| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pereira JP et al. | A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. | 2010 | PLoS ONE | pmid:20174580 |
| Williams PA et al. | Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). | 2015 | PLoS ONE | pmid:25875493 |
| Doi Y et al. | Fingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons. | 2013 | PLoS ONE | pmid:23593505 |
| Richerioux N et al. | Rho-ROCK and Rac-PAK signaling pathways have opposing effects on the cell-to-cell spread of Marek's Disease Virus. | 2012 | PLoS ONE | pmid:22952878 |
| Soltau I et al. | Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. | 2016 | PLoS ONE | pmid:27973607 |
| Castillo-Badillo JA et al. | α1B-adrenergic receptors differentially associate with Rab proteins during homologous and heterologous desensitization. | 2015 | PLoS ONE | pmid:25799564 |
| Brulhart-Meynet MC et al. | Improving reconstituted HDL composition for efficient post-ischemic reduction of ischemia reperfusion injury. | 2015 | PLoS ONE | pmid:25781943 |
| Abdel Hadi L et al. | Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells. | 2015 | PLoS ONE | pmid:26580959 |
| Kowalski GM et al. | Plasma sphingosine-1-phosphate is elevated in obesity. | 2013 | PLoS ONE | pmid:24039766 |
| Young-Gqamana B et al. | Migalastat HCl reduces globotriaosylsphingosine (lyso-Gb3) in Fabry transgenic mice and in the plasma of Fabry patients. | 2013 | PLoS ONE | pmid:23472096 |
| Engel N et al. | Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. | 2017 | PLoS ONE | pmid:28125641 |
| Lin CC et al. | Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation. | 2015 | PLoS ONE | pmid:25734900 |
| Claes N et al. | Compositional changes of B and T cell subtypes during fingolimod treatment in multiple sclerosis patients: a 12-month follow-up study. | 2014 | PLoS ONE | pmid:25360562 |
| Hisano Y et al. | Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. | 2012 | PLoS ONE | pmid:22723910 |
| Breslin JW et al. | Involvement of local lamellipodia in endothelial barrier function. | 2015 | PLoS ONE | pmid:25658915 |
| Yamamoto R et al. | ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. | 2014 | PLoS ONE | pmid:25347187 |
| Bot M et al. | Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice. | 2013 | PLoS ONE | pmid:23700419 |
| Zhong Y et al. | Nephrokeli, a Chinese herbal formula, may improve IgA nephropathy through regulation of the sphingosine-1-phosphate pathway. | 2015 | PLoS ONE | pmid:25633986 |
| Berdyshev EV et al. | Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. | 2011 | PLoS ONE | pmid:21304987 |
| Mair N et al. | Genetic evidence for involvement of neuronally expressed S1Pâ‚ receptor in nociceptor sensitization and inflammatory pain. | 2011 | PLoS ONE | pmid:21359147 |
| Fryer RM et al. | The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1Pâ‚) and hypertension (S1P₃) in rat. | 2012 | PLoS ONE | pmid:23285242 |
| Gjoni E et al. | Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cells. | 2014 | PLoS ONE | pmid:25350564 |
| Kotelevets N et al. | Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis. | 2012 | PLoS ONE | pmid:22761740 |
| Meng H et al. | Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia. | 2011 | PLoS ONE | pmid:22096531 |
| Hamidi Shishavan M et al. | Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. | 2016 | PLoS ONE | pmid:27583547 |
| Al-Jarallah A et al. | High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists. | 2014 | PLoS ONE | pmid:25188469 |
| Snider AJ et al. | Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. | 2014 | PLoS ONE | pmid:25460165 |
| Nojima H et al. | Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. | 2016 | PLoS ONE | pmid:27551720 |
| Yu H et al. | Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis. | 2013 | PLoS ONE | pmid:24349009 |
| Das A et al. | Delivery of bioactive lipids from composite microgel-microsphere injectable scaffolds enhances stem cell recruitment and skeletal repair. | 2014 | PLoS ONE | pmid:25077607 |
| Chen L et al. | FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels. | 2014 | PLoS ONE | pmid:25050888 |
| Pacheco A et al. | C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. | 2013 | PLoS ONE | pmid:24040213 |
