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Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes. |
1989 |
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1989 |
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Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells. |
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The protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (H-7) disinhibits CA1 pyramidal cells in rat hippocampal slices. |
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Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding. |
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Regulation of prostaglandin synthesis by protein kinase C in mouse peritoneal macrophages. |
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Regulation of protein kinase C by sphingosine and lysosphingolipids. |
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Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1). |
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Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor. |
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Protein kinase C is crucial in signal transduction during IFN-gamma induction in endothelial cells. |
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Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface. |
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Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3. |
1989 |
Cancer Res. |
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The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C. |
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H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells. |
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1990 |
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The determination of phytosphingosine-containing globotriaosylceramide from human kidney in the presence of lactosylceramide. |
1990 |
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Sphingosine differentially inhibits activation of the Na+/H+ exchanger by phorbol esters and growth factors. |
1990 |
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A novel mechanism of action of corticotropin releasing factor in rat Leydig cells. |
1990 |
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Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells. |
1990 |
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Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils. |
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Translocation of protein kinase C in human polymorphonuclear neutrophils. Regulation by cytosolic Ca2(+)-independent and Ca2(+)-dependent mechanisms. |
1990 |
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Protein kinase C is present in human sperm: possible role in flagellar motility. |
1990 |
Proc. Natl. Acad. Sci. U.S.A. |
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Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung. |
1990 |
J. Immunol. |
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Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated with the receptor in the down-regulation. |
1990 |
J. Biol. Chem. |
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Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C. |
1990 |
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Evidence for a role of protein kinase C in the stimulation of lipolysis by growth hormone and isoproterenol. |
1990 |
Endocrinology |
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Sphingosine interacts directly with the receptor complex to inhibit thyrotropin-releasing hormone binding. |
1990 |
Endocrinology |
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Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C. |
1990 |
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Substrate-dependent inhibition of protein kinase C by specific inhibitors. |
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1990 |
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The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system. |
1990 |
Neuron |
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Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells. |
1990 |
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Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors. |
1990 |
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Rapid inactivation and phosphorylation of pyroglutamyl peptidase II in Y-79 human retinoblastoma cells after exposure to phorbol ester. |
1990 |
Endocrinology |
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Protein kinase C modulation of queuine uptake in cultured human fibroblasts. |
1990 |
Biochem. Biophys. Res. Commun. |
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Signal transduction events in human basophils. A comparative study of the role of protein kinase C in basophils activated by anti-IgE antibody and formyl-methionyl-leucyl-phenylalanine. |
1990 |
J. Immunol. |
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Protein kinase C controls Fc gamma receptor-mediated endocytosis in human neutrophils. |
1990 |
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Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid. |
1990 |
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Differential down-regulation of protein kinase C selectively affects IgE-dependent exocytosis and inositol trisphosphate formation. |
1990 |
Biochem. J. |
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Collagen-induced platelet activation mainly involves the protein kinase C pathway. |
1990 |
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Study of pathogenesis in twitcher mouse, an enzymatically authentic model of Krabbe's disease. |
1990 |
J. Neurol. Sci. |
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New approach for characterization of lysosulfatide by TLC, fast atom bombardment mass spectrometry and NMR spectroscopy. |
1990 |
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Sphingosine inhibits the activity of rat liver CTP:phosphocholine cytidylyltransferase. |
1990 |
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A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. |
1990 |
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Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. |
1990 |
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Neuritogenesis in cerebellar granule cells in vitro: a role for protein kinase C. |
1990 |
Brain Res. Dev. Brain Res. |
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Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine. Dual action of sphingosine in diacylglycerol signal termination. |
1990 |
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Vasoactive intestinal peptide (VIP) activation of nuclear protein kinase C in purified nuclei of rat splenocytes. |
1990 |
Biochem. Pharmacol. |
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Preparative scale isolation of sphingosine. |
1990 |
J. Lipid Res. |
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Carbachol mimics phorbol esters in its ability to enhance cyclic GMP production by STa, the heat-stable toxin of Escherichia coli. |
