| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meacci E et al. | Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. | 2000 | FEBS Lett. | pmid:11018530 |
| Todoroki-Ikeda N et al. | Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase. | 2000 | FEBS Lett. | pmid:11018528 |
| Morita Y et al. | Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. | 2000 | Nat. Med. | pmid:11017141 |
| Casper RF and Jurisicova A | Protecting the female germ line from cancer therapy. | 2000 | Nat. Med. | pmid:11017136 |
| Klapisz E et al. | Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2). | 2000 | J. Lipid Res. | pmid:11013311 |
| Nikolova Z et al. | The peripheral lymphocyte count predicts graft survival in DA to Lewis heterotopic heart transplantation treated with FTY720 and SDZ RAD. | 2000 | Transpl. Immunol. | pmid:11005317 |
| Müller-Wieprecht V et al. | Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor alpha and 1 alpha, 25-dihydroxyvitamin D(3). | 2000 | Arch. Dermatol. Res. | pmid:11000289 |
| Sonnino S and Chigorno V | Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures. | 2000 | Biochim. Biophys. Acta | pmid:10998569 |
| Amin HM et al. | Characterization of apoptosis induced by protein kinase C inhibitors and its modulation by the caspase pathway in acute promyelocytic leukaemia. | 2000 | Br. J. Haematol. | pmid:10997964 |
| Hirokawa M et al. | Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10997557 |
| Pahlavani MA and Vargas DM | The effect of a ceramide analog, N-acetylsphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats. | 2000 | Immunopharmacology | pmid:10996032 |
| Koshiba T et al. | Tolerance induction with FTY720 and donor-specific blood transfusion: discrepancy between heart transplantation and intestinal transplantation. | 2000 | Transplant. Proc. | pmid:10995936 |
| King CC et al. | p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). | 2000 | J. Biol. Chem. | pmid:10995762 |
| Van Veldhoven PP et al. | Do sphingoid bases interact with the peroxisome proliferator activated receptor alpha (PPAR-alpha)? | 2000 | Cell. Signal. | pmid:10989283 |
| Kozawa O et al. | p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts: sphingosine inhibits prostaglandin F(2alpha)-induced phosphoinositide hydrolysis. | 2000 | Cell. Signal. | pmid:10989278 |
| Yanagawa Y et al. | The significance of timing of FTY720 administration on the immunosuppressive effect to prolong rat skin allograft survival. | 2000 | Int. J. Immunopharmacol. | pmid:10988354 |
| Parrill AL et al. | Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. | 2000 | J. Biol. Chem. | pmid:10982820 |
| Muriel MP et al. | Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death. | 2000 | J. Comp. Neurol. | pmid:10982470 |
| van der Westhuizen L et al. | The effect of a single gavage dose of fumonisin B(1) on the sphinganine and sphingosine levels in vervet monkeys. | 2001 Feb-Mar | Toxicon | pmid:10978745 |
| Nagahara Y et al. | Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria. | 2000 | J. Immunol. | pmid:10975841 |
| Menné C et al. | Ceramide-induced TCR up-regulation. | 2000 | J. Immunol. | pmid:10975817 |
| Kwon OS et al. | Biochemical and morphological effects of fumonisin B(1) on primary cultures of rat cerebrum. | 2000 Jul-Aug | Neurotoxicol Teratol | pmid:10974595 |
| Nakajima N et al. | Expression and characterization of Edg-1 receptors in rat cardiomyocytes: calcium deregulation in response to sphingosine 1-phosphate. | 2000 | Eur. J. Biochem. | pmid:10971577 |
| Di Nardo A et al. | Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes. | 2000 | Br. J. Dermatol. | pmid:10971319 |
| Higuchi K et al. | The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. | 2000 | Biochem. J. | pmid:10970788 |
| Nava VE et al. | Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. | 2000 | Cancer Res. | pmid:10969794 |
| MacLennan AJ et al. | Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth. | 2000 | Dev. Neurosci. | pmid:10965150 |
| Jiang Z et al. | Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. | 2000 | Cell. Mol. Life Sci. | pmid:10961348 |
| Peyruchaud O and Mosher DF | Differential stimulation of signaling pathways initiated by Edg-2 in response to lysophosphatidic acid or sphingosine-1-phosphate. | 2000 | Cell. Mol. Life Sci. | pmid:10961347 |
| Kiuchi M et al. | Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols. | 2000 | J. Med. Chem. | pmid:10956203 |
| Young KW et al. | Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. | 2000 | J. Biol. Chem. | pmid:10954727 |
| Fukunaga T et al. | Implication of sphingolipid metabolism in the stability of the Golgi apparatus. | 2000 | J. Cell. Sci. | pmid:10954427 |
