| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Okajima F et al. | Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling. | 1997 | Endocrinology | pmid:8977407 |
| Wang F et al. | Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. | 1997 | Biochem. J. | pmid:9182707 |
| Shatrov VA et al. | Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9168973 |
| Jarvis WD et al. | Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine. | 1997 | Mol. Pharmacol. | pmid:9415703 |
| Yatomi Y et al. | N,N-dimethylsphingosine 1-phosphate activates human platelets. | 1997 | FEBS Lett. | pmid:9409747 |
| Chueh SC et al. | Induction of tolerance toward rat cardiac allografts by treatment with allochimeric class I MHC antigen and FTY720. | 1997 | Transplantation | pmid:9392303 |
| Pörn-Ares MI et al. | Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609. | 1997 | Exp. Cell Res. | pmid:9281351 |
| Michel C et al. | Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. | 1997 | J. Biol. Chem. | pmid:9312549 |
| Besancon M et al. | Sites of reaction of the gastric H,K-ATPase with extracytoplasmic thiol reagents. | 1997 | J. Biol. Chem. | pmid:9278394 |
| Shinomiya T et al. | An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60. | 1997 | Immunology | pmid:9378500 |
| Rodriguez-Lafrasse C et al. | Modulation of protein kinase C by endogenous sphingosine: inhibition of phorbol dibutyrate binding in Niemann-Pick C fibroblasts. | 1997 | Biochem. J. | pmid:9271101 |
| Kim SH et al. | Sphingosine stimulates thrombin-induced gelation of the fibrinogen. | 1997 | Thromb. Res. | pmid:9263400 |
| Needleman DH et al. | Modulation of skeletal muscle Ca2(+)-release channel activity by sphingosine. | 1997 | Am. J. Physiol. | pmid:9176136 |
| Futamura Y | Amiodarone induces two different types of disorders in mouse alveolar macrophages. | 1997 | Jpn. J. Pharmacol. | pmid:9195293 |
| Pyne S et al. | Sphingolipids as differential regulators of cellular signalling processes. | 1997 | Biochem. Soc. Trans. | pmid:9191154 |
| Longo CA et al. | Sphingomyelin metabolism is developmentally regulated in rat lung. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9160843 |
| Matecki A and Pawelczyk T | Regulation of phospholipase C delta1 by sphingosine. | 1997 | Biochim. Biophys. Acta | pmid:9168154 |
| Oral H et al. | Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte. | 1997 | J. Biol. Chem. | pmid:9030540 |
| Fatatis A and Miller RJ | Platelet-derived growth factor (PDGF)-induced Ca2+ signaling in the CG4 oligodendroglial cell line and in transformed oligodendrocytes expressing the beta-PDGF receptor. | 1997 | J. Biol. Chem. | pmid:9020156 |
| Bansal SK et al. | Increased levels of protein kinase C in lymphocytes in asthma: possible mechanism of regulation. | 1997 | Eur. Respir. J. | pmid:9042625 |
| Czajkowski R et al. | Sphingosine modulates Ca2+ signals via phospholipase C dependent pathway in glioma C6 cells. | 1997 | Acta Neurobiol Exp (Wars) | pmid:9519554 |
| Suzuki S et al. | The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720. | 1997 | Clin. Exp. Immunol. | pmid:9010264 |
| Kimura T et al. | Inhibition of TSH-induced hydrogen peroxide production by TNF-alpha through a sphingomyelinase signaling pathway. | 1997 | Am. J. Physiol. | pmid:9316456 |
| Orlati S et al. | Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. | 1997 | Biochim. Biophys. Acta | pmid:9296526 |
| Im DS et al. | Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes. | 1997 | Am. J. Physiol. | pmid:9176218 |
| Olivera A et al. | Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts. | 1997 | Biochim. Biophys. Acta | pmid:9366247 |
| Xu M et al. | Effect of peritransplant FTY720 alone or in combination with posttransplant FK 506 in a rat model of cardiac allotransplantation. | 1997 | Transplant. Proc. | pmid:9365631 |
| Kennedy SD et al. | Measurement of in vitro P-selectin expression by flow cytometry. | 1997 | Am. J. Clin. Pathol. | pmid:8980375 |
| Paukku T et al. | Novel cationic liposomes for DNA-transfection with high efficiency and low toxicity. | 1997 | Chem. Phys. Lipids | pmid:9219346 |
| Mitsusada M et al. | Prevention of graft rejection and graft-versus-host reaction by a novel immunosuppressant, FTY720, in rat small bowel transplantation. | 1997 | Transpl. Int. | pmid:9287398 |
| Shirahama T et al. | In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. | 1997 | Clin. Cancer Res. | pmid:9815681 |
| Ku WC et al. | Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9434777 |
| Ducibella T and LeFevre L | Study of protein kinase C antagonists on cortical granule exocytosis and cell-cycle resumption in fertilized mouse eggs. | 1997 | Mol. Reprod. Dev. | pmid:9021753 |
| Conway AM et al. | Sphingosine 1-phosphate activation of MAP kinase--involvement of PI 3-kinase and protein kinase C. | 1997 | Biochem. Soc. Trans. | pmid:9450013 |
