sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Postma FR et al. Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. 1996 EMBO J. pmid:8665846
Kadokami T et al. Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1 beta in vivo. 1996 Circulation pmid:8674178
Uhrig ML et al. Characterization of inositolphospholipids in Trypanosoma cruzi trypomastigote forms. 1996 Biochim. Biophys. Acta pmid:8679689
Rotter BA et al. Response of growing swine to dietary exposure to pure fumonisin B1 during an eight-week period: growth and clinical parameters. 1996 Nat. Toxins pmid:8680753
Spiegel S and Milstien S Sphingoid bases and phospholipase D activation. 1996 Chem. Phys. Lipids pmid:8681426
Ng KH and Lanéelle MA Lipids of the yeast Hansenula anomala. 1977 Biochimie pmid:870084
Son H and Carpenter DO Protein kinase C activation is necessary but not sufficient for induction of long-term potentiation at the synapse of mossy fiber-CA3 in the rat hippocampus. 1996 Neuroscience pmid:8730701
Aussel C et al. Sphingosine, oleylamine and stearylamine inhibit both CD11a/CD18-dependent and -independent homotypic aggregation: demonstration by cytofluorimetry. 1995 Immunol. Lett. pmid:8747715
Wakita H et al. Inhibitors of sphingolipid synthesis modulate interferon (IFN)-gamma-induced intercellular adhesion molecule (ICAM)-1 and human leukocyte antigen (HLA)-DR expression on cultured normal human keratinocytes: possible involvement of ceramide in biologic action of IFN-gamma. 1996 J. Invest. Dermatol. pmid:8751967
Murata Y et al. Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? 1996 J. Invest. Dermatol. pmid:8752664
Tokura Y et al. Th2 suppressor cells are more susceptible to sphingosine than Th1 cells in murine contact photosensitivity. 1996 J. Invest. Dermatol. pmid:8752836
Meacci E et al. Activation of phospholipase D in human fibroblasts by ceramide and sphingosine: evaluation of their modulatory role in bradykinin stimulation of phospholipase D. 1996 Biochem. Biophys. Res. Commun. pmid:8753774
Sachs CW et al. Effects of sphingosine stereoisomers on P-glycoprotein phosphorylation and vinblastine accumulation in multidrug-resistant MCF-7 cells. 1996 Biochem. Pharmacol. pmid:8759033
Hägerstrand H et al. Vesiculation induced by amphiphiles and ionophore A23187 in porcine platelets: a transmission electron microscopic study. 1996 Chem. Biol. Interact. pmid:8760393
Mallampalli RK et al. Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP:cholinephosphate cytidylyltransferase activity in adult rat lung. 1996 Biochem. J. pmid:8761490
Riboni L et al. Salvage of catabolic products in ganglioside metabolism: a study on rat cerebellar granule cells in culture. 1996 FEBS Lett. pmid:8765002
Sabała P et al. Sphingosine stimulates calcium mobilization and modulates calcium signals evoked by thapsigargin in glioma C6 cells. 1996 Acta Neurobiol Exp (Wars) pmid:8768300
Huang WC and Chueh SH Calcium mobilization from the intracellular mitochondrial and nonmitochondrial stores of the rat cerebellum. 1996 Brain Res. pmid:8773778
Yasui K and Palade P Sphingolipid actions on sodium and calcium currents of rat ventricular myocytes. 1996 Am. J. Physiol. pmid:8779930
Shephard GS et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. 1996 Toxicon pmid:8783447
Bünemann M et al. Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate. 1995 J. Physiol. (Lond.) pmid:8788935
Berger A et al. Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity. 1996 Mol. Pharmacol. pmid:8794881
Murohara T et al. Effects of sphingomyelinase and sphingosine on arterial vasomotor regulation. 1996 J. Lipid Res. pmid:8827530
Spangelo BL and Jarvis WD Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. 1996 Endocrinology pmid:8828503
Kawamura A et al. Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. 1996 Bioorg. Med. Chem. pmid:8831974
Abbas HK and Riley RT The presence and phytotoxicity of fumonisins and AAL-toxin in Alternaria alternata. 1996 Toxicon pmid:8835341
Crossman MW and Hirschberg CB Biosynthesis of phytosphingosine by the rat. 1977 J. Biol. Chem. pmid:885884
Usuki S et al. Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. 1996 J. Neurochem. pmid:8863486
Valsecchi M et al. Changes of free long-chain bases in neuronal cells during differentiation and aging in culture. 1996 J. Neurochem. pmid:8863491
Hashizume T et al. Sphingosine enhances phosphatidylinositol 4-kinase activity in rabbit platelets. 1996 J. Biochem. pmid:8864845
Tolan D et al. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. 1996 Br. J. Pharmacol. pmid:8886394
