| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Che W et al. | Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24032470 |
| Chang N et al. | Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell. | 2014 | J. Cell. Biochem. | pmid:24038457 |
| Weil BR and Canty JM | Ceramide signaling in the coronary microcirculation: a double-edged sword? | 2014 | Circ. Res. | pmid:25124322 |
| Lee H et al. | Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons. | 2014 | Nat Commun | pmid:25417698 |
| Tan KB et al. | Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia. | 2014 | Nanomedicine (Lond) | pmid:24294981 |
| Xing Y et al. | FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1. | 2014 | J Dig Dis | pmid:24868599 |
| Uhlig S et al. | Differential regulation of lung endothelial permeability in vitro and in situ. | 2014 | Cell. Physiol. Biochem. | pmid:24977477 |
| Alroughani R et al. | Multiple sclerosis reactivation postfingolimod cessation: is it IRIS? | 2014 | BMJ Case Rep | pmid:25320259 |
| Fayyaz S et al. | Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. | 2014 | Diabetologia | pmid:24292566 |
| Bridel C and Lalive PH | Update on multiple sclerosis treatments. | 2014 | Swiss Med Wkly | pmid:25247669 |
| Villamil Giraldo AM et al. | Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death. | 2014 | Biochem. Soc. Trans. | pmid:25233432 |
| Nagamatsu T et al. | Emerging roles for lysophospholipid mediators in pregnancy. | 2014 | Am. J. Reprod. Immunol. | pmid:24689547 |
| Ohotski J et al. | Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4. | 2014 | Cell. Signal. | pmid:24486401 |
| Tibboel J et al. | Sphingolipids in lung growth and repair. | 2014 | Chest | pmid:24394822 |
| Kułakowska A et al. | Increased levels of sphingosine-1-phosphate in cerebrospinal fluid of patients diagnosed with tick-borne encephalitis. | 2014 | J Neuroinflammation | pmid:25421616 |
| Dai L et al. | Sphingosine 1-phosphate: a potential molecular target for ovarian cancer therapy? | 2014 | Cancer Invest. | pmid:24499107 |
| Aliouane L et al. | Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1. | 2014 | Bioorg. Med. Chem. | pmid:25047939 |
| Takeshita E et al. | Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24486543 |
| Dai Z and Green TK | Synthesis of aromatic sphingosine analogues by diastereoselective amination of enantioenriched trans-γ,δ-unsaturated β-hydroxyesters. | 2014 | J. Org. Chem. | pmid:25046474 |
| Kamiya T et al. | Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro. | 2014 | Exp. Eye Res. | pmid:24486793 |
| Colombo E et al. | Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide. | 2014 | Ann. Neurol. | pmid:25043204 |
| Leanza L et al. | Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines. | 2014 | Curr. Pharm. Des. | pmid:23701546 |
| Wang F and Ye P | Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein. | 2014 | Lipids Health Dis | pmid:25339382 |
| Guo S et al. | Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen. | 2014 | Biochim. Biophys. Acta | pmid:24603322 |
| Keller J et al. | Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. | 2014 | Nat Commun | pmid:25333900 |
| Lepletier A et al. | Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease. | 2014 | PLoS Negl Trop Dis | pmid:25330249 |
| Tao C et al. | Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes. | 2014 | Best Pract. Res. Clin. Endocrinol. Metab. | pmid:24417945 |
| Bradley E et al. | Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration. | 2014 | PLoS ONE | pmid:25330231 |
| Park K et al. | The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. | 2014 | J. Nutr. Biochem. | pmid:24768661 |
| Ocwieja M et al. | Effect of fingolimod (FTY720) on cerebral blood flow, platelet function and macular thickness in healthy volunteers. | 2014 | Br J Clin Pharmacol | pmid:24976291 |
| Tan SJ et al. | Targeted anti-apoptosis activity for ovarian protection against chemotherapy-induced ovarian gonadotoxicity. | 2014 | Reprod. Biomed. Online | pmid:25246113 |
| Goñi FM et al. | Biophysical properties of sphingosine, ceramides and other simple sphingolipids. | 2014 | Biochem. Soc. Trans. | pmid:25233422 |
| Nagahashi M et al. | Sphingosine-1-phosphate transporters as targets for cancer therapy. | 2014 | Biomed Res Int | pmid:25133174 |
| Nguyen AV et al. | STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. | 2014 | World J. Gastroenterol. | pmid:25132744 |
| Deng Y et al. | Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy. | 2014 | Chin. Med. J. | pmid:25131242 |
| Ogle ME et al. | Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. | 2014 | Acta Biomater | pmid:25128750 |
