Herzog BH et al. |
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. |
2013 |
Nature |
pmid:23995678
|
Eisenhoffer GT et al. |
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. |
2012 |
Nature |
pmid:22504183
|
Vu TM et al. |
Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. |
2017 |
Nature |
pmid:29045386
|
Olivera A and Spiegel S |
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. |
1993 |
Nature |
pmid:8413613
|
Choi OH et al. |
Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. |
1996 |
Nature |
pmid:8602265
|
Ng CK et al. |
Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. |
2001 |
Nature |
pmid:11279499
|
D'Angelo G et al. |
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. |
2007 |
Nature |
pmid:17687330
|
Cuvillier O et al. |
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. |
1996 |
Nature |
pmid:8657285
|
Martin R |
Multiple sclerosis: closing in on an oral treatment. |
2010 |
Nature |
pmid:20237554
|
Mendoza A et al. |
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. |
2017 |
Nature |
pmid:28538737
|
Ishii M et al. |
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. |
2009 |
Nature |
pmid:19204730
|
Malinow R et al. |
Persistent protein kinase activity underlying long-term potentiation. |
1988 |
Nature |
pmid:2847049
|
Premenko-Lanier M et al. |
Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection. |
2008 |
Nature |
pmid:18704087
|
Bevan MJ and Fink PJ |
Immunology: Surprising side effects. |
2008 |
Nature |
pmid:18704076
|
Alvarez SE et al. |
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. |
2010 |
Nature |
pmid:20577214
|
Coursol S et al. |
Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. |
2003 |
Nature |
pmid:12789341
|
Blaho VA et al. |
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. |
2015 |
Nature |
pmid:26053123
|
Jang GJ et al. |
C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration. |
2005 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:16231160
|
Czyborra C et al. |
Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. |
2006 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:16521006
|
Alemany R et al. |
Regulation and functional roles of sphingosine kinases. |
2007 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:17242884
|
Trifilieff A et al. |
Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. |
2009 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:19636535
|
Ryu SK et al. |
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat. |
2006 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:16521007
|
Jongsma M et al. |
Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors. |
2007 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:17497135
|
Pexa A and Deussen A |
Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC). |
2005 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:16200394
|
Stuebe S et al. |
Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene. |
2008 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:18046543
|
Hemmings DG |
Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. |
2006 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:16570136
|
Morales M |
[Participation of the phosphatidylinositol-3-kinase/Akt/endothelial-nitric-oxide synthase signaling in the processes of angiogenesis and vascular remodeling]. |
2002 |
Nefrologia |
pmid:12107910
|
Böhler T et al. |
FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors. |
2004 |
Nephrol. Dial. Transplant. |
pmid:14767029
|
Kim MG et al. |
CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. |
2011 |
Nephrol. Dial. Transplant. |
pmid:20702533
|
Westhoff TH et al. |
The impact of FTY720 (fingolimod) on vasodilatory function and arterial elasticity in renal transplant patients. |
2007 |
Nephrol. Dial. Transplant. |
pmid:17526535
|
Hanafusa N et al. |
Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. |
2002 |
Nephrol. Dial. Transplant. |
pmid:11917049
|
Sun XJ et al. |
Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. |
2017 |
Nephrol. Dial. Transplant. |
pmid:28206609
|
Hoitsma AJ et al. |
FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study. |
2011 |
Nephrol. Dial. Transplant. |
pmid:21911597
|
Domhan S et al. |
Immunosuppressive therapy and post-transplant malignancy. |
2009 |
Nephrol. Dial. Transplant. |
pmid:18978068
|
Kunzendorf U et al. |
FTY720--the first compound of a new promising class of immunosuppressive drugs. |
2004 |
Nephrol. Dial. Transplant. |
