| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugiki H et al. | C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line. | 2000 | Br. J. Dermatol. | pmid:11122015 |
| Hitomi K et al. | Characterization of human recombinant transglutaminase 1 purified from baculovirus-infected insect cells. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129585 |
| Gable K et al. | Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. | 2000 | J. Biol. Chem. | pmid:10713067 |
| Kitabayashi H et al. | FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10710126 |
| Fujisawa K et al. | Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo. | 2000 | Placenta | pmid:10833370 |
| Xu K and Thornalley PJ | Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10636242 |
| Bielawska A et al. | Radiolabeling of the sphingolipid backbone. | 2000 | Meth. Enzymol. | pmid:10563345 |
| Sonnino S et al. | Preparation of radioactive gangliosides, 3H or 14C isotopically labeled at oligosaccharide or ceramide moieties. | 2000 | Meth. Enzymol. | pmid:10563353 |
| Nofer JR et al. | Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux. | 2000 | Biochemistry | pmid:11106499 |
| Brandwagt BF et al. | A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781105 |
| Henry MH et al. | The toxicity of purified fumonisin B1 in broiler chicks. | 2000 | Poult. Sci. | pmid:11055840 |
| Merrill AH et al. | Analysis of sphingoid bases and sphingoid base 1-phosphates by high-performance liquid chromatography. | 2000 | Meth. Enzymol. | pmid:11070857 |
| Bodennec J et al. | Purification of sphingolipid classes by solid-phase extraction with aminopropyl and weak cation exchanger cartridges. | 2000 | Meth. Enzymol. | pmid:11070865 |
| Kawamura A et al. | Use of circular dichroism for assigning stereochemistry of sphingosine and other long-chain bases. | 2000 | Meth. Enzymol. | pmid:11070875 |
| Maurer BJ et al. | Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. | 2000 | J. Natl. Cancer Inst. | pmid:11106681 |
| Chung N et al. | Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. | 2000 | J. Biol. Chem. | pmid:10764732 |
| Napoli KL | The FTY720 story. | 2000 | Ther Drug Monit | pmid:10688258 |
| An S et al. | Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. | 2000 | J. Biol. Chem. | pmid:10617617 |
| Kozawa O et al. | p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts: sphingosine inhibits prostaglandin F(2alpha)-induced phosphoinositide hydrolysis. | 2000 | Cell. Signal. | pmid:10989278 |
| Zanolari B et al. | Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. | 2000 | EMBO J. | pmid:10856228 |
| Menné C et al. | Ceramide-induced TCR up-regulation. | 2000 | J. Immunol. | pmid:10975817 |
| Bodennec J et al. | Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges. | 2000 | Anal. Biochem. | pmid:10706795 |
| Kasinrerk W et al. | CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C-dependent pathway. | 2000 | Immunol. Lett. | pmid:10709783 |
| Van Veldhoven PP et al. | Do sphingoid bases interact with the peroxisome proliferator activated receptor alpha (PPAR-alpha)? | 2000 | Cell. Signal. | pmid:10989283 |
| Miura Y et al. | Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. | 2000 | J. Biochem. | pmid:10788802 |
| Bittman R and Verbicky CA | Methanolysis of sphingomyelin. Toward an epimerization-free methodology for the preparation of D-erythro-sphingosylphosphocholine. | 2000 | J. Lipid Res. | pmid:11108743 |
| Spiegel S and Milstien S | Functions of a new family of sphingosine-1-phosphate receptors. | 2000 | Biochim. Biophys. Acta | pmid:10760461 |
| Panetti TS et al. | Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10764666 |
| Boguslawski G et al. | Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833459 |
| Kimura T et al. | Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. | 2000 | Biochem. J. | pmid:10794715 |
| English D et al. | Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis. | 2000 | FASEB J. | pmid:11053247 |
| Edsall L et al. | Enzymatic method for measurement of sphingosine 1-phosphate. | 2000 | Meth. Enzymol. | pmid:11070858 |
| Sullards MC | Analysis of sphingomyelin, glucosylceramide, ceramide, sphingosine, and sphingosine 1-phosphate by tandem mass spectrometry. | 2000 | Meth. Enzymol. | pmid:11070861 |
| Xia P et al. | An oncogenic role of sphingosine kinase. | 2000 | Curr. Biol. | pmid:11114522 |
| Sabatini M et al. | Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623638 |
