sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Röder B et al. The determination of phytosphingosine-containing globotriaosylceramide from human kidney in the presence of lactosylceramide. 1990 Chem. Phys. Lipids pmid:2162261
Lowe JH et al. Sphingosine differentially inhibits activation of the Na+/H+ exchanger by phorbol esters and growth factors. 1990 J. Biol. Chem. pmid:2158991
Ulisse S et al. A novel mechanism of action of corticotropin releasing factor in rat Leydig cells. 1990 J. Biol. Chem. pmid:2153673
Fiore S et al. Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils. 1990 Biochem. J. pmid:2155608
Rotem R et al. Protein kinase C is present in human sperm: possible role in flagellar motility. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2402510
Peters-Golden M et al. Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung. 1990 J. Immunol. pmid:2160499
Gorin E et al. Evidence for a role of protein kinase C in the stimulation of lipolysis by growth hormone and isoproterenol. 1990 Endocrinology pmid:2161742
Winicov I et al. Sphingosine interacts directly with the receptor complex to inhibit thyrotropin-releasing hormone binding. 1990 Endocrinology pmid:2106432
Junco M et al. Substrate-dependent inhibition of protein kinase C by specific inhibitors. 1990 FEBS Lett. pmid:2332048
Kojima I et al. Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells. 1990 J. Biol. Chem. pmid:2120207
Suen CS and Wilk S Rapid inactivation and phosphorylation of pyroglutamyl peptidase II in Y-79 human retinoblastoma cells after exposure to phorbol ester. 1990 Endocrinology pmid:1979029
Elliott MS and Crane DL Protein kinase C modulation of queuine uptake in cultured human fibroblasts. 1990 Biochem. Biophys. Res. Commun. pmid:2118349
Warner JA and MacGlashan DW Signal transduction events in human basophils. A comparative study of the role of protein kinase C in basophils activated by anti-IgE antibody and formyl-methionyl-leucyl-phenylalanine. 1990 J. Immunol. pmid:1697313
Moraru II et al. Protein kinase C controls Fc gamma receptor-mediated endocytosis in human neutrophils. 1990 FEBS Lett. pmid:2147663
Gat-Yablonski G and Sagi-Eisenberg R Differential down-regulation of protein kinase C selectively affects IgE-dependent exocytosis and inositol trisphosphate formation. 1990 Biochem. J. pmid:2241900
Karniguian A et al. Collagen-induced platelet activation mainly involves the protein kinase C pathway. 1990 Biochem. J. pmid:2163606
Inui K et al. Study of pathogenesis in twitcher mouse, an enzymatically authentic model of Krabbe's disease. 1990 J. Neurol. Sci. pmid:2128519
Taketomi T et al. New approach for characterization of lysosulfatide by TLC, fast atom bombardment mass spectrometry and NMR spectroscopy. 1990 J. Biochem. pmid:2398033
Igarashi Y et al. A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. 1990 J. Biol. Chem. pmid:2318819
Khan WA et al. Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. 1990 Biochem. Biophys. Res. Commun. pmid:2241961
Cambray-Deakin MA et al. Neuritogenesis in cerebellar granule cells in vitro: a role for protein kinase C. 1990 Brain Res. Dev. Brain Res. pmid:2190715
Radin NS Preparative scale isolation of sphingosine. 1990 J. Lipid Res. pmid:2090723
Crane JK et al. Carbachol mimics phorbol esters in its ability to enhance cyclic GMP production by STa, the heat-stable toxin of Escherichia coli. 1990 FEBS Lett. pmid:2174803
Karrenbauer A et al. The rate of bulk flow from the Golgi to the plasma membrane. 1990 Cell pmid:2208286
Messing RO et al. Protein kinase C participates in up-regulation of dihydropyridine-sensitive calcium channels by ethanol. 1990 J. Neurochem. pmid:2168938
Lauener RP et al. Engagement of the monocyte surface antigen CD14 induces lymphocyte function-associated antigen-1/intercellular adhesion molecule-1-dependent homotypic adhesion. 1990 J. Immunol. pmid:1696596
Sugiya H and Furuyama S Sphingosine increases inositol trisphosphate in rat parotid acinar cells by a mechanism that is independent of protein kinase C but dependent on extracellular calcium. 1990 Cell Calcium pmid:2272081
Igisu H et al. Binding of galactosylsphingosine (psychosine) by albumin. 1990 Lipids pmid:2325508
Greenberg P et al. Human acid beta-glucosidase: use of sphingosyl and N-alkyl-glucosylamine inhibitors to investigate the properties of the active site. 1990 Biochim. Biophys. Acta pmid:2141287
Kiss Z and Anderson WB ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine. 1990 J. Biol. Chem. pmid:2185245
Sgarna R et al. Sphingosine inhibition of tyrosine aminotransferase and tryptophan oxygenase induction by dexamethasone in primary culture of rat hepatocytes. 1990 Biochem. Biophys. Res. Commun. pmid:1970728
