sphingosine

sphingosine is a lipid of Sphingolipids (SP) class.

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Current reference collection contains 26061 references associated with sphingosine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Burgoyne RD et al. A major role for protein kinase C in calcium-activated exocytosis in permeabilised adrenal chromaffin cells. 1988 FEBS Lett. pmid:3169247
Hamanaka S et al. Occurrence of galactosylceramide in pig epidermal cells. 1988 Biochim. Biophys. Acta pmid:3401502
Connor JA et al. Sustained dendritic gradients of Ca2+ induced by excitatory amino acids in CA1 hippocampal neurons. 1988 Science pmid:2452481
Lambeth JD et al. Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst. 1988 J. Biol. Chem. pmid:2831206
Merrill AH et al. Quantitation of free sphingosine in liver by high-performance liquid chromatography. 1988 Anal. Biochem. pmid:3407935
Igisu H et al. Inhibition of cytochrome c oxidase and hemolysis caused by lysosphingolipids. 1988 Lipids pmid:2840545
Wahl M and Carpenter G Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C. 1988 J. Biol. Chem. pmid:3259577
Fan XD et al. Interferon-gamma-induced transcriptional activation is mediated by protein kinase C. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3134657
Shu C and Selmanoff M Phorbol esters potentiate rapid dopamine release from median eminence and striatal synaptosomes. 1988 Endocrinology pmid:3131121
Wilson E et al. Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors. 1988 J. Biol. Chem. pmid:3132460
Winicov I and Gershengorn MC Sphingosine inhibits thyrotropin-releasing hormone binding to pituitary cells by a mechanism independent of protein kinase C. 1988 J. Biol. Chem. pmid:3137221
Trinchera M et al. Different metabolic recycling of the lipid components of exogenous sulphatide in human fibroblasts. 1988 Biochem. J. pmid:3415659
Canonico PL et al. Phorbol esters attenuate glutamate-stimulated inositol phospholipid hydrolysis in neuronal cultures. 1988 J. Neurochem. pmid:2901459
Phatak PD et al. Protein kinase C modulates actin conformation in human T lymphocytes. 1988 J. Immunol. pmid:3262672
Linnebjerg H et al. Inhibition by amiloride and by Na+-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells. 1988 FEBS Lett. pmid:2461320
Tyagi SR et al. Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst. 1988 J. Biol. Chem. pmid:2843513
Civan MM et al. Insulin and phorbol ester stimulate conductive Na+ transport through a common pathway. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3277184
Weikel CS et al. Phorbol esters specifically enhance the cytolytic activity of Entamoeba histolytica. 1988 Infect. Immun. pmid:2897334
Hall FL et al. Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C. 1988 J. Biol. Chem. pmid:3162237
Faucher M et al. Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells. 1988 J. Biol. Chem. pmid:3162730
Rider LG et al. Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils. 1988 J. Immunol. pmid:2826587
Tanaka K et al. The twitcher mouse: accumulation of galactosylsphingosine and pathology of the sciatic nerve. 1988 Brain Res. pmid:3409017
Kobayashi T et al. Free sphingoid bases in normal murine tissues. 1988 Eur. J. Biochem. pmid:3350021
Medlock KA and Merrill AH Rapid turnover of sphingosine synthesized de novo from [14C]serine by Chinese hamster ovary cells. 1988 Biochem. Biophys. Res. Commun. pmid:3143361
Malinow R et al. Persistent protein kinase activity underlying long-term potentiation. 1988 Nature pmid:2847049
Kobayashi T et al. Infantile and fetal globoid cell leukodystrophy: analysis of galactosylceramide and galactosylsphingosine. 1988 Ann. Neurol. pmid:3239954
