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Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. |
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Acta Biomater |
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Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients. |
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J. Lipid Res. |
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Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients. |
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Arch. Dermatol. Res. |
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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. |
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Blood |
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A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis. |
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Inflamm. Res. |
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Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. |
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Am. J. Pathol. |
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Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. |
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Neuropharmacology |
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Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. |
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PLoS ONE |
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Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. |
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Annu. Rev. Physiol. |
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The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. |
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Chemosphere |
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Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. |
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J. Pineal Res. |
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Valproic acid enforces the priming effect of sphingosine-1 phosphate on human mesenchymal stem cells. |
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Int. J. Mol. Med. |
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Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. |
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Med Res Rev |
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Khodorova A et al. |
The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor. |
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Neuroscience |
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The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis. |
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Elife |
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C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells. |
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DJ-1 Regulates Differentiation of Human Mesenchymal Stem Cells into Smooth Muscle-like Cells in Response to Sphingosylphosphorylcholine. |
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Proteomics |
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Sphingosine 1-Phosphate Signaling and Its Pharmacological Modulation in Allogeneic Hematopoietic Stem Cell Transplantation. |
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Int J Mol Sci |
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Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway. |
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Mol Med Rep |
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Eur. J. Pharmacol. |
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Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. |
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SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. |
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Autophagy |
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Targeting sphingosine-1-phosphate signaling for cancer therapy. |
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Sci China Life Sci |
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Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. |
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Proc. Natl. Acad. Sci. U.S.A. |
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J. Atheroscler. Thromb. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Trifunctional lipid probes for comprehensive studies of single lipid species in living cells. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. |
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Neuropharmacology |
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The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
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CNS Neurol Disord Drug Targets |
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High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
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Mol. Neurobiol. |
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The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. |
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Mol. Biol. Cell |
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Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. |
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BMC Genomics |
pmid:28851267
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A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. |
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Int J Mol Sci |
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Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. |
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Otol. Neurotol. |
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Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. |
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Int J Mol Sci |
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Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. |
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PLoS ONE |
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Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51). |
2017 |
Microb. Pathog. |
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Sphingosine metabolism as a therapeutic target in cutaneous melanoma. |
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Transl Res |
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Synthesis and degradation of long-chain base phosphates affect fumonisin B-induced cell death in Arabidopsis thaliana. |
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J. Plant Res. |
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Atherosclerotic dyslipidemia revealed by plasma lipidomics on ApoE mice fed a high-fat diet. |
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Atherosclerosis |
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DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion. |
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Cell Commun. Signal |
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Isolation and structural characterization of glucosylceramides from Ethiopian plants by LC/APCI-MS/MS. |
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J Pharm Biomed Anal |
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Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling. |
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Oncotarget |
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Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism. |
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Chem. Phys. Lipids |
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Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. |
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Free Radic. Biol. Med. |
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Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B. |
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Bioorg. Med. Chem. |
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The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. |
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Int J Mol Sci |
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Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic. |
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Biochimie |
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Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study. |
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Anticancer Res. |
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Mechanisms of sphingosine 1-phosphate receptor signalling in cancer. |
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Cell. Signal. |
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Autophagy inhibits C2-ceramide-mediated cell death by decreasing the reactive oxygen species levels in SH-SY5Y cells. |
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Neurosci. Lett. |
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Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis. |
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Gynecol. Endocrinol. |
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Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. |
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Hum. Mutat. |
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Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
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Adv Biol Regul |
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Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. |
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Clin. Chim. Acta |
pmid:28159438
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Linear ion-trap MS with high-resolution MS reveals structural diversity of 1-O-acylceramide family in mouse epidermis. |
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J. Lipid Res. |
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Sphingolipids modulate the function of human serotonin receptors: Insights from sphingolipid-deficient cells. |
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Biochim. Biophys. Acta |
pmid:27984018
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Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? |
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Shock |
pmid:27922551
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The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. |
2017 |
PLoS ONE |
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Reduction of Pertussis Inflammatory Pathology by Therapeutic Treatment With Sphingosine-1-Phosphate Receptor Ligands by a Pertussis Toxin-Insensitive Mechanism. |
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J. Infect. Dis. |
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Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
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Front Biosci (Landmark Ed) |
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Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise. |
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Biomed Res Int |
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HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. |
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J. Mol. Med. |
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Epithelial cell extrusion: Pathways and pathologies. |
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Semin. Cell Dev. Biol. |
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Identification of the ligand of Pru p 3, a peach LTP. |
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Plant Mol. Biol. |
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Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. |
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J. Endocrinol. |
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Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. |
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Cell. Physiol. Biochem. |
pmid:28934733
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Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. |
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Mol. Immunol. |
pmid:28846923
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Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. |
2017 |
PLoS ONE |
pmid:28806736
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Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. |
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Diabetes |
pmid:28698261
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Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment. |
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J. Nutr. Biochem. |
pmid:28456081
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Hutami IR et al. |
Fas/S1P crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. |
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Biochem. Biophys. Res. Commun. |
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β-Blockade Prevents Post-Ischemic Myocardial Decompensation Via βAR-Dependent Protective Sphingosine-1 Phosphate Signaling. |
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J. Am. Coll. Cardiol. |
pmid:28683966
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Punsawad C and Viriyavejakul P |
Reduction in serum sphingosine 1-phosphate concentration in malaria. |
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PLoS ONE |
pmid:28666023
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A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. |
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Dev. Cell |
pmid:28535372
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Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential. |
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Expert Opin. Ther. Targets |
pmid:28524744
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Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. |
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Invest. Ophthalmol. Vis. Sci. |
pmid:28492873
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Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma. |
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Invest. Ophthalmol. Vis. Sci. |
pmid:28418499
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Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation. |
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Vascul. Pharmacol. |
pmid:28797762
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Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
2017 |
Sci Signal |
pmid:28351953
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Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
2017 |
PLoS ONE |
pmid:28334008
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Karunakaran I and van Echten-Deckert G |
Sphingosine 1-phosphate - A double edged sword in the brain. |
2017 |
Biochim. Biophys. Acta |
pmid:28315304
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A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. |
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J Pharm Biomed Anal |
pmid:28314215
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Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. |
2017 |
Glia |
pmid:28300348
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Dyckman AJ |
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. |
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J. Med. Chem. |
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Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. |
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Trends Mol Med |
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Modulation of sphingosine-1-phosphate in inflammatory bowel disease. |
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Autoimmun Rev |
pmid:28279838
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Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. |
2017 |
Biochim. Biophys. Acta |
pmid:28188805
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Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. |
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J. Lipid Res. |
pmid:28188148
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ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs. |
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J. Physiol. Biochem. |
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HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. |
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Lipids Health Dis |
pmid:28179022
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Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. |
2017 |
Hum. Mol. Genet. |
pmid:28175299
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Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. |
2017 |
Diabetes |
pmid:28174291
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Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2. |
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J. Lipid Res. |
pmid:27993948
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Shear stress induces Gα activation independently of G protein-coupled receptor activation in endothelial cells. |
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Am. J. Physiol., Cell Physiol. |
pmid:28148497
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The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. |
2017 |
Aging Cell |
pmid:28139067
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Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. |
2017 |
Cancer Invest. |
pmid:28135860
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Kurano M et al. |
Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:28126827
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The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. |
2017 |
Hepatology |
pmid:28120434
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