| Keenan C et al. | Assay to determine the isoform specificity of protein kinase C inhibitors. | 1997 | Biochem. Soc. Trans. | pmid:9450019 |
| Kiss Z et al. | Extracellular sphingosine 1-phosphate stimulates formation of ethanolamine from phosphatidylethanolamine: modulation of sphingosine 1-phosphate-induced mitogenesis by ethanolamine. | 1997 | Biochem. J. | pmid:9371692 |
| Mitsuyoshi H et al. | Ursodeoxycholic acid enhances glucocorticoid-induced tyrosine aminotransferase-gene expression in cultured rat hepatocytes. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9398635 |
| Chigorno V et al. | Activity of 3-ketosphinganine synthase during differentiation and aging of neuronal cells in culture. | 1997 | J. Lipid Res. | pmid:9215544 |
| Sato K et al. | Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9388477 |
| Xie H and Johnson GV | Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. | 1997 | J. Neurochem. | pmid:9282924 |
| Tolan D et al. | Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle. | 1997 | Am. J. Physiol. | pmid:9316414 |
| Hashizume T et al. | Sphingosine enhances arachidonic acid liberation in response to U46619 through an increase in phospholipase A2 activity in rabbit platelets. | 1997 | J. Biochem. | pmid:9443821 |
| Separovic D et al. | Ceramide generation in response to photodynamic treatment of L5178Y mouse lymphoma cells. | 1997 | Cancer Res. | pmid:9135014 |
| GarcÃa-Ruiz C et al. | Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. | 1997 | J. Biol. Chem. | pmid:9111045 |
| Baker A et al. | Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. | 1997 | Cancer Res. | pmid:9371519 |
| Zehavi U | Synthesis of potentially caged sphingolipids, possible precursors of cellular modulators and second messengers. | 1997 | Chem. Phys. Lipids | pmid:9450322 |
| Kozawa O et al. | Activation of mitogen-activated protein kinase is involved in sphingosine 1-phosphate-stimulated interleukin-6 synthesis in osteoblasts. | 1997 | FEBS Lett. | pmid:9414115 |
| Reggiori F et al. | Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae. | 1997 | EMBO J. | pmid:9218793 |
| Bielawska AE et al. | Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. | 1997 | Am. J. Pathol. | pmid:9358751 |
| Lozanski G et al. | The sphingomyelin-ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not alpha-fibrinogen. | 1997 | Biochem. J. | pmid:9359864 |
| Gudz TI et al. | Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. | 1997 | J. Biol. Chem. | pmid:9305864 |
| Crowther GJ and Lynch DV | Characterization of sphinganine kinase activity in corn shoot microsomes. | 1997 | Arch. Biochem. Biophys. | pmid:9016824 |
| Yamamura S et al. | Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner. | 1997 | Biochemistry | pmid:9271506 |
| Edsall LC et al. | Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. | 1997 | J. Neurosci. | pmid:9278531 |
| Yatomi Y et al. | Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. | 1997 | J. Biochem. | pmid:9192741 |
| Törnquist K et al. | Sphingosine 1-phosphate mobilizes sequestered calcium, activates calcium entry, and stimulates deoxyribonucleic acid synthesis in thyroid FRTL-5 cells. | 1997 | Endocrinology | pmid:9322911 |
| Shirahama T et al. | Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression. | 1997 | FEBS Lett. | pmid:9141489 |
| Chung T et al. | ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate. | 1997 | J. Biol. Chem. | pmid:9006957 |
| Mano N et al. | Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry. | 1997 | Anal. Biochem. | pmid:9025946 |
| Herrmann JL et al. | Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells. | 1997 | Exp. Cell Res. | pmid:9260915 |
| Betto R et al. | Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes. | 1997 | Biochem. J. | pmid:9078280 |
| Igarashi Y | Functional roles of sphingosine, sphingosine 1-phosphate, and methylsphingosines: in regard to membrane sphingolipid signaling pathways. | 1997 | J. Biochem. | pmid:9498549 |
| Prinetti A et al. | Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells. | 1997 | FEBS Lett. | pmid:9315744 |
| Kozawa O et al. | Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. | 1997 | J. Biol. Chem. | pmid:9312119 |
| Kwon OS et al. | Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats. | 1997 Mar-Apr | Neurotoxicol Teratol | pmid:9136132 |
| Matsuda T et al. | Caspase requirement for the apoptotic death of WR19L-induced by FTY720. | 1998 | Transplant. Proc. | pmid:9723502 |
| Nakajima H et al. | FTY720 inhibits the mRNA expression of intragraft cytotoxic molecules, leading to cardiac allograft survival. | 1998 | Transplant. Proc. | pmid:9723446 |
| Kahan BD | FTY720: a new immunosuppressive agent with novel mechanism(s) of action. | 1998 | Transplant. Proc. | pmid:9723444 |
