sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Gbarah A et al. Involvement of protein kinase C in activation of human granulocytes and peritoneal macrophages by type 1 fimbriated (mannose specific) Escherichia coli. 1989 Biochem. Biophys. Res. Commun. pmid:2575378
Smal J and De Meyts P Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes. 1989 Proc. Natl. Acad. Sci. U.S.A. pmid:2660145
Kobayashi T et al. Metabolism of free sphingoid bases in murine tissues and in cultured human fibroblasts. 1989 Eur. J. Biochem. pmid:2606103
Bedoy CA and Mobley PL Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors. 1989 Brain Res. pmid:2548656
Swann K et al. Evidence for an inhibitory effect of protein kinase C on G-protein-mediated repetitive calcium transients in hamster eggs. 1989 EMBO J. pmid:2510999
Ling BN and Eaton DC Effects of luminal Na+ on single Na+ channels in A6 cells, a regulatory role for protein kinase C. 1989 Am. J. Physiol. pmid:2544105
Kolesnick RN Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells. 1989 J. Biol. Chem. pmid:2540198
Corradetti R et al. The protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (H-7) disinhibits CA1 pyramidal cells in rat hippocampal slices. 1989 Br. J. Pharmacol. pmid:2611497
Leyravaud S et al. Biosynthesis of paf-acether. X. Phorbol myristate acetate-induced paf-acether biosynthesis and acetyltransferase activation in human neutrophils. 1989 J. Immunol. pmid:2732470
Robertson DG et al. Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding. 1989 J. Biol. Chem. pmid:2651433
Pfannkuche HJ et al. Regulation of prostaglandin synthesis by protein kinase C in mouse peritoneal macrophages. 1989 Biochem. J. pmid:2764884
Hannun YA and Bell RM Regulation of protein kinase C by sphingosine and lysosphingolipids. 1989 Clin. Chim. Acta pmid:2695275
Sugawara T and Narisada M An efficient, stereoselective synthesis of 4-E- and 4-Z-D-erythro-sphingenine and related compounds from 2-amino-2-deoxy-D-glucose. 1989 Carbohydr. Res. pmid:2620296
Stinavage P et al. O antigen and lipid A phosphoryl groups in resistance of Salmonella typhimurium LT-2 to nonoxidative killing in human polymorphonuclear neutrophils. 1989 Infect. Immun. pmid:2478480
Bussolino F et al. Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1). 1989 J. Biol. Chem. pmid:2600088
Wedegaertner PB and Gill GN Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor. 1989 J. Biol. Chem. pmid:2661557
Mattila P et al. Protein kinase C is crucial in signal transduction during IFN-gamma induction in endothelial cells. 1989 FEBS Lett. pmid:2546804
Slife CW et al. Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum. 1989 J. Biol. Chem. pmid:2499578
Hattori R et al. Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface. 1989 J. Biol. Chem. pmid:2470750
Kawase T and Suzuki A Fluoride-induced cytoplasmic acidification: possible role of protein kinase C in BCECF-loaded L929 cells. 1989 Pharmacol. Toxicol. pmid:2771869
Stevens VL et al. Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3. 1989 Cancer Res. pmid:2720676
Whatley RE et al. The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C. 1989 J. Biol. Chem. pmid:2703492
Nakadate T et al. H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells. 1989 Mol. Pharmacol. pmid:2601687
Perotti M et al. Calcium-dependent DNA fragmentation in human synovial cells exposed to cold shock. 1990 FEBS Lett. pmid:2152884
Röder B et al. The determination of phytosphingosine-containing globotriaosylceramide from human kidney in the presence of lactosylceramide. 1990 Chem. Phys. Lipids pmid:2162261
Lowe JH et al. Sphingosine differentially inhibits activation of the Na+/H+ exchanger by phorbol esters and growth factors. 1990 J. Biol. Chem. pmid:2158991
Ulisse S et al. A novel mechanism of action of corticotropin releasing factor in rat Leydig cells. 1990 J. Biol. Chem. pmid:2153673
Zhang H et al. Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells. 1990 J. Biol. Chem. pmid:2250025
Fiore S et al. Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils. 1990 Biochem. J. pmid:2155608
O'Flaherty JT et al. Translocation of protein kinase C in human polymorphonuclear neutrophils. Regulation by cytosolic Ca2(+)-independent and Ca2(+)-dependent mechanisms. 1990 J. Biol. Chem. pmid:2160959
Rotem R et al. Protein kinase C is present in human sperm: possible role in flagellar motility. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2402510
Peters-Golden M et al. Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung. 1990 J. Immunol. pmid:2160499
Suzuki K et al. Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated with the receptor in the down-regulation. 1990 J. Biol. Chem. pmid:2358463
