sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Chen YJ et al. In vitro evaluation of the effect of a novel immunosuppressive agent, FTY720, on the function of feline neutrophils. 2006 Am. J. Vet. Res. pmid:16579750
Saigusa D et al. Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry. 2012 Anal Bioanal Chem pmid:22538778
Sánchez BA et al. Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. 2011 Anal Bioanal Chem pmid:21394454
Frej C et al. Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation. 2015 Anal Bioanal Chem pmid:26377937
Yatomi Y et al. Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride. 1995 Anal. Biochem. pmid:7503424
Naoi M and Yagi K A sensitive assay of galactocerebroside beta-galactosidase by high-performance liquid chromatography using galactosyl-N-dansyl-sphingosine as substrate. 1981 Anal. Biochem. pmid:6795970
Don AS and Rosen H A fluorescent plate reader assay for ceramide kinase. 2008 Anal. Biochem. pmid:18206978
Edsall LC and Spiegel S Enzymatic measurement of sphingosine 1-phosphate. 1999 Anal. Biochem. pmid:10405296
Berdyshev EV et al. Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. 2011 Anal. Biochem. pmid:20804717
Jin YX et al. A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry. 2008 Anal. Biochem. pmid:18541132
Maker HS et al. Microchemical assay of galactose containing cerebrosides. 1974 Anal. Biochem. pmid:4422683
Bodennec J et al. Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges. 2000 Anal. Biochem. pmid:10706795
Naoi M et al. Rapid and sensitive determination of sphingosine bases and sphingolipids with fluorescamine. 1974 Anal. Biochem. pmid:4827398
Olivera A et al. Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases. 1994 Anal. Biochem. pmid:7887476
Ohta H et al. Quantification of free sphingosine in cultured cells by acylation with radioactive acetic anhydride. 1994 Anal. Biochem. pmid:7864378
Merrill AH et al. Quantitation of free sphingosine in liver by high-performance liquid chromatography. 1988 Anal. Biochem. pmid:3407935
Vessey DA et al. A rapid radioassay for sphingosine kinase. 2005 Anal. Biochem. pmid:15649386
Siow DL and Wattenberg BW An assay system for measuring the acute production of sphingosine 1-phosphate in intact monolayers. 2007 Anal. Biochem. pmid:17884005
Lester RL and Dickson RC High-performance liquid chromatography analysis of molecular species of sphingolipid-related long chain bases and long chain base phosphates in Saccharomyces cerevisiae after derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. 2001 Anal. Biochem. pmid:11700984
Murata N et al. Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay. 2000 Anal. Biochem. pmid:10860507
Caligan TB et al. A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. 2000 Anal. Biochem. pmid:10847608
Billich A and Ettmayer P Fluorescence-based assay of sphingosine kinases. 2004 Anal. Biochem. pmid:14769343
Kralik SF et al. A method for quantitative extraction of sphingosine 1-phosphate into organic solvent. 2001 Anal. Biochem. pmid:11444818
Billich A et al. Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors. 2013 Anal. Biochem. pmid:23246729
Min JK et al. Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. 2002 Anal. Biochem. pmid:11950216
Kharel Y et al. A rapid assay for assessment of sphingosine kinase inhibitors and substrates. 2011 Anal. Biochem. pmid:21216217
Kuchar L et al. Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases. 2017 Anal. Biochem. pmid:28259515
McNabb TJ et al. The separation and direct detection of ceramides and sphingoid bases by normal-phase high-performance liquid chromatography and evaporative light-scattering detection. 1999 Anal. Biochem. pmid:10603247
He X et al. Simultaneous quantitative analysis of ceramide and sphingosine in mouse blood by naphthalene-2,3-dicarboxyaldehyde derivatization after hydrolysis with ceramidase. 2005 Anal. Biochem. pmid:15802137
Van Veldhoven PP et al. Enzymatic quantification of sphingosine in the picomole range in cultured cells. 1989 Anal. Biochem. pmid:2559626
Berdyshev EV et al. Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. 2005 Anal. Biochem. pmid:15766719
Sparling ML et al. Analysis of membrane lipids by 500 MHz 1H NMR. 1989 Anal. Biochem. pmid:2729581
Ichioka T et al. Simultaneous determination of psychosine and cerebrosides. 1987 Anal. Biochem. pmid:3674406
