sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Atkinson D et al. Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. 2017 Neurology pmid:28077491
Verhoeven K et al. SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I. 2004 Neurology pmid:15037712
Goldman MD and Naismith RT Multiple sclerosis, immunomodulation, and immunizations: balancing the benefits. 2015 Neurology pmid:25636716
Kowarik MC et al. Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. 2011 Neurology pmid:21464424
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Warnke C et al. Initial lymphocyte count and low BMI may affect fingolimod-induced lymphopenia. 2014 Neurology pmid:25361781
Antel J and Hohlfeld R Modulation of sphingosine 1-phosphate signaling in neurologic disease. 2011 Neurology pmid:21360856
Slavin AJ and Zamvil SS FTY720 and central memory: out of sight, out of mind. 2010 Neurology pmid:20610831
Schwarz A et al. Critical vasospasm during fingolimod (FTY720) treatment in a patient with multiple sclerosis. 2010 Neurology pmid:20548047
Giovannoni G and Naismith RT Natalizumab to fingolimod washout in patients at risk of PML: when good intentions yield bad outcomes. 2014 Neurology pmid:24610331
Jokubaitis VG et al. Fingolimod after natalizumab and the risk of short-term relapse. 2014 Neurology pmid:24610329
Rolf L et al. Paroxysmal atrial fibrillation after initiation of fingolimod for multiple sclerosis treatment. 2014 Neurology pmid:24523479
Jain N and Bhatti MT Fingolimod-associated macular edema: incidence, detection, and management. 2012 Neurology pmid:22371414
Henault D et al. Basis for fluctuations in lymphocyte counts in fingolimod-treated patients with multiple sclerosis. 2013 Neurology pmid:24132373
Wattjes MP et al. Author response. 2013 Neurology pmid:24044116
Schneider JS and DiStefano L Oral administration of semisynthetic sphingolipids promotes recovery of striatal dopamine concentrations in a murine model of parkinsonism. 1994 Neurology pmid:8164837
Kappos L et al. Switching from natalizumab to fingolimod: A randomized, placebo-controlled study in RRMS. 2015 Neurology pmid:26024899
Stüve O and Bourdette D Natalizumab to fingolimod: Questions answered, unanswered, and unasked. 2015 Neurology pmid:26024898
Kinney MO and McDonnell G Re: Tumefactive multiple sclerosis lesions under fingolimod treatment. 2013 Neurology pmid:23877798
McNamara PH et al. Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod. 2013 Neurology pmid:23858414
Tully T et al. Kaposi sarcoma in a patient with relapsing-remitting multiple sclerosis receiving fingolimod. 2015 Neurology pmid:25878178
Bielekova B and McDermott MP Will CSF biomarkers guide future therapeutic decisions in multiple sclerosis? 2015 Neurology pmid:25809305
Kuhle J et al. Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis. 2015 Neurology pmid:25809304
Ricklin ME et al. T-cell response against varicella-zoster virus in fingolimod-treated MS patients. 2013 Neurology pmid:23700335
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Acharya JK et al. Cell-nonautonomous function of ceramidase in photoreceptor homeostasis. 2008 Neuron pmid:18184565
Cline HT and Constantine-Paton M The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system. 1990 Neuron pmid:2361013
Bixby JL Protein kinase C is involved in laminin stimulation of neurite outgrowth. 1989 Neuron pmid:2561968
Darios F et al. Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. 2009 Neuron pmid:19524527
Zhang Z et al. Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury. 2008 Neuropathol. Appl. Neurobiol. pmid:17983426
Zhang ZY et al. FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis. 2009 Neuropathol. Appl. Neurobiol. pmid:19207263
O'Sullivan S and Dev KK Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. 2017 Neuropharmacology pmid:27825807
Pan CY et al. Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells. 2006 Neuropharmacology pmid:16616768
Osinde M et al. Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. 2007 Neuropharmacology pmid:17379261
Pierucci F et al. Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. 2017 Neuropharmacology pmid:28077289
Imeri F et al. Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. 2014 Neuropharmacology pmid:24863045
