sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Casellato R et al. Isolation and structural characterization of N-acetyl- and N-glycolylneuraminic-acid-containing GalNAc-GD1a isomers, IV4GalNAcIV3Neu5AcII3Neu5GcGgOse4Cer and IV4GalNAcIV3Neu5GcII3Neu5AcGgOse4Cer, from bovine brain. 1995 Eur. J. Biochem. pmid:8575436
Mayhan WG and Didion SP Activation of protein kinase C does not participate in disruption of the blood-brain barrier to albumin during acute hypertension. 1995 Brain Res. pmid:8574657
Campbell XZ and Neet KE Hierarchical analysis of the nerve growth factor-dependent and nerve growth factor-independent differentiation signaling pathways in PC12 cells with protein kinase inhibitors. 1995 J. Neurosci. Res. pmid:8568921
van Koppen C et al. Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. 1996 J. Biol. Chem. pmid:8567663
Latinis KM and Koretzky GA Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. 1996 Blood pmid:8562955
Katoh N Inhibition by phospholipids, lysophospholipids and gangliosides of melittin-induced phosphorylation in bovine mammary gland. 1995 Toxicology pmid:8560504
Shah J et al. Structural and thermotropic properties of synthetic C16:0 (palmitoyl) ceramide: effect of hydration. 1995 J. Lipid Res. pmid:8558082
Yatomi Y et al. N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. 1996 Biochemistry pmid:8555236
Cao YZ et al. The mechanism of sphingosine enhancement of phorbol ester-mediated phospholipase D activation in lymphocytes. 1995 Biochem. Biophys. Res. Commun. pmid:8554615
Lauritzen L and Hansen HS Differential phospholipid-labeling suggests two subtypes of phospholipase D in rat Leydig cells. 1995 Biochem. Biophys. Res. Commun. pmid:8554594
Fatatis A and Miller RJ Sphingosine and sphingosine 1-phosphate differentially modulate platelet-derived growth factor-BB-induced Ca2+ signaling in transformed oligodendrocytes. 1996 J. Biol. Chem. pmid:8550576
Lee TC et al. Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels. 1996 J. Biol. Chem. pmid:8550561
Bouhours JF and Bouhours D Biochemical characterization of blood group-active glycosphingolipids. 1995 Transfus Clin Biol pmid:8542020
Sugita M et al. Structural elucidation of two novel amphoteric glycosphingolipids from the earthworm, Pheretima hilgendorfi. 1995 Biochim. Biophys. Acta pmid:8541328
Nishio H and Mori K Synthesis of the esterified cerebroside in the epidermis of guinea pigs. 1995 Biosci. Biotechnol. Biochem. pmid:8520109
Nishio H and Mori K Reinvestigation of the structure of the esterified cerebroside in the epidermis of guinea pigs. 1995 Biosci. Biotechnol. Biochem. pmid:8520108
Sugiyama E et al. Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells. 1993 J. Biochem. pmid:8514735
Sabbadini R et al. Sphingosine is endogenous to cardiac and skeletal muscle. 1993 Biochem. Biophys. Res. Commun. pmid:8512573
Yule DI et al. Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells. 1993 J. Biol. Chem. pmid:8509375
Downing DT et al. Interaction between sphingosine and cholesteryl sulfate in epidermal lipids. 1993 J. Lipid Res. pmid:8496662
Soares-da-Silva P Enhanced protein kinase C mediated inhibition of renal dopamine synthesis during high sodium intake. 1993 Biochem. Pharmacol. pmid:8494538
Riboni L et al. Metabolism of exogenous ganglioside GM1 in cultured cerebellar granule cells. The fatty acid and sphingosine moieties formed during degradation are re-used for lipid biosynthesis. 1993 FEBS Lett. pmid:8486159
Mäkelä JH and Isomaa B Perturbation of the platelet plasma membrane is not sufficient for inhibition of thrombin-induced PKC-activity. 1993 Chem. Biol. Interact. pmid:8485783
Reston JT et al. Differential effects of the phorbol ester TPA on DNA-mediated transfection in a variety of cell lines. 1993 Biochim. Biophys. Acta pmid:8485168