| Nakajima N et al. | Expression and characterization of Edg-1 receptors in rat cardiomyocytes: calcium deregulation in response to sphingosine 1-phosphate. | 2000 | Eur. J. Biochem. | pmid:10971577 |
| Micoli KJ et al. | Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. | 2000 | J. Biol. Chem. | pmid:10625668 |
| Parrill AL et al. | Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. | 2000 | J. Biol. Chem. | pmid:10982820 |
| Schürmann A et al. | p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. | 2000 | Mol. Cell. Biol. | pmid:10611223 |
| Shin Y et al. | Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. | 2000 | Cell Calcium | pmid:10859593 |
| Orvisky E et al. | Glucosylsphingosine accumulation in mice and patients with type 2 Gaucher disease begins early in gestation. | 2000 | Pediatr. Res. | pmid:10926300 |
| Enomoto A et al. | Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. | 2000 | Cancer Lett. | pmid:10822128 |
| Posey SC et al. | Failure of gelsolin overexpression to regulate lymphocyte apoptosis. | 2000 | Blood | pmid:10828033 |
| Himmel HM et al. | Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. | 2000 | Mol. Pharmacol. | pmid:10908314 |
| Paolucci C et al. | Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way. | 2000 | J. Biol. Chem. | pmid:10777484 |
| Driever W | Developmental biology. Bringing two hearts together. | 2000 | Nature | pmid:10910341 |
| Tomita H et al. | Ceramide-induced cell death in cultured rat retinal pigment epithelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10778806 |
| Kupperman E et al. | A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. | 2000 | Nature | pmid:10910360 |
| Mandala SM et al. | Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10859351 |
| Murata N et al. | Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay. | 2000 | Anal. Biochem. | pmid:10860507 |
| De Nadai C et al. | Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792026 |
| Caligan TB et al. | A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. | 2000 | Anal. Biochem. | pmid:10847608 |
| Igarashi J and Michel T | Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. | 2000 | J. Biol. Chem. | pmid:10921915 |
| Holopainen JM et al. | Dimyristoylphosphatidylcholine/C16:0-ceramide binary liposomes studied by differential scanning calorimetry and wide- and small-angle x-ray scattering. | 2000 | Biophys. J. | pmid:10777742 |
| Cooke ME et al. | Contraction of collagen matrices mediated by alpha2beta1A and alpha(v)beta3 integrins. | 2000 | J. Cell. Sci. | pmid:10852817 |
| Kimura M et al. | Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide. | 2000 | J. Neurosci. Res. | pmid:11107162 |
| Navarro P et al. | Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. | 2000 | Growth Horm. IGF Res. | pmid:11042022 |
| Ikeda H et al. | Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10915638 |
| Ramos B et al. | Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine. | 2000 | Neuroreport | pmid:11043531 |
| Zhou H et al. | Akt regulates cell survival and apoptosis at a postmitochondrial level. | 2000 | J. Cell Biol. | pmid:11062251 |
| Di Nardo A et al. | Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes. | 2000 | Br. J. Dermatol. | pmid:10971319 |
| Ohba M et al. | Perioperative administration of FTY720 and CTLA4IG in rat heart transplantation. | 2000 | Transplant. Proc. | pmid:11120049 |
| Lee H et al. | Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10712250 |
| Chueh SC et al. | Rescuing acute rejection of rat cardiac allografts with FTY720. | 2000 | Transplant. Proc. | pmid:11119868 |
| Lei G et al. | New immunosuppressive reagent, FTY 720, spares immunologic memory. | 2000 | Transplant. Proc. | pmid:11119867 |
| Böhler T et al. | FTY 720A mediates reduction of lymphocyte counts in human renal allograft recipients by an apoptosis-independent mechanism. | 2000 | Transpl. Int. | pmid:11112021 |
| Motohashi K et al. | Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate. | 2000 | FEBS Lett. | pmid:10692584 |
| Ueda H et al. | Effect of a novel immunosuppressant, FTY720, on allograft survival after renal transplant in rats. | 2000 | Eur Surg Res | pmid:11111172 |
| Nikolova Z et al. | Prevention of graft vessel disease by combined FTY720/cyclosporine. A treatment in a rat carotid artery transplantation model. | 2000 | Transplantation | pmid:10910272 |
| Campbell V and Lynch MA | The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes. | 2000 | Cytokine | pmid:10857764 |
| Galve-Roperh I et al. | Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. | 2000 | Nat. Med. | pmid:10700234 |