1990 |
FEBS Lett. |
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The rate of bulk flow from the Golgi to the plasma membrane. |
1990 |
Cell |
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Protein kinase C participates in up-regulation of dihydropyridine-sensitive calcium channels by ethanol. |
1990 |
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Engagement of the monocyte surface antigen CD14 induces lymphocyte function-associated antigen-1/intercellular adhesion molecule-1-dependent homotypic adhesion. |
1990 |
J. Immunol. |
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Sphingosine increases inositol trisphosphate in rat parotid acinar cells by a mechanism that is independent of protein kinase C but dependent on extracellular calcium. |
1990 |
Cell Calcium |
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Bankov I and Barrett J |
Sphingomyelin synthesis in Fasciola hepatica. |
1990 |
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Bacon KB and Camp RD |
Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C. |
1990 |
Biochem. Biophys. Res. Commun. |
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Binding of galactosylsphingosine (psychosine) by albumin. |
1990 |
Lipids |
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Inhibitors of protein kinase C prolong the falling phase of each free-calcium transient in a hormone-stimulated hepatocyte. |
1990 |
Biochem. J. |
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Human acid beta-glucosidase: use of sphingosyl and N-alkyl-glucosylamine inhibitors to investigate the properties of the active site. |
1990 |
Biochim. Biophys. Acta |
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Kiss Z and Anderson WB |
ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine. |
1990 |
J. Biol. Chem. |
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Sphingosine inhibition of tyrosine aminotransferase and tryptophan oxygenase induction by dexamethasone in primary culture of rat hepatocytes. |
1990 |
Biochem. Biophys. Res. Commun. |
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Chakrabarti AK et al. |
Regulation of the calcium-activated neutral proteinase (CANP) of bovine brain by myelin lipids. |
1990 |
Biochim. Biophys. Acta |
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Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts. |
1990 |
Biochem. Biophys. Res. Commun. |
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Lavie Y and Liscovitch M |
Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells. |
1990 |
J. Biol. Chem. |
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P2-purinoceptor regulation of surfactant phosphatidylcholine secretion. Relative roles of calcium and protein kinase C. |
1990 |
Biochem. J. |
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The HIV protein, GP120, activates nuclear protein kinase C in nuclei from lymphocytes and brain. |
1990 |
Biochem. Biophys. Res. Commun. |
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Galactosylceramide and galactosylsphingosine loading studies in cultured skin fibroblasts in human and murine globoid cell leukodystrophy. |
1990 |
Biochem. Biophys. Res. Commun. |
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Sphingomyelin is synthesized in the cis Golgi. |
1990 |
FEBS Lett. |
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Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rats and humans. |
1990 |
J. Clin. Invest. |
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Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines. |
1990 |
Biochem. Biophys. Res. Commun. |
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Free sphingosine in human epidermis. |
1990 |
J. Invest. Dermatol. |
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Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemia K562 cells. |
1990 |
Jpn. J. Cancer Res. |
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Stinavage PS et al. |
A 59 kiloDalton outer membrane protein of Salmonella typhimurium protects against oxidative intraleukocytic killing due to human neutrophils. |
1990 |
Mol. Microbiol. |
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Intracellular calcium release mediated by sphingosine derivatives generated in cells. |
1990 |
Science |
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Inhibitory effect of phorbol ester on sodium transport in frog urinary bladder. |
1990 |
Am. J. Physiol. |
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Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids. |
1990 |
J. Pharmacol. Exp. Ther. |
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Bement WM and Capco DG |
Protein kinase C acts downstream of calcium at entry into the first mitotic interphase of Xenopus laevis. |
1990 |
Cell Regul. |
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Modulation of phosphoinositide metabolism in aortic smooth muscle cells by allylamine. |
1990 |
Exp. Mol. Pathol. |
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Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver. |
1990 |
Biochem. J. |
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Synergistic activation by serotonin and GTP analogue and inhibition by phorbol ester of cyclic Ca2+ rises in hamster eggs. |
1990 |
J. Physiol. (Lond.) |
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Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells. |
1990 |
Biochem. Pharmacol. |
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Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway. |
1990 |
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Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo. |
1990 |
Dev. Biol. |
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Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. |
1990 |
J. Biol. Chem. |
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Sphingosine potentiates IL-1-mediated prostaglandin E2 production in human fibroblasts. |
1990 |
J. Immunol. |
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Effects of sphingosine, staurosporine, and phorbol ester on neurites of rat sympathetic neurons growing in compartmented cultures. |
1991 |
J. Neurosci. |
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CaMKII mediates stimulation of chloride conductance by calcium in T84 cells. |
1991 |
Am. J. Physiol. |
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Sphingosine and unsaturated fatty acids modulate the base exchange enzyme activities of rat brain membranes. |
1991 |
FEBS Lett. |
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Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. |
1991 |
Biochem. J. |
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Histamine H1-receptor-mediated keratan sulfate production in rabbit chondrocytes: involvement of protein kinase C. |
1991 |
Am. J. Physiol. |
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Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. |
1991 |
Cancer Res. |
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