Ubai T et al. |
FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. |
|
Anticancer Res. |
pmid:17352219
|
Ahn EH and Schroeder JJ |
Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide. |
2010 |
Anticancer Res. |
pmid:20683027
|
Separovic D et al. |
Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study. |
2017 |
Anticancer Res. |
pmid:28314284
|
Fischer CL et al. |
Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. |
2012 |
Antimicrob. Agents Chemother. |
pmid:22155833
|
Vandenbosch D et al. |
Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. |
2012 |
Antimicrob. Agents Chemother. |
pmid:22354293
|
Hansen AB et al. |
Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells. |
1993 |
APMIS |
pmid:8103344
|
Wang J et al. |
Ceramide induces apoptosis via a peroxisome proliferator-activated receptor gamma-dependent pathway. |
2006 |
Apoptosis |
pmid:17036198
|
Hearps AC et al. |
Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. |
2002 |
Apoptosis |
pmid:12207171
|
Kim HJ et al. |
Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin. |
2004 |
Apoptosis |
pmid:15192327
|
Kim BM et al. |
N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF. |
2010 |
Apoptosis |
pmid:20512627
|
Noda T et al. |
Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. |
2009 |
Apoptosis |
pmid:19199036
|
Hamada M et al. |
Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol. |
2006 |
Apoptosis |
pmid:16374540
|
Kiyota M et al. |
FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors. |
2013 |
Apoptosis |
pmid:23851982
|
Rosenberg AJ et al. |
A practical process for the preparation of [(32)P]S1P and binding assay for S1P receptor ligands. |
2015 |
Appl Radiat Isot |
pmid:25931137
|
Nguyen UT et al. |
Small-molecule modulators of Listeria monocytogenes biofilm development. |
2012 |
Appl. Environ. Microbiol. |
pmid:22194285
|
Rupcić J and Marić V |
Cerebrosides of Candida lipolytica yeast. |
2004 |
Appl. Microbiol. Biotechnol. |
pmid:14740188
|
Ter Veld F et al. |
Production of tetraacetyl phytosphingosine (TAPS) in Wickerhamomyces ciferrii is catalyzed by acetyltransferases Sli1p and Atf2p. |
2013 |
Appl. Microbiol. Biotechnol. |
pmid:23318835
|
Jiang S et al. |
C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells. |
2017 |
Appl. Microbiol. Biotechnol. |
pmid:27807662
|
Conzett KB et al. |
Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report. |
2011 |
Arch Dermatol |
pmid:21844470
|
Asensio-Sánchez VM et al. |
[Cystoid macular oedema after fingolimod treatment in multiple sclerosis]. |
2014 |
Arch Soc Esp Oftalmol |
pmid:24269406
|
Sperling P et al. |
Functional identification of a delta8-sphingolipid desaturase from Borago officinalis. |
2001 |
Arch. Biochem. Biophys. |
pmid:11368168
|
Singh I and Kishimoto Y |
Ceramide synthesis in rat brain: characterization of the synthesis requiring pyridine nucleotide. |
1980 |
Arch. Biochem. Biophys. |
pmid:7396538
|
Huang JS et al. |
Ethanol potentiates the mitogenic effects of sphingosine 1-phosphate by a zinc- and calcium-dependent mechanism in fibroblasts. |
1999 |
Arch. Biochem. Biophys. |
pmid:10334873
|
Kiss Z and Anderson WH |
Hydrogen peroxide regulates phospholipase D-mediated hydrolysis of phosphatidylethanolamine and phosphatidylcholine by different mechanisms in NIH 3T3 fibroblasts. |
1994 |
Arch. Biochem. Biophys. |
pmid:8203906
|
Wright BS et al. |
Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. |
2003 |
Arch. Biochem. Biophys. |
pmid:12831841
|
Kolettas E et al. |
Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response. |
2006 |
Arch. Biochem. Biophys. |
pmid:16297852
|
Yun JK and Kester M |
Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. |
2002 |
Arch. Biochem. Biophys. |
pmid:12485605
|
Garmy N et al. |
Apical uptake and transepithelial transport of sphingosine monomers through intact human intestinal epithelial cells: physicochemical and molecular modeling studies. |
2005 |
Arch. Biochem. Biophys. |
pmid:16009329
|
Belichenko I et al. |
Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. |
2001 |
Arch. Biochem. Biophys. |
pmid:11368515
|
Phillips DC et al. |
Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. |
2002 |
Arch. Biochem. Biophys. |
pmid:12392710
|
Cavallini L et al. |
Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. |
1999 |
Arch. Biochem. Biophys. |
pmid:10510273
|
Hasan NM et al. |
Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. |
2012 |
Arch. Biochem. Biophys. |
pmid:22155656
|
Maciel DM et al. |
Glycosphingolipids from Magnaporthe grisea cells: expression of a ceramide dihexoside presenting phytosphingosine as the long-chain base. |
2002 |
Arch. Biochem. Biophys. |
pmid:12220534
|
Kong JY and Rabkin SW |
Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate. |
2003 |
Arch. Biochem. Biophys. |
pmid:12667483
|
Yamamoto H et al. |
Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages. |
2011 |
Arch. Biochem. Biophys. |
pmid:21081108
|
Kishimoto Y and Mitry MT |
A new procedure for synthesis of 3-keto derivatives of sphingolipids and its application for study of fatty acid composition of brain ceramides and cerebrosides containing dihydrosphingosine of sphingosine. |
1974 |
Arch. Biochem. Biophys. |
pmid:4365554
|
Sasaki H et al. |
Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. |
2014 |
Arch. Biochem. Biophys. |
pmid:24708996
|
Lev M and Milford AF |
The 3-ketodihydrosphingosine synthetase of Bacteroides melaninogenicus: induction by vitamin K. |
1973 |
Arch. Biochem. Biophys. |
pmid:4730806
|
Singh BN et al. |
Identification of the lipid moiety and further characterization of the novel lipophosphoglycan-like glycoconjugates of Trichomonas vaginalis and Trichomonas foetus. |
1994 |
Arch. Biochem. Biophys. |
pmid:8135538
|
Subbaiah PV et al. |
Effect of double bond geometry in sphingosine base on the antioxidant function of sphingomyelin. |
2009 |
Arch. Biochem. Biophys. |
pmid:18952047
|
Ullman MD and Radin NS |
Enzymatic formation of hydroxy ceramides and comparison with enzymes forming nonhydroxy ceramides. |
1972 |
Arch. Biochem. Biophys. |
pmid:4635790
|
Pawelczyk T and Lowenstein JM |
Regulation of phospholipase C delta activity by sphingomyelin and sphingosine. |
1992 |
Arch. Biochem. Biophys. |
pmid:1497353
|
Orlati S et al. |
Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. |
2000 |
Arch. Biochem. Biophys. |
pmid:10683250
|
Crowther GJ and Lynch DV |
Characterization of sphinganine kinase activity in corn shoot microsomes. |
1997 |
Arch. Biochem. Biophys. |
pmid:9016824
|
Ji L et al. |
Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells. |
1998 |
Arch. Biochem. Biophys. |
pmid:9799567
|
Gaveglio VL et al. |
Metabolic pathways for the degradation of phosphatidic acid in isolated nuclei from cerebellar cells. |
2011 |
Arch. Biochem. Biophys. |
pmid:21216221
|
Colina C et al. |
Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel. |
2005 |
Arch. Biochem. Biophys. |
pmid:15797246
|
Lan T et al. |
Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. |
2010 |
Arch. Biochem. Biophys. |
pmid:20646989
|
Furuchi T et al. |
Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells. |
2009 |
Arch. Biochem. Biophys. |
pmid:19720044
|
Meyer SG et al. |
Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. |
2012 |
Arch. Biochem. Biophys. |