Jefferson AB and Schulman H Sphingosine inhibits calmodulin-dependent enzymes. 1988 J. Biol. Chem. pmid:2844804
Grove DS and Mastro AM Prevention of the TPA-mediated down-regulation of protein kinase C. 1988 Biochem. Biophys. Res. Commun. pmid:3348799
Slivka SR et al. Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C. 1988 J. Biol. Chem. pmid:2842326
Northwood IC and Davis RJ Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization. 1988 J. Biol. Chem. pmid:2836384
Chow SC et al. Phosphoinositide breakdown and evidence for protein kinase C involvement during human NK killing. 1988 Cell. Immunol. pmid:2836072
Mitsuo K et al. A high-performance liquid chromatographic assay for acid ceramidase activity in cultured fibroblasts from patients with Farber's disease and from controls. 1988 Clin. Chim. Acta pmid:3383428
Davis RJ et al. Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor. 1988 J. Biol. Chem. pmid:3258597
Bruzik KS Conformation of the polar headgroup of sphingomyelin and its analogues. 1988 Biochim. Biophys. Acta pmid:3355820
Siffert W and Akkerman JW Protein kinase C enhances Ca2+ mobilization in human platelets by activating Na+/H+ exchange. 1988 J. Biol. Chem. pmid:2831223
Sanchez A et al. Thrombin-induced changes of intracellular [Ca2+] and pH in human platelets. Cytoplasmic alkalinization is not a prerequisite for calcium mobilization. 1988 Biochim. Biophys. Acta pmid:2831984
Hirabayashi Y et al. A novel glycosphingolipid hydrolyzing enzyme, glycosphingolipid ceramide deacylase, which cleaves the linkage between the fatty acid and sphingosine base in glycosphingolipids. 1988 J. Biochem. pmid:3360750
Bell RM et al. Protein kinase C regulation by sphingosine/lysosphingolipids. 1988 Cold Spring Harb. Symp. Quant. Biol. pmid:3076075
Gupta AK et al. Sphingosine inhibits phorbol ester-induced inflammation, ornithine decarboxylase activity, and activation of protein kinase C in mouse skin. 1988 J. Invest. Dermatol. pmid:3171222
Badwey JA et al. Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release. 1988 J. Biol. Chem. pmid:2830263
Hannun YA et al. Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. 1987 J. Biol. Chem. pmid:3115982
Nutter LM et al. Induction of virus enzymes by phorbol esters and n-butyrate in Epstein-Barr virus genome-carrying Raji cells. 1987 Cancer Res. pmid:3038311
Yasugi E et al. Branched long chain bases in cerebrosides of the guinea pig Harderian gland. 1987 J. Biochem. pmid:3448092
Bouchon B et al. Selective enrichment of phytosphingosine in glycosphingolipids of isolated human thyrocytes as compared to the whole thyroid. 1987 Biochem. Biophys. Res. Commun. pmid:3566758
Pittet D et al. Nonselective inhibition of neutrophil functions by sphinganine. 1987 J. Biol. Chem. pmid:3038865
Hope MJ and Cullis PR Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. 1987 J. Biol. Chem. pmid:3558410
Sripada PK et al. Partial synthesis and properties of a series of N-acyl sphingomyelins. 1987 J. Lipid Res. pmid:3611973
Ichioka T et al. Hematopoietic cell transplantation in murine globoid cell leukodystrophy (the twitcher mouse): effects on levels of galactosylceramidase, psychosine, and galactocerebrosides. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:2884662
Goda S et al. Hydrolysis of galactosylsphingosine and lactosylsphingosine by beta-galactosidases in human brain and cultured fibroblasts. 1987 Biochim. Biophys. Acta pmid:3111543
Hannun YA and Bell RM Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. 1987 Science pmid:3101176