Enosawa S et al. Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720. 1996 Immunopharmacology pmid:8886861
Suzuki S et al. Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats. 1996 Transpl. Immunol. pmid:8893458
Kaipia A et al. Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. 1996 Endocrinology pmid:8895358
Bünemann M et al. A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. 1996 EMBO J. pmid:8896446
Mizushima N et al. Ceramide induces apoptosis via CPP32 activation. 1996 FEBS Lett. pmid:8898109
Murad S and Kishimoto Y alpha-Hydroxylation of fatty acid in brain. Effects of cerebroside components on the synthesis of cerebronic acid. 1977 Biochim. Biophys. Acta pmid:889850
Yeung JM et al. Fumonisin B1 induces protein kinase C translocation via direct interaction with diacylglycerol binding site. 1996 Toxicol. Appl. Pharmacol. pmid:8917690
Boring DL et al. Cerebrodiene, arachidonyl-ethanolamide, and hybrid structures: potential for interaction with brain cannabinoid receptors. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8931121
Witty JP et al. Induction of apoptotic cell death in hen granulosa cells by ceramide. 1996 Endocrinology pmid:8940345
Sasaki JI et al. Sphingosine inhibition of NADPH oxidase activation in a cell-free system. 1996 J. Biochem. pmid:8947830
Hung WC and Chuang LY Induction of apoptosis by sphingosine-1-phosphate in human hepatoma cells is associated with enhanced expression of bax gene product. 1996 Biochem. Biophys. Res. Commun. pmid:8954076
Yang L et al. Activation of protein-tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate. 1996 Biochem. Biophys. Res. Commun. pmid:8954916
Orlati S et al. Sphingosine-induced inhibition of capacitative calcium influx in CFPAC-1 cells. 1996 Cell Calcium pmid:8955554
Inooka S and Toyokuni T Use of fumonisin B1 to test the intercellular transfer of sphingosine. 1996 Cell. Signal. pmid:8958448
Hartzell HC and Rinderknecht A Calphostin C, a widely used protein kinase C inhibitor, directly and potently blocks L-type Ca channels. 1996 Am. J. Physiol. pmid:8967428
Premakumara GA et al. Isolation of a non-steroidal contragestative agent from Sri Lankan marine red alga, Gelidiella acerosa. 1996 Contraception pmid:8968667
Okajima F et al. Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling. 1997 Endocrinology pmid:8977407
Groener JE et al. Metabolic fate of oleic acid derived from lysosomal degradation of cholesteryl oleate in human fibroblasts. 1996 J. Lipid Res. pmid:8978478
Kennedy SD et al. Measurement of in vitro P-selectin expression by flow cytometry. 1997 Am. J. Clin. Pathol. pmid:8980375
Krown KA et al. Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. 1996 J. Clin. Invest. pmid:8981934
Badiani K et al. Effect of fumonisin B1 on phosphatidylethanolamine biosynthesis in Chinese hamster ovary cells. 1996 Biochim. Biophys. Acta pmid:8982265
Chung T et al. ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate. 1997 J. Biol. Chem. pmid:9006957
Suzuki S et al. The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720. 1997 Clin. Exp. Immunol. pmid:9010264
Suzuki S et al. A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. 1996 Immunology pmid:9014815
Crowther GJ and Lynch DV Characterization of sphinganine kinase activity in corn shoot microsomes. 1997 Arch. Biochem. Biophys. pmid:9016824
Fatatis A and Miller RJ Platelet-derived growth factor (PDGF)-induced Ca2+ signaling in the CG4 oligodendroglial cell line and in transformed oligodendrocytes expressing the beta-PDGF receptor. 1997 J. Biol. Chem. pmid:9020156
Ducibella T and LeFevre L Study of protein kinase C antagonists on cortical granule exocytosis and cell-cycle resumption in fertilized mouse eggs. 1997 Mol. Reprod. Dev. pmid:9021753
Mano N et al. Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry. 1997 Anal. Biochem. pmid:9025946
Castegnaro M et al. Development of a new method for the analysis of sphinganine and sphingosine in urine and tissues. 1996 Nat. Toxins pmid:9029554
Oral H et al. Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte. 1997 J. Biol. Chem. pmid:9030540
Yatomi Y et al. Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid. 1997 J. Biol. Chem. pmid:9030602
Bansal SK et al. Increased levels of protein kinase C in lymphocytes in asthma: possible mechanism of regulation. 1997 Eur. Respir. J. pmid:9042625
Suchard SJ et al. Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes. 1997 Blood pmid:9058737
Yatomi Y et al. N,N-dimethylsphingosine phosphorylation in human platelets. 1997 Biochem. Biophys. Res. Commun. pmid:9070908
