sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for sphingosine

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with sphingosine

Download all related citations
Per page 10 20 50 100 | Total 6563
Authors Title Published Journal PubMed Link
Reza F et al. Anti-idiotypic monoclonal antibody recognizes a consensus recognition site for phosphatidylserine in phosphatidylserine-specific monoclonal antibody and protein kinase C. 1994 FEBS Lett. pmid:8112460
Schneider JS and DiStefano L LIGA 20 increases striatal dopamine levels in aged MPTP-treated mice refractory to GM1 ganglioside treatment. 1993 Neuroreport pmid:8110995
Breittmayer JP et al. Regulation by sphingomyelinase and sphingosine of Ca2+ signals elicited by CD3 monoclonal antibody, thapsigargin, or ionomycin in the Jurkat T cell line. 1994 J. Biol. Chem. pmid:8106482
Schroeder JJ et al. Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. 1994 J. Biol. Chem. pmid:8106389
Mattie M et al. Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. 1994 J. Biol. Chem. pmid:8106352
Hansen AB et al. Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells. 1993 APMIS pmid:8103344
Soares-da-Silva P Renal tubular dopamine outward transfer during Na(+)-H+ exchange activation by alpha 1- and alpha 2-adrenoceptor agonists. 1993 Br. J. Pharmacol. pmid:8102930
Ghosh TK et al. Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. 1994 J. Biol. Chem. pmid:8077214
Murphy NP et al. Is protein kinase C activity required for the N-methyl-D-aspartate-evoked rise in cytosolic Ca2+ in mouse striatal neurons? 1994 Eur. J. Neurosci. pmid:8075826
Cho Y and Ziboh VA Expression of protein kinase C isozymes in guinea pig epidermis: selective inhibition of PKC-beta activity by 13-hydroxyoctadecadienoic acid-containing diacylglycerol. 1994 J. Lipid Res. pmid:8071613
Hudson PL et al. Modulation by sphingolipids of calcium signals evoked by epidermal growth factor. 1994 J. Biol. Chem. pmid:8063833
Zhao C et al. Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity. 1994 J. Biol. Chem. pmid:8063782
Scita G and Wolf G The effect of sphingosine on the release of fibronectin from human lung fibroblasts. 1994 Biochim. Biophys. Acta pmid:8061052
Natarajan V et al. Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate. 1994 Am. J. Respir. Cell Mol. Biol. pmid:8049083
Larivée P et al. Platelet-activating factor induces airway mucin release via activation of protein kinase C: evidence for translocation of protein kinase C to membranes. 1994 Am. J. Respir. Cell Mol. Biol. pmid:8049080
Olivera A et al. Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation. 1994 J. Biol. Chem. pmid:8027049
Kharlamov A et al. LIGA20, a lyso derivative of ganglioside GM1, given orally after cortical thrombosis reduces infarct size and associated cognition deficit. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8022776
Kiss Z and Anderson WH Selective down-regulation of protein kinase c-epsilon by carcinogens does not prevent stimulation of phospholipase D by phorbol ester and platelet-derived growth factor. 1994 Biochem. J. pmid:8010956
Dettbarn CA et al. Modulation of cardiac sarcoplasmic reticulum ryanodine receptor by sphingosine. 1994 J. Mol. Cell. Cardiol. pmid:8006984
Ohta H et al. A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils. 1994 FEBS Lett. pmid:7988686
Meivar-Levy I et al. Analysis of glucocerebrosidase activity using N-(1-[14C]hexanoyl)-D-erythroglucosylsphingosine demonstrates a correlation between levels of residual enzyme activity and the type of Gaucher disease. 1994 Biochem. J. pmid:7980395
Kai H et al. Involvement of protein kinase C in mucus secretion by hamster tracheal epithelial cells in culture. 1994 Am. J. Physiol. pmid:7977763