Kim HS et al. Sphingosine blocks both membrane fusion and calmodulin-dependent phosphorylation of the 100-kDa protein of chick embryonic myoblasts. 1993 Exp. Cell Res. pmid:8482346
Bayat-Sarmadi M and Houdebine LM Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin. 1993 Mol. Cell. Endocrinol. pmid:8472863
Ladenson RC et al. Utilization of exogenously supplied sphingosine analogues for sphingolipid biosynthesis in Chinese hamster ovary and mouse LM cell fibroblasts. 1993 J. Biol. Chem. pmid:8463295
Crow T and Forrester J Down-regulation of protein kinase C and kinase inhibitors dissociate short- and long-term enhancement produced by one-trial conditioning of Hermissenda. 1993 J. Neurophysiol. pmid:8459291
Hirschberg K et al. The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. 1993 Biochem. J. pmid:8457204
Kanfer JN and McCartney DG Modulation of the serine base exchange enzyme activity of rat brain membranes by amphiphilic cations and amphiphilic anions. 1993 J. Neurochem. pmid:8455023
Archibald DD and Mann S Structural studies of lipid fibers formed by sphingosine. 1993 Biochim. Biophys. Acta pmid:8443231
Clarke BL et al. Regulation of parathyroid hormone release by protein kinase-C is dependent on extracellular calcium in bovine parathyroid cells. 1993 Endocrinology pmid:8440177
Riley RT et al. Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. 1993 Toxicol. Appl. Pharmacol. pmid:8430417
Pinkerton FD et al. D-erythro-sphingosine lowers 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Chinese hamster ovary cells. 1993 Biochem. Biophys. Res. Commun. pmid:8422261
Mangin EL et al. Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. 1993 Circ. Res. pmid:8417838
Olivera A and Spiegel S Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. 1993 Nature pmid:8413613
Ogawa A et al. Na+/H+ exchange activity induced by thrombin is not inhibited by protein kinase inhibitors, staurosporine, K-252a, H-7 and sphingosine, in human platelets. 1993 Thromb. Res. pmid:8391729
Desai NN et al. Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. 1993 J. Cell Biol. pmid:8389770
Thomas DJ et al. Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate. 1993 Metab. Clin. Exp. pmid:8387623
Zoukhri D et al. Phorbol ester-stimulated exocytosis in lacrimal gland: PKC might not be the sole effector. 1993 Am. J. Physiol. pmid:8386449
Burgers JA and Akkerman JW Regulation of the receptor for platelet-activating factor on human platelets. 1993 Biochem. J. pmid:8385926
Torossian K et al. Phorbol esters inhibit insulin-induced receptor down-regulation in cultured human lymphocytes: association with diminished insulin receptor autophosphorylation. 1993 Biochem. J. pmid:8382476
Pushkareva MYu A et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. 1993 Biochem. J. pmid:8379926
Wong K and Kwan-Yeung L Sphingosine mobilizes intracellular calcium in human neutrophils. 1993 Cell Calcium pmid:8358772
Crow T and Forrester J Protein kinase inhibitors do not block the expression of established enhancement in identified Hermissenda B-photoreceptors. 1993 Brain Res. pmid:8348304
Stewart SJ et al. Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C. 1993 Cell. Signal. pmid:8347422
Sitges M and Talamo BR Sphingosine, W-7, and trifluoperazine inhibit the elevation in cytosolic calcium induced by high K+ depolarization in synaptosomes. 1993 J. Neurochem. pmid:8336133
David MJ et al. Characterization of gangliosides from normal and osteoarthritic human articular cartilage. 1993 Arthritis Rheum. pmid:8318040
Wu WI et al. Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. 1993 J. Biol. Chem. pmid:8314751
Persat F et al. Gangliosides of Echinococcus multilocularis metacestodes. 1994 Biochim. Biophys. Acta pmid:8312377
