sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Herzog BH et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. 2013 Nature pmid:23995678
Eisenhoffer GT et al. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. 2012 Nature pmid:22504183
Vu TM et al. Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. 2017 Nature pmid:29045386
Olivera A and Spiegel S Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. 1993 Nature pmid:8413613
Choi OH et al. Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. 1996 Nature pmid:8602265
Ng CK et al. Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. 2001 Nature pmid:11279499
D'Angelo G et al. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. 2007 Nature pmid:17687330
Cuvillier O et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. 1996 Nature pmid:8657285
Martin R Multiple sclerosis: closing in on an oral treatment. 2010 Nature pmid:20237554
Mendoza A et al. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. 2017 Nature pmid:28538737
Ishii M et al. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. 2009 Nature pmid:19204730
Malinow R et al. Persistent protein kinase activity underlying long-term potentiation. 1988 Nature pmid:2847049
Premenko-Lanier M et al. Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection. 2008 Nature pmid:18704087
Bevan MJ and Fink PJ Immunology: Surprising side effects. 2008 Nature pmid:18704076
Alvarez SE et al. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. 2010 Nature pmid:20577214
Coursol S et al. Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. 2003 Nature pmid:12789341
Blaho VA et al. HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. 2015 Nature pmid:26053123
Jang GJ et al. C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration. 2005 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16231160
Czyborra C et al. Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16521006
Alemany R et al. Regulation and functional roles of sphingosine kinases. 2007 Naunyn Schmiedebergs Arch. Pharmacol. pmid:17242884
Trifilieff A et al. Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. 2009 Naunyn Schmiedebergs Arch. Pharmacol. pmid:19636535
Ryu SK et al. Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16521007
Jongsma M et al. Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors. 2007 Naunyn Schmiedebergs Arch. Pharmacol. pmid:17497135
Pexa A and Deussen A Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC). 2005 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16200394
Stuebe S et al. Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene. 2008 Naunyn Schmiedebergs Arch. Pharmacol. pmid:18046543
Hemmings DG Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16570136
Morales M [Participation of the phosphatidylinositol-3-kinase/Akt/endothelial-nitric-oxide synthase signaling in the processes of angiogenesis and vascular remodeling]. 2002 Nefrologia pmid:12107910
Böhler T et al. FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors. 2004 Nephrol. Dial. Transplant. pmid:14767029
Kim MG et al. CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. 2011 Nephrol. Dial. Transplant. pmid:20702533
Westhoff TH et al. The impact of FTY720 (fingolimod) on vasodilatory function and arterial elasticity in renal transplant patients. 2007 Nephrol. Dial. Transplant. pmid:17526535
Hanafusa N et al. Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. 2002 Nephrol. Dial. Transplant. pmid:11917049
Sun XJ et al. Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. 2017 Nephrol. Dial. Transplant. pmid:28206609
Hoitsma AJ et al. FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study. 2011 Nephrol. Dial. Transplant. pmid:21911597
Domhan S et al. Immunosuppressive therapy and post-transplant malignancy. 2009 Nephrol. Dial. Transplant. pmid:18978068
Kunzendorf U et al. FTY720--the first compound of a new promising class of immunosuppressive drugs. 2004 Nephrol. Dial. Transplant. pmid:15199193
Lee SY et al. Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. 2011 Nephrology (Carlton) pmid:21272128
Klatt J et al. [FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis]. 2007 Nervenarzt pmid:17668161
Haas J et al. [Fingolimod compassionate use program: case study on the concept of a therapy option for multiple sclerosis prior to marketing approval]. 2012 Nervenarzt pmid:23203160
Aktas O et al. [Oral fingolimod in multiple sclerosis: therapeutic modulation of the sphingosine-1-phosphate system]. 2011 Nervenarzt pmid:20842337
Winkelmann A et al. [Fingolimod treatment for multiple sclerosis patients. Infectiological aspects and recommendations for vaccinations]. 2012 Nervenarzt pmid:21845450
Estrada-Bernal A et al. Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma. 2012 Neuro-oncology pmid:22351749
He X et al. Deregulation of sphingolipid metabolism in Alzheimer's disease. 2010 Neurobiol. Aging pmid:18547682
Malaplate-Armand C et al. Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. 2006 Neurobiol. Dis. pmid:16626961
Schueler UH et al. Toxicity of glucosylsphingosine (glucopsychosine) to cultured neuronal cells: a model system for assessing neuronal damage in Gaucher disease type 2 and 3. 2003 Neurobiol. Dis. pmid:14678774
Hindle SJ et al. A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline. 2017 Neurobiol. Dis. pmid:27913291
Colombaioni L et al. Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells. 2002 Neurochem. Int. pmid:11792463
Li R et al. Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity. 2012 Neurochem. Int. pmid:22414529
Yang Y et al. Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. 2016 Neurochem. Int. pmid:26921668
Manev H and Cagnoli CM Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common? 1997 Neurochem. Int. pmid:9220452
Molderings GJ et al. S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands. 2007 Neurochem. Int. pmid:17559976
Pasquaré SJ and Giusto NM Diacylglyceride lipase activity in rod outer segments depends on the illumination state of the retina. 2008 Neurochem. Int. pmid:18926868