Graf C et al. A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. 2009 Anal. Biochem. pmid:18831956
Hancock SM et al. High-throughput screening of cell lysates for ganglioside synthesis. 2008 Anal. Biochem. pmid:18703011
Mano N et al. Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry. 1997 Anal. Biochem. pmid:9025946
Roberts JL et al. An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. 2004 Anal. Biochem. pmid:15246004
Masood MA et al. Enhanced detection of sphingoid bases via divalent ruthenium bipyridine complex derivatization and electrospray ionization tandem mass spectrometry. 2009 Anal. Chem. pmid:19055420
Neuber C et al. Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. 2014 Anal. Chem. pmid:25137547
Lee KJ et al. Determination of sphingosine kinase activity for cellular signaling studies. 2008 Anal. Chem. pmid:18197698
Zhang J et al. Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system. 2009 Anal. Chim. Acta pmid:19720167
Hemmings HC et al. Biochemical characterization of the stimulatory effects of halothane and propofol on purified brain protein kinase C. 1995 Anesth. Analg. pmid:7486107
Kinoshita H et al. Sevoflurane, but not propofol, prevents Rho kinase-dependent contraction induced by sphingosylphosphorylcholine in the porcine coronary artery. 2007 Anesth. Analg. pmid:17646484
Jiang H et al. Achieving molecular complexity by organocatalytic one-pot strategies - a fast entry for synthesis of sphingoids, amino sugars, and polyhydroxylated alpha-amino acids. 2009 Angew. Chem. Int. Ed. Engl. pmid:19437516
Kwak HI et al. Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. 2012 Angiogenesis pmid:22407449
Rivera-Lopez CM et al. Lysophosphatidic acid (LPA) and angiogenesis. 2008 Angiogenesis pmid:18504643
Zhang YL et al. Non-invasive assessment of culture media from goat cloned embryos associated with subjective morphology by gas chromatography - mass spectroscopy-based metabolomic analysis. 2018 Anim. Sci. J. pmid:28833899
Hernández-Coronado CG et al. Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles. 2015 Animal pmid:25245232
Williams PA et al. Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis. 2017 Ann Biomed Eng pmid:27904998
Hughes SK et al. Fluid shear stress modulates cell migration induced by sphingosine 1-phosphate and vascular endothelial growth factor. 2005 Ann Biomed Eng pmid:16133909
Alford SK et al. Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements. 2010 Ann Biomed Eng pmid:20358290
Brown BA et al. Fingolimod: a novel immunosuppressant for multiple sclerosis. 2007 Ann Pharmacother pmid:17785617
Kovarik JM et al. FTY720 and cyclosporine: evaluation for a pharmacokinetic interaction. 2004 Jul-Aug Ann Pharmacother pmid:15138297
Muramatsu K et al. A new immunosuppressant, FTY720, prolongs limb allograft survival in rats. 1998 Ann Plast Surg pmid:9495465
Ibarrola I et al. Production profile of the major allergen Alt a 1 in Alternaria alternata cultures. 2004 Ann. Allergy Asthma Immunol. pmid:15609770
Ohkawa R et al. Plasma sphingosine-1-phosphate measurement in healthy subjects: close correlation with red blood cell parameters. 2008 Ann. Clin. Biochem. pmid:18583619
Absher JR ACP Journal Club. In multiple sclerosis, use of fingolimod reduced immune responses to influenza and tetanus booster vaccines. 2015 Ann. Intern. Med. pmid:26075785
Riboni L et al. Metabolic fate of exogenous sphingosine in neuroblastoma neuro2A cells. Dose-dependence and biological effects. 1998 Ann. N. Y. Acad. Sci. pmid:9668342
Spiegel S et al. Sphingosine-1-phosphate in cell growth and cell death. 1998 Ann. N. Y. Acad. Sci. pmid:9668339
Igarashi Y Sphingosine-1-phosphate as an intercellular signaling molecule. 1998 Ann. N. Y. Acad. Sci. pmid:9668340
Liliom K et al. Sphingosylphosphorylcholine is a bona fide mediator regulating heart rate. 2000 Ann. N. Y. Acad. Sci. pmid:10818471
Lépine S et al. Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis. 2002 Ann. N. Y. Acad. Sci. pmid:12485859
Hla T et al. Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. 2000 Ann. N. Y. Acad. Sci. pmid:10818438
Spiegel S Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. 2000 Ann. N. Y. Acad. Sci. pmid:10818441
Ancellin N and Hla T Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. 2000 Ann. N. Y. Acad. Sci. pmid:10818459