McDonough PM et al. Control of cardiac Ca2+ levels. Inhibitory actions of sphingosine on Ca2+ transients and L-type Ca2+ channel conductance. 1994 Circ. Res. pmid:7955152
Chiang TM Activation of phospholipase D in human platelets by collagen and thrombin and its relationship to platelet aggregation. 1994 Biochim. Biophys. Acta pmid:7948037
Kiss Z et al. Phorbol ester selectively stimulates the phospholipase D-mediated hydrolysis of phosphatidylethanolamine in multidrug-resistant MCF-7 human breast carcinoma cells. 1994 Biochem. J. pmid:7945188
Lerner RA et al. Cerebrodiene: a brain lipid isolated from sleep-deprived cats. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7937797
Zhou XM et al. Modulation of adenylylcyclase by protein kinase C in human neurotumor SK-N-MC cells: evidence that the alpha isozyme mediates both potentiation and desensitization. 1994 J. Neurochem. pmid:7931287
Zimber A et al. Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro. 1994 Int. J. Cancer pmid:7927907
Riboni L et al. Formation of bioactive sphingoid molecules from exogenous sphingomyelin in primary cultures of neurons and astrocytes. 1994 FEBS Lett. pmid:7925994
Kõiv A and Kinnunen PK Binding of DNA to liposomes containing different derivatives of sphingosine. 1994 Chem. Phys. Lipids pmid:7923481
Pandol SJ et al. Sphingosine regulates Ca(2+)-ATPase and reloading of intracellular Ca2+ stores in the pancreatic acinar cell. 1994 Biochim. Biophys. Acta pmid:7918564
López-García F et al. A phase behavior study of mixtures of sphingosine with zwitterionic phospholipids. 1994 Biochim. Biophys. Acta pmid:7918541
Boumendjel A and Miller SP Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. 1994 J. Lipid Res. pmid:7897327
Hanada K et al. Both sphingolipids and cholesterol participate in the detergent insolubility of alkaline phosphatase, a glycosylphosphatidylinositol-anchored protein, in mammalian membranes. 1995 J. Biol. Chem. pmid:7890763
Kim S et al. Sphingolipid-gated Ca2+ release from intracellular stores of endothelial cells is mediated by a novel Ca(2+)-permeable channel. 1995 J. Biol. Chem. pmid:7890637
Jones MJ and Murray AW Evidence that ceramide selectively inhibits protein kinase C-alpha translocation and modulates bradykinin activation of phospholipase D. 1995 J. Biol. Chem. pmid:7890607
Olivera A et al. Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases. 1994 Anal. Biochem. pmid:7887476
Slomiany A and Slomiany BL Blood-group (A + H) fucolipids--a new group of complex glycosphingolipids. 1978 FEBS Lett. pmid:78860
Knöfler R et al. N,N,N-trimethylsphingosine modifies aggregatory response and ATP release from platelets in whole blood. 1994 Thromb. Res. pmid:7871492
Webster RJ et al. Sphingosine effects on the contractile behavior of skinned cardiac myocytes. 1994 J. Mol. Cell. Cardiol. pmid:7869389
Robson KJ et al. 6-Hydroxy-4-sphingenine in human epidermal ceramides. 1994 J. Lipid Res. pmid:7868984
Ohta H et al. Quantification of free sphingosine in cultured cells by acylation with radioactive acetic anhydride. 1994 Anal. Biochem. pmid:7864378
Qian J et al. Involvement of protein kinase C in the axonal growth-promoting effect on spinal cord neurons by target-derived astrocytes. 1994 J. Neurobiol. pmid:7861122
Wong K et al. N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx. 1995 J. Biol. Chem. pmid:7852386
Yamaguchi Y et al. The synthetic pathway for glucosylsphingosine in cultured fibroblasts. 1994 J. Biochem. pmid:7852294
Maneckjee R and Minna JD Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. 1994 Cell Growth Differ. pmid:7848904
Gniadecki R A vitamin D analogue KH 1060 activates the protein kinase C-c-fos signalling pathway to stimulate epidermal proliferation in murine skin. 1994 J. Endocrinol. pmid:7836898