| Bradley E et al. | Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration. | 2014 | PLoS ONE | pmid:25330231 |
| Farahat WA et al. | Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures. | 2012 | PLoS ONE | pmid:22662145 |
| Spijkers LJ et al. | Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide. | 2011 | PLoS ONE | pmid:21818267 |
| Fernández-Pisonero I et al. | Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells. | 2014 | PLoS ONE | pmid:25275309 |
| Bachmaier K et al. | Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin. | 2012 | PLoS ONE | pmid:22355325 |
| Sassoli C et al. | Mesenchymal stromal cell secreted sphingosine 1-phosphate (S1P) exerts a stimulatory effect on skeletal myoblast proliferation. | 2014 | PLoS ONE | pmid:25264785 |
| Zhang XE et al. | Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. | 2016 | PLoS ONE | pmid:27187066 |
| Huwiler A et al. | A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. | 2011 | PLoS ONE | pmid:21829623 |
| Yang W et al. | Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. | 2014 | PLoS ONE | pmid:25188412 |
| Yin Z et al. | FTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart disease. | 2012 | PLoS ONE | pmid:22916176 |
| Mutch DM et al. | Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery. | 2009 | PLoS ONE | pmid:19936240 |
| Pritchard AJ et al. | Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures. | 2014 | PLoS ONE | pmid:24911000 |
| Liu Q et al. | Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. | 2012 | PLoS ONE | pmid:22848628 |
| Beckham TH et al. | Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. | 2013 | PLoS ONE | pmid:24098536 |
| Engel N et al. | Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A. | 2012 | PLoS ONE | pmid:23112854 |
| Mendes-da-Cruz DA et al. | Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. | 2014 | PLoS ONE | pmid:25068647 |
| Kujjo LL et al. | Chemotherapy-induced late transgenerational effects in mice. | 2011 | PLoS ONE | pmid:21437292 |
| Samarska IV et al. | S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes. | 2014 | PLoS ONE | pmid:24819611 |
| Kurano M et al. | Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. | 2017 | PLoS ONE | pmid:28494002 |
| Messias CV et al. | Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation. | 2016 | PLoS ONE | pmid:26824863 |
| Zeng X et al. | Topographical and biological evidence revealed FTY720-mediated anergy-polarization of mouse bone marrow-derived dendritic cells in vitro. | 2012 | PLoS ONE | pmid:22693544 |
| Rahman MM et al. | Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. | 2014 | PLoS ONE | pmid:24647471 |
| Riccitelli E et al. | Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. | 2013 | PLoS ONE | pmid:23826381 |
| Chawla S et al. | Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypobaric hypoxia: assessment of haematological and metabolic effects. | 2014 | PLoS ONE | pmid:24887065 |
| Wallington-Beddoe CT et al. | Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia. | 2012 | PLoS ONE | pmid:22570713 |
| Abu Khweek A et al. | The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. | 2016 | PLoS ONE | pmid:26741365 |
| Hawksworth JS et al. | Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swine. | 2012 | PLoS ONE | pmid:22558085 |
| O'Sullivan MJ et al. | Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. | 2014 | PLoS ONE | pmid:24743449 |
| Ejsing CS et al. | Quantitative Profiling of Long-Chain Bases by Mass Tagging and Parallel Reaction Monitoring. | 2015 | PLoS ONE | pmid:26660097 |
| Kondo S et al. | Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. | 2014 | PLoS ONE | pmid:24714781 |
| Bergvall N et al. | Relapse rates in patients with multiple sclerosis switching from interferon to fingolimod or glatiramer acetate: a US claims database study. | 2014 | PLoS ONE | pmid:24516663 |
| Al-Jarallah A and Oriowo M | The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. | 2017 | PLoS ONE | pmid:28493876 |
| Colabardini AC et al. | Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK. | 2013 | PLoS ONE | pmid:23472095 |
| Oizumi A et al. | Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. | 2014 | PLoS ONE | pmid:24586752 |