Lavie Y et al. Formation of endogenous free sphingoid bases in cells induced by changing medium conditions. 1994 Biochim. Biophys. Acta pmid:8305506
Seren MS et al. Orally administered glycolipid derivative LIGA20 reduces infarct volume and behavioral impairment after focal cerebral ischemia. 1994 J. Pharmacol. Exp. Ther. pmid:8301588
Mazurek N et al. Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note. 1994 Biochem. Biophys. Res. Commun. pmid:8292009
Pahlavan P et al. Role of protein kinase C in the adaptive increase in Na-H antiporter in respiratory acidosis. 1993 J. Am. Soc. Nephrol. pmid:8286716
Uemura K et al. Inhibition of neurite outgrowth in neuroblastoma cells by sphingosine. 1993 J. Biochem. pmid:8276777
Perillo MA et al. Molecular parameters of semisynthetic derivatives of gangliosides and sphingosine in monolayers at the air-water interface. 1993 Chem. Phys. Lipids pmid:8269552
Merrill AH et al. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. 1993 J. Biol. Chem. pmid:8262970
Härmälä AS et al. Sphingosine inhibits sphingomyelinase-induced cholesteryl ester formation in cultured fibroblasts. 1993 Biochim. Biophys. Acta pmid:8257725
Skaper SD et al. A semisynthetic glycosphingolipid (LIGA20) reduces 2,4, 5-trihydroxyphenylalanine neurotoxicity in primary neuronal cultures. 1993 Eur. J. Pharmacol. pmid:8253129
Yung BY and Hui EK Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells. 1993 Biochem. Biophys. Res. Commun. pmid:8250895
Katoh N Modulation by sphingosine of substrate phosphorylation by protein kinase C in bovine mammary gland. 1993 Lipids pmid:8246685
López-García F et al. Interaction of sphingosine and stearylamine with phosphatidylserine as studied by DSC and NMR. 1993 Biochim. Biophys. Acta pmid:8241241
Maiese K et al. Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia. 1993 J. Neurosci. Res. pmid:8230323
Gardas A Studies on the I-blood-group-active sites on macro-glycolipids from human erythrocytes. 1976 Eur. J. Biochem. pmid:823020
Alexandrova AY et al. Motility of intracellular particles in rat fibroblasts is greatly enhanced by phorbol ester and by over-expression of normal p21N-ras. 1993 Cell Motil. Cytoskeleton pmid:8221903
Paige DG et al. The quantification of free sphingosine in the stratum corneum of patients with hereditary ichthyosis. 1993 Br. J. Dermatol. pmid:8217748
Jacobs LS and Kester M Sphingolipids as mediators of effects of platelet-derived growth factor in vascular smooth muscle cells. 1993 Am. J. Physiol. pmid:8214030
Su Y et al. Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts. 1994 J. Biol. Chem. pmid:8206962
Rodriguez-Lafrasse C et al. Free sphingoid bases in tissues from patients with type C Niemann-Pick disease and other lysosomal storage disorders. 1994 Biochim. Biophys. Acta pmid:8204660
Kiss Z and Anderson WH Hydrogen peroxide regulates phospholipase D-mediated hydrolysis of phosphatidylethanolamine and phosphatidylcholine by different mechanisms in NIH 3T3 fibroblasts. 1994 Arch. Biochem. Biophys. pmid:8203906
Petrou S et al. Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine. 1994 J. Gen. Physiol. pmid:8195783
Séror SJ et al. A mutant cysteinyl-tRNA synthetase affecting timing of chromosomal replication initiation in B. subtilis and conferring resistance to a protein kinase C inhibitor. 1994 EMBO J. pmid:8194536
Van Veldhoven PP and Mannaerts GP Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase. 1994 Biochem. J. pmid:8192648
Tschaikowsky K Protein kinase C inhibitors suppress LPS-induced TNF production in alveolar macrophages and in whole blood: the role of encapsulation into liposomes. 1994 Biochim. Biophys. Acta pmid:8186258
