sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Maiese K et al. Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia. 1993 J. Neurosci. Res. pmid:8230323
López-García F et al. Interaction of sphingosine and stearylamine with phosphatidylserine as studied by DSC and NMR. 1993 Biochim. Biophys. Acta pmid:8241241
Katoh N Modulation by sphingosine of substrate phosphorylation by protein kinase C in bovine mammary gland. 1993 Lipids pmid:8246685
Yung BY and Hui EK Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells. 1993 Biochem. Biophys. Res. Commun. pmid:8250895
Skaper SD et al. A semisynthetic glycosphingolipid (LIGA20) reduces 2,4, 5-trihydroxyphenylalanine neurotoxicity in primary neuronal cultures. 1993 Eur. J. Pharmacol. pmid:8253129
Härmälä AS et al. Sphingosine inhibits sphingomyelinase-induced cholesteryl ester formation in cultured fibroblasts. 1993 Biochim. Biophys. Acta pmid:8257725
Merrill AH et al. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. 1993 J. Biol. Chem. pmid:8262970
Perillo MA et al. Molecular parameters of semisynthetic derivatives of gangliosides and sphingosine in monolayers at the air-water interface. 1993 Chem. Phys. Lipids pmid:8269552
Uemura K et al. Inhibition of neurite outgrowth in neuroblastoma cells by sphingosine. 1993 J. Biochem. pmid:8276777
Pahlavan P et al. Role of protein kinase C in the adaptive increase in Na-H antiporter in respiratory acidosis. 1993 J. Am. Soc. Nephrol. pmid:8286716
Mazurek N et al. Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note. 1994 Biochem. Biophys. Res. Commun. pmid:8292009
Seren MS et al. Orally administered glycolipid derivative LIGA20 reduces infarct volume and behavioral impairment after focal cerebral ischemia. 1994 J. Pharmacol. Exp. Ther. pmid:8301588
Lavie Y et al. Formation of endogenous free sphingoid bases in cells induced by changing medium conditions. 1994 Biochim. Biophys. Acta pmid:8305506
Persat F et al. Gangliosides of Echinococcus multilocularis metacestodes. 1994 Biochim. Biophys. Acta pmid:8312377
Wu WI et al. Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. 1993 J. Biol. Chem. pmid:8314751
David MJ et al. Characterization of gangliosides from normal and osteoarthritic human articular cartilage. 1993 Arthritis Rheum. pmid:8318040
Sitges M and Talamo BR Sphingosine, W-7, and trifluoperazine inhibit the elevation in cytosolic calcium induced by high K+ depolarization in synaptosomes. 1993 J. Neurochem. pmid:8336133
Stewart SJ et al. Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C. 1993 Cell. Signal. pmid:8347422
Crow T and Forrester J Protein kinase inhibitors do not block the expression of established enhancement in identified Hermissenda B-photoreceptors. 1993 Brain Res. pmid:8348304
Wong K and Kwan-Yeung L Sphingosine mobilizes intracellular calcium in human neutrophils. 1993 Cell Calcium pmid:8358772
Pushkareva MYu A et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. 1993 Biochem. J. pmid:8379926
Torossian K et al. Phorbol esters inhibit insulin-induced receptor down-regulation in cultured human lymphocytes: association with diminished insulin receptor autophosphorylation. 1993 Biochem. J. pmid:8382476
Burgers JA and Akkerman JW Regulation of the receptor for platelet-activating factor on human platelets. 1993 Biochem. J. pmid:8385926
Zoukhri D et al. Phorbol ester-stimulated exocytosis in lacrimal gland: PKC might not be the sole effector. 1993 Am. J. Physiol. pmid:8386449
Thomas DJ et al. Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate. 1993 Metab. Clin. Exp. pmid:8387623
Desai NN et al. Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. 1993 J. Cell Biol. pmid:8389770
Ogawa A et al. Na+/H+ exchange activity induced by thrombin is not inhibited by protein kinase inhibitors, staurosporine, K-252a, H-7 and sphingosine, in human platelets. 1993 Thromb. Res. pmid:8391729
Olivera A and Spiegel S Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. 1993 Nature pmid:8413613
Mangin EL et al. Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. 1993 Circ. Res. pmid:8417838
Pinkerton FD et al. D-erythro-sphingosine lowers 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Chinese hamster ovary cells. 1993 Biochem. Biophys. Res. Commun. pmid:8422261
Riley RT et al. Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. 1993 Toxicol. Appl. Pharmacol. pmid:8430417
Clarke BL et al. Regulation of parathyroid hormone release by protein kinase-C is dependent on extracellular calcium in bovine parathyroid cells. 1993 Endocrinology pmid:8440177
Archibald DD and Mann S Structural studies of lipid fibers formed by sphingosine. 1993 Biochim. Biophys. Acta pmid:8443231
