| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Usatyuk PV et al. | Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21478254 |
| Nishiuma T et al. | Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18359884 |
| Harijith A et al. | Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27343196 |
| Sparkman L et al. | Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16183668 |
| Karmouty-Quintana H et al. | Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:22287614 |
| Sun X et al. | Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23911438 |
| Chen LY et al. | Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18502815 |
| Veltman M et al. | Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27663991 |
| Yin Z and Watsky MA | Chloride channel activity in human lung fibroblasts and myofibroblasts. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15681397 |
| Bhattacharya M et al. | IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:22561460 |
| Choi S et al. | A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26361873 |
| Szczepaniak WS et al. | S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20435688 |
| Schaphorst KL et al. | Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12626332 |
| Wadgaonkar R et al. | Differential regulation of sphingosine kinases 1 and 2 in lung injury. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19168577 |
| Schweitzer KS et al. | Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25979079 |
| Johnstone ED et al. | Epidermal growth factor and sphingosine-1-phosphate stimulate Na+/H+ exchanger activity in the human placental syncytiotrophoblast. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17913870 |
| Kirby RJ et al. | Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19073640 |
| Martini S et al. | S1P modulator FTY720 limits matrix expansion in acute anti-thy1 mesangioproliferative glomerulonephritis. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17356129 |
| Kim M et al. | Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17898040 |
| Zhu Q et al. | A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21478479 |
| Jackson EK | Role of sphingosine-1-phosphate in the renal medulla. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21511695 |
| Awad AS et al. | Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16403835 |
| Schaier M et al. | Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19535570 |
| Krämer S et al. | The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19439518 |
| Zhou H and Murthy KS | Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15075212 |
| Hung RJ et al. | Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15075215 |
| Danieli-Betto D et al. | Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20042733 |
| Omori K et al. | Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17686998 |
| Dalla Libera L et al. | Beneficial effects of GH/IGF-1 on skeletal muscle atrophy and function in experimental heart failure. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:13679302 |
| Igarashi J et al. | Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19710365 |
| Oberst MD et al. | HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15800053 |
| Clarke AL et al. | Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of action. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:12372805 |
| Lee MS et al. | Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15590895 |
| Whetzel AM et al. | Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19091959 |
| Liu D et al. | Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21734188 |
| Chang CL et al. | S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19474291 |
| Liu J et al. | Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10644522 |
| Zanin M et al. | Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:17942639 |
| Kim MY et al. | Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16267108 |
| Sarai K et al. | Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19657053 |
| Heit B et al. | Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:20926778 |
| Fan A et al. | Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:26669941 |
| Lee H et al. | Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10712250 |
| Danieli-Betto D et al. | Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15659717 |
| Hopson KP et al. | S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21270296 |
| Formigli L et al. | Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11997251 |
| Sumida GM and Stamer WD | S1Pâ‚‚ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21289286 |
| Bucki R et al. | Plasma gelsolin modulates cellular response to sphingosine 1-phosphate. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20810916 |
| Xu M et al. | Sphingosine 1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17670896 |
| Leiber D et al. | Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:16956968 |
| Lee H et al. | Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15294853 |
| Igarashi J et al. | Hydrogen peroxide induces S1P1 receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:16943246 |
| Souktani R et al. | Induction of apoptosis using sphingolipids activates a chloride current in Xenopus laevis oocytes. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10898727 |
| Dela Paz NG et al. | Shear stress induces Gα activation independently of G protein-coupled receptor activation in endothelial cells. | 2017 | Am. J. Physiol., Cell Physiol. | pmid:28148497 |
| Zeineh K et al. | Possible modulators of IL-8 and GRO-alpha production by granulosa cells. | 2003 | Am. J. Reprod. Immunol. | pmid:14506934 |
| Sun Y et al. | FTY720-induced conversion of conventional Foxp3- CD4+ T cells to Foxp3+ regulatory T cells in NOD mice. | 2011 | Am. J. Reprod. Immunol. | pmid:21623989 |
| Kawano Y et al. | Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells. | 2001 | Am. J. Reprod. Immunol. | pmid:11775008 |
| Nagamatsu T et al. | Emerging roles for lysophospholipid mediators in pregnancy. | 2014 | Am. J. Reprod. Immunol. | pmid:24689547 |
| Che W et al. | Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24032470 |
| Longo CA et al. | Sphingomyelin metabolism is developmentally regulated in rat lung. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9160843 |
| Monick MM et al. | Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:14742298 |
| Hashimoto M et al. | Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18367729 |
| Zhao Y et al. | Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21148740 |
| Rumzhum NN et al. | Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26098693 |
| Sorrentino R et al. | B cell depletion increases sphingosine-1-phosphate-dependent airway inflammation in mice. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25250941 |
| Larivée P et al. | Platelet-activating factor induces airway mucin release via activation of protein kinase C: evidence for translocation of protein kinase C to membranes. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8049080 |
| Roviezzo F et al. | Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19556602 |
| Natarajan V et al. | Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23449739 |
| Shea BS et al. | Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:20081052 |
| Chan C and Goldkorn T | Ceramide path in human lung cell death. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10745027 |
| Rahaman M et al. | Neutrophil sphingosine 1-phosphate and lysophosphatidic acid receptors in pneumonia. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16224106 |
| Xu Y et al. | Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23239501 |
| Liu F et al. | Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415936 |
| Elstad MR et al. | Protein kinase C regulates the synthesis of platelet-activating factor by human monocytes. | 1991 | Am. J. Respir. Cell Mol. Biol. | pmid:1846746 |
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| Ito S et al. | Actin cytoskeleton regulates stretch-activated Ca2+ influx in human pulmonary microvascular endothelial cells. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19648475 |
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| Peng X et al. | Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15020292 |
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| Bhattacharya J | Lung injury: sphingosine-1-phosphate to the rescue. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15504814 |
| McVerry BJ et al. | Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15282202 |
| Su G et al. | Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:21980034 |
| Brinkmann V et al. | FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. | 2004 | Am. J. Transplant. | pmid:15196057 |
| Schroeder G et al. | FTY720 prevents anti-CD4 mAb-induced tolerance but cannot reverse established tolerance in a rat kidney transplantation model. | 2004 | Am. J. Transplant. | pmid:15147419 |
| Fu S et al. | CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential. | 2004 | Am. J. Transplant. | pmid:14678036 |
| Mulgaonkar S et al. | FTY720/cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding study. | 2006 | Am. J. Transplant. | pmid:16771816 |
| Budde K et al. | Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients. | 2003 | Am. J. Transplant. | pmid:12814476 |
| Truong W et al. | Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720. | 2007 | Am. J. Transplant. | pmid:17617868 |
| Salvadori M et al. | FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia. | 2006 | Am. J. Transplant. | pmid:17061999 |
| Anselmo DM et al. | FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration. | 2002 | Am. J. Transplant. | pmid:12392290 |
| Man K et al. | Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival. | 2006 | Am. J. Transplant. | pmid:16468955 |
| Okazaki M et al. | Sphingosine 1-phosphate inhibits ischemia reperfusion injury following experimental lung transplantation. | 2007 | Am. J. Transplant. | pmid:17391120 |
| Lan YY et al. | The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. | 2005 | Am. J. Transplant. | pmid:16212624 |
| Koyrakh L et al. | The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I. | 2005 | Am. J. Transplant. | pmid:15707407 |
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sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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