pmid:15199193
|
Lee SY et al. |
Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. |
2011 |
Nephrology (Carlton) |
pmid:21272128
|
Klatt J et al. |
[FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis]. |
2007 |
Nervenarzt |
pmid:17668161
|
Haas J et al. |
[Fingolimod compassionate use program: case study on the concept of a therapy option for multiple sclerosis prior to marketing approval]. |
2012 |
Nervenarzt |
pmid:23203160
|
Aktas O et al. |
[Oral fingolimod in multiple sclerosis: therapeutic modulation of the sphingosine-1-phosphate system]. |
2011 |
Nervenarzt |
pmid:20842337
|
Winkelmann A et al. |
[Fingolimod treatment for multiple sclerosis patients. Infectiological aspects and recommendations for vaccinations]. |
2012 |
Nervenarzt |
pmid:21845450
|
Estrada-Bernal A et al. |
Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma. |
2012 |
Neuro-oncology |
pmid:22351749
|
He X et al. |
Deregulation of sphingolipid metabolism in Alzheimer's disease. |
2010 |
Neurobiol. Aging |
pmid:18547682
|
Malaplate-Armand C et al. |
Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. |
2006 |
Neurobiol. Dis. |
pmid:16626961
|
Schueler UH et al. |
Toxicity of glucosylsphingosine (glucopsychosine) to cultured neuronal cells: a model system for assessing neuronal damage in Gaucher disease type 2 and 3. |
2003 |
Neurobiol. Dis. |
pmid:14678774
|
Hindle SJ et al. |
A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline. |
2017 |
Neurobiol. Dis. |
pmid:27913291
|
Colombaioni L et al. |
Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells. |
2002 |
Neurochem. Int. |
pmid:11792463
|
Li R et al. |
Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity. |
2012 |
Neurochem. Int. |
pmid:22414529
|
Yang Y et al. |
Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. |
2016 |
Neurochem. Int. |
pmid:26921668
|
Manev H and Cagnoli CM |
Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common? |
1997 |
Neurochem. Int. |
pmid:9220452
|
Molderings GJ et al. |
S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands. |
2007 |
Neurochem. Int. |
pmid:17559976
|
Pasquaré SJ and Giusto NM |
Diacylglyceride lipase activity in rod outer segments depends on the illumination state of the retina. |
2008 |
Neurochem. Int. |
pmid:18926868
|
López-González MA et al. |
The production of free oxygen radicals and nitric oxide in the rat cochlea. |
1998 |
Neurochem. Int. |
pmid:9694043
|
Rodriguez-Lafrasse C and Vanier MT |
Sphingosylphosphorylcholine in Niemann-Pick disease brain: accumulation in type A but not in type B. |
1999 |
Neurochem. Res. |
pmid:9972865
|
Jang S et al. |
Cytochemical alterations in the rat retina by LPS administration. |
2007 |
Neurochem. Res. |
pmid:17160463
|
Giussani P et al. |
Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells. |
2007 |
Neurochem. Res. |
pmid:17151916
|
Heacock AM and Agranoff BW |
Protein kinase inhibitors block neurite outgrowth from explants of goldfish retina. |
1997 |
Neurochem. Res. |
pmid:9342720
|
Dasgupta S et al. |
Maternal alcohol consumption increases sphingosine levels in the brains of progeny mice. |
2007 |
Neurochem. Res. |
pmid:17701351
|
Taniwaki T et al. |
Ceramide induces apoptosis to immature cerebellar granule cells in culture. |
1999 |
Neurochem. Res. |
pmid:10344598
|
Podbielska M et al. |
Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. |
2012 |
Neurochem. Res. |
pmid:22451227
|
Pasquaré SJ et al. |
Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments. |
2008 |
Neurochem. Res. |
pmid:18288612
|
Bieberich E |
There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells. |
2011 |
Neurochem. Res. |
pmid:21136155
|
Yi H et al. |
Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells. |
2011 |
Neurochem. Res. |
pmid:21674237
|
Katsel P et al. |
Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease? |
|
Neurochem. Res. |
pmid:17342407
|
Larocca JN et al. |
Induction of oligodendrocyte apoptosis by C2-ceramide. |
1997 |
Neurochem. Res. |
pmid:9130266
|
Jang S et al. |
Changes in iNOS, GFAP and NR1 expression in various brain regions and elevation of sphingosine-1-phosphate in serum after immobilized stress. |
2008 |
Neurochem. Res. |
pmid:17940874
|
Saito M et al. |
Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons. |
1999 |
Neurochem. Res. |
pmid:10485581
|
Gassowska M et al. |
Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. |
2014 |
Neurochem. Res. |
pmid:24452756
|
Bieberich E |