Pollock J et al. TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones. 2002 Neuropharmacology pmid:11750919
Schneider JS and Distefano L Response of the damaged dopamine system to GM1 and semisynthetic gangliosides: effects of dose and extent of lesion. 1995 Neuropharmacology pmid:7566482
Anthony DC et al. Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model. 2014 Neuropharmacology pmid:24412675
Güntert T et al. 1-Deoxysphingolipid-induced neurotoxicity involves N-methyl-d-aspartate receptor signaling. 2016 Neuropharmacology pmid:27016021
Lim ST et al. Exogenous gangliosides increase the release of brain-derived neurotrophic factor. 2011 Neuropharmacology pmid:20971126
Callihan P et al. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. 2012 Neuropharmacology pmid:22016110
Masgrau R et al. BM88/Cend1 regulates stimuli-induced intracellular calcium mobilization. 2009 Neuropharmacology pmid:19061903
Lipartiti M et al. Ganglioside derivative LIGA20 reduces NMDA neurotoxicity in neonatal rat brain. 1992 Neuroreport pmid:1421099
Jiang Q et al. Nuclear translocation of extracellular signal-regulated kinases in neuronal excitotoxicity. 2001 Neuroreport pmid:11496121
Ramos B et al. Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine. 2000 Neuroreport pmid:11043531
McGuinness N et al. The effects of trans-ACPD on long-term potentiation in the rat hippocampal slice. 1991 Neuroreport pmid:1667272
Centeno F et al. Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons. 1998 Neuroreport pmid:9926873
Schneider JS and DiStefano L LIGA 20 increases striatal dopamine levels in aged MPTP-treated mice refractory to GM1 ganglioside treatment. 1993 Neuroreport pmid:8110995
Arboleda G et al. Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells. 2007 Neurosci. Lett. pmid:17573191
Tamai Y et al. Creutzfeldt-Jakob disease--alteration in ganglioside sphingosine in the brain of a patient. 1979 Neurosci. Lett. pmid:372860
Agudo-López A et al. Involvement of mitochondria on neuroprotective effect of sphingosine-1-phosphate in cell death in an in vitro model of brain ischemia. 2010 Neurosci. Lett. pmid:20045720
Muñoz-Sáez E et al. Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). 2015 Neurosci. Lett. pmid:25769802
Nishimura B et al. The influences of sphingolipid metabolites on gentamicin-induced hair cell loss of the rat cochlea. 2010 Neurosci. Lett. pmid:20709153
Boiron-Sargueil F et al. Cerebroside formation in the peripheral nervous system of normal and Trembler mice. 1995 Neurosci. Lett. pmid:7783943
Jaramillo-Gómez J et al. Overexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy. 2015 Neurosci. Lett. pmid:26222260
Matsumoto M and Barnard EA Effects of an activator and an inhibitor of protein kinase C on serotonin receptors induced by rat brain mRNA in Xenopus oocytes. 1994 Neurosci. Lett. pmid:8177520
Jatana M et al. Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine. 2002 Neurosci. Lett. pmid:12231442
Craighead M et al. Caspases mediate C2-ceramide-induced apoptosis of the human oligodendroglial cell line, MO3.13. 2000 Neurosci. Lett. pmid:10653009
Tavarini S et al. Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. 2000 Neurosci. Lett. pmid:10806317
Fan C et al. Autophagy inhibits C2-ceramide-mediated cell death by decreasing the reactive oxygen species levels in SH-SY5Y cells. 2017 Neurosci. Lett. pmid:28288862
Stessin AM et al. FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells. 2012 Neurosci. Lett. pmid:22507238
Zheng T et al. C2-ceramide attenuates prostaglandin F2alpha-induced vasoconstriction and elevation of [Ca2+]i in canine cerebral vascular smooth muscle. 1998 Neurosci. Lett. pmid:9853716
Kułakowska A et al. Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis. 2010 Neurosci. Lett. pmid:20434523
Boneh A et al. Effect of sphingosine on rat glial cells: inhibition of prostaglandin E2 and insensitivity of nitric oxide generation. 1997 Neurosci. Lett. pmid:9237488
Doyle T et al. Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia. 2011 Neurosci. Lett. pmid:21605625
Esche M et al. Signalling of sphingosine-1-phosphate in Müller glial cells via the S1P/EDG-family of G-protein-coupled receptors. 2010 Neurosci. Lett. pmid:20540988
Yang MS et al. Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia. 2001 Neurosci. Lett. pmid:11567796
