| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Knapp KM and English BK | Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. | 2000 | J. Leukoc. Biol. | pmid:10811015 |
| Xu Y et al. | Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. | 2000 | Nat. Cell Biol. | pmid:10806476 |
| Tavarini S et al. | Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. | 2000 | Neurosci. Lett. | pmid:10806317 |
| Nava VE et al. | Functional characterization of human sphingosine kinase-1. | 2000 | FEBS Lett. | pmid:10802064 |
| Raisova M et al. | Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. | 2000 | FEBS Lett. | pmid:10802053 |
| Meacci E et al. | Receptor-activated phospholipase D is present in caveolin-3-enriched light membranes of C2C12 myotubes. | 2000 | FEBS Lett. | pmid:10802049 |
| Goetzl EJ et al. | Cutting edge: differential constitutive expression of functional receptors for lysophosphatidic acid by human blood lymphocytes. | 2000 | J. Immunol. | pmid:10799850 |
| Meadows KA et al. | Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. | 2000 | J. Cell. Physiol. | pmid:10797307 |
| Kimura T et al. | Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. | 2000 | Biochem. J. | pmid:10794715 |
| De Nadai C et al. | Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792026 |
| Miura Y et al. | Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. | 2000 | J. Biochem. | pmid:10788802 |
| Takao N et al. | Protective roles for ATM in cellular response to oxidative stress. | 2000 | FEBS Lett. | pmid:10781820 |
| Brandwagt BF et al. | A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781105 |
| Tomita H et al. | Ceramide-induced cell death in cultured rat retinal pigment epithelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10778806 |
| Holopainen JM et al. | Dimyristoylphosphatidylcholine/C16:0-ceramide binary liposomes studied by differential scanning calorimetry and wide- and small-angle x-ray scattering. | 2000 | Biophys. J. | pmid:10777742 |
| Paolucci C et al. | Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way. | 2000 | J. Biol. Chem. | pmid:10777484 |
| Prinetti A et al. | Sphingolipid-enriched membrane domains from rat cerebellar granule cells differentiated in culture. A compositional study. | 2000 | J. Biol. Chem. | pmid:10766784 |
| Chung N et al. | Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. | 2000 | J. Biol. Chem. | pmid:10764732 |
| Panetti TS et al. | Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10764666 |
| Basu M et al. | Ceramide glycanase activities in human cancer cells. | 1999 | Biosci. Rep. | pmid:10763812 |
| Spiegel S and Milstien S | Functions of a new family of sphingosine-1-phosphate receptors. | 2000 | Biochim. Biophys. Acta | pmid:10760461 |
| Yeh MW et al. | Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. | 2000 | J. Immunol. | pmid:10754324 |
| Van Brocklyn JR et al. | Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. | 2000 | Blood | pmid:10753843 |
| Ahmed N and Berridge MV | Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. | 2000 | Pharmacol. Toxicol. | pmid:10752668 |
| Liu H et al. | Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. | 2000 | J. Biol. Chem. | pmid:10751414 |
| King CC et al. | Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. | 2000 | J. Biol. Chem. | pmid:10748151 |
| Cuvillier O et al. | Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. | 2000 | J. Biol. Chem. | pmid:10747891 |
| Brás A et al. | Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. | 2000 | Cell Death Differ. | pmid:10745271 |
| Chan C and Goldkorn T | Ceramide path in human lung cell death. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10745027 |
| Chin TY and Chueh SH | Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells. | 2000 | Br. J. Pharmacol. | pmid:10742292 |
| Cho S and Dawson G | Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. | 2000 | J. Neurochem. | pmid:10737604 |
| Sun E et al. | Apoptotic cells actively inhibit the expression of CD69 on Con A activated T lymphocytes. | 2000 | Scand. J. Immunol. | pmid:10736091 |
| Kim HS et al. | Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733907 |
| Perry DK et al. | Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. | 2000 | J. Biol. Chem. | pmid:10722759 |
| Kondo T et al. | Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. | 2000 | J. Biol. Chem. | pmid:10722733 |
| Hanada K et al. | Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques. | 2000 | J. Biol. Chem. | pmid:10722674 |