Betto R et al. Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes. 1997 Biochem. J. pmid:9078280
Oshima M et al. Combined gas chromatography-chemical ionization mass spectrometry of sphingolipids. I. Glucosyl sphingosine, ceramides and cerebrosides of the spleen in Gaucher's disease. 1977 Chem. Phys. Lipids pmid:908103
Yachida Y et al. Novel di-O-acetylated GM3s from equine erythrocytes, one containing 4,9-di-O-acetyl-N-glycolylneuraminic acid and another containing 4-O-acetyl-N-glycolylneuraminic acid and 6-O-acetyl-D-galactose. 1997 Carbohydr. Res. pmid:9090814
Nagiec MM et al. Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. 1997 J. Biol. Chem. pmid:9092515
Rani CS et al. Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. 1997 J. Biol. Chem. pmid:9099730
Chmura SJ et al. Loss of ceramide production confers resistance to radiation-induced apoptosis. 1997 Cancer Res. pmid:9102212
Vermelho AB et al. Heart muscle cells share common neutral glycosphingolipids with Trypanosoma cruzi. 1997 Acta Trop. pmid:9107361
García-Ruiz C et al. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. 1997 J. Biol. Chem. pmid:9111045
Yatomi Y et al. Distribution of sphingosine 1-phosphate, a bioactive sphingolipid, in rat tissues. 1997 FEBS Lett. pmid:9119058
Li XK et al. FTY720, a novel immunosuppressive agent, enhances upregulation of the cell adhesion molecular ICAM-1 in TNF-alpha treated human umbilical vein endothelial cells. Transplant. Proc. pmid:9123298
Li XK et al. Induction of lymphocyte apoptosis by a novel immunosuppressant FTY720: relation with Fas, Bcl-2 and Bax expression. Transplant. Proc. pmid:9123299
Törnquist K Sphingosine 1-phosphate stimulates Na+/H+ exchange in thyroid FRTL-5 cells. 1997 Am. J. Physiol. pmid:9124507
Keane RW et al. Activation of CPP32 during apoptosis of neurons and astrocytes. 1997 J. Neurosci. Res. pmid:9130145
Larocca JN et al. Induction of oligodendrocyte apoptosis by C2-ceramide. 1997 Neurochem. Res. pmid:9130266
Separovic D et al. Ceramide generation in response to photodynamic treatment of L5178Y mouse lymphoma cells. 1997 Cancer Res. pmid:9135014
Kwon OS et al. Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats. 1997 Mar-Apr Neurotoxicol Teratol pmid:9136132
Shirahama T et al. Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression. 1997 FEBS Lett. pmid:9141489
Longo CA et al. Sphingomyelin metabolism is developmentally regulated in rat lung. 1997 Am. J. Respir. Cell Mol. Biol. pmid:9160843
Iino M and Kisiel W Sphingosine-containing phospholipid vesicles support human factor VII autoactivation in the absence of tissue factor. 1996 Thromb. Res. pmid:9163065
Matecki A and Pawelczyk T Regulation of phospholipase C delta1 by sphingosine. 1997 Biochim. Biophys. Acta pmid:9168154
Shatrov VA et al. Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells. 1997 Biochem. Biophys. Res. Commun. pmid:9168973
Lehtonen JY et al. Characteristics of the binding of tacrine to acidic phospholipids. 1996 Biophys. J. pmid:9172742
Nakabo Y and Pabst MJ C2-ceramide and C6-ceramide inhibited priming for enhanced release of superoxide in monocytes, but had no effect on the killing of leukaemic cells by monocytes. 1997 Immunology pmid:9176098
Needleman DH et al. Modulation of skeletal muscle Ca2(+)-release channel activity by sphingosine. 1997 Am. J. Physiol. pmid:9176136
Im DS et al. Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes. 1997 Am. J. Physiol. pmid:9176218
Wang F et al. Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. 1997 Biochem. J. pmid:9182707
Sosnowski J et al. Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells. 1997 J. Urol. pmid:9186373
van Echten-Deckert G et al. cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. 1997 J. Biol. Chem. pmid:9188480
Pyne S et al. Sphingolipids as differential regulators of cellular signalling processes. 1997 Biochem. Soc. Trans. pmid:9191154
Yatomi Y et al. Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. 1997 J. Biochem. pmid:9192741
Futamura Y Amiodarone induces two different types of disorders in mouse alveolar macrophages. 1997 Jpn. J. Pharmacol. pmid:9195293
Qie L et al. Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids. 1997 J. Biol. Chem. pmid:9195906
Blakesley VA et al. Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk. 1997 J. Biol. Chem. pmid:9195921
Lai TS et al. Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. 1997 J. Biol. Chem. pmid:9195933
Shinkai M et al. Inhibitory action of sphingosine or ceramide on amylase secretion from isolated rat pancreatic acini. 1997 Biochem. Biophys. Res. Commun. pmid:9196062