| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Silva VR et al. | Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise. | 2016 | Aging (Albany NY) | pmid:28039439 |
| Kasbi-Chadli F et al. | Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. | 2016 | Eur J Nutr | pmid:25787885 |
| Fu P et al. | Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. | 2016 | J. Biol. Chem. | pmid:27864331 |
| Terashita T et al. | Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. | 2016 | Respir. Res. | pmid:27829417 |
| Brait VH et al. | Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice. | 2016 | Stroke | pmid:27827329 |
| Gharbaran R | Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma. | 2016 | Tumour Biol. | pmid:27317256 |
| Higashi K et al. | Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. | 2016 | Bone | pmid:27612439 |
| Sasset L et al. | Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. | 2016 | Trends Endocrinol. Metab. | pmid:27562337 |
| Roviezzo F et al. | Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate. | 2016 | Pharmacol. Res. | pmid:27713021 |
| Hemdan NY et al. | Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. | 2016 | Eur. J. Immunol. | pmid:27683081 |
| Chew WS et al. | To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. | 2016 | Pharmacol. Res. | pmid:27663260 |
| Wang X et al. | Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. | 2016 | PLoS Pathog. | pmid:27711202 |
| Adamiak M et al. | The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. | 2016 | Stem Cell Rev | pmid:27704316 |
| Steiner R et al. | Elucidating the chemical structure of native 1-deoxysphingosine. | 2016 | J. Lipid Res. | pmid:27165858 |
| Chen W et al. | Sphingosine 1-phosphate in metabolic syndrome (Review). | 2016 | Int. J. Mol. Med. | pmid:27600830 |
| Hamidi Shishavan M et al. | Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. | 2016 | PLoS ONE | pmid:27583547 |
| Gazit SL et al. | Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. | 2016 | Circ. Res. | pmid:27582371 |
| Machida T et al. | Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. | 2016 | J. Pharmacol. Sci. | pmid:27581589 |
| Nagahashi M et al. | High levels of sphingolipids in human breast cancer. | 2016 | J. Surg. Res. | pmid:27565080 |
| Dong T et al. | Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. | 2016 | J Neuroinflammation | pmid:27561600 |
| Nojima H et al. | Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. | 2016 | PLoS ONE | pmid:27551720 |
| Harris CM et al. | Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27519818 |
| Chen C et al. | Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. | 2016 | Mol. Cell. Endocrinol. | pmid:26948947 |
| Xu H et al. | Serum Metabonomics of Mild Acute Pancreatitis. | 2016 | J. Clin. Lab. Anal. | pmid:27169745 |
| Egom EE et al. | Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes. | 2016 | Mol. Cell. Biochem. | pmid:27372350 |
| Sanagawa A et al. | Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α. | 2016 | Mol Med Rep | pmid:27357063 |
| Tiper IV et al. | Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection. | 2016 | Pathog Dis | pmid:27354294 |
| Jung M et al. | Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. | 2016 | Sci Signal | pmid:27353364 |
| Rodvold JJ and Zanetti M | Tumor microenvironment on the move and the Aselli connection. | 2016 | Sci Signal | pmid:27353363 |
| Harijith A et al. | Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27343196 |
| Hernández-Coronado CG et al. | Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. | 2016 | Gen. Comp. Endocrinol. | pmid:27342378 |
| Chakrabarti SS et al. | Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. | 2016 | Curr Alzheimer Res | pmid:27335046 |
| Tsai HC and Han MH | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. | 2016 | Drugs | pmid:27318702 |
| Yang Z et al. | TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. | 2016 | Pharmacol. Res. | pmid:27317945 |
| Barnawi J et al. | Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. | 2016 | COPD | pmid:27144721 |
| Jin L et al. | The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. | 2016 | World J Surg Oncol | pmid:27129720 |
| Nagura Y et al. | Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction. | 2016 | Transfus Med | pmid:27350440 |
