| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Farnoud AM et al. | The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway. | 2015 | Infect. Immun. | pmid:25895971 |
| Chimen M et al. | Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. | 2015 | Nat. Med. | pmid:25894827 |
| Rosini JM et al. | Delayed cardiac dysrhythmias after fingolimod administration. | 2015 | Am J Emerg Med | pmid:25669873 |
| He A et al. | Comparison of switch to fingolimod or interferon beta/glatiramer acetate in active multiple sclerosis. | 2015 | JAMA Neurol | pmid:25665031 |
| Stüve O and Centonze D | Treatment decisions for patients with active multiple sclerosis. | 2015 | JAMA Neurol | pmid:25664937 |
| Sellebjerg F and Sørensen PS | Therapeutic interference with leukocyte recirculation in multiple sclerosis. | 2015 | Eur. J. Neurol. | pmid:25582213 |
| Carreira AC et al. | Tackling the biophysical properties of sphingolipids to decipher their biological roles. | 2015 | Biol. Chem. | pmid:25581755 |
| Martin TJ and Sims NA | Calcitonin physiology, saved by a lysophospholipid. | 2015 | J. Bone Miner. Res. | pmid:25581311 |
| Riley RT et al. | A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. | 2015 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:25833119 |
| Airas L et al. | In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis. | 2015 | J. Nucl. Med. | pmid:25572093 |
| Proia RL and Hla T | Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. | 2015 | J. Clin. Invest. | pmid:25831442 |
| Lee SY et al. | Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice. | 2015 | Hepatology | pmid:25808625 |
| Wehinger S et al. | Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells. | 2015 | Biochim. Biophys. Acta | pmid:25572853 |
| Salama MF et al. | A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. | 2015 | FASEB J. | pmid:25805832 |
| Potì F et al. | SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet. | 2015 | Atherosclerosis | pmid:25801013 |
| Castillo-Badillo JA et al. | α1B-adrenergic receptors differentially associate with Rab proteins during homologous and heterologous desensitization. | 2015 | PLoS ONE | pmid:25799564 |
| Hsu CK et al. | Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. | 2015 | J. Cell. Physiol. | pmid:25201048 |
| Rhee SH et al. | Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall. | 2015 | J Obstet Gynaecol | pmid:25692679 |
| Tay KH et al. | Involvement of vacuolar H(+)-ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720. | 2015 | Pigment Cell Melanoma Res | pmid:25358761 |
| Ji F et al. | K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25680461 |
| Holmes D | Bone: Key role for S1P in bone remodelling. | 2015 | Nat Rev Endocrinol | pmid:25350065 |
| Breslin JW et al. | Involvement of local lamellipodia in endothelial barrier function. | 2015 | PLoS ONE | pmid:25658915 |
| Grammatikos G et al. | Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in hepatitis C virus but not hepatitis B virus infection. | 2015 | Hepatology | pmid:25348752 |
| Othman A et al. | Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats. | 2015 | Diabetes | pmid:25277395 |
| Kurek K et al. | Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia. | 2015 | Lipids | pmid:25595595 |
| Chen LY et al. | The Arabidopsis alkaline ceramidase TOD1 is a key turgor pressure regulator in plant cells. | 2015 | Nat Commun | pmid:25591940 |
| Zhang L et al. | Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer. | 2015 | Clin. Cancer Res. | pmid:25589614 |
| Chavez A et al. | S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness. | 2015 | J. Cell. Sci. | pmid:25588843 |
| Woszczek G and Fuerst E | Ca2+ mobilization assays in GPCR drug discovery. | 2015 | Methods Mol. Biol. | pmid:25563178 |
| Esaki K et al. | L-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation. | 2015 | J. Biol. Chem. | pmid:25903138 |
| Roviezzo F et al. | S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. | 2015 | Br. J. Pharmacol. | pmid:25439580 |
| Pyne NJ and Kolesnick RN | The life and work of Dr. Robert Bittman (1942-2014). | 2015 | Biol. Chem. | pmid:25473803 |
| Hashimoto Y et al. | Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte. | 2015 | Mol. Cell. Biochem. | pmid:25445169 |
| Carroll B et al. | Sphingolipids in the DNA damage response. | 2015 | Adv Biol Regul | pmid:25434743 |
| Benesch MG et al. | Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate. | 2015 | J. Lipid Res. | pmid:25896349 |
| Moon MH et al. | Activation of S1P2 receptor, a possible mechanism of inhibition of adipogenic differentiation by sphingosine 1‑phosphate. | 2015 | Mol Med Rep | pmid:25351259 |