It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation. |
2012 |
Neurochem. Res. |
pmid:22246226
|
Jang S et al. |
Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety. |
2011 |
Neurochem. Res. |
pmid:21076868
|
Maciejek Z et al. |
Evaluation of efficacy, safety and tolerability of fingolimod in patients with the relapsing form of multiple sclerosis - 12-month observation. A preliminary report. |
|
Neurol. Neurochir. Pol. |
pmid:23650003
|
Hashiba Y et al. |
Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries. |
2007 |
Neurol. Res. |
pmid:17806208
|
La Mantia L et al. |
Multiple sclerosis rebound after fingolimod discontinuation for lymphopenia. |
2014 |
Neurol. Sci. |
pmid:24756193
|
Gasperini C and Ruggieri S |
New oral drugs for multiple sclerosis. |
2009 |
Neurol. Sci. |
pmid:19882371
|
Crespo C et al. |
Cost minimisation analysis of fingolimod vs natalizumab as a second line of treatment for relapsing-remitting multiple sclerosis. |
2014 |
Neurologia |
pmid:24161412
|
Atkinson D et al. |
Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. |
2017 |
Neurology |
pmid:28077491
|
Verhoeven K et al. |
SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I. |
2004 |
Neurology |
pmid:15037712
|
Goldman MD and Naismith RT |
Multiple sclerosis, immunomodulation, and immunizations: balancing the benefits. |
2015 |
Neurology |
pmid:25636716
|
Kappos L et al. |
Randomized trial of vaccination in fingolimod-treated patients with multiple sclerosis. |
2015 |
Neurology |
pmid:25636714
|
Kowarik MC et al. |
Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. |
2011 |
Neurology |
pmid:21464424
|
Issa NP and Hentati A |
VZV encephalitis that developed in an immunized patient during fingolimod therapy. |
2015 |
Neurology |
pmid:25416038
|
Hohlfeld R et al. |
Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy. |
2011 |
Neurology |
pmid:21339488
|
Antel J and Hohlfeld R |
Modulation of sphingosine 1-phosphate signaling in neurologic disease. |
2011 |
Neurology |
pmid:21360856
|
Nolan R et al. |
Fingolimod treatment in multiple sclerosis leads to increased macular volume. |
2013 |
Neurology |
pmid:23223539
|
Slavin AJ and Zamvil SS |
FTY720 and central memory: out of sight, out of mind. |
2010 |
Neurology |
pmid:20610831
|
Schwarz A et al. |
Critical vasospasm during fingolimod (FTY720) treatment in a patient with multiple sclerosis. |
2010 |
Neurology |
pmid:20548047
|
Hla T and Brinkmann V |
Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. |
2011 |
Neurology |
pmid:21339489
|
Soliven B et al. |
The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. |
2011 |
Neurology |
pmid:21339490
|
Giovannoni G and Naismith RT |
Natalizumab to fingolimod washout in patients at risk of PML: when good intentions yield bad outcomes. |
2014 |
Neurology |
pmid:24610331
|
Jokubaitis VG et al. |
Fingolimod after natalizumab and the risk of short-term relapse. |
2014 |
Neurology |
pmid:24610329
|
Pilz G et al. |
Tumefactive MS lesions under fingolimod: a case report and literature review. |
2013 |
Neurology |
pmid:24097813
|
Paul F and Bourdette D |
Tumefactive multiple sclerosis and fingolimod: Immunotherapies and unintended consequences. |
2013 |
Neurology |
pmid:24097812
|
Wattjes MP et al. |
Author response. |
2013 |
Neurology |
pmid:24044116
|
Schneider JS and DiStefano L |
Oral administration of semisynthetic sphingolipids promotes recovery of striatal dopamine concentrations in a murine model of parkinsonism. |
1994 |
Neurology |
pmid:8164837
|
McNamara PH et al. |
Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod. |
2013 |
Neurology |
pmid:23858414
|
Pfender N et al. |
Reactivation of herpesvirus under fingolimod: A case of severe herpes simplex encephalitis. |
2015 |
Neurology |
pmid:25957334
|
Tully T et al. |
Kaposi sarcoma in a patient with relapsing-remitting multiple sclerosis receiving fingolimod. |
2015 |
Neurology |
pmid:25878178
|
Bielekova B and McDermott MP |
Will CSF biomarkers guide future therapeutic decisions in multiple sclerosis? |
2015 |
Neurology |
pmid:25809305
|
Kuhle J et al. |
Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis. |
2015 |
Neurology |
pmid:25809304
|
Ricklin ME et al. |
T-cell response against varicella-zoster virus in fingolimod-treated MS patients. |
2013 |
Neurology |
pmid:23700335
|
Kappos L et al. |
Long-term effects of fingolimod in multiple sclerosis: the randomized FREEDOMS extension trial. |
2015 |
Neurology |
pmid:25795646
|