Stevens VL et al. Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C. 1990 Biochim. Biophys. Acta pmid:2297538
Gorin E et al. Evidence for a role of protein kinase C in the stimulation of lipolysis by growth hormone and isoproterenol. 1990 Endocrinology pmid:2161742
Winicov I et al. Sphingosine interacts directly with the receptor complex to inhibit thyrotropin-releasing hormone binding. 1990 Endocrinology pmid:2106432
Johnson JA and Clark RB Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C. 1990 Biochem. J. pmid:2163616
Junco M et al. Substrate-dependent inhibition of protein kinase C by specific inhibitors. 1990 FEBS Lett. pmid:2332048
Zhu Z et al. Glycosphingolipids of human myometrium and endometrium and their changes during the menstrual cycle, pregnancy and ageing. 1990 J. Reprod. Fertil. pmid:2313655
Cline HT and Constantine-Paton M The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system. 1990 Neuron pmid:2361013
Kojima I et al. Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells. 1990 J. Biol. Chem. pmid:2120207
Bishop WR et al. Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors. 1990 Biochem. J. pmid:2386487
Suen CS and Wilk S Rapid inactivation and phosphorylation of pyroglutamyl peptidase II in Y-79 human retinoblastoma cells after exposure to phorbol ester. 1990 Endocrinology pmid:1979029
Elliott MS and Crane DL Protein kinase C modulation of queuine uptake in cultured human fibroblasts. 1990 Biochem. Biophys. Res. Commun. pmid:2118349
Warner JA and MacGlashan DW Signal transduction events in human basophils. A comparative study of the role of protein kinase C in basophils activated by anti-IgE antibody and formyl-methionyl-leucyl-phenylalanine. 1990 J. Immunol. pmid:1697313
Moraru II et al. Protein kinase C controls Fc gamma receptor-mediated endocytosis in human neutrophils. 1990 FEBS Lett. pmid:2147663
Oishi K et al. Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid. 1990 J. Biol. Chem. pmid:2152929
Gat-Yablonski G and Sagi-Eisenberg R Differential down-regulation of protein kinase C selectively affects IgE-dependent exocytosis and inositol trisphosphate formation. 1990 Biochem. J. pmid:2241900
Karniguian A et al. Collagen-induced platelet activation mainly involves the protein kinase C pathway. 1990 Biochem. J. pmid:2163606
Inui K et al. Study of pathogenesis in twitcher mouse, an enzymatically authentic model of Krabbe's disease. 1990 J. Neurol. Sci. pmid:2128519
Taketomi T et al. New approach for characterization of lysosulfatide by TLC, fast atom bombardment mass spectrometry and NMR spectroscopy. 1990 J. Biochem. pmid:2398033
Sohal PS and Cornell RB Sphingosine inhibits the activity of rat liver CTP:phosphocholine cytidylyltransferase. 1990 J. Biol. Chem. pmid:2164014
Igarashi Y et al. A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. 1990 J. Biol. Chem. pmid:2318819
Khan WA et al. Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. 1990 Biochem. Biophys. Res. Commun. pmid:2241961
Cambray-Deakin MA et al. Neuritogenesis in cerebellar granule cells in vitro: a role for protein kinase C. 1990 Brain Res. Dev. Brain Res. pmid:2190715
Lavie Y et al. Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine. Dual action of sphingosine in diacylglycerol signal termination. 1990 FEBS Lett. pmid:2269371
Zorn NE and Russell DH Vasoactive intestinal peptide (VIP) activation of nuclear protein kinase C in purified nuclei of rat splenocytes. 1990 Biochem. Pharmacol. pmid:1979736
Radin NS Preparative scale isolation of sphingosine. 1990 J. Lipid Res. pmid:2090723
Crane JK et al. Carbachol mimics phorbol esters in its ability to enhance cyclic GMP production by STa, the heat-stable toxin of Escherichia coli. 1990 FEBS Lett. pmid:2174803
Karrenbauer A et al. The rate of bulk flow from the Golgi to the plasma membrane. 1990 Cell pmid:2208286
Messing RO et al. Protein kinase C participates in up-regulation of dihydropyridine-sensitive calcium channels by ethanol. 1990 J. Neurochem. pmid:2168938
Lauener RP et al. Engagement of the monocyte surface antigen CD14 induces lymphocyte function-associated antigen-1/intercellular adhesion molecule-1-dependent homotypic adhesion. 1990 J. Immunol. pmid:1696596
Sugiya H and Furuyama S Sphingosine increases inositol trisphosphate in rat parotid acinar cells by a mechanism that is independent of protein kinase C but dependent on extracellular calcium. 1990 Cell Calcium pmid:2272081
Bankov I and Barrett J Sphingomyelin synthesis in Fasciola hepatica. 1990 Int. J. Parasitol. pmid:2228421
Bacon KB and Camp RD Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C. 1990 Biochem. Biophys. Res. Commun. pmid:2163626
Igisu H et al. Binding of galactosylsphingosine (psychosine) by albumin. 1990 Lipids pmid:2325508
