| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brinkmann V et al. | FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation. | 2000 | Trends Pharmacol. Sci. | pmid:10664606 |
| Jarvis WD and Grant S | Protein kinase C targeting in antineoplastic treatment strategies. | 1999 | Invest New Drugs | pmid:10665476 |
| Niwa M et al. | Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production. | 2000 | Life Sci. | pmid:10666000 |
| Furukawa H et al. | Prolongation of canine liver allograft survival by a novel immunosuppressant, FTY720: effect of monotherapy and combined treatment with conventional drugs. | 2000 | Transplantation | pmid:10670633 |
| Carpio LC et al. | Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670688 |
| Kristal BS and Brown AM | Ganglioside GD3, the mitochondrial permeability transition, and apoptosis. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672258 |
| Salinas M et al. | Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. | 2000 | Mol. Cell. Neurosci. | pmid:10673324 |
| Mizuta K et al. | Effect of pretreatment with FTY720 and cyclosporin on ischaemia-reperfusion injury of the liver in rats. | 1999 | J. Pharm. Pharmacol. | pmid:10678498 |
| Tsushima H and Mori M | In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats. | 2000 | Brain Res. | pmid:10678764 |
| Yamazaki Y et al. | Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679247 |
| Mihai R et al. | C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679256 |
| Orlati S et al. | Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. | 2000 | Arch. Biochem. Biophys. | pmid:10683250 |
| Napoli KL | The FTY720 story. | 2000 | Ther Drug Monit | pmid:10688258 |
| Matsuura M et al. | Effect of FTY720, a novel immunosuppressant, on adjuvant- and collagen-induced arthritis in rats. | 2000 | Int. J. Immunopharmacol. | pmid:10689105 |
| Motohashi K et al. | Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate. | 2000 | FEBS Lett. | pmid:10692584 |
| Migita K et al. | Regulation of rheumatoid synovial cell growth by ceramide. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10694479 |
| Galve-Roperh I et al. | Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. | 2000 | Nat. Med. | pmid:10700234 |
| Zhang Y et al. | Effect of synthetic sialyl 2-->1 sphingosine and other glycosylsphingosines on the structure and function of the "glycosphingolipid signaling domain (GSD)" in mouse melanoma B16 cells. | 2000 | Biochemistry | pmid:10704195 |
| Bodennec J et al. | Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges. | 2000 | Anal. Biochem. | pmid:10706795 |
| Kasinrerk W et al. | CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C-dependent pathway. | 2000 | Immunol. Lett. | pmid:10709783 |
| Kitabayashi H et al. | FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10710126 |
| Lee H et al. | Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10712250 |
| Gable K et al. | Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. | 2000 | J. Biol. Chem. | pmid:10713067 |
| Fujita T et al. | Antibody against a novel, myriocin (ISP-I)-based immunosuppressant, FTY720. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10714494 |
| Yuzawa K et al. | FTY720 blocks allograft rejection by homing of lymphocytes in vivo. | 2000 | Transplant. Proc. | pmid:10715413 |
| Dawson G | Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. | 2000 Apr-Jun | Int. J. Dev. Neurosci. | pmid:10715579 |
| Lobner D | Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? | 2000 | J. Neurosci. Methods | pmid:10720679 |
| Hanada K et al. | Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques. | 2000 | J. Biol. Chem. | pmid:10722674 |
| Kondo T et al. | Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. | 2000 | J. Biol. Chem. | pmid:10722733 |
| Perry DK et al. | Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. | 2000 | J. Biol. Chem. | pmid:10722759 |
| Kim HS et al. | Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733907 |
| Sun E et al. | Apoptotic cells actively inhibit the expression of CD69 on Con A activated T lymphocytes. | 2000 | Scand. J. Immunol. | pmid:10736091 |
| Cho S and Dawson G | Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. | 2000 | J. Neurochem. | pmid:10737604 |