Calcerrada MC et al. Sphingosylphosphorylcholine increases calcium concentration in isolated brain nuclei. 1999 Neurosci. Res. pmid:10211767
Storchak LG et al. Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes. 1998 Neuroscience pmid:9639290
Nayak D et al. Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. 2010 Neuroscience pmid:20036321
Sivasubramanian M et al. Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. 2015 Neuroscience pmid:25637806
Tabarean IV et al. Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons. 2006 Neuroscience pmid:16777343
Son H and Carpenter DO Protein kinase C activation is necessary but not sufficient for induction of long-term potentiation at the synapse of mossy fiber-CA3 in the rat hippocampus. 1996 Neuroscience pmid:8730701
Moore AN et al. Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. 1999 Neuroscience pmid:10579204
Khodorova A et al. The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor. 2017 Neuroscience pmid:27826102
Willaime-Morawek S et al. C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. 2003 Neuroscience pmid:12770554
Vitale ML et al. Protein kinase C activation by phorbol esters induces chromaffin cell cortical filamentous actin disassembly and increases the initial rate of exocytosis in response to nicotinic receptor stimulation. 1992 Neuroscience pmid:1281530
Wadman WJ and Connor JA Persisting modification of dendritic calcium influx by excitatory amino acid stimulation in isolated Ca1 neurons. 1992 Neuroscience pmid:1351266
Kanno T et al. Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. 2010 Neuroscience pmid:20950672
Schilling T et al. Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCa1 Ca(2+)-dependent K(+) channels. 2002 Neuroscience pmid:11927165
Chen YJ et al. Inflammation triggers production of dimethylsphingosine from oligodendrocytes. 2014 Neuroscience pmid:25151189
Lin N and Friedlander RM T-cell activation in ischemic stroke: a new therapeutic target for delayed infarct expansion? 2009 Neurosurgery pmid:19934952
Tani K et al. Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea. 2016 Neurotox Res pmid:26472207
Kwon OS et al. Biochemical and morphological effects of fumonisin B(1) on primary cultures of rat cerebrum. 2000 Jul-Aug Neurotoxicol Teratol pmid:10974595
Kwon OS et al. Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats. 1997 Mar-Apr Neurotoxicol Teratol pmid:9136132
Rojas-Charry L et al. Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. 2014 Neurotoxicology pmid:24792327
Arboleda G et al. Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death. 2010 Neurotoxicology pmid:20696185
Saucedo-García M et al. MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. 2011 New Phytol. pmid:21534970
Michaelson LV New insights into cell death induced by long chain bases in Arabidopsis. 2011 New Phytol. pmid:21834911
Islam MN et al. Sphingosine in plants--more riddles from the Sphinx? 2012 New Phytol. pmid:22070536
Ternes P et al. Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana. 2011 New Phytol. pmid:21883234
Lynch DV Evidence that sphingolipid signaling is involved in responding to low temperature. 2012 New Phytol. pmid:22364118
Dutilleul C et al. Phytosphingosine-phosphate is a signal for AtMPK6 activation and Arabidopsis response to chilling. 2012 New Phytol. pmid:22236066
Chiba K [A new therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)]. 2009 Nihon Rinsho Meneki Gakkai Kaishi pmid:19404007
Fujii T and Watanabe M [An additional role of FTY720 in chronic colitis]. 2009 Nihon Rinsho Meneki Gakkai Kaishi pmid:19252372
Hirafuji M et al. [Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells]. 2002 Nippon Yakurigaku Zasshi pmid:12491784
Muraki K et al. [Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues]. 2002 Nippon Yakurigaku Zasshi pmid:12491795
Chiba K and Yoshii N [Pharmacological properties and clinical efficacy of fingolimod hydrochloride (Imusera®/Gilenya®) for the treatment of multiple sclerosis]. 2012 Nippon Yakurigaku Zasshi pmid:22728990
Kishi H et al. [Involvement of Fyn tyrosine kinase and membrane rafts in the signal transduction in Ca2+-sensitization of vascular smooth muscle contraction]. 2007 Nippon Yakurigaku Zasshi pmid:17435334