sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Inooka S and Toyokuni T Use of fumonisin B1 to test the intercellular transfer of sphingosine. 1996 Cell. Signal. pmid:8958448
Lee TC et al. Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels. 1996 J. Biol. Chem. pmid:8550561
Kadokami T et al. Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1 beta in vivo. 1996 Circulation pmid:8674178
Krown KA et al. Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. 1996 J. Clin. Invest. pmid:8981934
Riboni L et al. Salvage of catabolic products in ganglioside metabolism: a study on rat cerebellar granule cells in culture. 1996 FEBS Lett. pmid:8765002
Suzuki S et al. Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats. 1996 Transpl. Immunol. pmid:8893458
Sachs CW et al. Effects of sphingosine stereoisomers on P-glycoprotein phosphorylation and vinblastine accumulation in multidrug-resistant MCF-7 cells. 1996 Biochem. Pharmacol. pmid:8759033
Hägerstrand H et al. Vesiculation induced by amphiphiles and ionophore A23187 in porcine platelets: a transmission electron microscopic study. 1996 Chem. Biol. Interact. pmid:8760393
Meacci E et al. Activation of phospholipase D in human fibroblasts by ceramide and sphingosine: evaluation of their modulatory role in bradykinin stimulation of phospholipase D. 1996 Biochem. Biophys. Res. Commun. pmid:8753774
Son H and Carpenter DO Protein kinase C activation is necessary but not sufficient for induction of long-term potentiation at the synapse of mossy fiber-CA3 in the rat hippocampus. 1996 Neuroscience pmid:8730701
Iino M and Kisiel W Sphingosine-containing phospholipid vesicles support human factor VII autoactivation in the absence of tissue factor. 1996 Thromb. Res. pmid:9163065
Meacci E et al. Bradykinin increases ceramide and sphingosine content in human fibroblasts: possible involvement of glycosphingolipids. 1996 Biochem. Biophys. Res. Commun. pmid:8660316
Spangelo BL and Jarvis WD Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. 1996 Endocrinology pmid:8828503
Hartzell HC and Rinderknecht A Calphostin C, a widely used protein kinase C inhibitor, directly and potently blocks L-type Ca channels. 1996 Am. J. Physiol. pmid:8967428
Enosawa S et al. Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720. 1996 Immunopharmacology pmid:8886861
Verheij M et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. 1996 Nature pmid:8598911
Welsh N Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. 1996 J. Biol. Chem. pmid:8626526
Wiesner DA and Dawson G Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. 1996 J. Neurochem. pmid:8627293
Choi OH et al. Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. 1996 Nature pmid:8602265
Wu WI and Carman GM Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by phospholipids. 1996 Biochemistry pmid:8620000
Wang W et al. Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8622958
Lehtonen JY et al. Characteristics of the binding of tacrine to acidic phospholipids. 1996 Biophys. J. pmid:9172742
Jarvis WD et al. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. 1996 J. Biol. Chem. pmid:8626522
Shephard GS et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. 1996 Toxicon pmid:8783447
Kawamura A et al. Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. 1996 Bioorg. Med. Chem. pmid:8831974
Carfagna MA et al. Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation. 1996 Toxicol. Appl. Pharmacol. pmid:8661342
Rotter BA et al. Response of growing swine to dietary exposure to pure fumonisin B1 during an eight-week period: growth and clinical parameters. 1996 Nat. Toxins pmid:8680753
Mizushima N et al. Ceramide induces apoptosis via CPP32 activation. 1996 FEBS Lett. pmid:8898109
Payne CD et al. Cholesterol sulfate protects Candida albicans from inhibition by sphingosine in vitro. 1996 J. Invest. Dermatol. pmid:8648192
Yatomi Y et al. N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. 1996 Biochemistry pmid:8555236
Mallampalli RK et al. Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat lung. 1996 Biochem. J. pmid:8761490
Wakita H et al. Inhibitors of sphingolipid synthesis modulate interferon (IFN)-gamma-induced intercellular adhesion molecule (ICAM)-1 and human leukocyte antigen (HLA)-DR expression on cultured normal human keratinocytes: possible involvement of ceramide in biologic action of IFN-gamma. 1996 J. Invest. Dermatol. pmid:8751967
Sasaki JI et al. Sphingosine inhibition of NADPH oxidase activation in a cell-free system. 1996 J. Biochem. pmid:8947830