| Chin TY and Chueh SH | Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells. | 2000 | Br. J. Pharmacol. | pmid:10742292 |
| Chan C and Goldkorn T | Ceramide path in human lung cell death. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10745027 |
| Brás A et al. | Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. | 2000 | Cell Death Differ. | pmid:10745271 |
| Cuvillier O et al. | Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. | 2000 | J. Biol. Chem. | pmid:10747891 |
| King CC et al. | Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. | 2000 | J. Biol. Chem. | pmid:10748151 |
| Liu H et al. | Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. | 2000 | J. Biol. Chem. | pmid:10751414 |
| Ahmed N and Berridge MV | Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. | 2000 | Pharmacol. Toxicol. | pmid:10752668 |
| Van Brocklyn JR et al. | Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. | 2000 | Blood | pmid:10753843 |
| Yeh MW et al. | Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. | 2000 | J. Immunol. | pmid:10754324 |
| Spiegel S and Milstien S | Functions of a new family of sphingosine-1-phosphate receptors. | 2000 | Biochim. Biophys. Acta | pmid:10760461 |
| Basu M et al. | Ceramide glycanase activities in human cancer cells. | 1999 | Biosci. Rep. | pmid:10763812 |
| Panetti TS et al. | Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10764666 |
| Chung N et al. | Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. | 2000 | J. Biol. Chem. | pmid:10764732 |
| Prinetti A et al. | Sphingolipid-enriched membrane domains from rat cerebellar granule cells differentiated in culture. A compositional study. | 2000 | J. Biol. Chem. | pmid:10766784 |
| Paolucci C et al. | Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way. | 2000 | J. Biol. Chem. | pmid:10777484 |
| Holopainen JM et al. | Dimyristoylphosphatidylcholine/C16:0-ceramide binary liposomes studied by differential scanning calorimetry and wide- and small-angle x-ray scattering. | 2000 | Biophys. J. | pmid:10777742 |
| Tomita H et al. | Ceramide-induced cell death in cultured rat retinal pigment epithelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10778806 |
| Brandwagt BF et al. | A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781105 |
| Takao N et al. | Protective roles for ATM in cellular response to oxidative stress. | 2000 | FEBS Lett. | pmid:10781820 |
| Miura Y et al. | Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. | 2000 | J. Biochem. | pmid:10788802 |
| De Nadai C et al. | Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792026 |
| Kimura T et al. | Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. | 2000 | Biochem. J. | pmid:10794715 |
| Meadows KA et al. | Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. | 2000 | J. Cell. Physiol. | pmid:10797307 |
| Goetzl EJ et al. | Cutting edge: differential constitutive expression of functional receptors for lysophosphatidic acid by human blood lymphocytes. | 2000 | J. Immunol. | pmid:10799850 |
| Meacci E et al. | Receptor-activated phospholipase D is present in caveolin-3-enriched light membranes of C2C12 myotubes. | 2000 | FEBS Lett. | pmid:10802049 |
| Raisova M et al. | Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. | 2000 | FEBS Lett. | pmid:10802053 |
| Nava VE et al. | Functional characterization of human sphingosine kinase-1. | 2000 | FEBS Lett. | pmid:10802064 |
| Tavarini S et al. | Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. | 2000 | Neurosci. Lett. | pmid:10806317 |
| Xu Y et al. | Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. | 2000 | Nat. Cell Biol. | pmid:10806476 |
| Knapp KM and English BK | Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. | 2000 | J. Leukoc. Biol. | pmid:10811015 |
| Kanazawa T et al. | Inhibition of cytokinesis by a lipid metabolite, psychosine. | 2000 | J. Cell Biol. | pmid:10811833 |
| Katz SM et al. | New immunosuppressive agents. | 2000 | Transplant. Proc. | pmid:10812142 |
| Hla T et al. | Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818438 |
| Spiegel S | Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818441 |
| Ancellin N and Hla T | Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818459 |
| Yamamura S et al. | Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818470 |