Kobayashi T et al. Globoid cell leukodystrophy is a generalized galactosylsphingosine (psychosine) storage disease. 1987 Biochem. Biophys. Res. Commun. pmid:3579916
Ichioka T et al. Simultaneous determination of psychosine and cerebrosides. 1987 Anal. Biochem. pmid:3674406
Shinoda H et al. Accumulation of galactosylsphingosine (psychosine) in the twitcher mouse: determination by HPLC. 1987 J. Neurochem. pmid:3585345
McIntyre TM et al. Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils. 1987 J. Biol. Chem. pmid:2824456
Vaccarino F et al. Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:2825205
Osiecki-Newman K et al. Human acid beta-glucosidase: use of inhibitors, alternative substrates and amphiphiles to investigate the properties of the normal and Gaucher disease active sites. 1987 Biochim. Biophys. Acta pmid:2956992
Bazzi MD and Nelsestuen GL Mechanism of protein kinase C inhibition by sphingosine. 1987 Biochem. Biophys. Res. Commun. pmid:3606616
Inagaki F et al. Analysis of NMR spectra of sugar chains of glycolipids by multiple relayed COSY and 2D homonuclear Hartman-Hahn spectroscopy. 1987 FEBS Lett. pmid:3803612
Madden TD et al. Modelling the biological membrane. 1987 Biochem. Soc. Trans. pmid:3556743
Wertz PW and Downing DT Covalently bound omega-hydroxyacylsphingosine in the stratum corneum. 1987 Biochim. Biophys. Acta pmid:3790600
Wilson E et al. Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils. 1987 Arch. Biochem. Biophys. pmid:2825597
Taki T et al. A ganglioside of rat ascites hepatoma AH 7974F cells. Occurrence of a novel disialoganglioside (GD1 alpha) with a unique N-acetylneuraminosyl (alpha 2-6)-N-acetylgalactosamine structure. 1986 J. Biol. Chem. pmid:3949760
Nelson DH and Murray DK Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose. 1986 Biochem. Biophys. Res. Commun. pmid:3527163
Miyagi T and Tsuiki S Evidence for sialidase hydrolyzing gangliosides GM2 and GM1 in rat liver plasma membrane. 1986 FEBS Lett. pmid:3758350
Merrill AH and Wang E Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). 1986 J. Biol. Chem. pmid:3081509
Hara A and Taketomi T Chemical properties and stereoisomerism of heterogeneous long chain bases in lysosphingolipids by positive ion fast atom bombardment mass spectrometry and carbon-13 NMR spectroscopy. 1986 J. Biochem. pmid:3782058
Merrill AH et al. Differences in the long chain (sphingoid) base composition of sphingomyelin from rats bearing Morris hepatoma 7777. 1986 Lipids pmid:3762323
Igisu H and Nakamura M Inhibition of cytochrome c oxidase by psychosine (galactosylsphingosine). 1986 Biochem. Biophys. Res. Commun. pmid:3013184
Hannun YA et al. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. 1986 J. Biol. Chem. pmid:3462188
Wilson E et al. Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. 1986 J. Biol. Chem. pmid:3017982
Merrill AH et al. Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. 1986 J. Biol. Chem. pmid:3462189
Chatterjee S et al. Regulation of synthesis of lactosylceramide and long chain bases in normal and familial hypercholesterolemic cultured proximal tubular cells. 1986 J. Biol. Chem. pmid:3759973
Wertz PW and Downing DT Covalent attachment of omega-hydroxyacid derivatives to epidermal macromolecules: a preliminary characterization. 1986 Biochem. Biophys. Res. Commun. pmid:3729963
Vermelho AB et al. Isolation and characterization of a neutral glycosphingolipid from the epimastigote form of Trypanosoma mega. 1986 J. Protozool. pmid:3735150
MÃ¥nsson JE et al. Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line. 1986 FEBS Lett. pmid:3011500
Araki S et al. Characterization of a diphosphonopentaosylceramide containing 3-O-methylgalactose from the skin of Aplysia kurodai (sea hare) 1986 J. Biol. Chem. pmid:3957918