Sanchez-Bueno A et al. Inhibitors of protein kinase C prolong the falling phase of each free-calcium transient in a hormone-stimulated hepatocyte. 1990 Biochem. J. pmid:2363701
Greenberg P et al. Human acid beta-glucosidase: use of sphingosyl and N-alkyl-glucosylamine inhibitors to investigate the properties of the active site. 1990 Biochim. Biophys. Acta pmid:2141287
Kiss Z and Anderson WB ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine. 1990 J. Biol. Chem. pmid:2185245
Sgarna R et al. Sphingosine inhibition of tyrosine aminotransferase and tryptophan oxygenase induction by dexamethasone in primary culture of rat hepatocytes. 1990 Biochem. Biophys. Res. Commun. pmid:1970728
Chakrabarti AK et al. Regulation of the calcium-activated neutral proteinase (CANP) of bovine brain by myelin lipids. 1990 Biochim. Biophys. Acta pmid:2331482
Ramachandran CK et al. Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts. 1990 Biochem. Biophys. Res. Commun. pmid:2157410
Lavie Y and Liscovitch M Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells. 1990 J. Biol. Chem. pmid:2303483
Rice WR et al. P2-purinoceptor regulation of surfactant phosphatidylcholine secretion. Relative roles of calcium and protein kinase C. 1990 Biochem. J. pmid:2317195
Zorn NE et al. The HIV protein, GP120, activates nuclear protein kinase C in nuclei from lymphocytes and brain. 1990 Biochem. Biophys. Res. Commun. pmid:2306233
Ida H et al. Galactosylceramide and galactosylsphingosine loading studies in cultured skin fibroblasts in human and murine globoid cell leukodystrophy. 1990 Biochem. Biophys. Res. Commun. pmid:2302222
Jeckel D et al. Sphingomyelin is synthesized in the cis Golgi. 1990 FEBS Lett. pmid:2155131
Wolf BA et al. Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rats and humans. 1990 J. Clin. Invest. pmid:2405021
Sugiyama E et al. Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines. 1990 Biochem. Biophys. Res. Commun. pmid:2357225
Wertz PW and Downing DT Free sphingosine in human epidermis. 1990 J. Invest. Dermatol. pmid:2299191
Honma Y et al. Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemia K562 cells. 1990 Jpn. J. Cancer Res. pmid:2125038
Stinavage PS et al. A 59 kiloDalton outer membrane protein of Salmonella typhimurium protects against oxidative intraleukocytic killing due to human neutrophils. 1990 Mol. Microbiol. pmid:2187147
Ghosh TK et al. Intracellular calcium release mediated by sphingosine derivatives generated in cells. 1990 Science pmid:2163543
Satoh T and Endou H Inhibitory effect of phorbol ester on sodium transport in frog urinary bladder. 1990 Am. J. Physiol. pmid:2168677
Manev H et al. Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids. 1990 J. Pharmacol. Exp. Ther. pmid:1688945
Bement WM and Capco DG Protein kinase C acts downstream of calcium at entry into the first mitotic interphase of Xenopus laevis. 1990 Cell Regul. pmid:2100203
Cox LR et al. Modulation of phosphoinositide metabolism in aortic smooth muscle cells by allylamine. 1990 Exp. Mol. Pathol. pmid:2170166
Trinchera M et al. Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver. 1990 Biochem. J. pmid:2241913
Miyazaki S et al. Synergistic activation by serotonin and GTP analogue and inhibition by phorbol ester of cyclic Ca2+ rises in hamster eggs. 1990 J. Physiol. (Lond.) pmid:2121959
Tachikawa E et al. Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells. 1990 Biochem. Pharmacol. pmid:2121147
Zhang H et al. Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway. 1990 J. Biol. Chem. pmid:2294122
Winkel GK et al. Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo. 1990 Dev. Biol. pmid:2407575
van Echten G et al. Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. 1990 J. Biol. Chem. pmid:2111818
Ballou LR et al. Sphingosine potentiates IL-1-mediated prostaglandin E2 production in human fibroblasts. 1990 J. Immunol. pmid:2124239
Campenot RB et al. Effects of sphingosine, staurosporine, and phorbol ester on neurites of rat sympathetic neurons growing in compartmented cultures. 1991 J. Neurosci. pmid:2010808
Worrell RT and Frizzell RA CaMKII mediates stimulation of chloride conductance by calcium in T84 cells. 1991 Am. J. Physiol. pmid:1708204
Kanfer JN and McCartney D Sphingosine and unsaturated fatty acids modulate the base exchange enzyme activities of rat brain membranes. 1991 FEBS Lett. pmid:1936252
Khan WA et al. Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. 1991 Biochem. J. pmid:1898331
Fukuda K et al. Histamine H1-receptor-mediated keratan sulfate production in rabbit chondrocytes: involvement of protein kinase C. 1991 Am. J. Physiol. pmid:1887868
Endo K et al. Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. 1991 Cancer Res. pmid:1998952