pmid:22841978
|
LaMarco KL and Glew RH |
Galactosylsphingosine inhibition of the broad-specificity cytosolic beta-glucosidase of human liver. |
1985 |
Arch. Biochem. Biophys. |
pmid:3918500
|
Pasquaré SJ et al. |
Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes. |
2009 |
Arch. Biochem. Biophys. |
pmid:19691145
|
Wilson E et al. |
Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils. |
1987 |
Arch. Biochem. Biophys. |
pmid:2825597
|
Crilly KS et al. |
The choline kinase inhibitor hemicholinium-3 can inhibit mitogen-induced DNA synthesis independent of its effect on phosphocholine formation. |
1998 |
Arch. Biochem. Biophys. |
pmid:9521826
|
Williams RD et al. |
Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes. |
1984 |
Arch. Biochem. Biophys. |
pmid:6421234
|
Myśliwiec H et al. |
Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients. |
2017 |
Arch. Dermatol. Res. |
pmid:27988894
|
Suhr KB et al. |
Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. |
2003 |
Arch. Dermatol. Res. |
pmid:12563540
|
Popa I et al. |
Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs. |
2010 |
Arch. Dermatol. Res. |
pmid:20361334
|
Müller-Wieprecht V et al. |
Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor alpha and 1 alpha, 25-dihydroxyvitamin D(3). |
2000 |
Arch. Dermatol. Res. |
pmid:11000289
|
Lee JP et al. |
Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway. |
2012 |
Arch. Dermatol. Res. |
pmid:22566145
|
Klocke S et al. |
Slow-freezing versus vitrification for human ovarian tissue cryopreservation. |
2015 |
Arch. Gynecol. Obstet. |
pmid:25115279
|
Bode C and Gräler MH |
Immune regulation by sphingosine 1-phosphate and its receptors. |
2012 |
Arch. Immunol. Ther. Exp. (Warsz.) |
pmid:22159476
|
von Wenckstern H et al. |
The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. |
2006 Jul-Aug |
Arch. Immunol. Ther. Exp. (Warsz.) |
pmid:16830220
|
Simmons S and Ishii M |
Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. |
2014 |
Arch. Immunol. Ther. Exp. (Warsz.) |
pmid:24276789
|
Caruso-Neves C et al. |
Cytoskeleton elements mediate the inhibition of the (Na++K+)atpase activity by PKC in Rhodnius prolixus malpighian tubules during hyperosmotic shock. |
2001 |
Arch. Insect Biochem. Physiol. |
pmid:11568967
|
Sun D et al. |
Stimulation of trehalose efflux from cockroach (Periplaneta americana) fat body by hypertrehalosemic hormone is dependent on protein kinase C and calmodulin. |
2002 |
Arch. Insect Biochem. Physiol. |
pmid:11948974
|
Olmo ED et al. |
Efficacious In Vitro and In Vivo Effects of Dihydrosphingosine-Ethambutol Analogues Against Susceptible and Multi-drug-resistant Mycobacterium tuberculosis. |
2016 |
Arch. Med. Res. |
pmid:27664485
|
Fang R et al. |
Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. |
2017 |
Arch. Med. Res. |
pmid:28625317
|
Johnson TA et al. |
Distinct properties of circulating CD8+ T cells in FTY720-treated patients with multiple sclerosis. |
2010 |
Arch. Neurol. |
pmid:21149809
|
Racke MK |
Understanding the effects of FTY720 on leukocyte trafficking. |
2010 |
Arch. Neurol. |
pmid:21149807
|
Köhne A et al. |
Fingolimod impedes Schwann cell-mediated myelination: implications for the treatment of immune neuropathies? |
2012 |
Arch. Neurol. |
pmid:22751954
|
Radue EW et al. |
Impact of fingolimod therapy on magnetic resonance imaging outcomes in patients with multiple sclerosis. |
2012 |
Arch. Neurol. |
pmid:22751847
|
Havla JB et al. |
Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment. |
2012 |
Arch. Neurol. |
pmid:22332194
|
Saab G et al. |
Reversible cystoid macular edema secondary to fingolimod in a renal transplant recipient. |
2008 |