Sakano S et al. Ca2+ mobilizing action of sphingosine in Jurkat human leukemia T cells. Evidence that sphingosine releases Ca2+ from inositol trisphosphate- and phosphatidic acid-sensitive intracellular stores through a mechanism independent of inositol trisphosphate. 1996 J. Biol. Chem. pmid:8626660
Tolan D et al. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. 1996 Br. J. Pharmacol. pmid:8886394
Castegnaro M et al. Development of a new method for the analysis of sphinganine and sphingosine in urine and tissues. 1996 Nat. Toxins pmid:9029554
Hashizume T et al. Sphingosine enhances phosphatidylinositol 4-kinase activity in rabbit platelets. 1996 J. Biochem. pmid:8864845
Yamamura S et al. Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells. 1996 FEBS Lett. pmid:8612751
Pyne S et al. Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle. 1996 Eur. J. Biochem. pmid:8647130
Berger A et al. Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity. 1996 Mol. Pharmacol. pmid:8794881
Waggoner DW et al. Phosphatidate phosphohydrolase catalyzes the hydrolysis of ceramide 1-phosphate, lysophosphatidate, and sphingosine 1-phosphate. 1996 J. Biol. Chem. pmid:8663293
Sweeney EA et al. Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. 1996 Int. J. Cancer pmid:8621258
Fatatis A and Miller RJ Sphingosine and sphingosine 1-phosphate differentially modulate platelet-derived growth factor-BB-induced Ca2+ signaling in transformed oligodendrocytes. 1996 J. Biol. Chem. pmid:8550576
Abbas HK and Riley RT The presence and phytotoxicity of fumonisins and AAL-toxin in Alternaria alternata. 1996 Toxicon pmid:8835341
Boring DL et al. Cerebrodiene, arachidonyl-ethanolamide, and hybrid structures: potential for interaction with brain cannabinoid receptors. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8931121
Zanglis A et al. The biological activity of acetylated sphingosylphosphorylcholine derivatives. 1996 Int. J. Biochem. Cell Biol. pmid:8624845
Bünemann M et al. A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. 1996 EMBO J. pmid:8896446
Huang WC and Chueh SH Calcium mobilization from the intracellular mitochondrial and nonmitochondrial stores of the rat cerebellum. 1996 Brain Res. pmid:8773778
Nakamura S et al. Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. 1996 J. Biol. Chem. pmid:8576106
Sabała P et al. Sphingosine stimulates calcium mobilization and modulates calcium signals evoked by thapsigargin in glioma C6 cells. 1996 Acta Neurobiol Exp (Wars) pmid:8768300
Murohara T et al. Effects of sphingomyelinase and sphingosine on arterial vasomotor regulation. 1996 J. Lipid Res. pmid:8827530
Yachida Y et al. Novel di-O-acetylated GM3s from equine erythrocytes, one containing 4,9-di-O-acetyl-N-glycolylneuraminic acid and another containing 4-O-acetyl-N-glycolylneuraminic acid and 6-O-acetyl-D-galactose. 1997 Carbohydr. Res. pmid:9090814
Kaneshiro ES et al. Identification and initial characterizations of free, glycosylated, and phosphorylated ceramides of Paramecium. 1997 J. Lipid Res. pmid:9458264
Galve-Roperh I et al. Ceramide-induced translocation of protein kinase C zeta in primary cultures of astrocytes. 1997 FEBS Lett. pmid:9357981
Geeraert L et al. Conversion of dihydroceramide into ceramide: involvement of a desaturase. 1997 Biochem. J. pmid:9355743
Lombardi V et al. 1H NMR ganglioside ceramide resonance region on the differential diagnosis of low and high malignancy of brain gliomas. 1997 Cell. Mol. Neurobiol. pmid:9353593
Pawelczyk T and Matecki A Structural requirements of phospholipase C delta1 for regulation by spermine, sphingosine and sphingomyelin. 1997 Eur. J. Biochem. pmid:9346303
Hristova NI et al. Sphingosine-mediated electroporative DNA transfer through lipid bilayers. 1997 FEBS Lett. pmid:9326374
Heacock AM and Agranoff BW Protein kinase inhibitors block neurite outgrowth from explants of goldfish retina. 1997 Neurochem. Res. pmid:9342720
Zager RA et al. Altered ceramide and sphingosine expression during the induction phase of ischemic acute renal failure. 1997 Kidney Int. pmid:9211347
Qie L et al. Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids. 1997 J. Biol. Chem. pmid:9195906
Nagiec MM et al. Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. 1997 J. Biol. Chem. pmid:9092515
Wiktorek-Wójcik M et al. Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine. 1997 Biochem. Biophys. Res. Commun. pmid:9405236
Vermelho AB et al. Heart muscle cells share common neutral glycosphingolipids with Trypanosoma cruzi. 1997 Acta Trop. pmid:9107361
Chmura SJ et al. Loss of ceramide production confers resistance to radiation-induced apoptosis. 1997 Cancer Res. pmid:9102212
