014 | Viral Immunol. | pmid:24605791 |
| Stroh A et al. | Influence of a phytosphingosine-containing chlorhexidine shampoo on superficial bacterial counts and bacterial adherence to canine keratinocytes. | 2010 | Vet. Microbiol. | pmid:19781867 |
| Poersch AB et al. | Involvement of oxidative stress in subacute toxicity induced by fumonisin B1 in broiler chicks. | 2014 | Vet. Microbiol. | pmid:25219295 |
| Hilton H et al. | Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse. | 2008 | Vet. Dermatol. | pmid:19055613 |
| Mani R et al. | Non-immunosuppressive FTY720-derivative OSU-2S mediates reactive oxygen species-mediated cytotoxicity in canine B-cell lymphoma. | 2017 | Vet Comp Oncol | pmid:27136276 |
| Poti F et al. | Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-Râ»/â») mice. | 2012 | Vascul. Pharmacol. | pmid:22459073 |
| Zhang H et al. | Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation. | 2017 | Vascul. Pharmacol. | pmid:28797762 |
| Gharbaran R | Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma. | 2016 | Tumour Biol. | pmid:27317256 |
| Zhang L et al. | FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway. | 2014 | Tumour Biol. | pmid:25070489 |
| Müller R et al. | Expression of sphingosine-1-phosphate receptors and lysophosphatidic acid receptors on cultured and xenografted human colon, breast, melanoma, and lung tumor cells. | 2010 | Tumour Biol. | pmid:20480410 |
| Li J et al. | Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. | 2016 | Tumour Biol. | pmid:26857281 |
| Zhang Z et al. | SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-κB pathway in hepatocellular carcinoma. | 2015 | Tumour Biol. | pmid:25537088 |
| Nakajima M et al. | The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications. | 2017 | Tumour Biol. | pmid:28381169 |
| Hu L et al. | TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. | 2013 | Tumour Biol. | pmid:23616010 |
| Worrall D et al. | Sphingolipids, new players in plant signaling. | 2003 | Trends Plant Sci. | pmid:12878015 |
| Lynch DV et al. | Lipid signaling in Arabidopsis: no sphingosine? No problem! | 2009 | Trends Plant Sci. | pmid:19716747 |
| Napier JA et al. | A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. | 2002 | Trends Plant Sci. | pmid:12417141 |
| Lynch KR and Im DS | Life on the edg. | 1999 | Trends Pharmacol. Sci. | pmid:10603487 |
| Im DS | Linking Chinese medicine and G-protein-coupled receptors. | 2003 | Trends Pharmacol. Sci. | pmid:12498721 |
| Maguire JJ and Davenport AP | Regulation of vascular reactivity by established and emerging GPCRs. | 2005 | Trends Pharmacol. Sci. | pmid:16054240 |
| Salvemini D et al. | Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. | 2013 | Trends Pharmacol. Sci. | pmid:23318139 |
| Chi H | Sphingosine-1-phosphate and immune regulation: trafficking and beyond. | 2011 | Trends Pharmacol. Sci. | pmid:21159389 |
| Brinkmann V et al. | FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation. | 2000 | Trends Pharmacol. Sci. | pmid:10664606 |
| O'Sullivan C and Dev KK | The structure and function of the S1P1 receptor. | 2013 | Trends Pharmacol. Sci. | pmid:23763867 |
| Gardell SE et al. | Emerging medicinal roles for lysophospholipid signaling. | 2006 | Trends Mol Med | pmid:16406843 |
| Pyne S and Pyne NJ | Translational aspects of sphingosine 1-phosphate biology. | 2011 | Trends Mol Med | pmid:21514226 |
| Nielsen OH et al. | Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. | 2017 | Trends Mol Med | pmid:28283249 |
| Prager B et al. | Sphingosine 1-phosphate signaling at the blood-brain barrier. | 2015 | Trends Mol Med | pmid:25939882 |
| Walzer T and Vivier E | G-protein-coupled receptors in control of natural killer cell migration. | 2011 | Trends Immunol. | pmid:21664184 |
| Rosen H et al. | Tipping the gatekeeper: S1P regulation of endothelial barrier function. | 2007 | Trends Immunol. | pmid:17276731 |
