sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Ubai T et al. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Res. pmid:17352219
Ahn EH and Schroeder JJ Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide. 2010 Anticancer Res. pmid:20683027
Separovic D et al. Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study. 2017 Anticancer Res. pmid:28314284
Fischer CL et al. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. 2012 Antimicrob. Agents Chemother. pmid:22155833
Vandenbosch D et al. Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. 2012 Antimicrob. Agents Chemother. pmid:22354293
Hansen AB et al. Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells. 1993 APMIS pmid:8103344
Wang J et al. Ceramide induces apoptosis via a peroxisome proliferator-activated receptor gamma-dependent pathway. 2006 Apoptosis pmid:17036198
Hearps AC et al. Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. 2002 Apoptosis pmid:12207171
Kim HJ et al. Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin. 2004 Apoptosis pmid:15192327
Kim BM et al. N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF. 2010 Apoptosis pmid:20512627
Noda T et al. Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. 2009 Apoptosis pmid:19199036
Hamada M et al. Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. 2006 Apoptosis pmid:16374540
Kiyota M et al. FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors. 2013 Apoptosis pmid:23851982
Rosenberg AJ et al. A practical process for the preparation of [(32)P]S1P and binding assay for S1P receptor ligands. 2015 Appl Radiat Isot pmid:25931137
Nguyen UT et al. Small-molecule modulators of Listeria monocytogenes biofilm development. 2012 Appl. Environ. Microbiol. pmid:22194285
Rupcić J and Marić V Cerebrosides of Candida lipolytica yeast. 2004 Appl. Microbiol. Biotechnol. pmid:14740188
Ter Veld F et al. Production of tetraacetyl phytosphingosine (TAPS) in Wickerhamomyces ciferrii is catalyzed by acetyltransferases Sli1p and Atf2p. 2013 Appl. Microbiol. Biotechnol. pmid:23318835
Jiang S et al. C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells. 2017 Appl. Microbiol. Biotechnol. pmid:27807662
Conzett KB et al. Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report. 2011 Arch Dermatol pmid:21844470
Asensio-Sánchez VM et al. [Cystoid macular oedema after fingolimod treatment in multiple sclerosis]. 2014 Arch Soc Esp Oftalmol pmid:24269406
Sperling P et al. Functional identification of a delta8-sphingolipid desaturase from Borago officinalis. 2001 Arch. Biochem. Biophys. pmid:11368168
Singh I and Kishimoto Y Ceramide synthesis in rat brain: characterization of the synthesis requiring pyridine nucleotide. 1980 Arch. Biochem. Biophys. pmid:7396538
Huang JS et al. Ethanol potentiates the mitogenic effects of sphingosine 1-phosphate by a zinc- and calcium-dependent mechanism in fibroblasts. 1999 Arch. Biochem. Biophys. pmid:10334873
Kiss Z and Anderson WH Hydrogen peroxide regulates phospholipase D-mediated hydrolysis of phosphatidylethanolamine and phosphatidylcholine by different mechanisms in NIH 3T3 fibroblasts. 1994 Arch. Biochem. Biophys. pmid:8203906
Wright BS et al. Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. 2003 Arch. Biochem. Biophys. pmid:12831841
Kolettas E et al. Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response. 2006 Arch. Biochem. Biophys. pmid:16297852
Yun JK and Kester M Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. 2002 Arch. Biochem. Biophys. pmid:12485605
Garmy N et al. Apical uptake and transepithelial transport of sphingosine monomers through intact human intestinal epithelial cells: physicochemical and molecular modeling studies. 2005 Arch. Biochem. Biophys. pmid:16009329
Belichenko I et al. Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. 2001 Arch. Biochem. Biophys. pmid:11368515
Phillips DC et al. Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. 2002 Arch. Biochem. Biophys. pmid:12392710
Cavallini L et al. Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. 1999 Arch. Biochem. Biophys. pmid:10510273
Hasan NM et al. Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. 2012 Arch. Biochem. Biophys. pmid:22155656
Maciel DM et al. Glycosphingolipids from Magnaporthe grisea cells: expression of a ceramide dihexoside presenting phytosphingosine as the long-chain base. 2002 Arch. Biochem. Biophys. pmid:12220534
Kong JY and Rabkin SW Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate. 2003 Arch. Biochem. Biophys. pmid:12667483