| Liliom K et al. | Sphingosylphosphorylcholine is a bona fide mediator regulating heart rate. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818471 |
| Gallois C et al. | Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818472 |
| Gennero I et al. | Effect of sphingosine-1-phosphate and analogues of lysophosphatidic acid on mesangial cell proliferation. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818478 |
| Pinschewer DD et al. | FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. | 2000 | J. Immunol. | pmid:10820254 |
| Yagi H et al. | Immunosuppressant FTY720 inhibits thymocyte emigration. | 2000 | Eur. J. Immunol. | pmid:10820391 |
| Nagahara Y et al. | Evidence that FTY720 induces T cell apoptosis in vivo. | 2000 | Immunopharmacology | pmid:10822091 |
| Enomoto A et al. | Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. | 2000 | Cancer Lett. | pmid:10822128 |
| Posey SC et al. | Failure of gelsolin overexpression to regulate lymphocyte apoptosis. | 2000 | Blood | pmid:10828033 |
| Hanada K et al. | D-Serine inhibits serine palmitoyltransferase, the enzyme catalyzing the initial step of sphingolipid biosynthesis. | 2000 | FEBS Lett. | pmid:10828452 |
| Fujisawa K et al. | Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo. | 2000 | Placenta | pmid:10833370 |
| Boguslawski G et al. | Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833459 |
| Caligan TB et al. | A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. | 2000 | Anal. Biochem. | pmid:10847608 |
| Cooke ME et al. | Contraction of collagen matrices mediated by alpha2beta1A and alpha(v)beta3 integrins. | 2000 | J. Cell. Sci. | pmid:10852817 |
| Zanolari B et al. | Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. | 2000 | EMBO J. | pmid:10856228 |
| Friant S et al. | Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis. | 2000 | EMBO J. | pmid:10856229 |
| Campbell V and Lynch MA | The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes. | 2000 | Cytokine | pmid:10857764 |
| Mandala SM et al. | Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10859351 |
| Shin Y et al. | Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. | 2000 | Cell Calcium | pmid:10859593 |
| Murata N et al. | Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay. | 2000 | Anal. Biochem. | pmid:10860507 |
| Chigorno V et al. | Evidence that ganglioside enriched domains are distinct from caveolae in MDCK II and human fibroblast cells in culture. | 2000 | Eur. J. Biochem. | pmid:10866823 |
| Siess W et al. | Lysophosphatidic acid and sphingosine 1-phosphate: two lipid villains provoking cardiovascular diseases? | 2000 | IUBMB Life | pmid:10868905 |
| Loukaci A et al. | New lipids from the tunicate Cystodytes cf. dellechiajei, as PLA2 inhibitors. | 2000 | J. Nat. Prod. | pmid:10869204 |
| Racké K et al. | Potential role of EDG receptors and lysophospholipids as their endogenous ligands in the respiratory tract. | 2000 | Pulm Pharmacol Ther | pmid:10873548 |
| Liu R et al. | 1,25 dihydroxyvitamin D(3) activates sphingomyelin turnover in ROS17/2.8 osteosarcoma cells without sphingolipid-induced changes in cytosolic Ca(2+). | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873570 |
| Sugiyama A et al. | Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system. | 2000 | Jpn. J. Pharmacol. | pmid:10875754 |
| Spiegel S and Milstien S | Sphingosine-1-phosphate: signaling inside and out. | 2000 | FEBS Lett. | pmid:10878250 |
| Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling in mammalian cells. | 2000 | Biochem. J. | pmid:10880336 |
| López-Marure R et al. | Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levels. | 2000 | Eur. J. Biochem. | pmid:10880954 |
| Carpio LC et al. | Changes in sphingolipid levels induced by epidermal growth factor in osteoblastic cells. Effects of these metabolites on cytosolic calcium levels. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10882186 |
| Funakoshi T et al. | Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells. | 2000 | J. Biol. Chem. | pmid:10882735 |
| Ohashi Y et al. | Squid nerve sphingomyelin containing an unusual sphingoid base. | 2000 | J. Lipid Res. | pmid:10884294 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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