Schwartz GK et al. A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin. 1997 Clin. Cancer Res. pmid:9815717
Larocca JN et al. Induction of oligodendrocyte apoptosis by C2-ceramide. 1997 Neurochem. Res. pmid:9130266
Nikolova-Karakashian M et al. Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11. 1997 J. Biol. Chem. pmid:9228043
Gill ZP et al. Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner. 1997 J. Biol. Chem. pmid:9325280
Mao C et al. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. 1997 J. Biol. Chem. pmid:9353337
Nakabo Y and Pabst MJ C2-ceramide and C6-ceramide inhibited priming for enhanced release of superoxide in monocytes, but had no effect on the killing of leukaemic cells by monocytes. 1997 Immunology pmid:9176098
Wieder T et al. Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. 1997 FEBS Lett. pmid:9271217
Manev H and Cagnoli CM Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common? 1997 Neurochem. Int. pmid:9220452
Keane RW et al. Activation of CPP32 during apoptosis of neurons and astrocytes. 1997 J. Neurosci. Res. pmid:9130145
Suchard SJ et al. Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes. 1997 Blood pmid:9058737
Chigorno V et al. Metabolic processing of gangliosides by human fibroblasts in culture--formation and recycling of separate pools of sphingosine. 1997 Eur. J. Biochem. pmid:9461288
Kuo ML et al. Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells. 1997 Biochem. J. pmid:9581540
Porpaczy Z et al. Internalized plasma membrane cholesterol passes through an endosome compartment that is distinct from the acid vesicle-lysosome compartment. 1997 Exp. Cell Res. pmid:9260888
Oh CS et al. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. 1997 J. Biol. Chem. pmid:9211877
Kawa S et al. Inhibition of chemotactic motility and trans-endothelial migration of human neutrophils by sphingosine 1-phosphate. 1997 FEBS Lett. pmid:9459309
Sosnowski J et al. Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells. 1997 J. Urol. pmid:9186373
van Echten-Deckert G et al. cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. 1997 J. Biol. Chem. pmid:9188480
Rani CS et al. Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. 1997 J. Biol. Chem. pmid:9099730
Mattson MP et al. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. 1997 J. Neurosci. Res. pmid:9335256
Norred WP et al. Mycotoxin-induced elevation of free sphingoid bases in precision-cut rat liver slices: specificity of the response and structure-activity relationships. 1997 Toxicol. Appl. Pharmacol. pmid:9356308
Kishida E et al. Evaluation of a trans configuration for the apoptosis-inducing activity of ceramide. 1997 J Lipid Mediat Cell Signal pmid:9246602
Caldwell C et al. Regulatory differences among avian ecto-ATPases. 1997 Biochem. Biophys. Res. Commun. pmid:9325157
Yatomi Y et al. N,N-dimethylsphingosine phosphorylation in human platelets. 1997 Biochem. Biophys. Res. Commun. pmid:9070908
Boneh A et al. Effect of sphingosine on rat glial cells: inhibition of prostaglandin E2 and insensitivity of nitric oxide generation. 1997 Neurosci. Lett. pmid:9237488
Shinkai M et al. Inhibitory action of sphingosine or ceramide on amylase secretion from isolated rat pancreatic acini. 1997 Biochem. Biophys. Res. Commun. pmid:9196062
Kiss Z and Mukherjee JJ Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism. 1997 FEBS Lett. pmid:9257719
Blakesley VA et al. Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk. 1997 J. Biol. Chem. pmid:9195921
Yatomi Y et al. Distribution of sphingosine 1-phosphate, a bioactive sphingolipid, in rat tissues. 1997 FEBS Lett. pmid:9119058
Törnquist K Sphingosine 1-phosphate stimulates Na+/H+ exchange in thyroid FRTL-5 cells. 1997 Am. J. Physiol. pmid:9124507
Törnquist K et al. Sphingosylphosphorylcholine activates an amiloride-insensitive Na+-H+-exchange mechanism in GH4C1 cells. 1997 Eur. J. Biochem. pmid:9346294
Sueyoshi N et al. Preparation of a naturally occurring D-erythro-(2S, 3R)-sphingosylphosphocholine using Shewanella alga NS-589. 1997 J. Lipid Res. pmid:9323602
Yatomi Y et al. Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid. 1997 J. Biol. Chem. pmid:9030602
Lai TS et al. Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. 1997 J. Biol. Chem. pmid:9195933
Keenan C et al. Isoform specificity of activators and inhibitors of protein kinase C gamma and delta. 1997 FEBS Lett. pmid:9326378
Saba JD et al. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. 1997 J. Biol. Chem. pmid:9334171