| Li CX et al. | FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells. | 2012 | PLoS ONE | pmid:22384233 |
| Yasuo M et al. | Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. | 2013 | PLoS ONE | pmid:23326540 |
| Tibolla G et al. | Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. | 2013 | PLoS ONE | pmid:23320105 |
| Yang CR et al. | The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes. | 2012 | PLoS ONE | pmid:22685609 |
| Finley A et al. | Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. | 2013 | PLoS ONE | pmid:23372844 |
| Japtok L et al. | Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. | 2012 | PLoS ONE | pmid:23145172 |
| Barnawi J et al. | Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). | 2015 | PLoS ONE | pmid:26485657 |
| Kalhori V et al. | Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1α in Thyroid Follicular Carcinoma Cells. | 2013 | PLoS ONE | pmid:23824493 |
| Hagihara K et al. | Fingolimod (FTY720) stimulates Ca(2+)/calcineurin signaling in fission yeast. | 2013 | PLoS ONE | pmid:24312601 |
| Wang W and Fromm M | Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes. | 2015 | PLoS ONE | pmid:25906159 |
| Loh KC et al. | Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. | 2012 | PLoS ONE | pmid:22606352 |
| Wang M et al. | Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. | 2017 | PLoS ONE | pmid:29136008 |
| Tran HB et al. | Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. | 2017 | PLoS ONE | pmid:29112690 |
| Mensah SA et al. | Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. | 2017 | PLoS ONE | pmid:29023478 |
| Lv H et al. | Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. | 2016 | PLoS ONE | pmid:26727592 |
| Zhao YD et al. | A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung. | 2015 | PLoS ONE | pmid:26317340 |
| Matheu MP et al. | Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. | 2013 | PLoS ONE | pmid:23533579 |
| Nicholas SE et al. | Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. | 2017 | PLoS ONE | pmid:28806736 |
| Punsawad C and Viriyavejakul P | Reduction in serum sphingosine 1-phosphate concentration in malaria. | 2017 | PLoS ONE | pmid:28666023 |
| Harp JR and Onami TM | Naïve T cells re-distribute to the lungs of selectin ligand deficient mice. | 2010 | PLoS ONE | pmid:20532047 |
| Lim M et al. | The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. | 2012 | PLoS ONE | pmid:22532844 |
| Jongsma M et al. | LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor. | 2011 | PLoS ONE | pmid:22195035 |
| Soleimani R et al. | Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. | 2011 | PLoS ONE | pmid:21559342 |
| Hui S et al. | Sphingosine-1-Phosphate Signaling Regulates Myogenic Responsiveness in Human Resistance Arteries. | 2015 | PLoS ONE | pmid:26367262 |
| Spampinato SF et al. | Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli? | 2015 | PLoS ONE | pmid:26197437 |
| Brunkhorst R et al. | FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke. | 2013 | PLoS ONE | pmid:23936150 |
| McGowan EM et al. | Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay. | 2011 | PLoS ONE | pmid:21673993 |
| Prakash H et al. | Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages. | 2010 | PLoS ONE | pmid:20498849 |
| El-Najjar N et al. | Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. | 2015 | PLoS ONE | pmid:26466367 |
| Holliday MW et al. | C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines. | 2013 | PLoS ONE | pmid:24040340 |
| Valverde O et al. | GPR3 receptor, a novel actor in the emotional-like responses. | 2009 | PLoS ONE | pmid:19259266 |
| Liesz A et al. | FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia. | 2011 | PLoS ONE | pmid:21701599 |
| Whitehead SN et al. | Imaging mass spectrometry detection of gangliosides species in the mouse brain following transient focal cerebral ischemia and long-term recovery. | 2011 | PLoS ONE | pmid:21687673 |
| Nishihara H et al. | Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis. | 2015 | PLoS ONE | pmid:25774903 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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