Divecha N and Irvine RF Phospholipid signaling. 1995 Cell pmid:7834746
Ohta H et al. Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. 1995 Cancer Res. pmid:7834642
Slack BE et al. Phorbol ester stimulates choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C alpha. 1995 Biochem. J. pmid:7832781
Suh HW et al. Expression of the proenkephalin A gene and [Met5]-enkephalin secretion induced by arachidonic acid in bovine adrenal medullary chromaffin cells: involvement of second messengers. 1995 J. Neurochem. pmid:7830054
Bennett GS et al. Differential sensitivity to inhibitors discriminates between two types of kinases responsible for in vivo phosphorylation of different sites in the carboxy-terminal tail of chicken neurofilament-M. 1994 Mol. Cell. Neurosci. pmid:7804606
Terrian DM and Ways DK Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly. 1995 J. Neurochem. pmid:7798912
Yatomi Y et al. Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets. 1995 Blood pmid:7795224
López-García F et al. Effect of sphingosine and stearylamine on the interaction of phosphatidylserine with calcium. A study using DSC, FT-IR and 45Ca(2+)-binding. 1995 Biochim. Biophys. Acta pmid:7794967
Bornfeldt KE et al. Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. 1995 J. Cell Biol. pmid:7790372
Boiron-Sargueil F et al. Cerebroside formation in the peripheral nervous system of normal and Trembler mice. 1995 Neurosci. Lett. pmid:7783943
Kiss Z and Deli E Preferential inhibition of phorbol ester-induced hydrolysis of phosphatidylethanolamine by N-acetylsphingosine in NIH 3T3 fibroblasts. 1995 FEBS Lett. pmid:7781767
Xu Y et al. Effect of lysophospholipids on signaling in the human Jurkat T cell line. 1995 J. Cell. Physiol. pmid:7775587
Strum JC et al. Ceramide triggers meiotic cell cycle progression in Xenopus oocytes. A potential mediator of progesterone-induced maturation. 1995 J. Biol. Chem. pmid:7768956
Hanafin NM et al. Increased PKC activity in cultured human keratinocytes and fibroblasts after treatment with 1 alpha, 25-dihydroxyvitamin D3. 1995 J. Cell. Biochem. pmid:7759571
Law B and Rossie S The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide. 1995 J. Biol. Chem. pmid:7759536
Laviada ID et al. Phosphatidylcholine-phospholipase C mediates the induction of nerve growth factor in cultured glial cells. 1995 FEBS Lett. pmid:7758586
Flitsch SL et al. The chemoenzymatic synthesis of neoglycolipids and lipid-linked oligosaccharides using glycosyltransferases. 1994 Bioorg. Med. Chem. pmid:7757420
Sofer A and Futerman AH Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP. 1995 J. Biol. Chem. pmid:7744860
Wu J et al. Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism. 1995 J. Biol. Chem. pmid:7744787
Müller G et al. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid. 1995 EMBO J. pmid:7744003
Ridgway ND and Merriam DL Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells. 1995 Biochim. Biophys. Acta pmid:7742357
Ridgway ND Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide. 1995 Biochim. Biophys. Acta pmid:7742354
Lister MD et al. Interaction of sphingomyelinase with sphingomyelin analogs modified at the C-1 and C-3 positions of the sphingosine backbone. 1995 Biochim. Biophys. Acta pmid:7742352
Persat F et al. Free ceramides of Echinococcus multilocularis metacestodes. 1995 Biochim. Biophys. Acta pmid:7734444
Jalink K et al. Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis. 1995 Biochem. J. pmid:7733903
Goodemote KA et al. Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate. 1995 J. Biol. Chem. pmid:7730331
Hung CY et al. Temperature-induced alteration of inositolphosphorylceramides in the putative glycosylated lipid precursors of Tetrahymena mimbres glycosylphosphatidylinositol-anchored proteins. 1995 Biochem. J. pmid:7717964