| Alemany R et al. | Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation. | 2000 | Mol. Pharmacol. | pmid:10953041 |
| Bischoff A et al. | Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. | 2000 | Br. J. Pharmacol. | pmid:10952678 |
| Bischoff A et al. | Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. | 2000 | Br. J. Pharmacol. | pmid:10952677 |
| Pitson SM et al. | Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase. | 2000 | J. Biol. Chem. | pmid:10944534 |
| Okamoto H et al. | Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. | 2000 | Thromb. Res. | pmid:10942792 |
| Davaille J et al. | Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. | 2000 | J. Biol. Chem. | pmid:10942778 |
| Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
| Brunk UT | Lysosomotropic detergents induce time- and dose-dependent apoptosis/necrosis in cultured cells. | 2000 | Redox Rep. | pmid:10939278 |
| Zhang J et al. | FTY720 in combination with CsA inhibits islet xenograft rejection: a study in the pig-to-rat model. | 2000 | Transplant. Proc. | pmid:10936327 |
| Dawson G et al. | Selective phosphotyrosine phosphatase inhibition and increased ceramide formation is associated with B-cell death by apoptosis. | 2000 | FEBS Lett. | pmid:10930574 |
| Orvisky E et al. | Glucosylsphingosine accumulation in mice and patients with type 2 Gaucher disease begins early in gestation. | 2000 | Pediatr. Res. | pmid:10926300 |
| Devijver C et al. | (2R,3R,7Z)-2-Aminotetradec-7-ene-1,3-diol, a new amino alcohol from the caribbean sponge Haliclona vansoesti. | 2000 | J. Nat. Prod. | pmid:10924178 |
| Kawaguchi M et al. | Cerebrosides in grapevine leaves: distinct composition of sphingoid bases among the grapevine species having different tolerances to freezing temperature. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10923800 |
| Sadeghlar F et al. | Cell type specific localization of sphingomyelin biosynthesis. | 2000 | FEBS Lett. | pmid:10922460 |
| Igarashi J and Michel T | Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. | 2000 | J. Biol. Chem. | pmid:10921915 |
| Allan D et al. | Mechanisms by which short-chain ceramides cause apoptosis. | 1999 | Biochem. Soc. Trans. | pmid:10917615 |
| Pyne S et al. | Extracellular actions of sphingosine I-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis. | 1999 | Biochem. Soc. Trans. | pmid:10917611 |
| Takeshita A et al. | Selective stimulation by ceramide of the expression of the alpha isoform of retinoic acid and retinoid X receptors in osteoblastic cells. A role of sphingosine 1-phosphate-mediated AP-1 in the ligand-dependent transcriptional activity of these receptors. | 2000 | J. Biol. Chem. | pmid:10915783 |
| Ikeda H et al. | Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10915638 |
| Bose R and Kolesnick R | Measurement of ceramide synthase activity. | 2000 | Meth. Enzymol. | pmid:10914032 |
| Kozawa O et al. | Sphingosine 1-phosphate amplifies phosphoinositide hydrolysis stimulated by prostaglandin f2 alpha in osteoblasts: involvement of p38MAP kinase. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913228 |
| Kupperman E et al. | A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. | 2000 | Nature | pmid:10910360 |
| Driever W | Developmental biology. Bringing two hearts together. | 2000 | Nature | pmid:10910341 |
| Nikolova Z et al. | Prevention of graft vessel disease by combined FTY720/cyclosporine. A treatment in a rat carotid artery transplantation model. | 2000 | Transplantation | pmid:10910272 |
| Himmel HM et al. | Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. | 2000 | Mol. Pharmacol. | pmid:10908314 |
| Mao C et al. | Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. | 2000 | J. Biol. Chem. | pmid:10900202 |
| Souktani R et al. | Induction of apoptosis using sphingolipids activates a chloride current in Xenopus laevis oocytes. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10898727 |
| Yanai N et al. | Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers. | 2000 | Blood | pmid:10891442 |
| Bobeszko M et al. | Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester. | 2000 | Cell. Signal. | pmid:10889469 |
| O'Byrne D and Sansom D | Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells. | 2000 | Immunology | pmid:10886399 |
| Pignata C et al. | Clustering of distinct autoimmune diseases associated with functional abnormalities of T cell survival in children. | 2000 | Clin. Exp. Immunol. | pmid:10886239 |
| Ohashi Y et al. | Squid nerve sphingomyelin containing an unusual sphingoid base. | 2000 | J. Lipid Res. | pmid:10884294 |