| Matsuura M et al. | Effect of FTY720, a novel immunosuppressant, on adjuvant- and collagen-induced arthritis in rats. | 2000 | Int. J. Immunopharmacol. | pmid:10689105 |
| Koshiba T et al. | Tolerance induction with FTY720 and donor-specific blood transfusion: discrepancy between heart transplantation and intestinal transplantation. | 2000 | Transplant. Proc. | pmid:10995936 |
| King CC et al. | p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). | 2000 | J. Biol. Chem. | pmid:10995762 |
| Yanagawa Y et al. | The significance of timing of FTY720 administration on the immunosuppressive effect to prolong rat skin allograft survival. | 2000 | Int. J. Immunopharmacol. | pmid:10988354 |
| Tsushima H and Mori M | In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats. | 2000 | Brain Res. | pmid:10678764 |
| Nagahara Y et al. | Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria. | 2000 | J. Immunol. | pmid:10975841 |
| Mihai R et al. | C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679256 |
| Higuchi K et al. | The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. | 2000 | Biochem. J. | pmid:10970788 |
| Kozawa O et al. | Sphingosine 1-phosphate amplifies phosphoinositide hydrolysis stimulated by prostaglandin f2 alpha in osteoblasts: involvement of p38MAP kinase. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913228 |
| Devijver C et al. | (2R,3R,7Z)-2-Aminotetradec-7-ene-1,3-diol, a new amino alcohol from the caribbean sponge Haliclona vansoesti. | 2000 | J. Nat. Prod. | pmid:10924178 |
| Migita K et al. | Regulation of rheumatoid synovial cell growth by ceramide. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10694479 |
| Kawaguchi M et al. | Cerebrosides in grapevine leaves: distinct composition of sphingoid bases among the grapevine species having different tolerances to freezing temperature. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10923800 |
| Orlati S et al. | Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. | 2000 | Arch. Biochem. Biophys. | pmid:10683250 |
| Sadeghlar F et al. | Cell type specific localization of sphingomyelin biosynthesis. | 2000 | FEBS Lett. | pmid:10922460 |
| Friant S et al. | Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis. | 2000 | EMBO J. | pmid:10856229 |
| Nagahara Y et al. | Evidence that FTY720 induces T cell apoptosis in vivo. | 2000 | Immunopharmacology | pmid:10822091 |
| Prinetti A et al. | Sphingolipid-enriched membrane domains from rat cerebellar granule cells differentiated in culture. A compositional study. | 2000 | J. Biol. Chem. | pmid:10766784 |
| Muriel MP et al. | Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death. | 2000 | J. Comp. Neurol. | pmid:10982470 |
| Bielawska A et al. | Synthesis of key precursors of radiolabeled sphingolipids. | 2000 | Meth. Enzymol. | pmid:10563347 |
| Koskinen PM and Koskinen AM | Total synthesis of sphingosine and its analogs. | 2000 | Meth. Enzymol. | pmid:10563344 |
| Tamura K et al. | Cloning and characterization of a cDNA encoding serine palmitoyltransferase in Arabidopsis thaliana. | 2000 | Biochem. Soc. Trans. | pmid:11171191 |
| Hanada K et al. | D-Serine inhibits serine palmitoyltransferase, the enzyme catalyzing the initial step of sphingolipid biosynthesis. | 2000 | FEBS Lett. | pmid:10828452 |
| Zhang Y et al. | Effect of synthetic sialyl 2-->1 sphingosine and other glycosylsphingosines on the structure and function of the "glycosphingolipid signaling domain (GSD)" in mouse melanoma B16 cells. | 2000 | Biochemistry | pmid:10704195 |
| Chuang FY et al. | Convergence of Fc gamma receptor IIA and Fc gamma receptor IIIB signaling pathways in human neutrophils. | 2000 | J. Immunol. | pmid:10605030 |
| Takeshita A et al. | Selective stimulation by ceramide of the expression of the alpha isoform of retinoic acid and retinoid X receptors in osteoblastic cells. A role of sphingosine 1-phosphate-mediated AP-1 in the ligand-dependent transcriptional activity of these receptors. | 2000 | J. Biol. Chem. | pmid:10915783 |
| Liu H et al. | Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. | 2000 | J. Biol. Chem. | pmid:10751414 |
| Bose R and Kolesnick R | Measurement of ceramide synthase activity. | 2000 | Meth. Enzymol. | pmid:10914032 |
| Takao N et al. | Protective roles for ATM in cellular response to oxidative stress. | 2000 | FEBS Lett. | pmid:10781820 |
| Sautin Y et al. | Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation. | 2000 | Thyroid | pmid:11041449 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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