sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Soltau I et al. Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. 2016 PLoS ONE pmid:27973607
Zamora-Pineda J et al. Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. 2016 J. Exp. Med. pmid:27810923
Kobayashi N et al. Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes. 2016 J. Lipid Res. pmid:27655910
Evangelisti C et al. Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. 2016 Leukemia pmid:27461062
Stolwijk JA et al. Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function. 2016 J. Biol. Chem. pmid:27624938
Lepannetier S et al. Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. 2016 Cell Calcium pmid:27638096
Kemppainen K et al. Sphingosylphosphorylcholine regulates the Hippo signaling pathway in a dual manner. 2016 Cell. Signal. pmid:27634386
Custódio R et al. Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei. 2016 Mol. Microbiol. pmid:27632710
Ebenezer DL et al. Targeting sphingosine-1-phosphate signaling in lung diseases. 2016 Pharmacol. Ther. pmid:27621206
Tsuchida J et al. Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis. 2016 J. Surg. Res. pmid:27621003
Viswanathan P et al. Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. 2016 Biochem. Biophys. Res. Commun. pmid:27473658
Moruno Manchon JF et al. SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. 2016 Autophagy pmid:27467777
Nagahashi M et al. The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. 2016 J. Lipid Res. pmid:27459945
Poissonnier A et al. CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. 2016 Immunity pmid:27438772
Zhang Q et al. Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. 2016 Am. J. Chin. Med. pmid:27430910
Adamiak M et al. Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation. 2016 Cell Transplant pmid:27412411
Juif PE et al. Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators. 2016 Expert Opin Drug Metab Toxicol pmid:27249325
Hollands A et al. Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. 2016 J. Biol. Chem. pmid:27226531
Mirzaian M et al. Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. 2016 Clin. Chim. Acta pmid:27221202
Bao XH et al. [Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. 2016 Zhonghua Xin Xue Guan Bing Za Zhi pmid:27220580
Marfia G et al. The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling. 2016 Stem Cells Dev. pmid:27217090
Versmissen J et al. Familial hypercholesterolaemia: cholesterol efflux and coronary disease. 2016 Eur. J. Clin. Invest. pmid:27208892
Sauvé M et al. Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. 2016 Diabetes pmid:27207546
Zhang XE et al. Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. 2016 PLoS ONE pmid:27187066
Ohtoyo M et al. Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. 2016 Cell Chem Biol pmid:27185637
Fleming JK et al. A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. 2016 J. Lipid Res. pmid:27444045
Tong S et al. Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. 2016 J. Biol. Chem. pmid:27405756
Adams DR et al. Sphingosine Kinases: Emerging Structure-Function Insights. 2016 Trends Biochem. Sci. pmid:27021309
Lv M et al. Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion. 2016 Inflamm. Res. pmid:27002656
Fujii C et al. Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy. 2016 Sci Rep pmid:27752051
Frej C et al. Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons. 2016 J. Cell. Mol. Med. pmid:26990127
Pyne S et al. Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances. 2016 Prog. Lipid Res. pmid:26970273
Zhang H et al. Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening. 2016 Sci Rep pmid:27476912
Aoki M et al. Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. 2016 Mediators Inflamm. pmid:26966342
Gao H et al. Bacillus cereus strain S2 shows high nematicidal activity against Meloidogyne incognita by producing sphingosine. 2016 Sci Rep pmid:27338781
Brinck JW et al. Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. 2016 Arterioscler. Thromb. Vasc. Biol. pmid:26966278
Zhang M et al. Critical Role of COI1-Dependent Jasmonate Pathway in AAL toxin induced PCD in Tomato Revealed by Comparative Proteomics. 2016 Sci Rep pmid:27324416
Tang X et al. Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate. 2016 J. Lipid Res. pmid:26884614
Puli MR et al. Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. 2016 Planta pmid:27233507
Bien-Möller S et al. Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. 2016 Oncotarget pmid:26887055
Uranbileg B et al. Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. 2016 PLoS ONE pmid:26886371
Chumanevich A et al. Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. 2016 Mediators Inflamm. pmid:26884643
Ko P et al. Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. 2016 Sci Rep pmid:26877098
Luo B et al. Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. 2016 Immunity pmid:26872696
Pastor-Flores D et al. Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1. 2016 Biochim. Biophys. Acta pmid:26743850
Ghasemi R et al. Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage. 2016 Pharmacol. Res. pmid:26772814
Morel S et al. Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. 2016 Cardiovasc. Res. pmid:26762268
Sundaram K et al. Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. 2016 Biochem. J. pmid:26747710
Abu Khweek A et al. The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. 2016 PLoS ONE pmid:26741365
Deniz U et al. A systematic methodology for large scale compound screening: A case study on the discovery of novel S1PL inhibitors. 2016 J. Mol. Graph. Model. pmid:26724452
Beach JA et al. Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer. 2016 Oncotarget pmid:26716409
Deutsch G et al. Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis. 2016 Gene pmid:26707209
Maczis M et al. Sphingosine-1-phosphate and estrogen signaling in breast cancer. 2016 Adv Biol Regul pmid:26601898