| St John AL et al. | S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. | 2014 | Immunity | pmid:25238098 |
| Davis KM and Isberg RR | Plague's partners in crime. | 2014 | Immunity | pmid:25238090 |
| di Nuzzo L et al. | Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis. | 2014 | Drug Des Devel Ther | pmid:24876766 |
| van Rossum JA et al. | Fingolimod-induced asthma deterioration in a patient with relapsing-remitting multiple sclerosis. | 2014 | Mult. Scler. | pmid:24866203 |
| Imeri F et al. | Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. | 2014 | Neuropharmacology | pmid:24863045 |
| Rolin J and Maghazachi AA | Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. | 2014 | J. Leukoc. Biol. | pmid:24493826 |
| Marfia G et al. | Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells. | 2014 | Glia | pmid:25042636 |
| Fuerst E et al. | Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells. | 2014 | Allergy | pmid:25041788 |
| Murakami M et al. | Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment. | 2014 | Acta Biomater | pmid:25038462 |
| Park SJ et al. | Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4. | 2014 | Cell. Signal. | pmid:25035231 |
| Pippa R et al. | Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity. | 2014 | Leukemia | pmid:24781014 |
| Grammatikos G et al. | Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease. | 2014 | Biochim. Biophys. Acta | pmid:24769340 |
| Hait NC et al. | Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. | 2014 | Nat. Neurosci. | pmid:24859201 |
| van Echten-Deckert G et al. | Sphingosine-1-phosphate: boon and bane for the brain. | 2014 | Cell. Physiol. Biochem. | pmid:24977488 |
| Fayyaz S et al. | Divergent role of sphingosine 1-phosphate on insulin resistance. | 2014 | Cell. Physiol. Biochem. | pmid:24977487 |
| Halmer R et al. | Sphingolipids: important players in multiple sclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977485 |
| Laroni A et al. | Safety of the first dose of fingolimod for multiple sclerosis: results of an open-label clinical trial. | 2014 | BMC Neurol | pmid:24690227 |
| Arlt O et al. | Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. | 2014 | Cell. Physiol. Biochem. | pmid:24977479 |
| Sorensen PS | Effects of fingolimod in relapsing-remitting multiple sclerosis. | 2014 | Lancet Neurol | pmid:24685277 |
| Don AS et al. | Re-configuration of sphingolipid metabolism by oncogenic transformation. | 2014 | Biomolecules | pmid:24970218 |
| Calabresi PA et al. | Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial. | 2014 | Lancet Neurol | pmid:24685276 |
| Potì F et al. | Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P). | 2014 | Cardiovasc. Res. | pmid:24891400 |
| Chawla S et al. | Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypobaric hypoxia: assessment of haematological and metabolic effects. | 2014 | PLoS ONE | pmid:24887065 |
| Janes K et al. | The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. | 2014 | J. Biol. Chem. | pmid:24876379 |
| Silveira-Dorta G et al. | Direct stereoselective synthesis of enantiomerically pure anti-β-amino alcohols. | 2014 | J. Org. Chem. | pmid:24708186 |
| Tanaka K et al. | Individual profiles of free ceramide species and the constituent ceramide species of sphingomyelin and neutral glycosphingolipid and their alteration according to the sequential changes of environmental oxygen content in human colorectal cancer Caco-2 cells. | 2014 | Glycoconj. J. | pmid:24310545 |
| Giovannoni G and Naismith RT | Natalizumab to fingolimod washout in patients at risk of PML: when good intentions yield bad outcomes. | 2014 | Neurology | pmid:24610331 |
| Zhang GQ et al. | Sphingosine-1-phosphate receptors respond differently to early myocardial ischemia and ischemia-reperfusion in vivo. | 2014 | Sheng Li Xue Bao | pmid:24777407 |
| Jokubaitis VG et al. | Fingolimod after natalizumab and the risk of short-term relapse. | 2014 | Neurology | pmid:24610329 |
| Ceglarek U et al. | Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry. | 2014 | Clin. Chim. Acta | pmid:24768784 |
| Miyazaki Y et al. | Suppressed pro-inflammatory properties of circulating B cells in patients with multiple sclerosis treated with fingolimod, based on altered proportions of B-cell subpopulations. | 2014 | Clin. Immunol. | pmid:24607506 |
| Brizuela L et al. | Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells. | 2014 | Mol Oncol | pmid:24768038 |
| Seo YJ and Hahm B | Sphingosine analog AAL-R promotes activation of LCMV-infected dendritic cells. | 2014 | Viral Immunol. | pmid:24605791 |