Chakrabarti AK et al. Regulation of the calcium-activated neutral proteinase (CANP) of bovine brain by myelin lipids. 1990 Biochim. Biophys. Acta pmid:2331482
Ramachandran CK et al. Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts. 1990 Biochem. Biophys. Res. Commun. pmid:2157410
Lavie Y and Liscovitch M Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells. 1990 J. Biol. Chem. pmid:2303483
Rice WR et al. P2-purinoceptor regulation of surfactant phosphatidylcholine secretion. Relative roles of calcium and protein kinase C. 1990 Biochem. J. pmid:2317195
Honma Y et al. Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemia K562 cells. 1990 Jpn. J. Cancer Res. pmid:2125038
Satoh T and Endou H Inhibitory effect of phorbol ester on sodium transport in frog urinary bladder. 1990 Am. J. Physiol. pmid:2168677
Trinchera M et al. Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver. 1990 Biochem. J. pmid:2241913
Tachikawa E et al. Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells. 1990 Biochem. Pharmacol. pmid:2121147
Winkel GK et al. Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo. 1990 Dev. Biol. pmid:2407575
Gbarah A et al. Involvement of protein kinase C in activation of human granulocytes and peritoneal macrophages by type 1 fimbriated (mannose specific) Escherichia coli. 1989 Biochem. Biophys. Res. Commun. pmid:2575378
Smal J and De Meyts P Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes. 1989 Proc. Natl. Acad. Sci. U.S.A. pmid:2660145
Kobayashi T et al. Metabolism of free sphingoid bases in murine tissues and in cultured human fibroblasts. 1989 Eur. J. Biochem. pmid:2606103
Hwong CL et al. Phorbol ester transiently increases topoisomerase I mRNA levels in human skin fibroblasts. 1989 J. Biol. Chem. pmid:2549041
Bedoy CA and Mobley PL Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors. 1989 Brain Res. pmid:2548656
Messmer TO et al. Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins. 1989 J. Nutr. pmid:2495341
Weiss BA et al. Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells. 1989 Mol. Pharmacol. pmid:2549387
Swann K et al. Evidence for an inhibitory effect of protein kinase C on G-protein-mediated repetitive calcium transients in hamster eggs. 1989 EMBO J. pmid:2510999
Reinhold DS and Neet KE The lack of a role for protein kinase C in neurite extension and in the induction of ornithine decarboxylase by nerve growth factor in PC12 cells. 1989 J. Biol. Chem. pmid:2914963
Simpson RU et al. 1,25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C. 1989 J. Biol. Chem. pmid:2684961
Krishnamurthi S et al. Weak inhibition of protein kinase C coupled with various non-specific effects make sphingosine an unsuitable tool in platelet signal transduction studies. 1989 Biochim. Biophys. Acta pmid:2492201
Gordon PR and Gilchrest BA Human melanogenesis is stimulated by diacylglycerol. 1989 J. Invest. Dermatol. pmid:2794552
Ling BN and Eaton DC Effects of luminal Na+ on single Na+ channels in A6 cells, a regulatory role for protein kinase C. 1989 Am. J. Physiol. pmid:2544105
Bixby JL Protein kinase C is involved in laminin stimulation of neurite outgrowth. 1989 Neuron pmid:2561968
Stinavage P and Spitznagel JK Oxygen-independent antimicrobial action in sphingosine-treated neutrophils. 1989 J. Immunol. Methods pmid:2557368
Gerrard JM et al. A role for protein kinase C in the membrane fusion necessary for platelet granule secretion. 1989 Blood pmid:2553164
Martinez R and Gillies RJ Dimethylsulfoxide modifies the sensitivity of BALB/c-3T3 cells to the activation of Na+/H+ exchange by phorbol esters. 1989 J. Cell. Physiol. pmid:2540208
Ware JA et al. Response of aequorin-loaded platelets to activators of protein kinase C. 1989 Am. J. Physiol. pmid:2912135
Bertorello A and Aperia A Na+-K+-ATPase is an effector protein for protein kinase C in renal proximal tubule cells. 1989 Am. J. Physiol. pmid:2537029
Wertz PW and Downing DT Free sphingosines in porcine epidermis. 1989 Biochim. Biophys. Acta pmid:2930769
Kolesnick RN Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells. 1989 J. Biol. Chem. pmid:2540198
Gillies RJ et al. Sphingosine inhibits phorbol 12-myristate 13-acetate-, but not serum-induced, activation of Na+/H+ exchange in mammalian cells. 1989 J. Cell. Physiol. pmid:2540207
Conn PJ et al. Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia. 1989 J. Neurosci. pmid:2918372
Corradetti R et al. The protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (H-7) disinhibits CA1 pyramidal cells in rat hippocampal slices. 1989 Br. J. Pharmacol. pmid:2611497
Mills GB et al. Role of protein kinase C in interleukin 1, anti-T3, and mitogenic lectin-induced interleukin 2 secretion. 1989 J. Cell. Physiol. pmid:2808540
Van Veldhoven PP et al. A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. 1989 J. Lipid Res. pmid:2754341