Yamamoto H et al. Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages. 2011 Arch. Biochem. Biophys. pmid:21081108
Kishimoto Y and Mitry MT A new procedure for synthesis of 3-keto derivatives of sphingolipids and its application for study of fatty acid composition of brain ceramides and cerebrosides containing dihydrosphingosine of sphingosine. 1974 Arch. Biochem. Biophys. pmid:4365554
Sasaki H et al. Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. 2014 Arch. Biochem. Biophys. pmid:24708996
Lev M and Milford AF The 3-ketodihydrosphingosine synthetase of Bacteroides melaninogenicus: induction by vitamin K. 1973 Arch. Biochem. Biophys. pmid:4730806
Singh BN et al. Identification of the lipid moiety and further characterization of the novel lipophosphoglycan-like glycoconjugates of Trichomonas vaginalis and Trichomonas foetus. 1994 Arch. Biochem. Biophys. pmid:8135538
Subbaiah PV et al. Effect of double bond geometry in sphingosine base on the antioxidant function of sphingomyelin. 2009 Arch. Biochem. Biophys. pmid:18952047
Ullman MD and Radin NS Enzymatic formation of hydroxy ceramides and comparison with enzymes forming nonhydroxy ceramides. 1972 Arch. Biochem. Biophys. pmid:4635790
Pawelczyk T and Lowenstein JM Regulation of phospholipase C delta activity by sphingomyelin and sphingosine. 1992 Arch. Biochem. Biophys. pmid:1497353
Orlati S et al. Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. 2000 Arch. Biochem. Biophys. pmid:10683250
Crowther GJ and Lynch DV Characterization of sphinganine kinase activity in corn shoot microsomes. 1997 Arch. Biochem. Biophys. pmid:9016824
Ji L et al. Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells. 1998 Arch. Biochem. Biophys. pmid:9799567
Gaveglio VL et al. Metabolic pathways for the degradation of phosphatidic acid in isolated nuclei from cerebellar cells. 2011 Arch. Biochem. Biophys. pmid:21216221
Colina C et al. Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel. 2005 Arch. Biochem. Biophys. pmid:15797246
Lan T et al. Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. 2010 Arch. Biochem. Biophys. pmid:20646989
Furuchi T et al. Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells. 2009 Arch. Biochem. Biophys. pmid:19720044
Meyer SG et al. Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. 2012 Arch. Biochem. Biophys. pmid:22841978
LaMarco KL and Glew RH Galactosylsphingosine inhibition of the broad-specificity cytosolic beta-glucosidase of human liver. 1985 Arch. Biochem. Biophys. pmid:3918500
Pasquaré SJ et al. Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes. 2009 Arch. Biochem. Biophys. pmid:19691145
Wilson E et al. Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils. 1987 Arch. Biochem. Biophys. pmid:2825597
Crilly KS et al. The choline kinase inhibitor hemicholinium-3 can inhibit mitogen-induced DNA synthesis independent of its effect on phosphocholine formation. 1998 Arch. Biochem. Biophys. pmid:9521826
Williams RD et al. Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes. 1984 Arch. Biochem. Biophys. pmid:6421234
Myśliwiec H et al. Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients. 2017 Arch. Dermatol. Res. pmid:27988894
Suhr KB et al. Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. 2003 Arch. Dermatol. Res. pmid:12563540
Popa I et al. Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs. 2010 Arch. Dermatol. Res. pmid:20361334
Müller-Wieprecht V et al. Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor alpha and 1 alpha, 25-dihydroxyvitamin D(3). 2000 Arch. Dermatol. Res. pmid:11000289
Lee JP et al. Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway. 2012 Arch. Dermatol. Res. pmid:22566145
Klocke S et al. Slow-freezing versus vitrification for human ovarian tissue cryopreservation. 2015 Arch. Gynecol. Obstet. pmid:25115279
Bode C and Gräler MH Immune regulation by sphingosine 1-phosphate and its receptors. 2012 Arch. Immunol. Ther. Exp. (Warsz.) pmid:22159476
von Wenckstern H et al. The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. 2006 Jul-Aug Arch. Immunol. Ther. Exp. (Warsz.) pmid:16830220
Simmons S and Ishii M Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. 2014 Arch. Immunol. Ther. Exp. (Warsz.) pmid:24276789
Caruso-Neves C et al. Cytoskeleton elements mediate the inhibition of the (Na++K+)atpase activity by PKC in Rhodnius prolixus malpighian tubules during hyperosmotic shock. 2001 Arch. Insect Biochem. Physiol. pmid:11568967