Zhang F et al. Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. 2016 Am. J. Physiol. Heart Circ. Physiol. pmid:26589326
Pyne NJ and Tigyi GJ A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. 2016 Prog. Lipid Res. pmid:26584871
Rana A and Sharma S Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore. 2016 Clin. Exp. Pharmacol. Physiol. pmid:26582369
Yuasa D et al. C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart. 2016 FASEB J. pmid:26578687
Li S et al. Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. 2016 Oncotarget pmid:27811358
Priyadarsini S et al. Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma. 2016 Exp. Eye Res. pmid:27742548
Veltman M et al. Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27663991
Scotti L et al. Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. 2016 Mol. Hum. Reprod. pmid:27645281
Simula S et al. Modulation of sphingosine receptors influences circadian pattern of cardiac autonomic regulation. 2016 Physiol Rep pmid:27624686
Hoehn RS et al. Ischemia/Reperfusion Injury Alters Sphingolipid Metabolism in the Gut. 2016 Cell. Physiol. Biochem. pmid:27607915
Mikami D et al. Effects of Asterias amurensis-derived Sphingoid Bases on the de novo Ceramide Synthesis in Cultured Normal Human Epidermal Keratinocytes. 2016 J Oleo Sci pmid:27430385
Rice TC et al. Frontline Science: Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection. 2016 J. Leukoc. Biol. pmid:27418352
Nagahashi M et al. Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. 2016 J Mammary Gland Biol Neoplasia pmid:27194029
Tavakoli Tabazavareh S et al. Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis. 2016 Cell. Physiol. Biochem. pmid:27184795
Fischer C et al. Aptamer-based trapping of phytosphingosine in urine samples. 2016 J. Biotechnol. pmid:27637314
Nigro E et al. Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation. 2016 Pharmacol. Res. pmid:26462929
Sonnenberger S et al. Synthesis of ceramides NS and NP with perdeuterated and specifically ω deuterated N-acyl residues. 2016 J Labelled Comp Radiopharm pmid:27634543
Uemura M et al. Inhibitory Effect of Dihydrosphingosine with α-Tocopherol on Volatile Formation during the Autoxidation of Polyunsaturated Triacylglycerols. 2016 J Oleo Sci pmid:27477074
Serdar M et al. Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. 2016 Brain Behav. Immun. pmid:26456693
Liu B et al. Synthetic Studies on a Pachastrissamine Sulfur Analogue: Synthesis of a 4-epi-Sulfur Analogue. 2016 Chem. Pharm. Bull. pmid:27039834
Cheng JC et al. Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling. 2016 Cell. Signal. pmid:26994820
Arish M et al. Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases. 2016 Drug Discov. Today pmid:26456576
Benaim G et al. Sphingosine inhibits the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) activity. 2016 Biochem. Biophys. Res. Commun. pmid:27033604
Masching S et al. Gastrointestinal Degradation of Fumonisin B₁ by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine. 2016 Toxins (Basel) pmid:27007395
Güntert T et al. 1-Deoxysphingolipid-induced neurotoxicity involves N-methyl-d-aspartate receptor signaling. 2016 Neuropharmacology pmid:27016021
Zhang L et al. Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels. 2016 Microcirculation pmid:27015105
Bae SJ et al. The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study. 2016 Osteoporos Int pmid:26984570
Mezeiová E et al. Total synthesis and antiproliferative/cytotoxic profiling of 2-epi-jaspine B. 2016 Carbohydr. Res. pmid:26895543
Kolb JP and Martinez J Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage's Appetite for Apoptotic Cells. 2016 Immunity pmid:26885850
Park MK et al. Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phosphatase 2A and G-protein-coupled receptor-12. 2016 Eur. J. Pharmacol. pmid:26872988
Martinková M and Gonda J Marine cytotoxic jaspine B and its stereoisomers: biological activity and syntheses. 2016 Carbohydr. Res. pmid:26878486
Kurano M et al. Resveratrol exerts a biphasic effect on apolipoprotein M. 2016 Br. J. Pharmacol. pmid:26445217
Cohen MV et al. Cangrelor-Mediated Cardioprotection Requires Platelets and Sphingosine Phosphorylation. 2016 Cardiovasc Drugs Ther pmid:26780906
Lv H et al. Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. 2016 PLoS ONE pmid:26727592
Loru D et al. Intramolecular interactions in the polar headgroup of sphingosine: serinol. 2016 Chem. Commun. (Camb.) pmid:26727395
Gardner NM et al. Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects. 2016 Toxicol. Sci. pmid:26719367
Melnik BC Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. 2016 Acta Derm. Venereol. pmid:26304030
Haberkant P et al. Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions. 2016 ACS Chem. Biol. pmid:26555438
Tani K et al. Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea. 2016 Neurotox Res pmid:26472207
Pyne NJ et al. Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation. 2016 Adv Biol Regul pmid:26429117
Martínez-Montañés F et al. Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether. 2016 J. Lipid Res. pmid:27561298
Kim BJ et al. The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient. 2016 J. Endocrinol. Invest. pmid:26219613
Balakrishnan P et al. Ceramide and N,N,N-Trimethylphytosphingosine-Iodide (TMP-I)-Based Lipid Nanoparticles for Cancer Therapy. 2016 Pharm. Res. pmid:26337769
Medina CB and Ravichandran KS Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. 2016 Cell Death Differ. pmid:26891690
Wirrig C et al. Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells. 2016 Biochem. Pharmacol. pmid:27402344
Filipenko I et al. Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. 2016 Biochim. Biophys. Acta pmid:27616330
Lee EJ et al. Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells. 2016 Biochim. Biophys. Acta pmid:26876307