Kiss Z Sphingosine-like stimulatory effects of propranolol on phospholipase D activity in NIH 3T3 fibroblasts. 1994 Biochem. Pharmacol. pmid:8185671
Chigorno V et al. Biosynthesis of gangliosides containing C18:1 and C20:1 [3-14C]sphingosine after administrating [1-14C]palmitic acid and [1-14C]stearic acid to rat cerebellar granule cells in culture. 1994 Eur. J. Biochem. pmid:8181467
Hara A and Taketomi T Long chain base and fatty acid compositions of equine kidney sphingolipids. 1975 J. Biochem. pmid:818074
Sachs JR Soluble polycations and cationic amphiphiles inhibit volume-sensitive K-Cl cotransport in human red cell ghosts. 1994 Am. J. Physiol. pmid:8178972
Matsumoto M and Barnard EA Effects of an activator and an inhibitor of protein kinase C on serotonin receptors induced by rat brain mRNA in Xenopus oocytes. 1994 Neurosci. Lett. pmid:8177520
Bhat BG et al. Hepatic monoacylglycerol acyltransferase is regulated by sn-1,2-diacylglycerol and by specific lipids in Triton X-100/phospholipid-mixed micelles. 1994 J. Biol. Chem. pmid:8175745
Park YS et al. Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III. 1994 Cancer Res. pmid:8174128
Schmelz EM et al. Uptake and metabolism of sphingolipids in isolated intestinal loops of mice. 1994 J. Nutr. pmid:8169662
Törnquist K and Ekokoski E Effect of sphingosine derivatives on calcium fluxes in thyroid FRTL-5 cells. 1994 Biochem. J. pmid:8166643
Schneider JS and DiStefano L Oral administration of semisynthetic sphingolipids promotes recovery of striatal dopamine concentrations in a murine model of parkinsonism. 1994 Neurology pmid:8164837
Wegenka UM et al. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. 1994 Mol. Cell. Biol. pmid:8164674
Rivas CI et al. Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells. 1994 Blood pmid:8161785
Hayashi K and Niwayama S Effects of gangliosides on the growth of herpes simplex virus type 1-infected cells derived from neurons and on viral replication. 1993 Intervirology pmid:8150594
Miccheli A et al. Dexamethasone-dependent modulation of cholesterol levels in human lymphoblastoid B cell line through sphingosine production. 1994 Biochim. Biophys. Acta pmid:8148395
Ricciolini R et al. Dexamethasone-dependent modulation of human lymphoblastoid B cell line through sphingosine production. 1994 Biochim. Biophys. Acta pmid:8148386
Riley RT et al. Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. 1994 J. Nutr. pmid:8145083
Khan WA et al. Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. 1994 J. Biol. Chem. pmid:8144564
Yung BY et al. Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60). 1994 Biochem. Biophys. Res. Commun. pmid:8135836
Singh BN et al. Identification of the lipid moiety and further characterization of the novel lipophosphoglycan-like glycoconjugates of Trichomonas vaginalis and Trichomonas foetus. 1994 Arch. Biochem. Biophys. pmid:8135538
Gomez-Muñoz A et al. Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts. 1994 J. Biol. Chem. pmid:8132631
Pushkareva MYu YA and Hannun Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. 1994 Biochim. Biophys. Acta pmid:8130276
Kiss Z The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine, but not sphingosine and H2O2, on phospholipase D activity in NIH 3T3 fibroblasts. 1994 Biochem. J. pmid:8129736
Hauser JM et al. Role of ceramide in mitogenesis induced by exogenous sphingoid bases. 1994 J. Biol. Chem. pmid:8120042
Chao CP et al. Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization. 1994 J. Biol. Chem. pmid:8119927
Sadahira Y et al. Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells. 1994 FEBS Lett. pmid:8119417
Kõiv A et al. Influence of sphingosine on the thermal phase behaviour of neutral and acidic phospholipid liposomes. 1993 Chem. Phys. Lipids pmid:8118913