| Funakoshi T et al. | Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells. | 2000 | J. Biol. Chem. | pmid:10882735 |
| Carpio LC et al. | Changes in sphingolipid levels induced by epidermal growth factor in osteoblastic cells. Effects of these metabolites on cytosolic calcium levels. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10882186 |
| López-Marure R et al. | Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levels. | 2000 | Eur. J. Biochem. | pmid:10880954 |
| Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling in mammalian cells. | 2000 | Biochem. J. | pmid:10880336 |
| Spiegel S and Milstien S | Sphingosine-1-phosphate: signaling inside and out. | 2000 | FEBS Lett. | pmid:10878250 |
| Sugiyama A et al. | Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system. | 2000 | Jpn. J. Pharmacol. | pmid:10875754 |
| Liu R et al. | 1,25 dihydroxyvitamin D(3) activates sphingomyelin turnover in ROS17/2.8 osteosarcoma cells without sphingolipid-induced changes in cytosolic Ca(2+). | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873570 |
| Racké K et al. | Potential role of EDG receptors and lysophospholipids as their endogenous ligands in the respiratory tract. | 2000 | Pulm Pharmacol Ther | pmid:10873548 |
| Loukaci A et al. | New lipids from the tunicate Cystodytes cf. dellechiajei, as PLA2 inhibitors. | 2000 | J. Nat. Prod. | pmid:10869204 |
| Siess W et al. | Lysophosphatidic acid and sphingosine 1-phosphate: two lipid villains provoking cardiovascular diseases? | 2000 | IUBMB Life | pmid:10868905 |
| Chigorno V et al. | Evidence that ganglioside enriched domains are distinct from caveolae in MDCK II and human fibroblast cells in culture. | 2000 | Eur. J. Biochem. | pmid:10866823 |
| Murata N et al. | Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay. | 2000 | Anal. Biochem. | pmid:10860507 |
| Shin Y et al. | Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. | 2000 | Cell Calcium | pmid:10859593 |
| Mandala SM et al. | Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10859351 |
| Campbell V and Lynch MA | The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes. | 2000 | Cytokine | pmid:10857764 |
| Friant S et al. | Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis. | 2000 | EMBO J. | pmid:10856229 |
| Zanolari B et al. | Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. | 2000 | EMBO J. | pmid:10856228 |
| Cooke ME et al. | Contraction of collagen matrices mediated by alpha2beta1A and alpha(v)beta3 integrins. | 2000 | J. Cell. Sci. | pmid:10852817 |
| Caligan TB et al. | A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. | 2000 | Anal. Biochem. | pmid:10847608 |
| Boguslawski G et al. | Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833459 |
| Fujisawa K et al. | Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo. | 2000 | Placenta | pmid:10833370 |
| Hanada K et al. | D-Serine inhibits serine palmitoyltransferase, the enzyme catalyzing the initial step of sphingolipid biosynthesis. | 2000 | FEBS Lett. | pmid:10828452 |
| Posey SC et al. | Failure of gelsolin overexpression to regulate lymphocyte apoptosis. | 2000 | Blood | pmid:10828033 |
| Enomoto A et al. | Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. | 2000 | Cancer Lett. | pmid:10822128 |
| Nagahara Y et al. | Evidence that FTY720 induces T cell apoptosis in vivo. | 2000 | Immunopharmacology | pmid:10822091 |
| Yagi H et al. | Immunosuppressant FTY720 inhibits thymocyte emigration. | 2000 | Eur. J. Immunol. | pmid:10820391 |
| Pinschewer DD et al. | FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. | 2000 | J. Immunol. | pmid:10820254 |
| Gennero I et al. | Effect of sphingosine-1-phosphate and analogues of lysophosphatidic acid on mesangial cell proliferation. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818478 |
| Gallois C et al. | Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818472 |
| Liliom K et al. | Sphingosylphosphorylcholine is a bona fide mediator regulating heart rate. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818471 |
| Yamamura S et al. | Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818470 |
| Ancellin N and Hla T | Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818459 |
| Spiegel S | Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818441 |
| Hla T et al. | Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818438 |
| Katz SM et al. | New immunosuppressive agents. | 2000 | Transplant. Proc. | pmid:10812142 |
| Kanazawa T et al. | Inhibition of cytokinesis by a lipid metabolite, psychosine. | 2000 | J. Cell Biol. | pmid:10811833 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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