Bouhours D and Bouhours JF Developmental changes of the lipidic part of the neutral glycosphingolipids of the rat stomach. 1985 J. Biol. Chem. pmid:3972786
Nilsson O et al. Glycosphingolipid studies of visceral tissues and brain from type 1 Gaucher disease variants. 1985 Clin. Genet. pmid:3924448
Nishio H et al. Analysis of fatty acids and sphingosines from urinary sulfatides in a patient with metachromatic leukodystrophy by gas chromatography-mass spectrometry. 1985 Brain Dev. pmid:3832951
Wertz PW et al. The composition of the ceramides from human stratum corneum and from comedones. 1985 J. Invest. Dermatol. pmid:3158712
Egge H et al. Analysis of gangliosides using fast atom bombardment mass spectrometry. 1985 Chem. Phys. Lipids pmid:4017133
LaMarco KL and Glew RH Galactosylsphingosine inhibition of the broad-specificity cytosolic beta-glucosidase of human liver. 1985 Arch. Biochem. Biophys. pmid:3918500
Bankov I and Barrett J Sphingomyelin synthesis in Hymenolepis diminuta (Cestoda). 1985 Mol. Biochem. Parasitol. pmid:2993879
Grabowski GA et al. Gaucher disease types 1, 2, and 3: differential mutations of the acid beta-glucosidase active site identified with conduritol B epoxide derivatives and sphingosine. 1985 Am. J. Hum. Genet. pmid:4003396
Sarmientos F et al. Direct evidence by carbon-13 NMR spectroscopy for the erythro configuration of the sphingoid moiety in Gaucher cerebroside and other natural sphingolipids. 1985 Eur. J. Biochem. pmid:3967657
Igisu H and Suzuki K Progressive accumulation of toxic metabolite in a genetic leukodystrophy. 1984 Science pmid:6719111
Kaya K et al. On the formation of alpha-hydroxy fatty acids. Evidence for a direct hydroxylation of nonhydroxy fatty acid-containing sphingolipids. 1984 J. Biol. Chem. pmid:6423633
Bouhours D and Bouhours JF Phytosphingosine in intestinal glycolipids of the rat fetus. 1984 Biochim. Biophys. Acta pmid:6733126
Li YT et al. Isolation and characterization of a novel phytosphingosine-containing GM2 ganglioside from mullet roe (Mugil cephalus). 1984 J. Biol. Chem. pmid:6746635
Igisu H and Suzuki K Analysis of galactosylsphingosine (psychosine) in the brain. 1984 J. Lipid Res. pmid:6491533
Okada S et al. Use of a fluorescent analogue of galactocerebroside for assay of galactocerebroside beta-galactosidase activity in skin fibroblasts from patients with Krabbe's disease. 1984 Clin. Chim. Acta pmid:6692566
Sonnino S et al. High performance liquid chromatography preparation of the molecular species of GM1 and GD1a gangliosides with homogeneous long chain base composition. 1984 J. Lipid Res. pmid:6747465
Crossman MW and Hirschberg CB Conversion of erythro-D-sphinganine to its [1-2H1] and [1-3H1] derivatives. 1984 J. Lipid Res. pmid:6481245
Soltysiak RM et al. D,L-alpha-Fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells. 1984 Biochim. Biophys. Acta pmid:6696931
Crossman MW and Hirschberg CB Biosynthesis of 4D-hydroxysphinganine by the rat. En bloc incorporation of the sphinganine carbon backbone. 1984 Biochim. Biophys. Acta pmid:6477953
Nishimura K et al. Molecular species of monoglycosylceramides in embryonic and adult Japanese quail intestine. 1984 Biochim. Biophys. Acta pmid:6509078
Higgins TJ Simplified fluorometric assay for sphingosine bases. 1984 J. Lipid Res. pmid:6491534
Williams RD et al. Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes. 1984 Arch. Biochem. Biophys. pmid:6421234
Bouhours JF and Bouhours D Identification of free ceramide in human erythrocyte membrane. 1984 J. Lipid Res. pmid:6747464
Radin NS Biosynthesis of the sphingoid bases: a provocation. 1984 J. Lipid Res. pmid:6442338