| Lobner D | Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? | 2000 | J. Neurosci. Methods | pmid:10720679 |
| Dawson G | Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. | 2000 Apr-Jun | Int. J. Dev. Neurosci. | pmid:10715579 |
| Yuzawa K et al. | FTY720 blocks allograft rejection by homing of lymphocytes in vivo. | 2000 | Transplant. Proc. | pmid:10715413 |
| Fujita T et al. | Antibody against a novel, myriocin (ISP-I)-based immunosuppressant, FTY720. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10714494 |
| Gable K et al. | Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. | 2000 | J. Biol. Chem. | pmid:10713067 |
| Lee H et al. | Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10712250 |
| Kitabayashi H et al. | FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10710126 |
| Kasinrerk W et al. | CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C-dependent pathway. | 2000 | Immunol. Lett. | pmid:10709783 |
| Bodennec J et al. | Purification of free sphingoid bases by solid-phase extraction on weak cation exchanger cartridges. | 2000 | Anal. Biochem. | pmid:10706795 |
| Zhang Y et al. | Effect of synthetic sialyl 2-->1 sphingosine and other glycosylsphingosines on the structure and function of the "glycosphingolipid signaling domain (GSD)" in mouse melanoma B16 cells. | 2000 | Biochemistry | pmid:10704195 |
| Galve-Roperh I et al. | Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. | 2000 | Nat. Med. | pmid:10700234 |
| Migita K et al. | Regulation of rheumatoid synovial cell growth by ceramide. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10694479 |
| Motohashi K et al. | Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate. | 2000 | FEBS Lett. | pmid:10692584 |
| Matsuura M et al. | Effect of FTY720, a novel immunosuppressant, on adjuvant- and collagen-induced arthritis in rats. | 2000 | Int. J. Immunopharmacol. | pmid:10689105 |
| Napoli KL | The FTY720 story. | 2000 | Ther Drug Monit | pmid:10688258 |
| Orlati S et al. | Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. | 2000 | Arch. Biochem. Biophys. | pmid:10683250 |
| Mihai R et al. | C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679256 |
| Yamazaki Y et al. | Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679247 |
| Tsushima H and Mori M | In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats. | 2000 | Brain Res. | pmid:10678764 |
| Mizuta K et al. | Effect of pretreatment with FTY720 and cyclosporin on ischaemia-reperfusion injury of the liver in rats. | 1999 | J. Pharm. Pharmacol. | pmid:10678498 |
| Salinas M et al. | Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. | 2000 | Mol. Cell. Neurosci. | pmid:10673324 |
| Kristal BS and Brown AM | Ganglioside GD3, the mitochondrial permeability transition, and apoptosis. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672258 |
| Carpio LC et al. | Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670688 |
| Furukawa H et al. | Prolongation of canine liver allograft survival by a novel immunosuppressant, FTY720: effect of monotherapy and combined treatment with conventional drugs. | 2000 | Transplantation | pmid:10670633 |
| Niwa M et al. | Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production. | 2000 | Life Sci. | pmid:10666000 |
| Jarvis WD and Grant S | Protein kinase C targeting in antineoplastic treatment strategies. | 1999 | Invest New Drugs | pmid:10665476 |
| Brinkmann V et al. | FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation. | 2000 | Trends Pharmacol. Sci. | pmid:10664606 |
| Tamura A et al. | Immunosuppressive therapy using FTY720 combined with tacrolimus in rat liver transplantation. | 2000 | Surgery | pmid:10660758 |
| Sharma C et al. | Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. | 2000 | Chem. Phys. Lipids | pmid:10660207 |
| van der Westhuizen L et al. | Sphinganine/sphingosine ratio in plasma and urine as a possible biomarker for fumonisin exposure in humans in rural areas of Africa. | 1999 | Food Chem. Toxicol. | pmid:10654591 |
| Craighead M et al. | Caspases mediate C2-ceramide-induced apoptosis of the human oligodendroglial cell line, MO3.13. | 2000 | Neurosci. Lett. | pmid:10653009 |
| Lee OH et al. | Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652210 |
| English D et al. | Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis. | 1999 | J. Hematother. Stem Cell Res. | pmid:10645770 |