| Zhu Z et al. | Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria. | 2015 | Brain Res. | pmid:25998538 |
| Landi D et al. | Oral fingolimod reduces glutamate-mediated intracortical excitability in relapsing-remitting multiple sclerosis. | 2015 | Clin Neurophysiol | pmid:25022794 |
| Di Bartolomeo S et al. | Differential apoptotic effect and metabolism of N-acetylsphingosine and N-hexanoylsphingosine in CHP-100 human neurotumor cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25656578 |
| Mani R et al. | Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia. | 2015 | Leukemia | pmid:24947019 |
| Gómez-Torres MJ et al. | Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization. | 2015 | Reprod. Biol. Endocrinol. | pmid:26553294 |
| Wysoczynski M et al. | Identification of heme oxygenase 1 (HO-1) as a novel negative regulator of mobilization of hematopoietic stem/progenitor cells. | 2015 | Stem Cell Rev | pmid:25086571 |
| Hadaczek P et al. | GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. | 2015 | Exp. Neurol. | pmid:25448159 |
| Fogarty CE and Bergmann A | The Sound of Silence: Signaling by Apoptotic Cells. | 2015 | Curr. Top. Dev. Biol. | pmid:26431570 |
| Burow P et al. | Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages. | 2015 | Pflugers Arch. | pmid:24965069 |
| Denli M et al. | Efficacy of AdiDetoxâ„¢ in reducing the toxicity of fumonisin B1 in rats. | 2015 | Food Chem. Toxicol. | pmid:25660482 |
| Abdel-Latif A et al. | Lysophospholipids in coronary artery and chronic ischemic heart disease. | 2015 | Curr. Opin. Lipidol. | pmid:26270808 |
| Oskeritzian CA | Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer. | 2015 | Mol. Immunol. | pmid:24766823 |
| Cuvillier O | [SphingomabTM, an anti-sphingosine 1-phosphate antibody to inhibit hypoxia]. | 2015 | Med Sci (Paris) | pmid:26576602 |
| Moon E et al. | Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling. | 2015 | Mediators Inflamm. | pmid:26576074 |
| Tang H et al. | Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits. | 2015 | Acta Cir Bras | pmid:26560422 |
| Zhao C et al. | Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts. | 2015 | Mediators Inflamm. | pmid:26556954 |
| Deng Z et al. | Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. | 2015 | Nat Commun | pmid:25907800 |
| Kassmer SH et al. | Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. | 2015 | Nat Commun | pmid:26456232 |
| Megson ZA et al. | Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol. | 2015 | Biochim. Biophys. Acta | pmid:26277409 |
| Hoffmann FS et al. | Fingolimod induces neuroprotective factors in human astrocytes. | 2015 | J Neuroinflammation | pmid:26419927 |
| Sattler K et al. | Defects of High-Density Lipoproteins in Coronary Artery Disease Caused by Low Sphingosine-1-Phosphate Content: Correction by Sphingosine-1-Phosphate-Loading. | 2015 | J. Am. Coll. Cardiol. | pmid:26403344 |
| Poulsen C et al. | Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells. | 2015 | Toxicol. Lett. | pmid:26005054 |
| Wang W and Fromm M | Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes. | 2015 | PLoS ONE | pmid:25906159 |
| Kim ES et al. | A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells. | 2015 | Chem. Biol. Interact. | pmid:25980589 |
| Boczkowska-Radziwon B et al. | Ozonation of human blood increases sphingosine-1-phosphate in plasma. | 2015 | J. Physiol. Pharmacol. | pmid:25903957 |
| Cheng Y et al. | Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. | 2015 | FASEB J. | pmid:25690654 |
| Piccolini VM et al. | Cerebellum neurotransmission during postnatal development: [Pt(O,O'-acac)(γ-acac)(DMS)] vs cisplatin and neurotoxicity. | 2015 | Int. J. Dev. Neurosci. | pmid:25450526 |
| Liu H et al. | [Effect of C8-ceramide on apoptosis of alveolar type II epithelial cells]. | 2015 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:26702858 |
| Cantalupo A et al. | Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. | 2015 | Nat. Med. | pmid:26301690 |
| Adamiak M et al. | Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow. | 2015 | Oncotarget | pmid:26299919 |
| Mori H et al. | Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis. | 2015 | Am. J. Pathol. | pmid:26272361 |
| Camp SM et al. | Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720. | 2015 | Chem. Phys. Lipids | pmid:26272033 |
| Murakami S et al. | Producing human ceramide-NS by metabolic engineering using yeast Saccharomyces cerevisiae. | 2015 | Sci Rep | pmid:26573460 |