López-González MA et al. The production of free oxygen radicals and nitric oxide in the rat cochlea. 1998 Neurochem. Int. pmid:9694043
Rodriguez-Lafrasse C and Vanier MT Sphingosylphosphorylcholine in Niemann-Pick disease brain: accumulation in type A but not in type B. 1999 Neurochem. Res. pmid:9972865
Jang S et al. Cytochemical alterations in the rat retina by LPS administration. 2007 Neurochem. Res. pmid:17160463
Giussani P et al. Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells. 2007 Neurochem. Res. pmid:17151916
Heacock AM and Agranoff BW Protein kinase inhibitors block neurite outgrowth from explants of goldfish retina. 1997 Neurochem. Res. pmid:9342720
Dasgupta S et al. Maternal alcohol consumption increases sphingosine levels in the brains of progeny mice. 2007 Neurochem. Res. pmid:17701351
Taniwaki T et al. Ceramide induces apoptosis to immature cerebellar granule cells in culture. 1999 Neurochem. Res. pmid:10344598
Podbielska M et al. Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. 2012 Neurochem. Res. pmid:22451227
Pasquaré SJ et al. Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments. 2008 Neurochem. Res. pmid:18288612
Bieberich E There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells. 2011 Neurochem. Res. pmid:21136155
Yi H et al. Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells. 2011 Neurochem. Res. pmid:21674237
Katsel P et al. Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease? Neurochem. Res. pmid:17342407
Larocca JN et al. Induction of oligodendrocyte apoptosis by C2-ceramide. 1997 Neurochem. Res. pmid:9130266
Jang S et al. Changes in iNOS, GFAP and NR1 expression in various brain regions and elevation of sphingosine-1-phosphate in serum after immobilized stress. 2008 Neurochem. Res. pmid:17940874
Saito M et al. Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons. 1999 Neurochem. Res. pmid:10485581
Gassowska M et al. Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. 2014 Neurochem. Res. pmid:24452756
Bieberich E It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation. 2012 Neurochem. Res. pmid:22246226
Jang S et al. Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety. 2011 Neurochem. Res. pmid:21076868
Maciejek Z et al. Evaluation of efficacy, safety and tolerability of fingolimod in patients with the relapsing form of multiple sclerosis - 12-month observation. A preliminary report. Neurol. Neurochir. Pol. pmid:23650003
Hashiba Y et al. Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries. 2007 Neurol. Res. pmid:17806208
La Mantia L et al. Multiple sclerosis rebound after fingolimod discontinuation for lymphopenia. 2014 Neurol. Sci. pmid:24756193
Gasperini C and Ruggieri S New oral drugs for multiple sclerosis. 2009 Neurol. Sci. pmid:19882371
Crespo C et al. Cost minimisation analysis of fingolimod vs natalizumab as a second line of treatment for relapsing-remitting multiple sclerosis. 2014 Neurologia pmid:24161412
Atkinson D et al. Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. 2017 Neurology pmid:28077491
Verhoeven K et al. SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I. 2004 Neurology pmid:15037712
Goldman MD and Naismith RT Multiple sclerosis, immunomodulation, and immunizations: balancing the benefits. 2015 Neurology pmid:25636716
Kappos L et al. Randomized trial of vaccination in fingolimod-treated patients with multiple sclerosis. 2015 Neurology pmid:25636714
Kowarik MC et al. Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. 2011 Neurology pmid:21464424
Issa NP and Hentati A VZV encephalitis that developed in an immunized patient during fingolimod therapy. 2015 Neurology pmid:25416038
Hohlfeld R et al. Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy. 2011 Neurology pmid:21339488
Antel J and Hohlfeld R Modulation of sphingosine 1-phosphate signaling in neurologic disease. 2011 Neurology pmid:21360856
Nolan R et al. Fingolimod treatment in multiple sclerosis leads to increased macular volume. 2013 Neurology pmid:23223539
Slavin AJ and Zamvil SS FTY720 and central memory: out of sight, out of mind. 2010 Neurology pmid:20610831
Schwarz A et al. Critical vasospasm during fingolimod (FTY720) treatment in a patient with multiple sclerosis. 2010 Neurology pmid:20548047
Hla T and Brinkmann V Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. 2011 Neurology pmid:21339489
Soliven B et al. The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. 2011 Neurology pmid:21339490
Giovannoni G and Naismith RT Natalizumab to fingolimod washout in patients at risk of PML: when good intentions yield bad outcomes. 2014 Neurology pmid:24610331
Jokubaitis VG et al. Fingolimod after natalizumab and the risk of short-term relapse. 2014 Neurology pmid:24610329
Pilz G et al. Tumefactive MS lesions under fingolimod: a case report and literature review. 2013 Neurology pmid:24097813
Paul F and Bourdette D Tumefactive multiple sclerosis and fingolimod: Immunotherapies and unintended consequences. 2013 Neurology pmid:24097812
Wattjes MP et al. Author response. 2013 Neurology pmid:24044116
Schneider JS and DiStefano L Oral administration of semisynthetic sphingolipids promotes recovery of striatal dopamine concentrations in a murine model of parkinsonism. 1994 Neurology pmid:8164837
McNamara PH et al. Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod. 2013 Neurology pmid:23858414
Pfender N et al. Reactivation of herpesvirus under fingolimod: A case of severe herpes simplex encephalitis. 2015 Neurology pmid:25957334
Tully T et al. Kaposi sarcoma in a patient with relapsing-remitting multiple sclerosis receiving fingolimod. 2015 Neurology pmid:25878178
Bielekova B and McDermott MP Will CSF biomarkers guide future therapeutic decisions in multiple sclerosis? 2015 Neurology pmid:25809305
Kuhle J et al. Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis. 2015 Neurology pmid:25809304
Ricklin ME et al. T-cell response against varicella-zoster virus in fingolimod-treated MS patients. 2013 Neurology pmid:23700335
Kappos L et al. Long-term effects of fingolimod in multiple sclerosis: the randomized FREEDOMS extension trial. 2015 Neurology pmid:25795646