Kanfer JN and McCartney DG Modulation of the serine base exchange enzyme activity of rat brain membranes by amphiphilic cations and amphiphilic anions. 1993 J. Neurochem. pmid:8455023
Hirschberg K et al. The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. 1993 Biochem. J. pmid:8457204
Crow T and Forrester J Down-regulation of protein kinase C and kinase inhibitors dissociate short- and long-term enhancement produced by one-trial conditioning of Hermissenda. 1993 J. Neurophysiol. pmid:8459291
Ladenson RC et al. Utilization of exogenously supplied sphingosine analogues for sphingolipid biosynthesis in Chinese hamster ovary and mouse LM cell fibroblasts. 1993 J. Biol. Chem. pmid:8463295
Bayat-Sarmadi M and Houdebine LM Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin. 1993 Mol. Cell. Endocrinol. pmid:8472863
Kim HS et al. Sphingosine blocks both membrane fusion and calmodulin-dependent phosphorylation of the 100-kDa protein of chick embryonic myoblasts. 1993 Exp. Cell Res. pmid:8482346
Reston JT et al. Differential effects of the phorbol ester TPA on DNA-mediated transfection in a variety of cell lines. 1993 Biochim. Biophys. Acta pmid:8485168
Mäkelä JH and Isomaa B Perturbation of the platelet plasma membrane is not sufficient for inhibition of thrombin-induced PKC-activity. 1993 Chem. Biol. Interact. pmid:8485783
Riboni L et al. Metabolism of exogenous ganglioside GM1 in cultured cerebellar granule cells. The fatty acid and sphingosine moieties formed during degradation are re-used for lipid biosynthesis. 1993 FEBS Lett. pmid:8486159
Soares-da-Silva P Enhanced protein kinase C mediated inhibition of renal dopamine synthesis during high sodium intake. 1993 Biochem. Pharmacol. pmid:8494538
Downing DT et al. Interaction between sphingosine and cholesteryl sulfate in epidermal lipids. 1993 J. Lipid Res. pmid:8496662
Yule DI et al. Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells. 1993 J. Biol. Chem. pmid:8509375
Sabbadini R et al. Sphingosine is endogenous to cardiac and skeletal muscle. 1993 Biochem. Biophys. Res. Commun. pmid:8512573
Sugiyama E et al. Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells. 1993 J. Biochem. pmid:8514735
Nishio H and Mori K Reinvestigation of the structure of the esterified cerebroside in the epidermis of guinea pigs. 1995 Biosci. Biotechnol. Biochem. pmid:8520108
Nishio H and Mori K Synthesis of the esterified cerebroside in the epidermis of guinea pigs. 1995 Biosci. Biotechnol. Biochem. pmid:8520109
Sugita M et al. Structural elucidation of two novel amphoteric glycosphingolipids from the earthworm, Pheretima hilgendorfi. 1995 Biochim. Biophys. Acta pmid:8541328
Bouhours JF and Bouhours D Biochemical characterization of blood group-active glycosphingolipids. 1995 Transfus Clin Biol pmid:8542020
Lee TC et al. Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels. 1996 J. Biol. Chem. pmid:8550561
Fatatis A and Miller RJ Sphingosine and sphingosine 1-phosphate differentially modulate platelet-derived growth factor-BB-induced Ca2+ signaling in transformed oligodendrocytes. 1996 J. Biol. Chem. pmid:8550576
Lauritzen L and Hansen HS Differential phospholipid-labeling suggests two subtypes of phospholipase D in rat Leydig cells. 1995 Biochem. Biophys. Res. Commun. pmid:8554594
Cao YZ et al. The mechanism of sphingosine enhancement of phorbol ester-mediated phospholipase D activation in lymphocytes. 1995 Biochem. Biophys. Res. Commun. pmid:8554615
Yatomi Y et al. N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. 1996 Biochemistry pmid:8555236
Shah J et al. Structural and thermotropic properties of synthetic C16:0 (palmitoyl) ceramide: effect of hydration. 1995 J. Lipid Res. pmid:8558082
Katoh N Inhibition by phospholipids, lysophospholipids and gangliosides of melittin-induced phosphorylation in bovine mammary gland. 1995 Toxicology pmid:8560504
Latinis KM and Koretzky GA Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. 1996 Blood pmid:8562955
van Koppen C et al. Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. 1996 J. Biol. Chem. pmid:8567663
Campbell XZ and Neet KE Hierarchical analysis of the nerve growth factor-dependent and nerve growth factor-independent differentiation signaling pathways in PC12 cells with protein kinase inhibitors. 1995 J. Neurosci. Res. pmid:8568921
Mayhan WG and Didion SP Activation of protein kinase C does not participate in disruption of the blood-brain barrier to albumin during acute hypertension. 1995 Brain Res. pmid:8574657
Casellato R et al. Isolation and structural characterization of N-acetyl- and N-glycolylneuraminic-acid-containing GalNAc-GD1a isomers, IV4GalNAcIV3Neu5AcII3Neu5GcGgOse4Cer and IV4GalNAcIV3Neu5GcII3Neu5AcGgOse4Cer, from bovine brain. 1995 Eur. J. Biochem. pmid:8575436
Nakamura S et al. Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. 1996 J. Biol. Chem. pmid:8576106