| Liu J et al. | Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10644522 |
| Kurose S et al. | Effects of FTY720, a novel immunosuppressant, on experimental autoimmune uveoretinitis in rats. | 2000 | Exp. Eye Res. | pmid:10644416 |
| Allan D | Lipid metabolic changes caused by short-chain ceramides and the connection with apoptosis. | 2000 | Biochem. J. | pmid:10642519 |
| Denisova NA et al. | The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calcium "dysregulation" in PC12 cells. | 1999 | Free Radic. Biol. Med. | pmid:10641723 |
| Sato K et al. | Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells. | 1999 | Brain Res. Mol. Brain Res. | pmid:10640689 |
| Xu K and Thornalley PJ | Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10636242 |
| Wang F et al. | Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. | 1999 | Cancer Res. | pmid:10626811 |
| Micoli KJ et al. | Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. | 2000 | J. Biol. Chem. | pmid:10625668 |
| Sabatini M et al. | Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623638 |
| Ando M et al. | Non-steroidal anti-inflammatory drugs (NSAIDs) block the late, prostanoid-dependent/ceramide-independent component of ovarian IL-1 action: implications for the ovulatory process. | 1999 | Mol. Cell. Endocrinol. | pmid:10619394 |
| An S et al. | Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. | 2000 | J. Biol. Chem. | pmid:10617617 |
| Schürmann A et al. | p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. | 2000 | Mol. Cell. Biol. | pmid:10611223 |
| Quesniaux V et al. | A novel immunosuppressant, FTY720, induces peripheral lymphodepletion of both T- and B cells and immunosuppression in baboons. | 1999 | Transpl. Immunol. | pmid:10608298 |
| Susen K et al. | Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR). | 1999 | FEBS Lett. | pmid:10606727 |
| Yang SH and Hong CY | Trilinolein potentiates the pro-aggregating effect of phorbol-12-myristate 13-acetate in human polymorphonuclear leukocytes. | 1999 | Int. J. Immunopharmacol. | pmid:10606003 |
| Chuang FY et al. | Convergence of Fc gamma receptor IIA and Fc gamma receptor IIIB signaling pathways in human neutrophils. | 2000 | J. Immunol. | pmid:10605030 |
| Lynch KR and Im DS | Life on the edg. | 1999 | Trends Pharmacol. Sci. | pmid:10603487 |
| McNabb TJ et al. | The separation and direct detection of ceramides and sphingoid bases by normal-phase high-performance liquid chromatography and evaporative light-scattering detection. | 1999 | Anal. Biochem. | pmid:10603247 |
| Vasta V et al. | Sphingosine 1-phosphate induces arachidonic acid mobilization in A549 human lung adenocarcinoma cells. | 2000 | Biochim. Biophys. Acta | pmid:10601704 |
| Ogura M and Handa S | Induction of apoptosis by novel synthesized acylamides of human lymphocytes. | 2000 | Biochim. Biophys. Acta | pmid:10601700 |
| Veldman RJ et al. | Inhibition of P-glycoprotein activity and chemosensitization of multidrug-resistant ovarian carcinoma 2780AD cells by hexanoylglucosylceramide. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10600530 |
| Ito A et al. | Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells. | 1999 | Biochim. Biophys. Acta | pmid:10590315 |
| Wang F et al. | Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. | 1999 | J. Biol. Chem. | pmid:10585401 |
| Fujikawa K et al. | Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells. | 1999 | Exp. Cell Res. | pmid:10585289 |
| Ramstedt B et al. | Analysis of natural and synthetic sphingomyelins using high-performance thin-layer chromatography. | 1999 | Eur. J. Biochem. | pmid:10583394 |
| Yang L et al. | Metabolism and functional effects of sphingolipids in blood cells. | 1999 | Br. J. Haematol. | pmid:10583213 |
| Rodrigues CO et al. | Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10581161 |
| Moolenaar WH | Bioactive lysophospholipids and their G protein-coupled receptors. | 1999 | Exp. Cell Res. | pmid:10579925 |
| Horton JW | Tumor necrosis factor-alpha, sphingosine, ceramide: which is the appropriate marker of inflammation? | 1999 | Crit. Care Med. | pmid:10579290 |
| Moore AN et al. | Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. | 1999 | Neuroscience | pmid:10579204 |
| Fujiwara I et al. | Prolongation of concordant xenograft survival by a newly developed drug, FTY720. | 1999 | Transplant. Proc. | pmid:10578306 |
sphingosine
sphingosine is a lipid of Sphingolipids (SP) class.
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