| Galvani S et al. | HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. | 2015 | Sci Signal | pmid:26268607 |
| Badimon JJ and Santos-Gallego CG | HDL Dysfunction: Is the Answer in the Sphinx's Riddle? | 2015 | J. Am. Coll. Cardiol. | pmid:26403345 |
| Biegelmeyer R et al. | Sphingosines Derived from Marine Sponge as Potential Multi-Target Drug Related to Disorders in Cancer Development. | 2015 | Mar Drugs | pmid:26308014 |
| Vettorazzi S et al. | Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. | 2015 | Nat Commun | pmid:26183376 |
| Michels M et al. | Decreased plasma levels of the endothelial protective sphingosine-1-phosphate are associated with dengue-induced plasma leakage. | 2015 | J. Infect. | pmid:26183296 |
| Checa A et al. | Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment. | 2015 | Sci Rep | pmid:26174087 |
| Schaffert SA et al. | mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. | 2015 | J. Immunol. | pmid:26163591 |
| Gao Y et al. | Sphingosine kinase 1 as an anticancer therapeutic target. | 2015 | Drug Des Devel Ther | pmid:26150697 |
| Denimal D et al. | Significant abnormalities of the HDL phosphosphingolipidome in type 1 diabetes despite normal HDL cholesterol concentration. | 2015 | Atherosclerosis | pmid:26142685 |
| Garcia V et al. | A novel jaspine B-ceramide hybrid modulates sphingolipid metabolism. | 2015 | Chem. Biodivers. | pmid:26172331 |
| Yagi K et al. | Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage. | 2015 | Stroke | pmid:26138121 |
| Kundooru S et al. | Substrate and stereocontrolled iodocycloetherification of highly functionalized enantiomerically pure allylic alcohols: application to synthesis of cytotoxic 2-epi jaspine B and its biological evaluation. | 2015 | Org. Biomol. Chem. | pmid:26133669 |
| Kappos L et al. | Switching from natalizumab to fingolimod: A randomized, placebo-controlled study in RRMS. | 2015 | Neurology | pmid:26024899 |
| Stüve O and Bourdette D | Natalizumab to fingolimod: Questions answered, unanswered, and unasked. | 2015 | Neurology | pmid:26024898 |
| Nejrup RG et al. | Lipid hydrolysis products affect the composition of infant gut microbial communities in vitro. | 2015 | Br. J. Nutr. | pmid:25992463 |
| Książek M et al. | Sources, metabolism, and regulation of circulating sphingosine-1-phosphate. | 2015 | J. Lipid Res. | pmid:26014962 |
| Liu G et al. | Specific chemotherapeutic agents induce metastatic behaviour through stromal- and tumour-derived cytokine and angiogenic factor signalling. | 2015 | J. Pathol. | pmid:25988668 |
| Berger B et al. | Severe disease reactivation in four patients with relapsing-remitting multiple sclerosis after fingolimod cessation. | 2015 | J. Neuroimmunol. | pmid:25903738 |
| Hyder CL et al. | Sphingolipids inhibit vimentin-dependent cell migration. | 2015 | J. Cell. Sci. | pmid:25908861 |
| Zhang JN et al. | The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction. | 2015 | Bone | pmid:25988659 |
| Rossman IT and Cohen JA | Multiple sclerosis: Switching sides--fingolimod versus injectable MS therapies. | 2015 | Nat Rev Neurol | pmid:25896088 |
| Shaifta Y et al. | Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species. | 2015 | Cardiovasc. Res. | pmid:25661082 |
| Parham KA et al. | Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis. | 2015 | FASEB J. | pmid:25985799 |
| Shirao S et al. | A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts. | 2015 | J. Cereb. Blood Flow Metab. | pmid:25605290 |
| Lei YC et al. | Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells. | 2015 | World J. Gastroenterol. | pmid:26676341 |
| Fujiwara M et al. | Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720. | 2015 | Clin. Immunol. | pmid:25829233 |
| Shaikh RS et al. | Synthesis and evaluation of fluorinated fingolimod (FTY720) analogues for sphingosine-1-phosphate receptor molecular imaging by positron emission tomography. | 2015 | J. Med. Chem. | pmid:25826109 |
| Camaré C et al. | Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. | 2015 | Br. J. Pharmacol. | pmid:25176316 |
| Bielekova B and McDermott MP | Will CSF biomarkers guide future therapeutic decisions in multiple sclerosis? | 2015 | Neurology | pmid:25809305 |
| Kuhle J et al. | Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis. | 2015 | Neurology | pmid:25809304 |
| Kappos L et al. | Long-term effects of fingolimod in multiple sclerosis: the randomized FREEDOMS extension trial. | 2015 | Neurology | pmid:25795646 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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