| Sanchez T | Sphingosine-1-Phosphate Signaling in Endothelial Disorders. | 2016 | Curr Atheroscler Rep | pmid:27115142 |
| Crespo I et al. | Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. | 2016 | J. Pineal Res. | pmid:27101794 |
| Riganti L et al. | Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment. | 2016 | J. Neurosci. | pmid:27098703 |
| Cai Y et al. | FOXF1 maintains endothelial barrier function and prevents edema after lung injury. | 2016 | Sci Signal | pmid:27095594 |
| Castaldi A et al. | Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. | 2016 | Cell. Signal. | pmid:27094722 |
| Anbazhagan AN et al. | Transcriptional modulation of SLC26A3 (DRA) by sphingosine-1-phosphate. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:27079615 |
| Wang H et al. | Potential serum biomarkers from a metabolomics study of autism. | 2016 | J Psychiatry Neurosci | pmid:26395811 |
| Chawla S et al. | S1P prophylaxis mitigates acute hypobaric hypoxia-induced molecular, biochemical, and metabolic disturbances: A preclinical report. | 2016 | IUBMB Life | pmid:26959531 |
| Vito CD et al. | Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications. | 2016 | Platelets | pmid:26950429 |
| Jin J et al. | Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. | 2016 | Sci Rep | pmid:26948042 |
| Guerrero M et al. | Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). | 2016 | Expert Opin Ther Pat | pmid:26947494 |
| Watterson SH et al. | Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. | 2016 | J. Med. Chem. | pmid:26924461 |
| Liu W et al. | Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. | 2016 | Eur. J. Pharmacol. | pmid:26921757 |
| Yang Y et al. | Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. | 2016 | Neurochem. Int. | pmid:26921668 |
| Li J et al. | Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. | 2016 | Tumour Biol. | pmid:26857281 |
| Camaré C et al. | The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. | 2016 | Free Radic. Biol. Med. | pmid:26855418 |
| Kim SE et al. | The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. | 2016 | Invest. Ophthalmol. Vis. Sci. | pmid:26830367 |
| Messias CV et al. | Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation. | 2016 | PLoS ONE | pmid:26824863 |
| Testard A et al. | Calcium- and Nitric Oxide-Dependent Nuclear Accumulation of Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase in Response to Long Chain Bases in Tobacco BY-2 Cells. | 2016 | Plant Cell Physiol. | pmid:27585463 |
| Pászti-Gere E et al. | Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status. | 2016 | Oxid Med Cell Longev | pmid:26823955 |
| Vijai Kumar Reddy T et al. | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. | 2016 | Eur J Med Chem | pmid:27128176 |
| Wiltshire R et al. | Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors. | 2016 | Sci Rep | pmid:26813587 |
| Farez MF and Correale J | Sphingosine 1-phosphate signaling in astrocytes: Implications for progressive multiple sclerosis. | 2016 | J. Neurol. Sci. | pmid:26810518 |
| Santos-Cortez RL et al. | Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. | 2016 | Am. J. Hum. Genet. | pmid:26805784 |
| Luttgeharm KD et al. | Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis. | 2016 | Biochem. J. | pmid:26635357 |
| Bock S et al. | Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells. | 2016 | J. Dermatol. Sci. | pmid:26803226 |
| Marycz K et al. | The influence of metal-based biomaterials functionalized with sphingosine-1-phosphate on the cellular response and osteogenic differentaion potenial of human adipose derived mesenchymal stem cells in vitro. | 2016 | J Biomater Appl | pmid:26801473 |
| Xu R et al. | Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. | 2016 | Oncotarget | pmid:26943039 |
| Kim YH and Tabata Y | Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure. | 2016 | J Biomed Mater Res A | pmid:26704185 |
| Gomez-Muñoz A et al. | Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate. | 2016 | Prog. Lipid Res. | pmid:26703189 |
| Ottenlinger F et al. | Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. | 2016 | Eur. J. Immunol. | pmid:26683421 |
| Fan A et al. | Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:26669941 |