| Fukuda Y et al. | Effect of FTY720 on immunoregulation in concordant xenotransplantation. | 1998 | Transpl. Int. | pmid:9665039 |
| Searl TJ and Silinsky EM | Increases in acetylcholine release produced by phorbol esters are not mediated by protein kinase C at motor nerve endings. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9536018 |
| Tas PW and Koschel K | Sphingosine-1-phosphate induces a Ca2+ signal in primary rat astrocytes and a Ca2+ signal and shape changes in C6 rat glioma cells. | 1998 | J. Neurosci. Res. | pmid:9589387 |
| Jarvis WD et al. | Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. | 1998 | Mol. Pharmacol. | pmid:9804619 |
| Reggiori F and Conzelmann A | Biosynthesis of inositol phosphoceramides and remodeling of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae are mediated by different enzymes. | 1998 | J. Biol. Chem. | pmid:9804825 |
| Collins TF et al. | Effects of fumonisin B1 in pregnant rats. | 1998 | Food Chem. Toxicol. | pmid:9662415 |
| Cuvillier O et al. | Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. | 1998 | J. Biol. Chem. | pmid:9446602 |
| Sakai T et al. | Effects of alpha- and beta-galactosylated C2-ceramides on the immune system. | 1998 | J. Med. Chem. | pmid:9484513 |
| Chiba K et al. | FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. | 1998 | J. Immunol. | pmid:9590253 |
| Simon CG and Gear AR | Membrane-destabilizing properties of C2-ceramide may be responsible for its ability to inhibit platelet aggregation. | 1998 | Biochemistry | pmid:9485333 |
| Monney L et al. | Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis. | 1998 | Eur. J. Biochem. | pmid:9492297 |
| Wang ME et al. | Immunosuppressive effects of FTY720 alone or in combination with cyclosporine and/or sirolimus. | 1998 | Transplantation | pmid:9565092 |
| Lee SC et al. | The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway. | 1998 | J. Protein Chem. | pmid:9491924 |
| Takeda H et al. | Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts. | 1998 | FEBS Lett. | pmid:9490019 |
| Van Brocklyn JR et al. | Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. | 1998 | J. Cell Biol. | pmid:9660876 |
| Pfau JC et al. | A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. | 1998 | Cell. Immunol. | pmid:9665757 |
| Cartus T et al. | Distribution of protein phosphatases type 1 and 2A in RINm5F cells. | 1998 | Regul. Pept. | pmid:9809799 |
| Mizushima N et al. | Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells. | 1998 | Ann. Rheum. Dis. | pmid:9797556 |
| Ji L et al. | Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells. | 1998 | Arch. Biochem. Biophys. | pmid:9799567 |
| Lakics V and Vogel SN | Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages. | 1998 | J. Immunol. | pmid:9725248 |
| Xu M et al. | FTY720 compares with FK 506 as rescue therapy in rat heterotopic cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9723447 |
| Canova C et al. | Epigenetic control of programmed cell death: inhibition by 5-azacytidine of 1,25-dihydroxyvitamin D3-induced programmed cell death in C6.9 glioma cells. | 1998 | Mech. Ageing Dev. | pmid:9593321 |
| Auzenne E et al. | Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro. | 1998 | Melanoma Res. | pmid:9664144 |
| Tsunoda M et al. | Early fumonisin B1 toxicity in relation to disrupted sphingolipid metabolism in male BALB/c mice. | 1998 | J. Biochem. Mol. Toxicol. | pmid:9664234 |
| Stepkowski SM et al. | Synergistic interaction of FTY720 with cyclosporine or sirolimus to prolong heart allograft survival. | 1998 | Transplant. Proc. | pmid:9723445 |
| Piperno M et al. | Osteoarthritic cartilage fibrillation is associated with a decrease in chondrocyte adhesion to fibronectin. | 1998 | Osteoarthr. Cartil. | pmid:10343772 |
| Melendez A et al. | FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. | 1998 | J. Biol. Chem. | pmid:9545263 |
| Yanagawa Y et al. | FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720-induced lymphocyte homing. | 1998 | Immunology | pmid:9893050 |
| Sánchez C et al. | Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes. | 1998 | Mol. Pharmacol. | pmid:9804618 |
| Marks N et al. | Activation of caspase-3 and apoptosis in cerebellar granule cells. | 1998 | J. Neurosci. Res. | pmid:9590441 |
| Riboni L et al. | The effects of exogenous sphingosine on Neuro2a cells are strictly related to the overall capacity of cells to metabolize sphingosine. | 1998 | J. Biochem. | pmid:9792911 |
| RodrÃguez-Fernández JL and Rozengurt E | Bombesin, vasopressin, lysophosphatidic acid, and sphingosylphosphorylcholine induce focal adhesion kinase activation in intact Swiss 3T3 cells. | 1998 | J. Biol. Chem. | pmid:9668122 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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