Pedrera C et al. Receptor-independent mechanisms are involved in the priming of neutrophil's oxidase by vasoactive intestinal peptide. 1994 Regul. Pept. pmid:7716283
Huang C et al. Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungal encoded toxin which is a carcinogen. 1995 Cancer Res. pmid:7712470
Dettbarn C et al. Involvement of ryanodine receptors in sphingosylphosphorylcholine-induced calcium release from brain microsomes. 1995 Brain Res. pmid:7712168
Sanguedolce MV et al. Zymosan-induced tyrosine phosphorylations in human monocytes. Role of protein kinase C. 1993 J. Immunol. pmid:7686943
Durieux ME et al. Responses to sphingosine-1-phosphate in X. laevis oocytes: similarities with lysophosphatidic acid signaling. 1993 Am. J. Physiol. pmid:7684565
Hui EK and Yung BY Cell cycle phase-dependent effect of retinoic acid on the induction of granulocytic differentiation in HL-60 promyelocytic leukemia cells. Evidence for sphinganine potentiation of retinoic acid-induced differentiation. 1993 FEBS Lett. pmid:7680007
Liu R et al. Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. 1995 Biochem. Biophys. Res. Commun. pmid:7677781
Zorn NE and Sauro MD Retinoic acid induces translocation of protein kinase C (PKC) and activation of nuclear PKC (nPKC) in rat splenocytes. 1995 Int. J. Immunopharmacol. pmid:7672881
Ridgway ND 25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells. 1995 J. Lipid Res. pmid:7666011
Kedderis LB et al. Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents. 1995 Fundam Appl Toxicol pmid:7665004
Dbaibo GS et al. Activation of a retinoblastoma-protein-dependent pathway by sphingosine. 1995 Biochem. J. pmid:7654183
Ramasamy S et al. Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. 1995 Toxicol. Appl. Pharmacol. pmid:7645031
Smith ER and Merrill AH Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture. 1995 J. Biol. Chem. pmid:7642524
Kasinathan C et al. Effect of lipids on glycoprotein sulphotransferase activity in rat submandibular salivary glands. 1995 Arch. Oral Biol. pmid:7639646
Morris RC et al. Activation of transfer RNA-guanine ribosyltransferase by protein kinase C. 1995 Nucleic Acids Res. pmid:7630727
Akanuma H and Kishimoto Y Synthesis of ceramides and cerebrosides containing both alpha-hydroxy and nonhydroxy fatty acids from lignoceroyl-CoA by rat brain microsomes. 1979 J. Biol. Chem. pmid:762114
Rajewski RA et al. Stereo-specific analysis of a novel protein kinase C inhibitor. 1995 J Pharm Biomed Anal pmid:7619884
Lau B and Macdonald PM Determination of the pKa of membrane-bound N,N-dimethylsphingosine using deuterium NMR spectroscopy. 1995 Biochim. Biophys. Acta pmid:7619840
Kisic A et al. Sphingolipid bases. A revisitation of the O-methyl derivatives of sphingosine. Isolation and characterization of diacetate derivatives, with revised 13C nuclear magnetic resonance assignments for D-erythro-sphingosine. 1995 J. Lipid Res. pmid:7616124
Berger A et al. Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7597047
Sawai H et al. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. 1995 J. Biol. Chem. pmid:7592995
Riboni L et al. A mediator role of ceramide in the regulation of neuroblastoma Neuro2a cell differentiation. 1995 J. Biol. Chem. pmid:7592930
Sachs CW et al. Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. 1995 J. Biol. Chem. pmid:7592889
Okajima F and Kondo Y Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids. 1995 J. Biol. Chem. pmid:7592844
Gómez-Muñoz A et al. Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity. 1995 J. Biol. Chem. pmid:7592842
Seufferlein T and Rozengurt E Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway. 1995 J. Biol. Chem. pmid:7592646