| Sasset L et al. | Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. | 2016 | Trends Endocrinol. Metab. | pmid:27562337 |
| Garbers DL et al. | Membrane guanylyl cyclase receptors: an update. | 2006 | Trends Endocrinol. Metab. | pmid:16815030 |
| Alvarez SE et al. | Autocrine and paracrine roles of sphingosine-1-phosphate. | 2007 | Trends Endocrinol. Metab. | pmid:17904858 |
| Spiegel S et al. | Sphingosine 1-phosphate signaling: providing cells with a sense of direction. | 2002 | Trends Cell Biol. | pmid:12062172 |
| Maceyka M et al. | Sphingosine-1-phosphate signaling and its role in disease. | 2012 | Trends Cell Biol. | pmid:22001186 |
| Morris AJ et al. | Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation. | 2009 | Trends Cardiovasc. Med. | pmid:19818950 |
| Marletta MA | Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated? | 2001 | Trends Biochem. Sci. | pmid:11551775 |
| Adams DR et al. | Sphingosine Kinases: Emerging Structure-Function Insights. | 2016 | Trends Biochem. Sci. | pmid:27021309 |
| Böhler T et al. | FTY720 mediates apoptosis-independent lymphopenia in human renal allograft recipients: different effects on CD62L+ and CCR5+ T lymphocytes. | 2004 | Transplantation | pmid:15167602 |
| Calne SR | FTY: not just a homely drug. | 2004 | Transplantation | pmid:15167585 |
| Koshiba T et al. | FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A. | 2003 | Transplantation | pmid:12698078 |
| Wijkstrom M et al. | Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720. | 2004 | Transplantation | pmid:15077021 |
| Yin N et al. | Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival. | 2011 | Transplantation | pmid:21508896 |
| Lee RS et al. | FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model. | 2003 | Transplantation | pmid:14578745 |
| Furukawa H et al. | Prolongation of canine liver allograft survival by a novel immunosuppressant, FTY720: effect of monotherapy and combined treatment with conventional drugs. | 2000 | Transplantation | pmid:10670633 |
| Delbridge MS et al. | Reduction of ischemia-reperfusion injury in the rat kidney by FTY720, a synthetic derivative of sphingosine. | 2007 | Transplantation | pmid:17667810 |
| Nikolova Z et al. | Combined FTY720/cyclosporine treatment promotes graft survival and lowers the peripheral lymphocyte count in a murine cardiac allotransplantation model. | 2001 | Transplantation | pmid:11468555 |
| Li Q et al. | The reduction of allograft arteriosclerosis in intestinal transplant is associated with sphingosine kinase 1/sphingosine-1-phosphate signaling after fish oil treatment. | 2012 | Transplantation | pmid:22466786 |
| Suzuki S et al. | A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. | 1996 | Transplantation | pmid:8600623 |
| Oppenheimer F et al. | Impact of long-term therapy with FTY720 or mycophenolate mofetil on cardiac conduction and rhythm in stable adult renal transplant patients. | 2007 | Transplantation | pmid:17353787 |
| Fuller TF et al. | Cytoprotective Actions of FTY720 Modulate Severe Preservation Reperfusion Injury in Rat Renal Transplants. | 2010 | Transplantation | pmid:20177341 |
| Brinkmann V et al. | FTY720: altered lymphocyte traffic results in allograft protection. | 2001 | Transplantation | pmid:11571432 |
| Schuurman HJ et al. | Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD. | 2002 | Transplantation | pmid:12394836 |
| Tedesco-Silva H et al. | FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. | 2005 | Transplantation | pmid:15940045 |
| Sedláková K et al. | FTY720 in corneal concordant xenotransplantation. | 2005 | Transplantation | pmid:15699759 |
| Tedesco-Silva H et al. | FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. | 2004 | Transplantation | pmid:15223899 |
| Fujishiro J et al. | Effect of FTY720 on rat small bowel transplantation. | 2004 | Transplantation | pmid:15223918 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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