| Masera S et al. | Occurrence of ecchymotic angioedema-like cutaneous lesions as a possible side effect of fingolimod. | 2014 | Mult. Scler. | pmid:24603883 |
| Jörns A et al. | Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes. | 2014 | J. Mol. Med. | pmid:24599515 |
| Gatfield J et al. | Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. | 2014 | Cell. Signal. | pmid:24704119 |
| Shin KO et al. | Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. | 2014 | Arch. Pharm. Res. | pmid:24687256 |
| Bird CH et al. | The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress. | 2014 | Cell Death Differ. | pmid:24488096 |
| Borge M et al. | The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406. | 2014 | J. Immunol. | pmid:25127862 |
| Swinnen E et al. | The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. | 2014 | Mol. Biol. Cell | pmid:24196832 |
| Nagahara Y et al. | Loss of Bcl-2 expression correlates with increasing sensitivity to apoptosis in differentiating ES cells. | 2014 | Cell Biol. Int. | pmid:24293136 |
| Kerage D et al. | Review: novel insights into the regulation of vascular tone by sphingosine 1-phosphate. | 2014 | Placenta | pmid:24411702 |
| Anthony DC et al. | Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model. | 2014 | Neuropharmacology | pmid:24412675 |
| Shen Z et al. | Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). | 2014 | Cell Stress Chaperones | pmid:24293320 |
| Fernández Ó et al. | [Usefulness of electronic drug registers: Spanish register of patients treated with fingolimod (Gilenya ®)]. | 2014 | Rev Neurol | pmid:24399624 |
| Chuang WL et al. | Lyso-sphingomyelin is elevated in dried blood spots of Niemann-Pick B patients. | 2014 | Mol. Genet. Metab. | pmid:24418695 |
| Mendes-Braz M et al. | The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. | 2014 | Liver Int. | pmid:24107124 |
| Egom EE | Sphingosine-1-phosphate signalling as a therapeutic target for patients with abnormal glucose metabolism and ischaemic heart disease. | 2014 | J Cardiovasc Med (Hagerstown) | pmid:23839592 |
| Voon V et al. | Fingolimod-induced atrioventricular conduction defects in a young lady with multiple sclerosis--insights into possible drug mechanism. | 2014 | Eur. J. Clin. Pharmacol. | pmid:24309839 |
| Di Pardo A et al. | FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease. | 2014 | Hum. Mol. Genet. | pmid:24301680 |
| Cha HJ et al. | Phytosphigosine-1-phosphate increases sensitivity of EGF-dependent cell proliferation. | 2014 | Int. J. Mol. Med. | pmid:24398588 |
| Wu YF et al. | First total synthesis of ganglioside DSG-A possessing neuritogenic activity. | 2014 | Org. Biomol. Chem. | pmid:25338766 |
| Hutchinson M et al. | Efficacy and safety of BG-12 (dimethyl fumarate) and other disease-modifying therapies for the treatment of relapsing-remitting multiple sclerosis: a systematic review and mixed treatment comparison. | 2014 | Curr Med Res Opin | pmid:24195574 |
| Spinedi A | Brefeldin A limits N-hexanoylsphingosine-induced accumulation of natural ceramide via the salvage pathway by enhancing glucosylation. | 2014 | Lipids | pmid:24194457 |
| Farhat M et al. | Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases. | 2014 | Cell Death Dis | pmid:24787013 |
| Pyszko J and Strosznajder JB | Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. | 2014 | Mol. Neurobiol. | pmid:24399507 |
| Wang XQ et al. | Sphingosylphosphorylcholine induces α-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P2 receptor and Rho/Rho-kinase pathway. | 2014 | Prostaglandins Other Lipid Mediat. | pmid:24614064 |
| Asle-Rousta M et al. | Prominence of central sphingosine-1-phosphate receptor-1 in attenuating aβ-induced injury by fingolimod. | 2014 | J. Mol. Neurosci. | pmid:25239520 |
| Cencetti F et al. | Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis. | 2014 | FEBS J. | pmid:25131845 |
| Wipfler P et al. | Natalizumab saturation: biomarker for individual treatment holiday after natalizumab withdrawal? | 2014 | Acta Neurol. Scand. | pmid:24032536 |
| Neuber C et al. | Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. | 2014 | Anal. Chem. | pmid:25137547 |
| Nishi T et al. | Molecular and physiological functions of sphingosine 1-phosphate transporters. | 2014 | Biochim. Biophys. Acta | pmid:23921254 |
| Ratajczak MZ et al. | The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells. | 2014 | Expert Opin. Ther. Targets | pmid:24188167 |
| Chawla S et al. | Exogenous sphingosine 1-phosphate protects murine splenocytes against hypoxia-induced injury. | 2014 | Lipids | pmid:24190514 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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