Sun D et al. Stimulation of trehalose efflux from cockroach (Periplaneta americana) fat body by hypertrehalosemic hormone is dependent on protein kinase C and calmodulin. 2002 Arch. Insect Biochem. Physiol. pmid:11948974
Olmo ED et al. Efficacious In Vitro and In Vivo Effects of Dihydrosphingosine-Ethambutol Analogues Against Susceptible and Multi-drug-resistant Mycobacterium tuberculosis. 2016 Arch. Med. Res. pmid:27664485
Fang R et al. Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. 2017 Arch. Med. Res. pmid:28625317
Johnson TA et al. Distinct properties of circulating CD8+ T cells in FTY720-treated patients with multiple sclerosis. 2010 Arch. Neurol. pmid:21149809
Racke MK Understanding the effects of FTY720 on leukocyte trafficking. 2010 Arch. Neurol. pmid:21149807
Köhne A et al. Fingolimod impedes Schwann cell-mediated myelination: implications for the treatment of immune neuropathies? 2012 Arch. Neurol. pmid:22751954
Radue EW et al. Impact of fingolimod therapy on magnetic resonance imaging outcomes in patients with multiple sclerosis. 2012 Arch. Neurol. pmid:22751847
Havla JB et al. Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment. 2012 Arch. Neurol. pmid:22332194
Saab G et al. Reversible cystoid macular edema secondary to fingolimod in a renal transplant recipient. 2008 Arch. Ophthalmol. pmid:18195237
Raveney BJ et al. Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease. 2008 Arch. Ophthalmol. pmid:18852417
Kasinathan C et al. Effect of lipids on glycoprotein sulphotransferase activity in rat submandibular salivary glands. 1995 Arch. Oral Biol. pmid:7639646
Jin YX et al. Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. 2006 Arch. Pharm. Res. pmid:17146975
Lee DH et al. Identification and evaluation of neutral sphingomyelinase 2 inhibitors. 2011 Arch. Pharm. Res. pmid:21380806
Chang YJ et al. Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line. 2006 Arch. Pharm. Res. pmid:16964761
Chung FY et al. Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells. 2008 Arch. Pharm. Res. pmid:19023540
Pham VT et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine. 2007 Arch. Pharm. Res. pmid:17328238
Kim YS et al. The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells. 2007 Arch. Pharm. Res. pmid:18254249
Kim HL and Im DS N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells. 2008 Arch. Pharm. Res. pmid:18277608
Shin KO et al. Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. 2014 Arch. Pharm. Res. pmid:24687256
Tian YS et al. Stereoselective synthesis of L-threo-sphingosine, L-threo-sphinganine, D-threo-sphingosine, and D-threo-sphinganine via oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues. 2007 Arch. Pharm. Res. pmid:17366737
Cho JY Non-specific anti-proliferative effect of FTY720, a derivative of fungal metabolite from Iscaria sinclarii. 2008 Arch. Pharm. Res. pmid:18365684
Choi CH et al. Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. 2007 Arch. Pharm. Res. pmid:17489368
Kim DH et al. Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. 2007 Arch. Pharm. Res. pmid:17879749
Lee CW et al. Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis. 2010 Arch. Pharm. Res. pmid:21052934
Yoon HT et al. Improved fluorescent determination method of cellular sphingoid bases in high-performance liquid chromatography. 1999 Arch. Pharm. Res. pmid:10403133
Kim DS et al. Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis. 2003 Arch. Pharm. Res. pmid:14560924
Yu CH et al. Differential effects of fumonisin B1 on cell death in cultured cells: the significance of the elevated sphinganine. 2001 Arch. Pharm. Res. pmid:11339633
Pierucci F et al. Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. 2017 Arch. Toxicol. pmid:27318803
Tsuji T et al. [Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 (fingolimod) in combination with betamethasone ointment in NC/Nga mice]. 2012 Arerugi pmid:23007332
Domijan AM et al. Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia. 2009 Arh Hig Rada Toksikol pmid:20061238
Fragoso YD et al. The real-life experience with cardiovascular complications in the first dose of fingolimod for multiple sclerosis. 2014 Arq Neuropsiquiatr pmid:25252236
Sato DK and Callegaro D Oral fingolimod to treat multiple sclerosis: see your cardiologist first. 2014 Arq Neuropsiquiatr pmid:25252227
Klingenberg R et al. Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17761943
Medlin MD et al. Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:20702813
Gaengel K et al. Endothelial-mural cell signaling in vascular development and angiogenesis. 2009 Arterioscler. Thromb. Vasc. Biol. pmid:19164813