Igarashi Y and Hakomori S Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine: N-methyltransferase in mouse brain. 1989 Biochem. Biophys. Res. Commun. pmid:2686639
Leyravaud S et al. Biosynthesis of paf-acether. X. Phorbol myristate acetate-induced paf-acether biosynthesis and acetyltransferase activation in human neutrophils. 1989 J. Immunol. pmid:2732470
Robertson DG et al. Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding. 1989 J. Biol. Chem. pmid:2651433
Toda K et al. Accumulation of lysosulfatide (sulfogalactosylsphingosine) in tissues of a boy with metachromatic leukodystrophy. 1989 Biochem. Biophys. Res. Commun. pmid:2539117
Pfannkuche HJ et al. Regulation of prostaglandin synthesis by protein kinase C in mouse peritoneal macrophages. 1989 Biochem. J. pmid:2764884
Vartanian T et al. Phosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP. 1989 Glia pmid:2478466
Hannun YA and Bell RM Regulation of protein kinase C by sphingosine and lysosphingolipids. 1989 Clin. Chim. Acta pmid:2695275
Tanaka K et al. The twitcher mouse: accumulation of galactosylsphingosine and pathology of the central nervous system. 1989 Brain Res. pmid:2706492
Sugawara T and Narisada M An efficient, stereoselective synthesis of 4-E- and 4-Z-D-erythro-sphingenine and related compounds from 2-amino-2-deoxy-D-glucose. 1989 Carbohydr. Res. pmid:2620296
Stinavage P et al. O antigen and lipid A phosphoryl groups in resistance of Salmonella typhimurium LT-2 to nonoxidative killing in human polymorphonuclear neutrophils. 1989 Infect. Immun. pmid:2478480
Van Veldhoven PP et al. Enzymatic quantification of sphingosine in the picomole range in cultured cells. 1989 Anal. Biochem. pmid:2559626
Conkling PR et al. Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. 1989 J. Biol. Chem. pmid:2808383
Rosengren B et al. Lysosulfatide (galactosylsphingosine-3-O-sulfate) from metachromatic leukodystrophy and normal human brain. 1989 J. Neurochem. pmid:2926387
Reddy SS and Kahn CR Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome. 1989 J. Clin. Invest. pmid:2808704
Bussolino F et al. Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1). 1989 J. Biol. Chem. pmid:2600088
Draznin B et al. Mechanism of insulin resistance induced by sustained levels of cytosolic free calcium in rat adipocytes. 1989 Endocrinology pmid:2551647
O'Flaherty JT and Jacobson D Protein kinase C blockers and neutrophil receptors for leukotriene B4. 1989 Biochem. Biophys. Res. Commun. pmid:2551291
Bottega R et al. Inhibition of protein kinase C by sphingosine correlates with the presence of positive charge. 1989 Biochem. Biophys. Res. Commun. pmid:2803286
Petty HR Regulation of RAW264 macrophage morphology and spreading: studies with protein kinase C activators, inhibitors and a cyclic AMP analog. 1989 Biochim. Biophys. Acta pmid:2547441
Wedegaertner PB and Gill GN Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor. 1989 J. Biol. Chem. pmid:2661557
Mattila P et al. Protein kinase C is crucial in signal transduction during IFN-gamma induction in endothelial cells. 1989 FEBS Lett. pmid:2546804
Slife CW et al. Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum. 1989 J. Biol. Chem. pmid:2499578
Hattori R et al. Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface. 1989 J. Biol. Chem. pmid:2470750
Szamel M et al. Activation signals in human lymphocytes. Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C. 1989 J. Immunol. pmid:2530278
Kawase T and Suzuki A Fluoride-induced cytoplasmic acidification: possible role of protein kinase C in BCECF-loaded L929 cells. 1989 Pharmacol. Toxicol. pmid:2771869
Sparling ML et al. Analysis of membrane lipids by 500 MHz 1H NMR. 1989 Anal. Biochem. pmid:2729581
Bader MF et al. A reassessment of guanine nucleotide effects on catecholamine secretion from permeabilized adrenal chromaffin cells. 1989 J. Biol. Chem. pmid:2674132
Agam G et al. Thrombin-induced platelet aggregation is affected by external Na+ independently of the Na+/H+ exchange. 1989 FEBS Lett. pmid:2538349
Merrill AH and Stevens VL Modulation of protein kinase C and diverse cell functions by sphingosine--a pharmacologically interesting compound linking sphingolipids and signal transduction. 1989 Biochim. Biophys. Acta pmid:2643437
Hannun YA and Bell RM Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. 1989 Science pmid:2643164
Stevens VL et al. Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3. 1989 Cancer Res. pmid:2720676
Sakane F et al. Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol. 1989 FEBS Lett. pmid:2551742
Whatley RE et al. The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C. 1989 J. Biol. Chem. pmid:2703492
Nakadate T et al. H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells. 1989 Mol. Pharmacol. pmid:2601687