Arch. Ophthalmol. |
pmid:18195237
|
Raveney BJ et al. |
Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease. |
2008 |
Arch. Ophthalmol. |
pmid:18852417
|
Kasinathan C et al. |
Effect of lipids on glycoprotein sulphotransferase activity in rat submandibular salivary glands. |
1995 |
Arch. Oral Biol. |
pmid:7639646
|
Jin YX et al. |
Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. |
2006 |
Arch. Pharm. Res. |
pmid:17146975
|
Lee DH et al. |
Identification and evaluation of neutral sphingomyelinase 2 inhibitors. |
2011 |
Arch. Pharm. Res. |
pmid:21380806
|
Chang YJ et al. |
Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line. |
2006 |
Arch. Pharm. Res. |
pmid:16964761
|
Chung FY et al. |
Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells. |
2008 |
Arch. Pharm. Res. |
pmid:19023540
|
Pham VT et al. |
A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine. |
2007 |
Arch. Pharm. Res. |
pmid:17328238
|
Kim YS et al. |
The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells. |
2007 |
Arch. Pharm. Res. |
pmid:18254249
|
Kim HL and Im DS |
N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells. |
2008 |
Arch. Pharm. Res. |
pmid:18277608
|
Shin KO et al. |
Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. |
2014 |
Arch. Pharm. Res. |
pmid:24687256
|
Tian YS et al. |
Stereoselective synthesis of L-threo-sphingosine, L-threo-sphinganine, D-threo-sphingosine, and D-threo-sphinganine via oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues. |
2007 |
Arch. Pharm. Res. |
pmid:17366737
|
Cho JY |
Non-specific anti-proliferative effect of FTY720, a derivative of fungal metabolite from Iscaria sinclarii. |
2008 |
Arch. Pharm. Res. |
pmid:18365684
|
Choi CH et al. |
Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. |
2007 |
Arch. Pharm. Res. |
pmid:17489368
|
Kim DH et al. |
Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. |
2007 |
Arch. Pharm. Res. |
pmid:17879749
|
Lee CW et al. |
Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis. |
2010 |
Arch. Pharm. Res. |
pmid:21052934
|
Yoon HT et al. |
Improved fluorescent determination method of cellular sphingoid bases in high-performance liquid chromatography. |
1999 |
Arch. Pharm. Res. |
pmid:10403133
|
Kim DS et al. |
Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis. |
2003 |
Arch. Pharm. Res. |
pmid:14560924
|
Yu CH et al. |
Differential effects of fumonisin B1 on cell death in cultured cells: the significance of the elevated sphinganine. |
2001 |
Arch. Pharm. Res. |
pmid:11339633
|
Pierucci F et al. |
Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. |
2017 |
Arch. Toxicol. |
pmid:27318803
|
Tsuji T et al. |
[Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 (fingolimod) in combination with betamethasone ointment in NC/Nga mice]. |
2012 |
Arerugi |
pmid:23007332
|
Domijan AM et al. |
Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia. |
2009 |
Arh Hig Rada Toksikol |
pmid:20061238
|
Fragoso YD et al. |
The real-life experience with cardiovascular complications in the first dose of fingolimod for multiple sclerosis. |
2014 |
Arq Neuropsiquiatr |
pmid:25252236
|
Sato DK and Callegaro D |
Oral fingolimod to treat multiple sclerosis: see your cardiologist first. |
2014 |
Arq Neuropsiquiatr |
pmid:25252227
|
Klingenberg R et al. |
Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:17761943
|
Medlin MD et al. |
Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. |
2010 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:20702813
|
Gaengel K et al. |
Endothelial-mural cell signaling in vascular development and angiogenesis. |
2009 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:19164813
|