Yamamura S et al. Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho. 2000 Ann. N. Y. Acad. Sci. pmid:10818470
Gallois C et al. Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition. 2000 Ann. N. Y. Acad. Sci. pmid:10818472
Gennero I et al. Effect of sphingosine-1-phosphate and analogues of lysophosphatidic acid on mesangial cell proliferation. 2000 Ann. N. Y. Acad. Sci. pmid:10818478
Condrescu M et al. Cellular regulation of sodium-calcium exchange. 2002 Ann. N. Y. Acad. Sci. pmid:12502564
Xue X et al. Differential effects of G protein coupled receptors on hematopoietic progenitor cell growth depend on their signaling capacities. 2007 Ann. N. Y. Acad. Sci. pmid:17360805
Kristal BS and Brown AM Ganglioside GD3, the mitochondrial permeability transition, and apoptosis. 1999 Ann. N. Y. Acad. Sci. pmid:10672258
Saito M et al. The semisynthetic glycosphingolipid LIGA20 potently protects neurons against apoptosis. 1998 Ann. N. Y. Acad. Sci. pmid:9668359
Kalincik T et al. Switch to natalizumab versus fingolimod in active relapsing-remitting multiple sclerosis. 2015 Ann. Neurol. pmid:25546031
Mehling M et al. Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients. 2011 Ann. Neurol. pmid:21387383
Wei Y et al. Fingolimod provides long-term protection in rodent models of cerebral ischemia. 2011 Ann. Neurol. pmid:21280082
Colombo E et al. Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide. 2014 Ann. Neurol. pmid:25043204
Miron VE et al. FTY720 modulates human oligodendrocyte progenitor process extension and survival. 2008 Ann. Neurol. pmid:17918267
Cohen JA and Chun J Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. 2011 Ann. Neurol. pmid:21520239
Winkelmann A et al. Fingolimod treatment for multiple sclerosis patients What do we do with varicella? 2011 Ann. Neurol. pmid:22028236
Kobayashi T et al. Infantile and fetal globoid cell leukodystrophy: analysis of galactosylceramide and galactosylsphingosine. 1988 Ann. Neurol. pmid:3239954
Mizushima N et al. Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells. 1998 Ann. Rheum. Dis. pmid:9797556
Malinowski M et al. The influence of commonly used immunosuppressive drugs on the small bowel functions - a comparative experimental study. 2009 Apr-Jun Ann. Transplant. pmid:19487793
Tarbell JM et al. Mechanosensing at the vascular interface. 2014 Annu Rev Biomed Eng pmid:24905872
Gatt S and Barenholz Y Enzymes of complex lipid metabolism. 1973 Annu. Rev. Biochem. pmid:4600375
Cyster JG and Schwab SR Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. 2012 Annu. Rev. Immunol. pmid:22149932
Cyster JG Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. 2005 Annu. Rev. Immunol. pmid:15771568
Yanagida K and Hla T Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. 2017 Annu. Rev. Physiol. pmid:27813829
Lucki NC and Sewer MB Nuclear sphingolipid metabolism. 2012 Annu. Rev. Physiol. pmid:21888508
Petrache I and Berdyshev EV Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. 2016 Annu. Rev. Physiol. pmid:26667073
Peyruchaud O Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer. 2009 Anticancer Agents Med Chem pmid:19442039
Burns TA and Luberto C Sphingolipid metabolism and leukemia: a potential for novel therapeutic approaches. 2011 Anticancer Agents Med Chem pmid:21707485
Cuvillier O and Ader I Hypoxia-inducible factors and sphingosine 1-phosphate signaling. 2011 Anticancer Agents Med Chem pmid:21707486
Bedia C et al. Regulation of autophagy by sphingolipids. 2011 Anticancer Agents Med Chem pmid:21707487
Weigert A et al. S1P regulation of macrophage functions in the context of cancer. 2011 Anticancer Agents Med Chem pmid:21707489
Watters RJ et al. Targeting sphingosine-1-phosphate receptors in cancer. 2011 Anticancer Agents Med Chem pmid:21707490
Stevenson CE et al. Targeting sphingosine-1-phosphate in hematologic malignancies. 2011 Anticancer Agents Med Chem pmid:21707492
Kawahara S et al. Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells. 2013 Anticancer Drugs pmid:23426175
Hoffmann TK et al. Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines. 2002 Anticancer Drugs pmid:11914646
Ubai T et al. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Res. pmid:17352219
Ahn EH and Schroeder JJ Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. 2006 Jan-Feb Anticancer Res. pmid:16475687