| Ordóñez YF et al. | 3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells. | 2016 | Mol Biosyst | pmid:26928714 |
| Petrache I and Berdyshev EV | Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. | 2016 | Annu. Rev. Physiol. | pmid:26667073 |
| Delgado A and MartÃnez-Cartro M | Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. | 2016 | Curr. Med. Chem. | pmid:26639095 |
| Yamamoto S et al. | A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). | 2016 | Mol. Biol. Cell | pmid:26631556 |
| Bohannon JK and Sherwood ER | Editorial: Feeling the burn: sphingolipids and infection risk after thermal injury. | 2016 | J. Leukoc. Biol. | pmid:27909176 |
| Im J et al. | Desensitization of idiopathic pulmonary fibrosis fibroblasts to Alternaria alternata extract-mediated necrotic cell death. | 2016 | Physiol Rep | pmid:27905295 |
| Realini N et al. | Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. | 2016 | J. Biol. Chem. | pmid:26553872 |
| Campos LS et al. | Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling. | 2016 | Mol. Cell. Biol. | pmid:26552704 |
| Neubauer HA et al. | An oncogenic role for sphingosine kinase 2. | 2016 | Oncotarget | pmid:27588496 |
| Zeng Y et al. | Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. | 2016 | Oncotarget | pmid:27556509 |
| Nagahashi M et al. | DNA damage response and sphingolipid signaling in liver diseases. | 2016 | Surg. Today | pmid:26514817 |
| Zhang D et al. | FTY-720P Suppresses Osteoclast Formation by Regulating Expression of Interleukin-6 (IL-6), Interleukin-4 (IL-4), and Matrix Metalloproteinase 2 (MMP-2). | 2016 | Med. Sci. Monit. | pmid:27344392 |
| Yönel N et al. | Anti-erosive effects of fluoride and phytosphingosine: an in vitro study. | 2016 | Eur. J. Oral Sci. | pmid:27342101 |
| Patmanathan SN et al. | Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. | 2016 | Sci Rep | pmid:27160553 |
| Li N and Zhang F | Implication of sphingosin-1-phosphate in cardiovascular regulation. | 2016 | Front Biosci (Landmark Ed) | pmid:27100508 |
| Ohtoyo M et al. | Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. | 2016 | Lipids | pmid:27585475 |
| Ratajczak MZ and Suszynska M | Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells. | 2016 | Stem Cell Rev | pmid:26400757 |
| Yaghobian D et al. | Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. | 2016 | Clin. Exp. Pharmacol. Physiol. | pmid:26414003 |
| Kalhori V et al. | FTY720 (Fingolimod) attenuates basal and sphingosine-1-phosphate-evoked thyroid cancer cell invasion. | 2016 | Endocr. Relat. Cancer | pmid:26935838 |
| Bae YC et al. | Effects of sphingosylphosphorylcholine on cryopreserved fat tissue graft survival. | 2016 | Mol Med Rep | pmid:27572900 |
| Kugelberg E | Cell death: Find me and eat me. | 2016 | Nat. Rev. Immunol. | pmid:26922908 |
| Vanier MT et al. | Diagnostic tests for Niemann-Pick disease type C (NP-C): A critical review. | 2016 | Mol. Genet. Metab. | pmid:27339554 |
| Liu X et al. | Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells. | 2016 | Exp. Biol. Med. (Maywood) | pmid:26376826 |
| Dielschneider RF et al. | Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism. | 2016 | Leukemia | pmid:26859075 |
| Setoguchi R | IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature. | 2016 | Int. Immunol. | pmid:26857736 |
| Fujiwara T et al. | Practical Synthesis of Pachastrissamine (Jaspine B), 2-epi-Pachastrissamine, and the 2-epi-Pyrrolidine Analogue. | 2016 | Chem. Pharm. Bull. | pmid:26833446 |
| Gowda SG et al. | Highly efficient preparation of sphingoid bases from glucosylceramides by chemoenzymatic method. | 2016 | J. Lipid Res. | pmid:26667669 |
| Nojima H et al. | Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. | 2016 | J. Hepatol. | pmid:26254847 |
| Lee WJ et al. | Inhibitory effects of N,N,N-trimethyl phytosphingosine-iodide on melanogenesis via ERK activation-mediated MITF degradation. | 2016 | Biosci. Biotechnol. Biochem. | pmid:26263195 |
| Grammatikos G et al. | Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. | 2016 | Oncotarget | pmid:26933996 |
| Stahlberg S et al. | Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by ²H Solid-State NMR Spectroscopy. | 2016 | Langmuir | pmid:26828109 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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