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Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension. |
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Cardiovasc. Res. |
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Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. |
2017 |
Neurology |
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The role of sphingolipid signalling in diabetes‑associated pathologies (Review). |
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Int. J. Mol. Med. |
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Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. |
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Nature |
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J. Biol. Chem. |
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High-Density Lipoprotein-Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1. |
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Arterioscler. Thromb. Vasc. Biol. |
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Barnawi J et al. |
Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. |
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Respirology |
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High-density lipoprotein-associated sphingosine-1-phosphate activity in heterozygous familial hypercholesterolaemia. |
2017 |
Eur. J. Clin. Invest. |
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Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. |
2017 |
Nat. Immunol. |
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Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. |
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Am. J. Pathol. |
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A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
2017 |
Cancer |
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C2-ceramide influences alveolar epithelial barrier function by downregulating Zo-1, occludin and claudin-4 expression. |
2017 |
Toxicol. Mech. Methods |
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The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis. |
2017 |
Elife |
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Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. |
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Arch. Toxicol. |
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Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. |
2017 |
Neuropharmacology |
pmid:28077289
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Leo A et al. |
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
2017 |
CNS Neurol Disord Drug Targets |
pmid:27823573
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Xiao W et al. |
Fingolimod Suppresses a Cascade of Core Vicious Cycle in Dry Eye NOD Mouse Model: Involvement of Sphingosine-1-Phosphate Receptors in Infiltrating Leukocytes. |
2017 |
Invest. Ophthalmol. Vis. Sci. |
pmid:29214311
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Roch L et al. |
High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
2017 |
Mol. Neurobiol. |
pmid:27631876
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Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. |
2017 |
Thromb. Res. |
pmid:28609704
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Meissner A |
S1PR (Sphingosine-1-Phosphate Receptor) Signaling in the Regulation of Vascular Tone and Blood Pressure: Is S1PR1 Doing the Trick? |
2017 |
Hypertension |
pmid:28607129
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Di Pietro M et al. |
In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome. |
2017 |
Mol. Hum. Reprod. |
pmid:28379469
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Pulkoski-Gross MJ et al. |
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. |
2017 |
Prostaglandins Other Lipid Mediat. |
pmid:28377281
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Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves' orbitopathy. |
2017 |
Inflamm. Res. |
pmid:28364200
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The sphingosine 1-phosphate breakdown product, (2)-hexadecenal, forms protein adducts and glutathione conjugates in vitro. |
2017 |
J. Lipid Res. |
pmid:28588048
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The Utility of Biomarkers in Osteoporosis Management. |
2017 |
Mol Diagn Ther |
pmid:28271451
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Schonauer S et al. |
Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease. |
2017 |
J. Biol. Chem. |
pmid:28258214
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The sphingosine rheostat is involved in the cnidarian heat stress response but not necessarily in bleaching. |
2017 |
J. Exp. Biol. |
pmid:28250108
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Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
2017 |
Adv Biol Regul |
pmid:27720306
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Barbour M et al. |
Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis. |
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Br. J. Pharmacol. |
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
2017 |
Atherosclerosis |
pmid:28038379
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Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. |
2017 |
Exp. Dermatol. |
pmid:27574180
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HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. |
2017 |
J. Mol. Med. |
pmid:27543493
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Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases. |
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Anal. Biochem. |
pmid:28259515
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Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. |
2017 |
PLoS ONE |
pmid:29136008
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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. |
2017 |
PLoS ONE |
pmid:29112690
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Luo J et al. |
The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28655617
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Chang CH and Randolph GJ |
Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. |
2017 |
Dev. Cell |
pmid:28633013
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Fang R et al. |
Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. |
2017 |
Arch. Med. Res. |
pmid:28625317
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Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology. |
2017 |
Crit. Rev. Biochem. Mol. Biol. |
pmid:28618839
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Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. |
2017 |
J. Immunol. |
pmid:28600291
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The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications. |
2017 |
Tumour Biol. |
pmid:28381169
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Garbowska M et al. |
Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes. |
2017 |
J. Cell. Physiol. |
pmid:28369933
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Ageing adversely affects the migration and function of marginal zone B cells. |
2017 |
Immunology |
pmid:28369800
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Müller J et al. |
Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration. |
2017 |
Biomed Res Int |
pmid:28367448
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Su K et al. |
FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines. |
2017 |
Mediators Inflamm. |
pmid:28270699
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Serafimidis I et al. |
Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. |
2017 |
PLoS Biol. |
pmid:28248965
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Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. |
2017 |
J. Pathol. |
pmid:28240350
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Alvares DS et al. |
Phosphatidylserine lipids and membrane order precisely regulate the activity of Polybia-MP1 peptide. |
2017 |
Biochim. Biophys. Acta |
pmid:28274844
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Jadhav S et al. |
Inositol Depletion Induced by Acute Treatment of the Bipolar Disorder Drug Valproate Increases Levels of Phytosphingosine. |
2017 |
J. Biol. Chem. |
pmid:28100786
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Fujii A et al. |
Selective Absorption of Dietary Sphingoid Bases from the Intestine via Efflux by P-Glycoprotein in Rats. |
2017 |
J. Nutr. Sci. Vitaminol. |
pmid:28367925
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