Inooka S and Toyokuni T Sphingosine transfer in cell-to-cell interaction. 1996 Biochem. Biophys. Res. Commun. pmid:8579607
Maulik PR and Shipley GG X-ray diffraction and calorimetric study of N-lignoceryl sphingomyelin membranes. 1995 Biophys. J. pmid:8580334
Prelusky DB et al. Pilot study on the plasma pharmacokinetics of fumonisin B1 in cows following a single dose by oral gavage or intravenous administration. 1995 Nat. Toxins pmid:8581325
Gumprecht LA et al. Effects of intravenous fumonisin B1 in rabbits: nephrotoxicity and sphingolipid alterations. 1995 Nat. Toxins pmid:8581326
Abbas HK et al. Biological activities of synthetic analogues of Alternaria alternata toxin (AAL-toxin) and fumonisin in plant and mammalian cell cultures. 1995 Phytochemistry pmid:8590636
Verheij M et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. 1996 Nature pmid:8598911
Nickels JT and Broach JR A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. 1996 Genes Dev. pmid:8600023
Suzuki S et al. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. 1996 Transplantation pmid:8600623
Sun L et al. A new wound healing agent--sphingosylphosphorylcholine. 1996 J. Invest. Dermatol. pmid:8601721
Choi OH et al. Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. 1996 Nature pmid:8602265
Okajima F et al. Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cells. 1996 FEBS Lett. pmid:8603702
Scalia R et al. Myocardial protection by N,N,N-trimethylsphingosine in ischemia reperfusion injury is mediated by inhibition of P-selectin. 1996 J. Leukoc. Biol. pmid:8604008
Karasavvas N et al. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. 1996 Eur. J. Biochem. pmid:8612651
Yamamura S et al. Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells. 1996 FEBS Lett. pmid:8612751
Wu WI and Carman GM Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by phospholipids. 1996 Biochemistry pmid:8620000
Sweeney EA et al. Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. 1996 Int. J. Cancer pmid:8621258
Wang W et al. Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8622958
Zanglis A et al. The biological activity of acetylated sphingosylphosphorylcholine derivatives. 1996 Int. J. Biochem. Cell Biol. pmid:8624845
Jarvis WD et al. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. 1996 J. Biol. Chem. pmid:8626522
Welsh N Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. 1996 J. Biol. Chem. pmid:8626526
Sakano S et al. Ca2+ mobilizing action of sphingosine in Jurkat human leukemia T cells. Evidence that sphingosine releases Ca2+ from inositol trisphosphate- and phosphatidic acid-sensitive intracellular stores through a mechanism independent of inositol trisphosphate. 1996 J. Biol. Chem. pmid:8626660
Wiesner DA and Dawson G Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. 1996 J. Neurochem. pmid:8627293
Sakakura C et al. Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation. 1996 FEBS Lett. pmid:8635587
McKay C and Miller A Relationship among cellular diacylglycerol, sphingosine formation, protein kinase C activity, and parathyroid hormone secretion from dispersed bovine parathyroid cells. 1996 Endocrinology pmid:8641201
Coroneos E et al. Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades. 1996 Biochem. J. pmid:8645194
Pyne S et al. Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle. 1996 Eur. J. Biochem. pmid:8647130
Payne CD et al. Cholesterol sulfate protects Candida albicans from inhibition by sphingosine in vitro. 1996 J. Invest. Dermatol. pmid:8648192
Van Koppen CJ et al. A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils. 1996 Mol. Pharmacol. pmid:8649355
Yang SD et al. Okadaic acid, sphingosine, and phorbol ester reversibly modulate heat induction on protein kinase FA/GSK-3 alpha in A431 cells. 1996 J. Cell. Biochem. pmid:8655632
Cuvillier O et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. 1996 Nature pmid:8657285
Yoo HS et al. Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity. 1996 Toxicol. Appl. Pharmacol. pmid:8658522
Meacci E et al. Bradykinin increases ceramide and sphingosine content in human fibroblasts: possible involvement of glycosphingolipids. 1996 Biochem. Biophys. Res. Commun. pmid:8660316
Carfagna MA et al. Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation. 1996 Toxicol. Appl. Pharmacol. pmid:8661342
Abe A et al. A novel enzyme that catalyzes the esterification of N-acetylsphingosine. Metabolism of C2-ceramides. 1996 J. Biol. Chem. pmid:8662981
Hirschberg K et al. Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis. 1996 J. Biol. Chem. pmid:8663007
Waggoner DW et al. Phosphatidate phosphohydrolase catalyzes the hydrolysis of ceramide 1-phosphate, lysophosphatidate, and sphingosine 1-phosphate. 1996 J. Biol. Chem. pmid:8663293